Citation Impact
Citing Papers
Analysis of Wild-Type and Mutant p21 WAF-1 Gene Activities
1996
Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors
1996
Cell Growth Inhibition by Antitumor Prostaglandin and its Modulation by MRP/GS-X Pump
1997 StandoutNobel
Cip/Kip cyclin-dependent kinase inhibitors: brakes of the cell cycle engine during development
1999
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
1994 Nature
A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage
1995 StandoutNobel
Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
1995
Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA
1996
CDK inhibitors: positive and negative regulators of G1-phase progression
1999 Standout
The p16INK4a/CDKN2A tumor suppressor and its relatives
1998
Ordering S phase and M phase in the cell cycle
1994 StandoutNobel
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase
1995 StandoutNobel
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Genetic alterations in human gastrointestinal cancers. The application to molecular diagnosis
1995
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1
1997
Oxidative stress and gene regulation
2000
The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.
1997
Tumor suppressors and oncogenes in cellular senescence☆
2000
Inhibitors of the Cip/Kip Family
1998
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Cdk inhibitors: on the threshold of checkpoints and development
1994
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.
1995
Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle
1994
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Senescence of human fibroblasts induced by oncogenic Raf
1998 Nobel
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
1995 Nature
When Checkpoints Fail
1997 StandoutNobel
Building a Replisome from Interacting Pieces
1999 StandoutNobel
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
1994 Standout
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
1997 StandoutNobel
The Hallmarks of Cancer
2000 Standout
Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?
1995
p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast
1995 StandoutNobel
Regulation of cellular senescence by p53
2001
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
2005 Standout
A Long Twentieth Century of the Cell Cycle and Beyond
2000 StandoutNobel
Radiation-induced cell cycle arrest compromised by p21 deficiency
1995 Nature
Inhibition of Myogenic Differentiation in Proliferating Myoblasts by Cyclin D1-Dependent Kinase
1995 Science
KLF4, p21 and context-dependent opposing forces in cancer
2005
Evidence for a p53‐independent pathway for upregulation of SDI1/CIP1/WAF1/P21 RNA in human cells
1994
Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19
1997
Role of Ceramide in Cellular Senescence
1995
Epigenetic Modulation of miR-122 Facilitates Human Embryonic Stem Cell Self-Renewal and Hepatocellular Carcinoma Proliferation
2011
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen
1995
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
Biochemical properties and biological effects of p53
1995
Genetic analysis of cellular senescence
1995
Potent Prostaglandin A1 Analogs That Suppress Tumor Cell Growth through Induction of p21 and Reduction of Cyclin E
1998 StandoutNobel
The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2
1998
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
1997 Standout
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
1998
The biology of replicative senescence
1997
Regulating S Phase: CDKs, Licensing and Proteolysis
1996 StandoutNobel
Cyclin-dependent Kinases Are Inactivated by a Combination of p21 and Thr-14/Tyr-15 Phosphorylation after UV-induced DNA Damage
1996
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
1997
Mechanisms of cellular senescence
1997
Differential Interaction of the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1 with Cyclin A-Cdk2 and Cyclin D2-Cdk4
1997
Origins of G1 arrest in senescent human fibroblasts
1995
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice
1996
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Oncogenic functions of tumour suppressor p21Waf1/Cip1/Sdi1: association with cell senescence and tumour-promoting activities of stromal fibroblasts
2002
Principles of CDK regulation
1995 StandoutNature
Role of Cyclin-Dependent Kinases and Their Inhibitors in Cellular Differentiation and Development
1998
Absence of p53 allows direct immortalization of hematopoietic cells by the myc and raf oncogenes
1995
Genes involved in senescence and immortalization
2000
Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation
1994
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
Inhibitors of mammalian G1 cyclin-dependent kinases.
1995 Standout
Abrogation of p27 by cDNA Antisense Suppresses Quiescence (G0 State) in Fibroblasts
1996
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
1994 Standout
The Influence of the Proliferating Cell Nuclear Antigen-interacting Domain of p21 on DNA Synthesis Catalyzed by the Human and Saccharomyces cerevisiae Polymerase δ Holoenzymes
1997
The C-terminal Region of p21 Is Involved in Proliferating Cell Nuclear Antigen Binding but Does Not Appear to Be Required for Growth Inhibition
1995
A critical role for telomeres in suppressing and facilitating carcinogenesis
2000
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Cdk inhibitors in development and cancer
1996
Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
1998
Inhibition of Nucleotide Excision Repair by the Cyclin-dependent Kinase Inhibitor p21
1995 StandoutNobel
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
1995 Standout
Prostaglandin A2 Blocks the Activation of G1 Phase Cyclin-dependent Kinase without Altering Mitogen-activated Protein Kinase Stimulation
1996
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
1994 Standout
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
1994
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1
2000 Science
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
Reinitiation of DNA Synthesis and Cell Division in Senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies
1998
Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.
1994
MyoD-Induced Expression of p21 Inhibits Cyclin-Dependent Kinase Activity upon Myocyte Terminal Differentiation
1995
p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors.
1995
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.
1994
Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1
2002
p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells
1998
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
1999 StandoutNobel
Anti-cancer-prostaglandin-induced cell-cycle arrest and its modulation by an inhibitor of the ATP-dependent glutathione S-conjugate export pump (GS-X pump)
1998 StandoutNobel
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
1999 StandoutNobel
Cooperating oncogenes converge to regulate cyclin/cdk complexes.
1997
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
1994
Absence of WAF1 mutations in a variety of human malignancies
1994
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
1995 StandoutNobel
Human Fibroblast Commitment to a Senescence-Like State in Response to Histone Deacetylase Inhibitors Is Cell Cycle Dependent
1996
Formation of p27-CDK complexes during the human mitotic cell cycle.
1996
Analysis of Wild-Type and Mutant p21WAF-1 Gene Activities
1996
CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein.
1996
Regulation of p16CDKN2 Expression and Its Implications for Cell Immortalization and Senescence
1996
Cyclin E-CDK2 is a regulator of p27Kip1.
1997
Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.
1994
Cancer Cell Cycles
1996 StandoutScience
Ku is associated with the telomere in mammals
1999 StandoutNobel
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Inhibition of p53-Mediated Growth Arrest by Overexpression of Cyclin-Dependent Kinases
1996
Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1.
1995
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
1994
Cyclin-Binding Motifs Are Essential for the Function of p21CIP1
1996
Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts
1999 Standout
Tumor cell senescence in cancer treatment.
2003
The Prognostic Significance of Altered Cyclin-Dependent Kinase Inhibitors in Human Cancer
1999
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.
1995
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.
1996
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.
1995
Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD
1995 Science
Differential regulation of E2F transactivation by cyclin/cdk2 complexes.
1994
Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts
1997 Science
Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation.
1995
p53-dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells
1998
Induction of p21WAF1/CIP1 and Inhibition of Cdk2 Mediated by the Tumor Suppressor p16INK4a
1999
Increased activity of p53 in senescing fibroblasts.
1995
The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein.
1996
Inhibition of cyclin-dependent kinases by p21.
1995
Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation.
1996
PML is induced by oncogenicrasand promotes premature senescence
2000
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
1995
Mutations and altered expression of p16INK4 in human cancer.
1994
p53-dependent repression of CDK4 translation in TGF-beta-induced G1 cell-cycle arrest.
1995
Inhibition of G1 Cyclin-Dependent Kinase Activity during Growth Arrest of Human Breast Carcinoma Cells by Prostaglandin A2
1996
A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication.
1996 StandoutNobel
Translational Control of p27 Kip1 Accumulation During the Cell Cycle
1996 Science
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Transforming Growth Factor β Stabilizes p15INK4B Protein, Increases p15INK4B-cdk4 Complexes, and Inhibits Cyclin D1-cdk4 Association in Human Mammary Epithelial Cells
1997
New functional activities for the p21 family of CDK inhibitors.
1997
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
1996
Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.
1995
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Cyclin D-CDK Subunit Arrangement Is Dependent on the Availability of Competing INK4 and p21 Class Inhibitors
1999
Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16ink4
1995
p53-Independent Expression of p21 Cip1 in Muscle and Other Terminally Differentiating Cells
1995 Science
A p16 INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma
1995 Science
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.
1994
Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias [see comments]
1994
Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulating proteins
1997 StandoutNobel
Works of Susan Venable being referenced
MRG15 Activates the B-myb Promoter through Formation of a Nuclear Complex with the Retinoblastoma Protein and the Novel Protein PAM14
2001
Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen
1994
Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA.
1995
Transcriptional Profiling of Bipotential Embryonic Liver Cells to Identify Liver Progenitor Cell Surface Markers
2007