Citation Impact
Citing Papers
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA
2006
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP
1985 StandoutNatureNobel
Crystal Structure of lac Repressor Core Tetramer and Its Implications for DNA Looping
1995 StandoutScienceNobel
Genetic studies of the lac repressor
1990
Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli
1989 StandoutNatureNobel
Oxytrichatelomeric nucleoprotein complexes reconstituted with synthetic DNA
1989 StandoutNobel
Sequence-specific DNA binding by theMspl DNA methyltransferase
1992 StandoutNobel
DNA supercoiling promotes formation of a bent repression loop in lac DNA
1987
A mediator required for activation of RNA polymerase II transcription in vitro
1991 StandoutNatureNobel
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion
2012
PAS is a dimerization domain common to Drosophila Period and several transcription factors
1993 StandoutNatureNobel
The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function
1988
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
1990 StandoutNatureNobel
Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin lattice
2010
Electric, optical and hydrodynamic parameters of lac repressor from measurements of the electric dichroism High permanent dipole moment associated with
1987
Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells
1989 StandoutNatureNobel
CD4+CD25+ Immunoregulatory T Cells
2002
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
1990 StandoutNatureNobel
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
Tethering DNA Damage Checkpoint Mediator Proteins Topoisomerase IIβ-binding Protein 1 (TopBP1) and Claspin to DNA Activates Ataxia-Telangiectasia Mutated and RAD3-related (ATR) Phosphorylation of Checkpoint Kinase 1 (Chk1)
2011 StandoutNobel
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Lysine 188 of the catabolite gene activator protein (CAP) plays no role in specificity at base pair 7 of the DNA half site
1990
Cyclic adenosine 5'-monophosphate in Escherichia coli
1976
Ion effects on ligand-nucleic acid interactions
1976
Multiple forms of the human gene-specific transcription factor USF. II. DNA binding properties and transcriptional activity of the purified HeLa USF.
1988
Crystal Structure of LacI Member, PurR, Bound to DNA: Minor Groove Binding by α Helices
1994 Science
ISOLATION OF THE LAC REPRESSOR
1966 StandoutNobel
lac Repressor headpiece binds specifically to half of the lac operator: a proton nuclear magnetic resonance study
1983
Receptor-specific desensitization of the S49 lymphoma cell adenylyl cyclase. Unaltered behavior of the regulatory component.
1981
Overproduction of phage Lambda repressor under control of the lac promotor of Escherichia coli
1976
Lac Repressor
1973
The Nucleotide Sequence of the lac Operator
1973 StandoutNobel
Interpretation of monovalent and divalent cation effects on the lac repressor-operator interaction
1977
The EcoRI restriction endonuclease with bacteriophage λ DNA. Equilibrium binding studies
1980
Does the specific recongnition of DNA by the restriction endonucleaseEcoRI involve a linear diffusion step? Investigation of the processivity of theEcoRI endonuclease
1983
Isolation of Pure lac Operon DNA*
1969 Nature
Primary structure and expression of a functional human glucocorticoid receptor cDNA
1985 StandoutNature
A single polypeptide possesses the binding and transcription activities of the adenovirus major late transcription factor.
1986
The three operators of the lac operon cooperate in repression.
1990
Influence of supercoiling and sequence context on operator DNA binding with lac repressor.
1987
Characterization of steady state, single-turnover, and binding kinetics of the TaqI restriction endonuclease.
1992
Non-specific DNA Binding of Genome Regulating Proteins as a Biological Control Mechanism: 1. The lac Operon: Equilibrium Aspects
1974
Characterization of mutations in oligomerization domain of Lac repressor protein.
1991
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis
1981 Standout
The Amino-Acid Sequence of lac Repressor
1973
Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells
1984 Nature
5-azacytidine permits gene activation in a previously noninducible cell type
1985
Mapping of the lactose operator
1971
Ion effects on the lac repressor-operator equilibrium
1981
Molecular basis of base substitution hotspots in Escherichia coli
1978 StandoutNatureNobel
Specific binding of the glucocorticoid-receptor complex to the mouse mammary tumor proviral promoter region
1982
Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning
1977 StandoutScienceNobel
How lac Repressor Binds to DNA
1972 Nature
Structure of the lac repressor studied by negative staining
1975
Secondary structural complementarity between DNA and proteins.
1977
A model for the non-specific binding of catabolite gene activator protein to DNA
1984 StandoutNobel
High-resolution nuclear magnetic resonance studies of the lac repressor. 1. Assignments of tyrosine resonances in the N-terminal headpiece
1981
A recurrent DNA sequence at sites of protein interaction
1985
Evidence for leucine zipper motif in lactose repressor protein
1991
Down-Regulation of Glucocorticoid Receptors in Mouse Lymphoma Cell Variants
1984
Isolation of a set of hybrid lac repressors made in vitro between normal lac repressor and its homogeneous tryptic core.
1976
Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP
1994 StandoutScienceNobel
A functional analysis of the rel gene in Escherichia coli
1969
ATP-independent diffusion of double-stranded RNA binding proteins
2012 StandoutNobel
Structure, sequence and expression of the hepatitis delta (δ) viral genome
1986 StandoutNatureNobel
Lac repressor purification without inactivation of DNA binding activity
1977
An amino-terminal fragment of lac repressor binds specifically to lac operator
1978 StandoutNobel
Variables affecting the selectivity and efficiency of retention of DNA fragments by E. coli RNA polymerase in the nitrocellulose-filter-binding assay
1981
Analysis of gene control signals by DNA fusion and cloning in Escherichia coli
1980 Standout
Structure of catabolite gene activator protein at 2.9 Å resolution suggests binding to left-handed B-DNA
1981 StandoutNatureNobel
The lac Repressor and the lac Operator
1972 StandoutNobel
Molecular Biology of Learning: Modulation of Transmitter Release
1982 StandoutScienceNobel
On the determination of deoxyribonucleic acid-protein interaction parameters using the nitrocellulose filter-binding assay
1983
Purification and DNA-Binding Properties of the Catabolite Gene Activator Protein
1971
Kinky helix
1975 Nature
Effect of DNA polymerase I and DNA helicase II on the turnover rate of UvrABC excision nuclease.
1985 StandoutNobel
Binding of the ATP-dependent DNase from Hemophilus influenzae to duplex DNA molecules.
1976 StandoutNobel
Coordinate ion pair formation between EcoRI endonuclease and DNA.
1983
Down-regulation of glucocorticoid receptors in mouse lymphoma cell variants.
1984
Statistical characterization of nucleic acid sequence functional domains
1983
Conformational transitions of the lac repressor from Escherichia coli
1976
A RAPID ASSAY FOR DNA PHOTOLYASE USING A MEMBRANE‐BINDING TECHNIQUE*
1973
1H NMR study of the lactose repressor from Escherichia coli
1978
A Single Polypeptide Possesses the Binding and Transcription Activities of the Adenovirus Major Late Transcription Factor
1986
CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high affinity binding of agonists to intact cells.
1983
Neutron scattering studies of lac repressor
1980 Nature
Facilitated Target Location in Biological Systems
1989
Binding of T4 endonuclease V to deoxyribonucleic acid irradiated with ultraviolet light
1980
Direct measurement of association constants for the binding of Escherichia coli lac repressor to non-operator DNA
1977
Two Compounds implicated in the Function of the RC Gene of Escherichia coli
1969 Nature
Binding of synthetic lactose operator DNAs to lactose repressors
1977
Cocrystals of the DNA-binding domain of phage 434 repressor and a synthetic phage 434 operator.
1984
Crystal Structure of DNA Photolyase from Escherichia coli
1995 StandoutScienceNobel
DNA looping in cellular repression of transcription of the galactose operon.
1990
Genetic Regulation: The Lac Control Region
1975 Science
The lac Repressor Protein: Molecular Shape, Subunit Structure, and Proposed Model for Operator Interaction Based on Structural Studies of Microcrystals
1974 StandoutNobel
Isolation of the amino-terminal fragment of lactose repressor necessary for DNA binding
1977
Binding of Escherichia coli DNA photolyase to UV-irradiated DNA
1985 StandoutNobel
DNA binding characteristics of lactose repressor and the trypsin-resistant core repressor.
1980
Protein-DNA interaction investigated by binding Escherichia coli lac repressor protein to poly[d(A · U-HgX)]
1976 StandoutNobel
Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°
1991 StandoutScienceNobel
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
1997 Standout
Rate enhancement by guided diffusion. Chain length dependence of repressor-operator association rates
1978
Purification and Properties of Drosophila Heat Shock Activator Protein
1987 Science
MSI and MSII made on Ribosome in Idling Step of Protein Synthesis
1972 StandoutNatureNobel
Thermodynamic parameters governing interaction of EcoRI endonuclease with specific and nonspecific DNA sequences.
1983 StandoutNobel
Structure of the DNA-binding region of lac repressor inferred from its homology with cro repressor.
1982
Kinetics of Protein-Nucleic Acid Interactions: Use of Salt Effects to Probe Mechanisms of Interactio
1986
Equilibrium studies of the cyclic AMP receptor protein-DNA interaction
1984
Lac DNA, RNA Polymerase and Cyclic AMP Receptor Protein, Cyclic AMP, Lac Repressor and Inducer are the Essential Elements for Controlled Lac Transcription
1971
Assignment of the human gene for the glucocorticoid receptor to chromosome 5.
1985
The Stereochemistry of Actinomycin Binding to DNA and Its Implications in Molecular Biology
1973
High-resolution nuclear magnetic resonance studies of the lac repressor. 2. Partial analysis of the aliphatic region of the lac repressor headpiece spectrum
1981
Identification of mRNAs Associated with Programmed Cell Death in Immature Thymocytes
1991
B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo
1985 StandoutScienceNobel
Structure of nucleosome core particles of chromatin
1977 StandoutNatureNobel
DNA sequence for a low-level promoter of the lac repressor gene and an ‘up’ promoter mutation
1978 Nature
Diffusion-driven mechanisms of protein translocation on nucleic acids. 2. The Escherichia coli lac repressor-operator interaction: equilibrium measurements
1981
Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor
1991 Science
Repressor-operator interaction in the lac operon
1982
Facilitated diffusion during catalysis by EcoRI endonuclease. Nonspecific interactions in EcoRI catalysis.
1985 StandoutNobel
polA6, a mutation affecting the DNA binding capacity of DNA polymerase I
1976
Genetic studies of the lac repressor
1977
Glucocorticoid and thyroid hormones transcriptionally regulate growth hormone gene expression.
1982
Selection of DNA binding sites by regulatory proteins
1987
lac repressor forms loops with linear DNA carrying two suitably spaced lac operators.
1987
Nonspecific interaction of lac repressor with DNA: an association reaction driven by counterion release
1977
Diffusion controlled reaction rates in spheroidal geometry
1974
Escherichia coli lac repressor is elongated with its operator DNA binding domains located at both ends
1982 StandoutNobel
Lac Repressor
1971
Photochemically induced dynamic nuclear polarization investigation of complex formation of the NH2-terminal DNA-binding domain of lac repressor with poly[d(AT)].
1980
Action mechanism of Escherichia coli DNA photolyase. I. Formation of the enzyme-substrate complex.
1987 StandoutNobel
Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model
1985 StandoutNatureNobel
Isolation of the Operators of Phage λ
1973
Secondary structure of the lac repressor DNA-binding domain by two-dimensional 1H nuclear magnetic resonance in solution.
1983 StandoutNobel
A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system
1981 Standout
Involvement of outside DNA sequences in the major kinetic path by which EcoRI endonuclease locates and leaves its recognition sequence.
1982 StandoutNobel
Plasmids containing many tandem copies of a synthetic lactose operator
1980
Structures and mechanisms of DNA restriction and modification enzymes
1979 StandoutNobel
DNA sequence at the integration sites of the insertion element IS1
1978
lac repressor-lac operator interaction: NMR observations.
1982
Cell-type-specific contacts to immunoglobulin enhancers in nuclei
1985 StandoutNatureNobel
Association kinetics with coupled diffusion
1978
New Features of the Regulation of the Tryptophan Operon
1975 Science
Ligand‐Induced Conformational Changes in Proteins
1983 StandoutNobel
Salt dependence of the kinetics of the lac repressor-operator interaction: role of nonoperator deoxyribonucleic acid (DNA) in the association reaction
1981
Mutations affecting the quaternary structure of the lac repressor.
1976
Association kinetics with coupled three- and one-dimensional diffusion
1982
Identification of Human Glucocorticoid Receptor Complementary DNA Clones by Epitope Selection
1985 Science
Lac Operator Analogues: Bromodeoxyuridine Substitution in the lac Operator Affects the Rate of Dissociation of the lac Repressor
1972
λ Repressor and cro—components of an efficient molecular switch
1981 Nature
Characterization of wild type and mutant glucocorticoid receptors from rat hepatoma and mouse lymphoma cells.
1985
Structure and function of telomeres
1991 StandoutNatureNobel
Use of the membrane binding technique to study the kinetics of yeast deoxyribonucleic acid photolyase reactions. Formation of enzyme-substrate complexes in the dark and their photolysis
1974
Role of glutamic acid-181 in DNA-sequence recognition by the catabolite gene activator protein (CAP) of Escherichia coli: altered DNA-sequence-recognition properties of [Val181]CAP and [Leu181]CAP.
1987
Specific protein binding to far upstream activating sequences in polymerase II promoters.
1985 StandoutNobel
Diffusion-driven mechanisms of protein translocation on nucleic acids. 1. Models and theory
1981 Standout
Limited proteolytic digestion of lac repressor by trypsin. Chemical nature of the resulting trypsin-resistant core.
1976
Genetic studies of the lac repressor
1979
Enzymatic properties of purified Escherichia coli uvrABC proteins.
1983
Initiation of in vitro mRNA synthesis from the wild-type lac promoter.
1975
On the specificity of DNA-protein interactions.
1986
Sequences at the somatic recombination sites of immunoglobulin light-chain genes
1979 StandoutNatureNobel
lac represser binding to non-operator DNA: Detailed studies and a comparison of equilibrium and rate competition methods
1972
Diffusion-driven mechanisms of protein translocation on nucleic acids. 3. The Escherichia coli lac repressor-operator interaction: kinetic measurements and conclusions
1981
A comprehensive set of sequence analysis programs for the VAX
1984 StandoutNobel
The Nucleotide Sequence of the Lactose Messenger Ribonucleic Acid Transcribed from the UV5 Promoter Mutant of Escherichia coli
1973
DNA-binding site of lac repressor probed by dimethylsulfate methylation of lac operator
1979 StandoutNobel
Studies on Sequence Recognition By Type II Restriction and Modification Enzyme
1982 StandoutNobel
Nucleotide sequence of bacteriophage φX174 DNA
1977 StandoutNatureNobel
Represser-operator interaction in the lac operon
1982
Contacts between the lac repressor and the thymines in the lac operator.
1977
Works of Suzanne Bourgeois being referenced
Repressor Recognition of Operator and Effectors
1980
Identification of a Gene Induced by Glucocorticoids in Murine T-Cells: A Potential G Protein-Coupled Receptor
1991
Diploid and haploid states of the glucocorticoid receptor gene of mouse lymphoid cell lines
1977
Composite predictions of secondary structures of lac repressor
1979
The lac repressor-operator interaction
1972
Measurements of unwinding of lac operator by repressor
1974 Nature
Repressors
1976
“Second” and “third operator” of the lac operon: An investigation of their role in the regulatory mechanism
1979
lac repressor-operator interaction
1972
A new determinant of glucocorticoid sensitivity in lymphoid cell lines.
1983
lac repressor-operator interaction
1970
Role of de novo DNA methylation in the glucocorticoid resistance of a T-lymphoid cell line
1983 Nature
lac repressor—Operator interaction
1970
DNA binding of the lac repressor
1968
Correlation between glucocorticoid receptor and cytolytic response of murine lymphoid cell lines.
1979
Interaction of effecting ligands with lac repressor and repressor-operator complex
1975
lac Repressor-operator interaction
1974
lac repressor-operator interaction
1972
The lac represser-operator interaction
1970
Characterization of the glucocorticoid receptor. Comparison of wild type and variant receptors.
1984
Lac represser-operator interaction
1973
DNA binding properties of glucocorticosteroid receptors bound to the steroid antagonist RU-486.
1984
The lac repressor-operator interaction IV. Assay and purification of operator DNA
1970
General features of steroid resistance in lymphoid cell lines
1978
Analysis of steroid resistance in lymphoid cell hybrids
1980
Isolation and Characterization of Glucocorticoid- and Cyclic AMP-Induced Genes in T Lymphocytes
1989
On the assay, isolation and characterization of the lac repressor
1968
Suppression of and complementation among mutants of the regulatory gene of the lactose operon of Escherichia coli
1965
Inhibition of RNA polymerase by RNA
1963
Interaction of glucocorticoid receptors from lymphoid cell lines with their nuclear acceptor sites
1978