Standout Papers
- Mutational analysis of the fission yeast p34cdc2 protein kinase gene (1993)
- The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27. (1996)
- Genetic interactions in the control of mitosis in fission yeast (1989)
- Genetic analysis of human p34CDC2 function in fission yeast (1993)
- Isolation, characterisation and molecular cloning of new mutant alleles of the fission yeast p34 cdc2+ protein kinase gene: identification of temperature-sensitive G2-arresting alleles (1991)
- Molecular cloning and sequence analysis of mutant alleles of the fission yeast cdc2 protein kinase gene: Implications for cdc2 + protein structure and function (1989)
- Cold-sensitive mutants of p34dc2 that suppress a mitotic catastrophe phenotype in fission yeast (1992)
Citation Impact
Citing Papers
[56] Molecular genetic analysis of fission yeast Schizosaccharomyces pombe
1991 StandoutNobel
A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins
2002
Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases
1994 StandoutNobel
Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene
1994 StandoutNatureNobel
Cyclin activation of p34cdc2
1990
Ordering S phase and M phase in the cell cycle
1994 StandoutNobel
MicroRNAs
2004 Standout
Biochemical analysis of human Dna2
2006
cDNA cloning of a novel cdc2+/CDC28‐related protein kinase from rice
1991
Molecular genetic studies of the Cdc7 protein kinase and induced mutagenesis in yeast.
1992
Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes
1991
Isolation and characterization of goldfish cdk2, a cognate variant of the cell cycle regulator cdc2
1992
Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication
1990 StandoutNobel
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
1992
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
When Checkpoints Fail
1997 StandoutNobel
Pre-meiotic S phase is linked to reductional chromosome segregation and recombination
2001 StandoutNatureNobel
Population explosion in the cyclin family
1991
Involvement of p34cdc2 in establishing the dependency of S phase on mitosis
1991 StandoutNatureNobel
Cell Cycle Regulation in the Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe
1991 StandoutNobel
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
2006
Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK
1994 StandoutNobel
A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex
1992
A Long Twentieth Century of the Cell Cycle and Beyond
2000 StandoutNobel
Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle
1991
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase
1990 StandoutNatureNobel
Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase
1991 Nature
Dissociation of meiotic and mitotic roles of the fission yeastcdc2 gene
1990
Expression of a dominant negative allele of cdc2 prevents activation of the endogenous p34cdc2 kinase
1991 StandoutNobel
Mutations in the cdc10 start gene of Schizosaccbaromyces pombe implicate the region of homology between cdc10 and SWl6 as important for p85cdc10 function
1992
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
Crystal structure of cyclin-dependent kinase 2
1993 Nature
Mechanism of Stimulation of Human DNA Ligase I by the Rad9-Rad1-Hus1 Checkpoint Complex
2006 StandoutNobel
A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock
2001 StandoutNobel
Substrates for p34cdc2: In vivo veritas?
1990 StandoutNobel
DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts
2000 StandoutNobel
The Cdt1 protein is required to license DNA for replication in fission yeast
2000 StandoutNatureNobel
The fission yeast cdc18+ gene product couples S phase to START and mitosis
1993 StandoutNobel
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
1991
Identification of self peptides bound to purified HLA-B27
1991 Nature
Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination
1998 StandoutNatureNobel
Identification of a Gl-type cyclin puc1+ in the fission yeast Schizosaccharomyces pombe
1991 StandoutNatureNobel
A brain-specific activator of cyclin-dependent kinase 5
1994 StandoutNatureNobel
CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint
1997 StandoutNobel
Cohesin Rec8 is required for reductional chromosome segregation at meiosis
1999 StandoutNatureNobel
Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast
1990 StandoutNatureNobel
FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation
1990
Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation
1994
RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes
2001 Nature
Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family
1991
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex
1994 StandoutNobel
Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.
1991
Role of phosphorylation in p34cdc2 activation: identification of an activating kinase.
1992
A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.
1995 StandoutNobel
Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase.
1992
A Dominant Negative Allele of p34cdc2 Shows Altered Phosphoamino Acid Content and Sequesters p56cdc13 Cyclin
1992 StandoutNobel
Kap104p: A Karyopherin Involved in the Nuclear Transport of Messenger RNA Binding Proteins
1996 StandoutScienceNobel
NAB2: a Yeast Nuclear Polyadenylated RNA-Binding Protein Essential for Cell Viability
1993
Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro.
1993
Both cdc2 and cdk2 promote S phase initiation in Xenopus egg extracts
1995
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily.
1990
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.
1993
A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins.
1996 StandoutNobel
Checkpoints and spindles
1991 StandoutNatureNobel
Dominant mutants identify new roles for p34cdc2 in mitosis.
1995 StandoutNobel
Complementation of the Mitotic Activator, p80 cdc25 , by a Human Protein-tyrosine Phosphatase
1990 StandoutScienceNobel
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
A family of human cdc2-related protein kinases.
1992
Correction: Identification of a Gl-type cyclin puc+ in the fission yeast Schizosaccharomyces pombe
1991 StandoutNatureNobel
The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs.
1993 StandoutNobel
A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.
1991
p34cdc2 acts as a lamin kinase in fission yeast.
1991 StandoutNobel
The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.
1993 StandoutNobel
Cyclin D1 is a nuclear protein required for cell cycle progression in G1.
1993
B-type cyclins regulate G1 progression in fission yeast in opposition to the p25rum1 cdk inhibitor.
1996
THE DNA REPLICATION FORK IN EUKARYOTIC CELLS
1998
On the synthesis and destruction of A- and B-type cyclins during oogenesis and meiotic maturation in Xenopus laevis.
1991 StandoutNobel
The Incredible Life and Times of Biological Cells
2000 StandoutScienceNobel
Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.
1992
The cyclin‐dependent protein kinases and the control of cell division
1994
Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.
1992
Cyclin A is required at two points in the human cell cycle.
1992
Mutations at sites involved in Suc1 binding inactivate Cdc2.
1991
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
cdc2 phosphorylation is required for its interaction with cyclin.
1991
Activation of human cyclin-dependent kinases in vitro.
1992
Hepatitis C Virus IRES RNA-Induced Changes in the Conformation of the 40 S Ribosomal Subunit
2001 StandoutScienceNobel
CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15.
1993
A dominant negative allele of p34cdc2 shows altered phosphoamino acid content and sequesters p56cdc13 cyclin.
1992 StandoutNobel
Purification and characterization of a novel proline-directed protein kinase from bovine brain.
1992
A B-type cyclin negatively regulates conjugation via interacting with cell cycle ‘start’ genes in fission yeast.
1994
Cell cycle arrest and c-mos
1992 StandoutNatureNobel
A Fission Yeast Homolog of CDC20/p55CDC/Fizzy Is Required for Recovery from DNA Damage and Genetically Interacts with p34cdc2
1997
A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans
1994
Fission Yeast Cdc24 Is a Replication Factor C- and Proliferating Cell Nuclear Antigen-Interacting Factor Essential for S-Phase Completion
1999
Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation.
1995 StandoutNobel
Vertebrate p34cdc2 phosphorylation site mutants: effects upon cell cycle progression in the fission yeast Schizosaccharomyces pombe
1992
Replication Factor C3 ofSchizosaccharomyces pombe, a Small Subunit of Replication Factor C Complex, Plays a Role in Both Replication and Damage Checkpoints
1999
The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.
1993
Fission Yeast cdc24+ Encodes a Novel Replication Factor Required for Chromosome Integrity
1998
Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits.
1992 StandoutNobel
Pyp3 PTPase acts as a mitotic inducer in fission yeast.
1992
A cdc2-related kinase oscillates in the cell cycle independently of cyclins G2/M and cdc2.
1992
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
1994 Standout
Works of Stuart A. MacNeill being referenced
Genetic interactions in the control of mitosis in fission yeast
1989 StandoutNobel
A key role for replication factor C in DNA replication checkpoint function in fission yeast
1999
Mutational analysis of the fission yeast p34cdc2 protein kinase gene
1993 StandoutNobel
Genetic analysis of human p34CDC2 function in fission yeast
1993 StandoutNobel
Molecular cloning and sequence analysis of cdc27 + required for the G2-M transition in the fission yeast Schizosaccharomyces pombe
1992
Isolation, characterisation and molecular cloning of new mutant alleles of the fission yeast p34 cdc2+ protein kinase gene: identification of temperature-sensitive G2-arresting alleles
1991 StandoutNobel
Molecular cloning and sequence analysis of mutant alleles of the fission yeast cdc2 protein kinase gene: Implications for cdc2 + protein structure and function
1989 StandoutNobel
ATP-dependent DNA ligases.
2002
Cold-sensitive mutants of p34dc2 that suppress a mitotic catastrophe phenotype in fission yeast
1992 StandoutNobel
DNA replication: Partners in the Okazaki two-step
2001
Genetic Analyses ofSchizosaccharomyces pombe dna2+ Reveal That Dna2 Plays an Essential Role in Okazaki Fragment Metabolism
2000
p68 RNA Helicase: Identification of a Nucleolar Form and Cloning of Related Genes Containing a Conserved Intron in Yeasts
1991
The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27.
1996 StandoutNobel
Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2.
1991
p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts.
1991
New Elements in the Mitotic Control of the Fission Yeast Schizosaccharomyces pombe
1991
DNA polymerase δ isolated from Schizosaccharomyces pombe contains five subunits
1997