Citation Impact
Citing Papers
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies
2009 StandoutNobel
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells
2004
Jinx , an MCMV susceptibility phenotype caused by disruption of Unc13d : a mouse model of type 3 familial hemophagocytic lymphohistiocytosis
2007 StandoutNobel
Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice
2011 StandoutNobel
Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH
2011
Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)
2013 StandoutNobel
Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism
2005 StandoutNobel
The Yellow Fever Virus Vaccine Induces a Broad and Polyfunctional Human Memory CD8+ T Cell Response
2009 StandoutNobel
Neutralization of IFNγ defeats haemophagocytosis in LCMV‐infected perforin‐ and Rab27a‐deficient mice
2009
Munc13-4 Is Essential for Cytolytic Granules Fusion and Is Mutated in a Form of Familial Hemophagocytic Lymphohistiocytosis (FHL3)
2003
Analysis of the Lysosomal Storage Disease Chediak–Higashi Syndrome
2000
Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future
2004
Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia
2013 Standout
Non-MHC ligands for inhibitory immune receptors: Novel insights and implications for immune regulation
2006
Efficient T Cell Activation via a Toll-Interleukin 1 Receptor-Independent Pathway
2006 StandoutNobel
Modern management of children with haemophagocytic lymphohistiocytosis
2003
Regulatory T cells exert checks and balances on self tolerance and autoimmunity
2009 StandoutNobel
Analysis of the molecular mechanism involved in 2B4-mediated NK cell activation: evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells
2000
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
2003 Standout
Correlation between phenotypic heterogeneity and gene mutational characteristics in familial hemophagocytic lymphohistiocytosis (FHL)
2005
Spectrum of Perforin Gene Mutations in Familial Hemophagocytic Lymphohistiocytosis
2001
Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation
2003
Autoinflammatory Disease Reloaded: A Clinical Perspective
2010 Standout
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Genetic analysis of resistance to viral infection
2007 StandoutNobel
Up on the tightrope: natural killer cell activation and inhibition
2008
Natural killer cell dysfunction: A common pathway in systemic‐onset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis?
2004
Juvenile idiopathic arthritis
2007 Standout
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
Viral infections associated with haemophagocytic syndrome
2010
New insights into nNOS regulation of vascular homeostasis
2005 StandoutNobel
The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease
2003
Early diagnostic and prognostic significance of a specific Th1/Th2 cytokine pattern in children with haemophagocytic syndrome
2008
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
2008 StandoutNature
Inherited defects in lymphocyte cytotoxic activity
2010
Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome
2005
The Presynaptic Active Zone
2012 StandoutNobel
ATP-sensitive potassium channels mediate survival during infection in mammals and insects
2007 StandoutNobel
Subtyping of natural killer cell cytotoxicity deficiencies in haemophagocytic lymphohistocytosis provides therapeutic guidance
2005
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy
2016 StandoutNobel
HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis
2006 Standout
NK cells and NKT cells in innate defense against viral infections
2001
Tolerance and Autoimmunity: Lessons at the Bedside of Primary Immunodeficiencies
2007
Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11
2005
How Do Natural Killer Cells Find Self to Achieve Tolerance?
2006
Hermansky–Pudlak syndrome: a disease of protein trafficking and organelle function
2006
Functional Impairment of CD8+ T Cells by Regulatory T Cells during Persistent Retroviral Infection
2004 StandoutNobel
Perforin and Granzymes Have Distinct Roles in Defensive Immunity and Immunopathology
2006
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Coordination of activating and inhibitory signals in natural killer cells
2004
Experience With Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome at a Single Institution
2009
Familial and Acquired Hemophagocytic Lymphohistiocytosis
2005
TCR Specificity Dictates CD94/NKG2A Expression by Human CTL
2002
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
2005 Standout
Missing self recognition and self tolerance of natural killer (NK) cells
2006
Histiocyte disorders
2004
Strategies of Natural Killer Cell Recognition and Signaling
2005
Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses ofPRF1, UNC13D, STX11, andRAB27A
2005
Oncogenic stress sensed by the immune system: role of natural killer cell receptors
2009
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Apoptosis
2002 Standout
Activation, coactivation, and costimulation of resting human natural killer cells
2006
Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo
2000
Hemophagocytic lymphohistiocytosis and primary immune deficiency disorders
2014
2B4 stimulation of YT cells induces natural killer cell cytolytic function and invasiveness
2000
T Cell Surveillance of Oncogene-Induced Prostate Cancer Is Impeded by T Cell-Derived TGF-β1 Cytokine
2011 StandoutNobel
Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome
2000
Griscelli Syndrome: Characterization of a New Mutation and Rescue of T-Cytotoxic Activity by Retroviral Transfer of RAB27A Gene
2004
The blockade of immune checkpoints in cancer immunotherapy
2012 Standout
Familial Hemophagocytic Lymphohistiocytosis: Too Little Cell Death Can Seriously Damage Your Health
2001
Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation
2002
FOXP3+ regulatory T cells in the human immune system
2010 StandoutNobel
The LLT1 receptor induces IFN-γ production by human natural killer cells
2003
Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13‐4 polymorphisms
2008
Macrophage activation syndrome: a potentially fatal complication of rheumatic disorders
2001
Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity
2000
Elimination of Antigen-Presenting Cells and Autoreactive T Cells by Fas Contributes to Prevention of Autoimmunity
2007
The genetics of macrophage activation syndrome
2020
Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death
2004
The CD2-subset of the Ig superfamily of cell surface molecules: receptor–ligand pairs expressed by NK cells and other immune cells
2000
The Immunology of Macrophage Activation Syndrome
2019
IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity
2001 StandoutNature
The dual-function CD150 receptor subfamily: the viral attraction
2002
Identification of NKp80, a novel triggering molecule expressed by human NK cells
2001
A new self: MHC-class-I-independent Natural-killer-cell self-tolerance
2005
Epstein–Barr Virus Infection
2000 Standout
Haematopoietic stem cell transplantation in haemophagocytic lymphohistiocytosis
2005
Natural killer cells, viruses and cancer
2001
Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease
2009
Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection
2001
NK CELL RECOGNITION
2004 Standout
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
2009 Standout
Clinical and Genetic Studies of Familial Hemophagocytic Lymphohistiocytosis in Oman: Need for Early Treatment
2003
X-Linked Lymphoproliferative Disease
2000
Hematopoietic Stem Cell Transplantation in Hemophagocytic Lymphohistiocytosis: A Single-Center Report of 48 Patients
2006
Hemophagocytic lymphohistiocytosis due to germline mutations inSH2D1A, the X-linked lymphoproliferative disease gene
2001
Cutting Edge: Defective NK Cell Activation in X-Linked Lymphoproliferative Disease
2000
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function
2009 StandoutNobel
Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-γ-producing lymphocytes and IL-6- and TNF-α-producing macrophages
2004
Cutting Edge: Activation of NK Cell-Mediated Cytotoxicity by a SAP-Independent Receptor of the CD2 Family
2001
Intrahepatic Gene Expression during Chronic Hepatitis C Virus Infection in Chimpanzees
2004
Cutting Edge: Human 2B4, an Activating NK Cell Receptor, Recruits the Protein Tyrosine Phosphatase SHP-2 and the Adaptor Signaling Protein SAP
1999
Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells
2010 StandoutNobel
Treatment of E pstein B arr virus‐induced haemophagocytic lymphohistiocytosis with rituximab‐containing chemo‐immunotherapeutic regimens
2013
Impact of β2 integrin deficiency on mouse natural killer cell development and function
2011 StandoutNobel
An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder
2004
Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis
2001 Standout
Perforin expression in cytotoxic lymphocytes from patients with hemophagocytic lymphohistiocytosis and their family members
2002
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
2011 StandoutScience
Inhibitory Receptors on Lymphocytes: Insights from Infections
2012
Molecular Interactions Mediating T Cell Antigen Recognition
2003
Stem cell transplantation with reduced-intensity conditioning for hemophagocytic lymphohistiocytosis
2005
Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells
2002 StandoutNobel
Linking Albinism and Immunity: The Secrets of Secretory Lysosomes
2004 Science
Cytokine Storm
2020 Standout
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Familial and Acquired Hemophagocytic Lymphohistiocytosis
2011
Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by Interacting with the Poliovirus Receptor (CD155)
2004
Dendritic cell maturation by innate lymphocytes
2005 StandoutNobel
Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma
2000
TLRs and innate immunity
2008 StandoutNobel
Macrophage activation syndrome
2002
Gntb-A, a Novel Sh2d1a-Associated Surface Molecule Contributing to the Inability of Natural Killer Cells to Kill Epstein-Barr Virus–Infected B Cells in X-Linked Lymphoproliferative Disease
2001
Alterations of the X-linked lymphoproliferative disease geneSH2D1A in common variable immunodeficiency syndrome
2001
Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect
2001
2B4 Is Constitutively Associated with Linker for the Activation of T Cells in Glycolipid-Enriched Microdomains: Properties Required for 2B4 Lytic Function
2002
Activation of NK cell cytotoxicity
2004
Analysis of natural killer–cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease
2006
A Unique Mechanism for Innate Cytokine Promotion of T Cell Responses to Viral Infections
2002
Regulation of Adaptive Immunity by the Innate Immune System
2010 StandoutScience
Whole‐Exome Sequencing Reveals Overlap Between Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis and Familial Hemophagocytic Lymphohistiocytosis
2014
NK cell–mediated killing of target cells triggers robust antigen-specific T cell–mediated and humoral responses
2009 StandoutNobel
Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals
2007 StandoutNobel
Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon γ
2002
GITR Activation Induces an Opposite Effect on Alloreactive CD4+ and CD8+ T Cells in Graft-Versus-Host Disease
2004 StandoutNobel
Perforin is a critical physiologic regulator of T-cell activation
2011
The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon γ production
2002
Ly-49P Activates NK-Mediated Lysis by Recognizing H-2Dd 1
2000
Place Cells and Place Recognition Maintained by Direct Entorhinal-Hippocampal Circuitry
2002 StandoutScienceNobel
Innate or Adaptive Immunity? The Example of Natural Killer Cells
2011 StandoutScience
Hemophagocytic lymphohistiocytosis is associated with deficiencies of cellular cytolysis but normal expression of transcripts relevant to killer-cell–induced apoptosis
2002
Systemic Juvenile Idiopathic Arthritis–like Syndrome in Mice Following Stimulation of the Immune System With Freund's Complete Adjuvant: Regulation by Interferon‐γ
2014
Gene expression profiling of peripheral blood from patients with untreated new‐onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome
2007
Works of Susan E. Stepp being referenced
Dynamics of Ly49 expressing cytotoxic lymphocyte subsets in response to virus infection
2002
Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4
1999
Potential pathways for regulation of NK and T cell responses: differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4
2000
Molecular cloning of transmembrane and soluble forms of a novel rat natural killer cell receptor related to 2B4
2000
Gene structure of the murine NK cell receptor 2B4: presence of two alternatively spliced isoforms with distinct cytoplasmic domains
1999
2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes
2001
Virus-Specific CD8 T Cells in Peripheral Tissues Are More Resistant to Apoptosis Than Those in Lymphoid Organs
2003
Perforin: more than just an effector molecule
2000
Characterization of inhibitory and stimulatory forms of the murine natural killer cell receptor 2B4
1999
2B4 Acts As a Non–Major Histocompatibility Complex Binding Inhibitory Receptor on Mouse Natural Killer Cells
2004
Targeted Disruption of the 2B4 Gene in Mice Reveals an In Vivo Role of 2B4 (CD244) in the Rejection of B16 Melanoma Cells
2005
Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis
1999 Science