Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Crystal Structure of a Lipid G Protein–Coupled Receptor
2012 Science
Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
2009 StandoutScience
Lipid Rafts As a Membrane-Organizing Principle
2009 StandoutScience
Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network
2009
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice
2001 StandoutScienceNobel
Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi
2002 StandoutScience
The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist
2008 StandoutScience
Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ
2015
Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation
2015
Hallmarks of Cancer: The Next Generation
2011 Standout
Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs
2002
HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation
2015 Nature
Functional architecture of an intracellular membrane t-SNARE
2000 StandoutNatureNobel
C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p
2001
Control of somatic tissue differentiation by the long non-coding RNA TINCR
2012 StandoutNature
Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase
1998
Structure and function of the spleen
2005 Standout
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
2009
Sphingolipid transport in eukaryotic cells
2000
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis
2010 Standout
Sphingosine 1-Phosphate, Present in Serum-derived Lipoproteins, Activates Matriptase
2002
CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs
2006 Nature
The vascular S1P gradient—Cellular sources and biological significance
2008
A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
2010 Standout
De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway
2002
Finding a way out: lymphocyte egress from lymphoid organs
2007
Role for ELOVL3 and Fatty Acid Chain Length in Development of Hair and Skin Function
2004 StandoutNobel
Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation
2016
Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae
2000
Pathogenesis and therapy of psoriasis
2007 StandoutNature
Identification of a Mammalian Long Chain Fatty Acyl Elongase Regulated by Sterol Regulatory Element-binding Proteins
2001
International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature
2002
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment
2014
Sphingolipids and their metabolism in physiology and disease
2017 Standout
Sphingosine 1-Phosphate, a Key Cell Signaling Molecule
2002
Calcium Influx and Signaling in Yeast Stimulated by Intracellular Sphingosine 1-Phosphate Accumulation
2001
Lcb4p sphingoid base kinase localizes to the Golgi and late endosomes
2002
Sphingosine 1‐phosphate and its G protein‐coupled receptors constitute a multifunctional immunoregulatory system
2004
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
The therapeutic potential of modulating the ceramide/sphingomyelin pathway
2002
The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors
2002
Marked Perinatal Lethality and Cellular Signaling Deficits in Mice Null for the Two Sphingosine 1-Phosphate (S1P) Receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3
2002
Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival
2007
Systematic identification of regulatory proteins critical for T-cell activation
2003
Rapid gating and anion permeability of an intracellular aquaporin
1999 StandoutNatureNobel
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
2004 StandoutNature
FTY720 modulates human oligodendrocyte progenitor process extension and survival
2007
Genetic identification of exported proteins in Streptococcus pneumoniae
1993
Sphingosine 1-phosphate receptors
2001
Structure, Function, and Evolution of Proton-ATPases
1988
Immunosurveillance by Hematopoietic Progenitor Cells Trafficking through Blood, Lymph, and Peripheral Tissues
2007
FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity
2002
The Immunomodulator FTY720 Has a Direct Cytoprotective Effect in Oligodendrocyte Progenitors
2007
Enzymatic Measurement of Sphingosine 1-Phosphate
1999
Lymphangiogenesis in development and human disease
2005 StandoutNature
Structural and functional features of central nervous system lymphatic vessels
2015 StandoutNature
Identification of C18:1-Phytoceramide as the Candidate Lipid Mediator for Hydroxyurea Resistance in Yeast
2013
Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells
2001
HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes
2012
Molecular Basis of Sphingosine Kinase 1 Substrate Recognition and Catalysis
2013
Role for de Novo Sphingoid Base Biosynthesis in the Heat-induced Transient Cell Cycle Arrest of Saccharomyces cerevisiae
2001
Sphingosine kinases: A novel family of lipid kinases
2002
Sphingosine 1-phosphate signaling pathway in inner ear biology. New therapeutic strategies for hearing loss?
2015
Dual Functions of the Trans-2-Enoyl-CoA Reductase TER in the Sphingosine 1-Phosphate Metabolic Pathway and in Fatty Acid Elongation
2014
Diet–microbiota interactions as moderators of human metabolism
2016 StandoutNature
Cig30 and Pitx3 Genes Are Arranged in a Partially Overlapping Tail-to-Tail Array Resulting in Complementary Transcripts
1999
Misfolded Proteins and Retinal Dystrophies
2009
Sphingosine Kinases Are Not Required for Inflammatory Responses in Macrophages
2013
Meiotic Silencing by Unpaired DNA
2001
FTY720: Sphingosine 1-Phosphate Receptor-1 in the Control of Lymphocyte Egress and Endothelial Barrier Function
2004
Identification of Two Mammalian Reductases Involved in the Two-carbon Fatty Acyl Elongation Cascade
2003
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
Lipid signalling in disease
2008
Amelioration of Experimental Autoimmune Encephalomyelitis in Lewis Rats by FTY720 Treatment
2003
Membrane Fusion
2003 StandoutNobel
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules
2009
T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation
2008
FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system
2009
Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone
2004
Sphingosine-1-phosphate in chronic intestinal inflammation and cancer
2013
Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism
2015
Chemokine regulation of naıve T cell traffic in health and disease
2003
Lcb4p Is a Key Regulator of Ceramide Synthesis from Exogenous Long Chain Sphingoid Base in Saccharomyces cerevisiae
2003
Functional molecular masses of vacuolar membrane H+‐ATPase from Saccharomyces cerevisiae as studied by radiation inactivation analysis
1989 StandoutNobel
Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, phase I study
2003
Emergence of vancomycin tolerance in Streptococcus pneumoniae
1999 StandoutNatureNobel
Identification and Characterization of Saccharomyces cerevisiae Dihydrosphingosine-1-phosphate Phosphatase
1997
Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands
2002
Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis
2006
Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology
2007
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Sphingosine 1-Phosphate and Isoform-specific Activation of Phosphoinositide 3-Kinase β
2001
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015 StandoutNature
A Dominant Complement Fixation Pathway for Pneumococcal Polysaccharides Initiated by SIGN-R1 Interacting with C1q
2006 StandoutNobel
Defining a role for sphingosine kinase 1 in p53-dependent tumors
2011
Structural and functional characteristics of S1P receptors
2004
A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy
2001
Sphingosine 1-Phosphate Induces Membrane Ruffling and Increases Motility of Human Umbilical Vein Endothelial Cells via Vascular Endothelial Growth Factor Receptor and CrkII
2002
Spinster Homolog 2 (Spns2) Deficiency Causes Early Onset Progressive Hearing Loss
2014
Immunosuppressive Drugs for Kidney Transplantation
2004 Standout
What's in the Pipeline? New Immunosuppressive Drugs in Transplantation
2002
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Sphingosine-1-phosphate: an enigmatic signalling lipid
2003 Standout
Ceramide synthases in biomedical research
2015
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
Ozanimod Induction and Maintenance Treatment for Ulcerative Colitis
2016
Sphingolipids and lysosomal pathologies
2013
Identification and Characterization of a Novel Human Sphingosine-1-phosphate Phosphohydrolase, hSPP2
2003
Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis
2007
Sphingosine-1-phosphate receptors and the development of the vascular system
2002
Sphingosine 1-Phosphate-induced Endothelial Cell Migration Requires the Expression of EDG-1 and EDG-3 Receptors and Rho-dependent Activation of αvβ3- and β1-containing Integrins
2001
TheDPL1Gene Is Involved in Mediating the Response to Nutrient Deprivation inSaccharomyces cerevisiae
1999
Electrospray Ionization Tandem Mass Spectrometry (Esi-Ms/Ms) Analysis of the Lipid Molecular Species Composition of Yeast Subcellular Membranes Reveals Acyl Chain-Based Sorting/Remodeling of Distinct Molecular Species En Route to the Plasma Membrane
1999
Salt Tolerance Conferred by Overexpression of a Vacuolar Na + /H + Antiport in Arabidopsis
1999 StandoutScience
Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival
1999
T cell-intrinsic S1PR1 regulates endogenous effector T-cell egress dynamics from lymph nodes during infection
2016
Development of Monocytes, Macrophages, and Dendritic Cells
2010 StandoutScience
Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist
2003
Lipid mediators of angiogenesis and the signalling pathways they initiate
2002
Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis
2009
Structural studies of the vacuolar membrane ATPase from Neurospora crassa and comparison with the tonoplast membrane ATPase from Zea mays.
1986
Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.
1988 Standout
Characterization of the subunit structure of the maize tonoplast ATPase. Immunological and inhibitor binding studies.
1986
Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis
2002
Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues
2005
Lipid phosphate phosphatase 3 enables efficient thymic egress
2011
Oral fingolimod (FTY720) in multiple sclerosis
2009
Isolation of genes encoding the Neurospora vacuolar ATPase. Analysis of vma-1 encoding the 67-kDa subunit reveals homology to other ATPases.
1988
Involvement of Long Chain Fatty Acid Elongation in the Trafficking of Secretory Vesicles in Yeast
1998
Suppression of Acid Sphingomyelinase Protects the Retina from Ischemic Injury
2016
The purified ATPase from chromaffin granule membranes is an anion-dependent proton pump.
1987
Characterization and function of catalytic subunit alpha of H+-translocating adenosine triphosphatase from vacuolar membranes of Saccharomyces cerevisiae. A study with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole.
1988 StandoutNobel
A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum
2010 StandoutNobel
Microbial Type I Fatty Acid Synthases (FAS): Major Players in a Network of Cellular FAS Systems
2004
Properties of the partially purified tonoplast H+-pumping ATPase from oat roots.
1986
Tonoplast energization: Two H+ pumps, one membrane
1987
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions
2000
Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids
2000
Identification of 3-O-(4-benzoyl)benzoyladenosine 5‘-triphosphate- and N,N‘-dicyclohexylcarbodiimide-binding subunits of a higher plant H+-translocating tonoplast ATPase.
1985
TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids
2014
Genetic dissection of polyunsaturated fatty acid synthesis in Caenorhabditis elegans
2002
The cDNA sequence of the 69-kDa subunit of the carrot vacuolar H+-ATPase. Homology to the beta-chain of F0F1-ATPases.
1988
Lysophospholipids--Receptor Revelations
2001 Science
Development of primer sets designed for use with the PCR to amplify conserved genes from filamentous ascomycetes
1995 Standout
Drugging Sphingosine Kinases
2014
Characterization and function of catalytic subunit alpha of H+-translocating adenosine triphosphatase from vacuolar membranes of Saccharomyces cerevisiae. A study with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole.
1988 StandoutNobel
Isolation and sequence of a cDNA clone encoding the 31-kDa subunit of bovine kidney vacuolar H+-ATPase.
1988
Sphingolipids as Targets for Treatment of Fungal Infections
2016
Role of a New Mammalian Gene Family in the Biosynthesis of Very Long Chain Fatty Acids and Sphingolipids
2000
Role for sphingosine kinase 1 in colon carcinogenesis
2008
Catalytic Asymmetric Conjugate Addition and Allylic Alkylation with Grignard Reagents
2008 StandoutNobel
H+-ATPases from mitochondria, plasma membranes, and vacuoles of fungal cells
1986
Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins
1998 StandoutNobel
Activation‐regulated expression and chemotactic function of sphingosine 1‐phosphate receptors in mouse splenic T cells
2002
Intracellular Role for Sphingosine Kinase 1 in Intestinal Adenoma Cell Proliferation
2006
Three-dimensional localization of T-cell receptors in relation to microvilli using a combination of superresolution microscopies
2016
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Sphingosine 1‐phosphate induces Chemotaxis of immature dendritic cells and modulates cytokine‐release in mature human dendritic cells for emergence of Th2 immune responses
2002
The therapeutic potential of modulating the ceramide/sphingomyelin pathway
2002
gem-Diacetates as Carbonyl Surrogates for Asymmetric Synthesis. Total Syntheses of Sphingofungins E and F
2001
Antibody to Langerin/CD207 localizes large numbers of CD8α + dendritic cells to the marginal zone of mouse spleen
2009 StandoutNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses
1999
The Sensitivity of Yeast Mutants to Oleic Acid Implicates the Peroxisome and Other Processes in Membrane Function
2006
Inhibitory Regulation of Rac Activation, Membrane Ruffling, and Cell Migration by the G Protein-Coupled Sphingosine-1-Phosphate Receptor EDG5 but Not EDG1 or EDG3
2000
CLEVER-1 mediates lymphocyte transmigration through vascular and lymphatic endothelium
2004
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
2012 StandoutNobel
Cutting Edge: Suppression of T Cell Chemotaxis by Sphingosine 1-Phosphate
2002
Works of Suzanne Mandala being referenced
Inhibition of Fungal Sphingolipid Biosynthesis by Rustmicin, Galbonolide B and Their New 21-Hydroxy Analogs.
1998
Identification of Leu276 of the S1P1 Receptor and Phe263 of the S1P3 Receptor in Interaction with Receptor Specific Agonists by Molecular Modeling, Site-Directed Mutagenesis, and Affinity Studies
2006
[35] Isolation and characterization of novel inhibitors of sphingolipid synthesis: Australifungin, viridiofungins, rustmicin, and khafrefungin
2000
Phytosphingosine 1-phosphate: a high affinity ligand for the S1P4/Edg-6 receptor
2002
The Discovery of Australifungin, a Novel Inhibitor of Sphinganine N-Acyltransferase from Sporormiella australis. Producing Organism, Fermentation, Isolation, and Biological Activity.
1995
Partial Purification of a Tonoplast ATPase from Corn Coleoptiles
1985
Essential role of sphingosine 1–phosphate receptor 2 in pathological angiogenesis of the mouse retina
2007
Sphingosine 1-phosphate receptor agonists attenuate relapsing–remitting experimental autoimmune encephalitis in SJL mice
2004
Proton Transport in Isolated Vacuoles from Corn Coleoptiles
1985
Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720
2004
Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8
2000
ELO2 and ELO3, Homologues of theSaccharomyces cerevisiae ELO1 Gene, Function in Fatty Acid Elongation and Are Required for Sphingolipid Formation
1997
Rustmicin, a Potent Antifungal Agent, Inhibits Sphingolipid Synthesis at Inositol Phosphoceramide Synthase
1998
Expression of the Sphingosine 1-Phosphate Receptor, S1P1, on T-cells Controls Thymic Emigration
2004
Sphingofungins F and F: Novel serinepalmitoyl transferase inhibitors from Paecilomyces variotii.
1992
Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death
2000
Sphingosine-1-Phosphate Phosphatases
2001
The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell–expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches
2005
Sphingosine-1-Phosphate Agonists Increase Macrophage Homing, Lymphocyte Contacts, and Endothelial Junctional Complex Formation in Murine Lymph Nodes
2005
Sphingoid base 1-phosphate phosphatase: A key regulator of sphingolipid metabolism and stress response
1998
Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
2002 StandoutScience
Characterization of Murine Sphingosine-1-phosphate Phosphohydrolase
2002
Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement
2005
Amino acid sequence of the plasma membrane ATPase of Neurospora crassa: deduction from genomic and cDNA sequences.
1986