Citation Impact
Citing Papers
Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor
2000 StandoutScience
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist
2008 StandoutScience
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT1B receptor
1999
EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins
1996 StandoutNobel
S. cerevisiae α pheromone receptors activate a novel signal transduction pathway for mating partner discrimination
1991 StandoutNobel
Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities
2005
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta
1999
Sequence Alignment of the G-Protein Coupled Receptor Superfamily
1992
Distribution and function of prostanoid receptors: studies from knockout mice
2000
Generation of a conditional allele of the mouse prostaglandin EP4 receptor
2004
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
A Mutation in the Second Transmembrane Region of the CB1 Receptor Selectively Disrupts G Protein Signaling and Prevents Receptor Internalization
1999
The Role of a Conserved Inter-Transmembrane Domain Interface in Regulating α2a-Adrenergic Receptor Conformational Stability and Cell-Surface Turnover
2001
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Involvement of Gs and Gi Proteins in Dual Coupling of the Luteinizing Hormone Receptor to Adenylyl Cyclase and Phospholipase C
1996
Immunology and immunotherapy approaches for prostate cancer
2007
ORL1, a novel member of the opioid receptor family
1994
Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid
1993 StandoutNature
Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors
2006
Related Contribution of Specific Helix 2 and 7 Residues to Conformational Activation of the Serotonin 5-HT2A Receptor
1995
Identification of an Allosteric Binding Site for Zn2+on the β2 Adrenergic Receptor
2002 StandoutNobel
Allosteric Modulation of β2-Adrenergic Receptor by Zn2+
2002 StandoutNobel
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Mutational analysis of muscarinic acetylcholine receptors: Structural basis of ligand/receptor/g protein interactions
1993
Nanoparticles functionalised with reversible molecular and supramolecular switches
2010 StandoutNobel
G Protein-coupled Receptors
1998 StandoutNobel
Prostaglandin E Receptors
2007
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
1999 StandoutNatureNobel
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes
2001
Delineation of three pharmacological subtypes of α2‐adrenoceptor in the rat kidney
1991
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Spinophilin Stabilizes Cell Surface Expression of α2B-Adrenergic Receptors
2003
Prostaglandin E2 induces the expression of functional inhibitory CD94/NKG2A receptors in human CD8+ T lymphocytes by a cAMP-dependent protein kinase A type I pathway
2005
Cancer immunotherapy comes of age
2011 StandoutNature
Eicosanoids and cancer
2010 Standout
Importance of quantitative genetic variations in the etiology of hypertension
2000 StandoutNobel
Heterotrimeric C proteins: Organizers of transmembrane signals
1995
Receptors and G proteins as primary components of transmembrane signal transduction
1995
This is not a G protein-coupled receptor
1993
A novel family of genes encoding putative pheromone receptors in mammals
1995 StandoutNobel
Insight into prostaglandin, leukotriene, and other eicosanoid functions using mice with targeted gene disruptions☆
1999
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
1993 StandoutNatureNobel
Structure of the δ-opioid receptor bound to naltrindole
2012 StandoutNatureNobel
PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment
2022 StandoutNobel
Allosteric modulation of A2A adenosine receptors by amiloride analogues and sodium ions
2000
Genetic and pharmacological analysis of prostanoid receptor function
2001
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
1995 StandoutNature
Sequential Binding of Agonists to the β2 Adrenoceptor
2003 StandoutNobel
Cancer-related inflammation
2008 StandoutNature
The transmembrane 7-alpha-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints
1997
EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival
2006
Roles of PPARs in health and disease
2000 StandoutNature
Allosteric binding sites on cell-surface receptors: novel targets for drug discovery
2002
Ligand Efficacy and Potency at Recombinant α2 Adrenergic Receptors
1998
Stimulation of Mitogen-activated Protein Kinase by G Protein-coupled α2-Adrenergic Receptors Does Not Require Agonist-elicited Endocytosis
1999
A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.
1994 StandoutNobel
Interleukin-10 and the immune response against cancer: a counterpoint
2005
CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition
2006
Prostanoid Receptors: Structures, Properties, and Functions
1999 Standout
Expression cloning of an ATP receptor from mouse neuroblastoma cells.
1993 StandoutNobel
SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade
2008 StandoutNobel
Purification of the alpha 2-adrenergic receptor from porcine brain using a yohimbine-agarose affinity matrix.
1987
Genetic and pharmacological analysis of prostanoid receptor function
2001
Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor
2004 StandoutNobel
MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans
2000 StandoutNatureNobel
A Point Mutation of the α 2 -Adrenoceptor that Blocks Coupling to Potassium but not Calcium Currents
1992 Science
Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse
2001 StandoutNobel
Targeting G βγ signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis
1999 StandoutNobel
Functional role of internal water molecules in rhodopsin revealed by x-ray crystallography
2002
Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms
1988
Mutation of an aspartate residue highly conserved among G-protein-coupled receptors results in nonreciprocal disruption of alpha 2-adrenergic receptor-G-protein interactions. A negative charge at amino acid residue 79 forecasts alpha 2A-adrenergic receptor sensitivity to allosteric modulation by monovalent cations and fully effective receptor/G-protein coupling.
1994
Host and Direct Antitumor Effects and Profound Reduction in Tumor Metastasis with Selective EP4 Receptor Antagonism
2006
Heterozygous α 2A -adrenergic receptor mice unveil unique therapeutic benefits of partial agonists
2002 StandoutNobel
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.
1993
Cardiovascular Regulation in Mice Lacking α 2 -Adrenergic Receptor Subtypes b and c
1996 StandoutScienceNobel
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
2001 StandoutScience
Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis.
2006
Substitution of a mutant α 2a -adrenergic receptor via “hit and run” gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo
1997
Targeting the Receptor-G q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy
1998 StandoutScienceNobel
High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype.
1994
In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors
1992
Central Hypotensive Effects of the α 2a -Adrenergic Receptor Subtype
1996 Science
Mechanisms Regulating the Cell Surface Residence Time of the α2A-Adrenergic Receptor
2000
Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs.
1990
Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor
1995 StandoutScience
Allosteric activation of the CaR by l -amino acids
2000 StandoutNobel
Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α 2 -Adrenergic Receptor
1987 StandoutScienceNobel
Prostaglandin E2 Promotes Tumor Progression by Inducing Myeloid-Derived Suppressor Cells
2007
The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.
1996
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
Prevention of Both Direct and Cross-Priming of Antitumor CD8+ T-Cell Responses following Overproduction of Prostaglandin E2 by Tumor CellsIn vivo
2008
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2
2001 StandoutNobel
Dopamine D2 receptor stimulation of Na+/H+ exchange assessed by quantification of extracellular acidification.
1992
Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP 2
1999
The Prostaglandin E2 Receptor EP2 Is Required for Cyclooxygenase 2–Mediated Mammary Hyperplasia
2005
Dopamine Receptors: From Structure to Function
1998 Standout
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors
2000 StandoutNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes
2001
Works of Suzanne Brandon being referenced
Monovalent cation and amiloride analog modulation of adrenergic ligand binding to the unglycosylated alpha 2B-adrenergic receptor subtype.
1991
Characterization of Murine Vasopressor and Vasodepressor Prostaglandin E2Receptors
2000
Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system.
1994
Regulation of porcine brain alpha 2-adrenergic receptors by Na+,H+ and inhibitors of Na+/H+ exchange.
1987
An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium.
1990
Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor
2003
Salt–sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor
1999