Citation Impact
Citing Papers
Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4
2012
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling
2011
NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer
2010 StandoutNobel
LGR5-Targeted Antibody–Drug Conjugate Eradicates Gastrointestinal Tumors and Prevents Recurrence
2016
Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells
2002
TOR Signaling in Growth and Metabolism
2006 Standout
Dendritic Cell Targeting of Survivin Protein in a Xenogeneic Form Elicits Strong CD4+ T Cell Immunity to Mouse Survivin
2006 StandoutNobel
Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics
2003
Transcriptional Regulation of Mitotic Checkpoint Gene MAD1 by p53
2003
Overcoming Endocrine Therapy Resistance by Signal Transduction Inhibition
2004
ERBB receptors and cancer: the complexity of targeted inhibitors
2005 Standout
Industrial biocatalysis today and tomorrow
2001 StandoutNature
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Actin' up: RhoB in cancer and apoptosis
2001
Repression of New p53 Targets Revealed by ChIP on Chip Experiments
2006
Cancer nanomedicine: progress, challenges and opportunities
2016 Standout
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
2010 StandoutNature
Nucleotide signalling during inflammation
2014 StandoutNature
Survivin, versatile modulation of cell division and apoptosis in cancer
2003
Tumor suppressor p53 represses transcription of RECQ4 helicase
2005
Extracellular adenosine triphosphate and adenosine in cancer
2010
Tracking Down the Stem Cells of the Intestine: Strategies to Identify Adult Stem Cells
2007
High‐Throughput Screening for Terpene‐Synthase‐Cyclization Activity and Directed Evolution of a Terpene Synthase
2013 StandoutNobel
Therapeutic Strategies for Targeting Ras Proteins
2011
Wound repair and regeneration
2008 StandoutNature
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
A microRNA component of the p53 tumour suppressor network
2007 StandoutNature
Farnesyltransferase inhibitors: promises and realities
2002
Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells
2010
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
2011 Standout
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
2014
Detection of Peptides, Proteins, and Drugs That Selectively Interact With Protein Targets
2002 StandoutNobel
LGR6 Is a High Affinity Receptor of R-Spondins and Potentially Functions as a Tumor Suppressor
2012
VHL and p53: Tumor Suppressors Team Up to Prevent Cancer
2006 StandoutNobel
Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis
2013
p21/CDKN1A Mediates Negative Regulation of Transcription by p53
2003
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
2014 Standout
Cancer stem cells revisited
2017 Standout
Decision making by p53: life, death and cancer
2003
The role of p53 in hypoxia-induced apoptosis
2005
Cancer genes and the pathways they control
2004 Standout
WNT signaling in bone homeostasis and disease: from human mutations to treatments
2013 Standout
Targeting cancer with small molecule kinase inhibitors
2008 Standout
Blinded by the Light: The Growing Complexity of p53
2009 Standout
The Farnesyl Transferase Inhibitor (FTI) SCH66336 (lonafarnib) Inhibits Rheb Farnesylation and mTOR Signaling
2005
Wnt/β-Catenin Signaling and Disease
2012 Standout
p21 in cancer: intricate networks and multiple activities
2009 Standout
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies
2000
Targeting RAS signalling pathways in cancer therapy
2003 Standout
Validating survivin as a cancer therapeutic target
2003
Comparative study of gene set enrichment methods
2009
Remodelling the extracellular matrix in development and disease
2014 Standout
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
Differential effects of cell cycle regulatory protein p21WAF1/Cip1 on apoptosis and sensitivity to cancer chemotherapy
2003
Poly(ADP-ribose): novel functions for an old molecule
2006 Standout
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Mitochondrial localization of p53 during adenovirus infection and regulation of its activity by E1B-19K
2005
Microtubules as a target for anticancer drugs
2004 Standout
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Revealing the world of RNA interference
2004 StandoutNatureNobel
Molecular Mechanisms of Transactivation and Doxorubicin-mediated Repression of survivin Gene in Cancer Cells
2006
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Centromere Proteins Cenpa, Cenpb, and Bub3 Interact with Poly(ADP-ribose) Polymerase-1 Protein and Are Poly(ADP-ribosyl)ated
2002
Repression of hsp90β Gene by p53 in UV Irradiation-induced Apoptosis of Jurkat Cells
2004
XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease
2008 Standout
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
2009 Standout
G protein-coupled receptors: novel targets for drug discovery in cancer
2010
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
Crypt stem cells as the cells-of-origin of intestinal cancer
2008 StandoutNature
Identification of stem cells in small intestine and colon by marker gene Lgr5
2007 StandoutNature
Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice
2008
Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals
2007 Standout
Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression
2003
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Modeling Development and Disease with Organoids
2016 Standout
KLF5 Interacts with p53 in Regulating Survivin Expression in Acute Lymphoblastic Leukemia
2006
Immunogenic cell death and DAMPs in cancer therapy
2012 Standout
The spindle-assembly checkpoint in space and time
2007 Standout
Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage
2008
Organization of the bacterial chromosome
1990
Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis
2009
Novel folded protein domains generated by combinatorial shuffling of polypeptide segments
2000 StandoutNobel
Palmitoylation of oncogenic NRAS is essential for leukemogenesis
2010
BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors
2007
Transcriptional control of human p53-regulated genes
2008 Standout
Click-Chemistry Based High Throughput Screening Platform for Modulators of Ras Palmitoylation
2017 StandoutNobel
Four faces of cellular senescence
2011 Standout
Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss
2003
BindingDB Entry 2025: Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.
2007
Causal analysis approaches in Ingenuity Pathway Analysis
2013 Standout
Targeting LGR5 + cells with an antibody-drug conjugate for the treatment of colon cancer
2015
Farnesyl Diphosphate Analogues with ω-Bioorthogonal Azide and Alkyne Functional Groups for Protein Farnesyl Transferase-Catalyzed Ligation Reactions
2007
Emerging Targets in Photopharmacology
2016 StandoutNobel
Molecular mechanisms of resistance of leukemia to imatinib mesylate
2003
Direct p53 Transcriptional Repression: In Vivo Analysis of CCAAT-Containing G2/M Promoters
2005
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
2010 StandoutScience
Engineering of a Stable Whole-Cell Biocatalyst Capable of ( S )-Styrene Oxide Formation for Continuous Two-Liquid-Phase Applications
1999
Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies
2003
Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor.
2001
Works of Stuart Black being referenced
Transcriptional Regulation during p21/-induced Apoptosis in Human Ovarian Cancer Cells
2002
The Farnesyl Transferase Inhibitor SCH 66336 Induces a G2 → M or G1 Pause in Sensitive Human Tumor Cell Lines
2001
Farnesyl Transferase Inhibitors Block the Farnesylation of CENP-E and CENP-F and Alter the Association of CENP-E with the Microtubules
2000
Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway
2002
Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors
2006
Use of the Escherichia coli ssb Gene to Prevent Bioreactor Takeover by Plasmidless Cells
1990
RNA interference targeting of A1 receptor-overexpressing breast carcinoma cells leads to diminished rates of cell proliferation and induction of apoptosis
2005