Citation Impact
Citing Papers
Essential Cytoplasmic Translocation of a Cytokine Receptor–Assembled Signaling Complex
2008 Science
Comprehensive genomic characterization of head and neck squamous cell carcinomas
2015 StandoutNature
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
2004 Standout
Crystal Structure of the HSV-1 Fc Receptor Bound to Fc Reveals a Mechanism for Antibody Bipolar Bridging
2006 StandoutNobel
Mechanisms of Thrombus Formation
2008 Standout
The NEDD8 Pathway Is Essential for SCFβ-TrCP-mediated Ubiquitination and Processing of the NF-κB Precursor p105
2002 StandoutNobel
Triggering Cell Death
1999
The multifaceted roles of TRAFs in the regulation of B-cell function
2004
Necroptosis and its role in inflammation
2015 StandoutNature
Tumor necrosis factor receptor-associated factors (TRAFs)
2001
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
Oncogenic kinase signalling
2001 StandoutNature
The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity
2000
IKK1-deficient mice exhibit abnormal development of skin and skeleton
1999
Quantitative analysis of LP-BM5 murine leukemia retrovirus RNA using real-time RT-PCR
2003
Shared Principles in NF-κB Signaling
2008 Standout
Molecular mechanism and function of CD40/CD40L engagement in the immune system
2009
The IκB Kinase (IKK) Complex Is Tripartite and Contains IKKγ but Not IKAP as a Regular Component
2000
Hypoxia and Inflammation
2011 Standout
Macrophages in the Pathogenesis of Atherosclerosis
2011 Standout
TNF? and the TNF receptor superfamily: Structure-function relationship(s)
2000
The regulation of immunoglobulin E class-switch recombination
2003
The Structural Basis for the Recognition of Diverse Receptor Sequences by TRAF2
1999
CD40 Ligation Induces Tissue Factor Expression in Human Vascular Smooth Muscle Cells
2000
Nuclear Localization in the Biology of the CD40 Receptor in Normal and Neoplastic Human B Lymphocytes
2006
CD40 regulates the processing of NF-kappaB2 p100 to p52
2002
Distinct molecular mechanism for initiating TRAF6 signalling
2002 Nature
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
Missing Pieces in the NF-κB Puzzle
2002 Standout
Nuclear factor-κB in cancer development and progression
2006 StandoutNature
Processing of p105 Is Inhibited by Docking of p50 Active Subunits to the Ankyrin Repeat Domain, and Inhibition Is Alleviated by Signaling via the Carboxyl-terminal Phosphorylation/ Ubiquitin-Ligase Binding Domain
2001 StandoutNobel
Signalling pathways of the TNF superfamily: a double-edged sword
2003 Standout
Structural basis for self-association and receptor recognition of human TRAF2
1999 Nature
The development of allergic inflammation
2008 StandoutNature
CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism
2002
Characterization of the Recombinant IKK1/IKK2 Heterodimer
2000
Inhibition of NF-κB Activation by Arsenite through Reaction with a Critical Cysteine in the Activation Loop of IκB Kinase
2000 StandoutNobel
Osteoclast differentiation and activation
2003 StandoutNature
NF-kappa B p105 is a target of Ikappa B kinases and controls signal induction of Bcl-3-p50 complexes
1999
Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis
2001
TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
2021
Identification of TIFA as an Adapter Protein That Links Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) to Interleukin-1 (IL-1) Receptor-associated Kinase-1 (IRAK-1) in IL-1 Receptor Signaling
2003
The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling
2000
Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell–mediated spontaneous autoimmune arthritis in mice
2004 StandoutNobel
NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase
1999 StandoutNature
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Determination of tumor necrosis factor receptor-associated factor trimerization in living cells by CFP->YFP->mRFP FRET detected by flow cytometry
2005
The NF-κB Activation Pathway:A Paradigm in Information Transfer from Membrane to Nucleus
1999
Tumor Necrosis Factor Receptor-associated Factor 2 (TRAF2)-deficient B Lymphocytes Reveal Novel Roles for TRAF2 in CD40 Signaling
2003
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
2005 Standout
Atherosclerosis
2000 StandoutNature
The TNF and TNF Receptor Superfamilies
2001 Standout
Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Family: Adapter Proteins That Mediate Cytokine Signaling
2000
Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice
1999
TRAF2 Deficiency Results in Hyperactivity of Certain TNFR1 Signals and Impairment of CD40-Mediated Responses
1999
Selenium incorporation using recombinant techniques
2010
Selenomethionine Incorporation in Saccharomyces cerevisiae RNA Polymerase II
2001 StandoutNobel
CD40-Associated TRAF 6 Signaling Is Required for Disease Induction in a Retrovirus-Induced Murine Immunodeficiency
2004
Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance
2002 StandoutNobel
Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs
2009
TRANCE is a TNF family member that regulates dendritic cell and osteoclast function
1999
Protein–protein interactions define specificity in signal transduction
2000
A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα
2010 StandoutNobel
Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile
2010
A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1
2016
CD40-CD40 ligand
2000
TNF-R1 Signaling: A Beautiful Pathway
2002 StandoutScience
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Regulation and Function of NF-κB Transcription Factors in the Immune System
2009 Standout
Second Generation Light-Driven Molecular Motors. Unidirectional Rotation Controlled by a Single Stereogenic Center with Near-Perfect Photoequilibria and Acceleration of the Speed of Rotation by Structural Modification
2002 StandoutNobel
Analysis of Homologous Gene Clusters inCaenorhabditis elegansReveals Striking Regional Cluster Domains
2005
Self-Assembled RANK Induces Osteoclastogenesis Ligand-Independently
2005
TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-κB pathway by TRAF-binding TNFRs
2005
TNF Receptor-Associated Factor 6-Dependent CD40 Signaling Primes Macrophages to Acquire Antimicrobial Activity in Response to TNF-α
2005
Trance, a Tumor Necrosis Factor Family Member, Enhances the Longevity and Adjuvant Properties of Dendritic Cells in Vivo
2000 StandoutNobel
Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ
2001 StandoutScience
Functional Isoforms of IκB Kinase α (IKKα) Lacking Leucine Zipper and Helix-Loop-Helix Domains Reveal that IKKα and IKKβ Have Different Activation Requirements
2000
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
2018 StandoutNobel
Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1
2000 StandoutScience
Benzimidazole Inhibitors Induce a DFG-Out Conformation of Never in Mitosis Gene A-Related Kinase 2 (Nek2) without Binding to the Back Pocket and Reveal a Nonlinear Structure−Activity Relationship
2011
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Shared Pathways of IκB Kinase-Induced SCFβTrCP-Mediated Ubiquitination and Degradation for the NF-κB Precursor p105 and IκBα
2001
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin
2000
The Programmed Death-1 and Interleukin-10 Pathways Play a Down-Modulatory Role in LP-BM5 Retrovirus-Induced Murine Immunodeficiency Syndrome
2007 StandoutNobel
CD154 Activates Macrophage Antimicrobial Activity in the Absence of IFN-γ through a TNF-α-Dependent Mechanism
2003
Anatomy and Dynamics of a Supramolecular Membrane Protein Cluster
2007 StandoutScienceNobel
RIP Links TLR4 to Akt and Is Essential for Cell Survival in Response to LPS Stimulation
2004
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
2021 StandoutNobel
Molecular basis for CD40 signaling mediated by TRAF3
2000
Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell–mediated spontaneous autoimmune arthritis in mice
2004 StandoutNobel
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity
2000 Standout
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Nuclear CD40 interacts with c-Rel and enhances proliferation in aggressive B-cell lymphoma
2007
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
2001 Standout
I-κB Kinases α and β Have Distinct Roles in Regulating Murine T Cell Function
2002
X-linked immunodeficiency with hyper-IgM (XHIM)
2000
Works of Steven S. Pullen being referenced
CD40 Signaling through Tumor Necrosis Factor Receptor-associated Factors (TRAFs)
1999
Structural and Biochemical Analysis of Signal Transduction by the TRAF Family of Adapter Proteins
1999
Itk kinase inhibitors: Initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead
2008
Cellular responses to murine CD40 in a mouse B cell line may be TRAF dependent or independent
2002
Recombinant IκB Kinases α and β Are Direct Kinases of IκBα
1998
The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells
2002
High-Affinity Interactions of Tumor Necrosis Factor Receptor-Associated Factors (TRAFs) and CD40 Require TRAF Trimerization and CD40 Multimerization
1999
Crystallographic analysis of CD40 recognition and signaling by human TRAF2
1999
CD40−Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Interactions: Regulation of CD40 Signaling through Multiple TRAF Binding Sites and TRAF Hetero-Oligomerization
1998