Citation Impact
Citing Papers
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
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Origins of coevolution between residues distant in protein 3D structures
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1994
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin
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The Pipecolate‐Incorporating Enzyme for the Biosynthesis of the Immunosuppressant Rapamycin — Nucleotide Sequence Analysis, Disruption and Heterologous Expression of Rap P from Streptomyces Hygroscopicus
1997
First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determinationElectronic supplementary information (ESI) available: LCMS spectra and detailed experimental procedures for all reported experiments. See http://www.rsc.org/suppdata/cc/b3/b300847a/
2003
Engineered Biosynthesis of Novel Polyketides: Properties of the whiE Aromatase/Cyclase
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Combinatorial and computational challenges for biocatalyst design
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Acylation of Streptomyces type II polyketide synthase acyl carrier proteins
1998
Type I polyketide biosynthesis in bacteria (Part A — erythromycin biosynthesis) (1994 to 2000)
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Molecular Characterization of a Phospholipase D Generating Anandamide and Its Congeners
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antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
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Asymmetric Organocatalytic Domino Reactions
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Protein–Protein Interactions in Multienzyme Megasynthetases
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A global synthesis reveals biodiversity loss as a major driver of ecosystem change
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Polyketide Synthase Genes from Marine Dinoflagellates
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Click Chemistry: Diverse Chemical Function from a Few Good Reactions
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Molecular breeding of carotenoid biosynthetic pathways
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Natural Product Hybrids as New Leads for Drug Discovery
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Malonyl-Coenzyme A:Acyl Carrier Protein Acyltransferase of Streptomyces glaucescens: A Possible Link between Fatty Acid and Polyketide Biosynthesis
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Prediction and Manipulation of the Stereochemistry of Enoylreduction in Modular Polyketide Synthases
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Polyketide biosynthesis: a millennium review
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Platform biochemicals for a biorenewable chemical industry
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Identification ofStreptomyces violaceoruber Tü22 genes involved in the biosynthesis of granaticin
1995
A crevice adjoining the ribosome tunnel: Hints for cotranslational folding
2005 StandoutNobel
Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues
1999
Post-translational modification of polyketide and nonribosomal peptide synthases
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Production of a novel polyketide through the construction of a hybrid polyketide synthase
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Engineering new functions and altering existing functions
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Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork
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Construction of new vectors for high-level expression in actinomycetes
1998
Octaketide‐producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericins
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Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate ‘Streptomyces maritimus’: evidence for the derailment of an aromatic polyketide synthase
2000
Expansion of the zinc metallo‐hydrolase family of the β‐lactamase fold
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The contentious nature of soil organic matter
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Structure and function of “metalloantibiotics”
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Recent developments in natural product synthesis using metal-catalysed C–H bond functionalisation
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Conserved secondary structure in the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2) and the fatty acid synthase acyl carrier protein from Escherichia coli
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Combinatorial biosynthesis of polyketides and nonribosomal peptides
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Context-Dependent Behavior of the Enterocin Iterative Polyketide Synthase
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Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes
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The type I fatty acid and polyketide synthases: a tale of two megasynthases
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Functional Analyses of Oxygenases in Jadomycin Biosynthesis and Identification of JadH as a Bifunctional Oxygenase/Dehydrase
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Molecular engineering approaches to peptide, polyketide and other antibiotics
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Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase
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A gene cluster involved in nogalamycin biosynthesis fromStreptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway
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Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus
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The Biosynthetic Logic of Polyketide Diversity
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Biosynthesis of fatty acids and related metabolites
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Regulation and manipulation of the gene clusters encoding type-I PKSs
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Engineering Anthracycline Biosynthesis toward Angucyclines
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Combinatorial Biosynthesis–An Approach in the Near Future?
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Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel “unnatural” natural products
1999
Purification of a malonyltransferase from Streptomyces coelicolor A3(2) and analysis of its genetic determinant
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Engineered Biosynthesis of Aklanonic Acid Analogues
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Harnessing the Biosynthetic Code: Combinations, Permutations, and Mutations
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Engineering precision RNA molecular switches
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Constituents from Salvia Species and Their Biological Activities
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Orchestration of Discoid Polyketide Cyclization in the Resistomycin Pathway
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Ribosomal Synthesis of N-Methyl Peptides
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Functional Nucleic Acid Sensors
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Chemical engineering of cellular processes
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Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
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Genetic Contributions to Understanding Polyketide Synthases
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Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis
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23S rRNA 2058A→G Alteration Mediates Ketolide Resistance in Combination with Deletion in L22
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Cloning and Heterologous Expression of the Macrotetrolide Biosynthetic Gene Cluster Revealed a Novel Polyketide Synthase that Lacks an Acyl Carrier Protein
2001
Biosynthesis of Polyketides in Heterologous Hosts
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Analysis of the Molecular Recognition Features of Individual Modules Derived from the Erythromycin Polyketide Synthase
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Rv2131c fromMycobacterium tuberculosisIs a CysQ 3′-Phosphoadenosine-5′-phosphatase
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Evolution of polyketide synthases in bacteria
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Engineered Biosynthesis of a Complete Macrolactone in a Heterologous Host
1994 Science
Alcohol Stereochemistry in Polyketide Backbones Is Controlled by the β-Ketoreductase Domains of Modular Polyketide Synthases
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Kombinatorische Biosynthese – eine Zukunftsstrategie?
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Tolerance and Specificity of Polyketide Synthases
1999
Genetically Modified Bacterial Strains and Novel Bacterial Artificial Chromosome Shuttle Vectors for Constructing Environmental Libraries and Detecting Heterologous Natural Products in Multiple Expression Hosts
2004
Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2)
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Solution Structure of the Actinorhodin Polyketide Synthase Acyl Carrier Protein from Streptomyces coelicolor A3(2),
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Genetics ofStreptomyces rimosus, the Oxytetracycline Producer
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Translation and Protein Synthesis: Macrolides
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Technology development for the production of biobased products from biorefinery carbohydrates—the US Department of Energy’s “Top 10” revisited
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Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution
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Catalytic Asymmetric Hydroalkoxylation of C–C Multiple Bonds
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Constructing Polyketides: From Collie to Combinatorial Biosynthesis
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Microbial metabolites: 45 years of wandering, wondering and discovering
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Mycotoxins
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Rational Design and Engineered Biosynthesis of a Novel 18-Carbon Aromatic Polyketide
1997
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
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Harnessing the Biosynthetic Potential of Modular Polyketide Synthases
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Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds
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13C NMR Flux Ratio Analysis of Escherichia coli Central Carbon Metabolism in Microaerobic Bioprocesses
1999 StandoutNobel
Biosynthesis of Erythromycin and Rapamycin
1997
Straightforward Synthesis of α,β-Unsaturated Thioesters via Ruthenium-Catalyzed Olefin Cross-Metathesis with Thioacrylate
2008 StandoutNobel
Dissecting the Chain Length Specificity in Bacterial Aromatic Polyketide Synthases using Chimeric Genes
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Engineered Biosynthesis of Structurally Diverse Tetraketides by a Trimodular Polyketide Synthase
1996
MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence
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Anthracycline Biosynthesis in Streptomyces galilaeus
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Natural Products in Drug Discovery and Development
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Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus
1994
Structural Modeling and Site-Directed Mutagenesis of the Actinorhodin β-Ketoacyl-Acyl Carrier Protein Synthase
2000
Deconstruction of Iterative Multidomain Polyketide Synthase Function
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Cloning and Heterologous Expression of the Epothilone Gene Cluster
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Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases
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Engineering Broader Specificity into an Antibiotic-Producing Polyketide Synthase
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Organic Chemistry on Solid Supports
1996
Redirecting the Cyclization Steps of Fungal Polyketide Synthase
2007
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Organische Chemie an fester Phase
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Forty years of genetics with Streptomyces: from in vivo through in vitro to in silico
1999
A two-vector system for the production of recombinant polyketides in Streptomyces
2000
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
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Enzyme Redesign
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Biosynthetic Studies of Daunorubicin and Tetracenomycin C
1997
Impact of Natural Products on Developing New Anti-Cancer Agents
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Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes
1999
Identification and Characterization of a Gene Cluster for Synthesis of the Polyketide Antibiotic 2,4-Diacetylphloroglucinol fromPseudomonas fluorescensQ2-87
1999
Resistance, resilience, and redundancy in microbial communities
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Production of actinorhodin-related "blue pigments" by Streptomyces coelicolor A3(2)
1996
Advances in Copper Complexes as Anticancer Agents
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The Nature of the Starter Unit for the Rapamycin Polyketide Synthase
1996
Origins and Evolution of Antibiotic Resistance
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Engineered Biosynthesis of a Novel Amidated Polyketide, Using the Malonamyl-Specific Initiation Module from the Oxytetracycline Polyketide Synthase
2006
EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions
2004
C-O Bond Formation by Polyketide Synthases
2002 Science
Cloning, Sequencing, and Functional Analysis of an Iterative Type I Polyketide Synthase Gene Cluster for Biosynthesis of the Antitumor Chlorinated Polyenone Neocarzilin in “ Streptomyces carzinostaticus ”
2004
Dynamic Control of Chiral Space in a Catalytic Asymmetric Reaction Using a Molecular Motor
2011 StandoutScienceNobel
Natural Product Biosynthesis: A New Interface between Enzymology and Medicine
2000
Engineering of modular polyketide synthases to produce novel polyketides
1998
A C 35 Carotenoid Biosynthetic Pathway
2003 StandoutNobel
Genetics of Zwittermicin A Production by Bacillus cereus
2004
Discovery and Development of Antineoplastic Agents from Natural Sources
1989
Polyketide Chain Length Control by Chain Length Factor
2003
Works of Susanne Ebert‐Khosla being referenced
Targeted gene replacements in a Streptomyces polyketide synthase gene cluster: role for the acyl carrier protein
1992
Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits
1995 Nature
Relaxed Specificity of the Oxytetracycline Polyketide Synthase for an Acetate Primer in the Absence of a Malonamyl Primer
1994
Erythromycin Biosynthesis: Kinetic Studies on a Fully Active Modular Polyketide Synthase Using Natural and Unnatural Substrates
1996
Engineered Biosynthesis of Novel Polyketides
1993 Science
Engineered Biosynthesis of Novel Polyketides: actVII and actIV Genes Encode Aromatase and Cyclase Enzymes, Respectively
1994
Erythromycin Biosynthesis: Kinetic Studies on a Fully Active Modular Polyketide Synthase Using Natural and Unnatural Substrates
1996
Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase.
1994
Engineered Biosynthesis of Novel Polyketides: Dissection of the Catalytic Specificity of the act Ketoreductase
1994
Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins
1993
Engineered biosynthesis of novel polyketides: manipulation and analysis of an aromatic polyketide synthase with unproven catalytic specificities
1993