Citation Impact
Citing Papers
Quantitative analysis of the expression of ACAT genes in human tissues by real-time PCR2
2004
Effect of tumor necrosis factor (TNF) on lipid metabolism in the diabetic rat. Evidence that inhibition of adipose tissue lipoprotein lipase activity is not required for TNF-induced hyperlipidemia.
1989
Promoter Choice Determines Splice Site Selection in Protocadherin α and γ Pre-mRNA Splicing
2002 StandoutNobel
Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates
2000
Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay
2004 StandoutNobel
Microenvironmental modulation breaks intrinsic pH limitations of nanozymes to boost their activities
2024 StandoutNobel
Identification of the Interaction Site within Acyl-CoA:Cholesterol Acyltransferase 2 for the Isoform-specific Inhibitor Pyripyropene A
2008 StandoutNobel
Medicinal strategies in the treatment of obesity
2000 Nature
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
2024 StandoutNobel
Control of somatic tissue differentiation by the long non-coding RNA TINCR
2012 StandoutNature
SIRT6 protects against pathological damage caused by diet‐induced obesity
2009
Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women
1998 Standout
Membrane Topology and Identification of Key Functional Amino Acid Residues of Murine Acyl-CoA:Diacylglycerol Acyltransferase-2
2006
Potential therapeutics for obesity and atherosclerosis: Inhibitors of neutral lipid metabolism from microorganisms
2007 StandoutNobel
Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver
2007
The Enzymes of Neutral Lipid Synthesis
2001
Characterization of Two Human Genes Encoding Acyl Coenzyme A:Cholesterol Acyltransferase-related Enzymes
1998
Selectivity of Pyripyropene Derivatives in Inhibition toward Acyl-CoA:cholesterol Acyltransferase 2 Isozyme
2008 StandoutNobel
Role for ELOVL3 and Fatty Acid Chain Length in Development of Hair and Skin Function
2004 StandoutNobel
Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme
2020 Nature
Orphan Nuclear Receptors as eLiXiRs and FiXeRs of Sterol Metabolism
2001
Human Acyl-CoA:Cholesterol Acyltransferase-1 (ACAT-1) Gene Organization and Evidence That the 4.3-Kilobase ACAT-1 mRNA Is Produced from Two Different Chromosomes
1999
Synthesis and structure–activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 3
2013 StandoutNobel
Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1
2002
Absence of ACAT-1 Attenuates Atherosclerosis but Causes Dry Eye and Cutaneous Xanthomatosis in Mice with Congenital Hyperlipidemia
2000
27-Hydroxycholesterol Is an Endogenous Ligand for Liver X Receptor in Cholesterol-loaded Cells
2001
Macrophages in the Pathogenesis of Atherosclerosis
2011 Standout
Roles of acyl-coenzyme A : cholesterol acyltransferase-1 and -2
2001
Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery
2002 Standout
Dramatic Accumulation of Triglycerides and Precipitation of Cardiac Hemodynamic Dysfunction during Brief Caloric Restriction in Transgenic Myocardium Expressing Human Calcium-independent Phospholipase A2γ
2007
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
2000
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members
2001
Human Acyl-CoA:Cholesterol Acyltransferase-1 Is a Homotetrameric Enzyme in Intact Cells and in Vitro
1999
Primates Highly Responsive to Dietary Cholesterol Up-regulate Hepatic ACAT2, and Less Responsive Primates Do Not
2002
Immunological Quantitation and Localization of ACAT-1 and ACAT-2 in Human Liver and Small Intestine
2000
Mechanisms of gallstone formation in women. Effects of exogenous estrogen (Premarin) and dietary cholesterol on hepatic lipid metabolism.
1991
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
2000 Standout
The Endoplasmic Reticulum Enzyme DGAT2 Is Found in Mitochondria-associated Membranes and Has a Mitochondrial Targeting Signal That Promotes Its Association with Mitochondria
2008
Multicenter, Placebo-Controlled Trial of Lorcaserin for Weight Management
2010
Fatty acid metabolism pathway play an important role in carcinogenesis of human colorectal cancers by Microarray-Bioinformatics analysis
2005
Synthesis and structure–activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 2
2013 StandoutNobel
Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion
2006
Wnt/β-Catenin Signaling and Disease
2012 Standout
Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance
2007
A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management
2015 Standout
Synthesis and structure–activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 1
2013 StandoutNobel
Selectivity of Microbial Acyl-CoA : cholesterol Acyltransferase Inhibitors toward Isozymes
2007 StandoutNobel
3 ACAT Inhibitors: The Search for a Novel and Effective Treatment of Hypercholesterolemia and Atherosclerosis
2002
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
2000
Mammalian acyl-CoA:cholesterol acyltransferases
2000
LIN28A Is a Suppressor of ER-Associated Translation in Embryonic Stem Cells
2012
Effect of ACAT Inhibition on the Progression of Coronary Atherosclerosis
2006
Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight gain, hyperlipidemia, and hepatic steatosis in db/db mice
2010
Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root ofSalvia miltiorrhiza
2002
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
2002 StandoutNobel
Lipopenia and Skin Barrier Abnormalities in DGAT2-deficient Mice
2004
Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans
2006
A Simple Enantioconvergent and Chemoenzymatic Synthesis of Optically Active α‐Substituted Amides
2011 StandoutNobel
DGAT and Triglyceride Synthesis A New Target for Obesity Treatment?
2000
Human Acyl-CoA:Cholesterol Acyltransferase-1 in the Endoplasmic Reticulum Contains Seven Transmembrane Domains
1999
Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation
2003
Increased atherosclerosis in LDL receptor–null mice lacking ACAT1 in macrophages
2001
Hepatitis C Virus Entry
2007 StandoutNobel
Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands
2002
DGAT2 Is a New Diacylglycerol Acyltransferase Gene Family
2001
Stratum Corneum Defensive Functions: An Integrated View
2005
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Obesity and the Regulation of Energy Balance
2001 Standout
The unfolded protein response transducer IRE1α prevents ER stress‐induced hepatic steatosis
2011
Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans
2015 StandoutNobel
The Hallmarks of Aging
2013 Standout
Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipase-deficient white adipose tissue
2003
Atherosclerosis
2000 StandoutNature
Interleukin-6 stimulates hepatic triglyceride secretion in rats.
1995
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice
2000
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
Atherosclerosis
2001 Standout
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Inhibition of Acyl‐CoA Cholesterol Acyltransferase by F12511 (Eflucimibe): Could it be a New Antiatherosclerotic Therapeutic?
2008
Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1
2002
The Role of the High-Density Lipoprotein Receptor SR-BI in the Lipid Metabolism of Endocrine and Other Tissues
2003
Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice
2003
Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ
1999 Nobel
The Nine Lives of ACAT Inhibitors
2006
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
2002 StandoutNobel
Absolute Stereochemistry of Fungal Beauveriolide III and ACAT Inhibitory Activity of Four Stereoisomers
2006
Biosynthesis of the Caenorhabditis elegans dauer pheromone
2009 StandoutNobel
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
Effects of the Acyl Coenzyme A:Cholesterol Acyltransferase Inhibitor Avasimibe on Human Atherosclerotic Lesions
2004
Inhibition of Triglyceride Synthesis as a Treatment Strategy for Obesity
2004
ACAT1 and ACAT2 Membrane Topology Segregates a Serine Residue Essential for Activity to Opposite Sides of the Endoplasmic Reticulum Membrane
2000
Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo.
1987
Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance
2007
Pyripyropene A, an Acyl–Coenzyme A:Cholesterol Acyltransferase 2–Selective Inhibitor, Attenuates Hypercholesterolemia and Atherosclerosis in Murine Models of Hyperlipidemia
2011 StandoutNobel
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Persistence of the hypertriglyceridemic effect of tumor necrosis factor despite development of tachyphylaxis to its anorectic/cachectic effects in rats.
1989
A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans
2009 StandoutNobel
ACAT2 Is Localized to Hepatocytes and Is the Major Cholesterol-Esterifying Enzyme in Human Liver
2004 StandoutNobel
Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages
2004
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands
2002
Isoform-Specific Inhibitors of Acats: Recent Advances and Promising Developments
2011
Plasma Cholesteryl Esters Provided by Lecithin:Cholesterol Acyltransferase and Acyl-Coenzyme A:Cholesterol Acyltransferase 2 Have Opposite Atherosclerotic Potential
2004
Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies
2018
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
1993 StandoutScience
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
2004 StandoutScience
Advances in Copper Complexes as Anticancer Agents
2013 Standout
Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1
2011
ACAT2 Is a Target for Treatment of Coronary Heart Disease Associated With Hypercholesterolemia
2005
Human Acyl-Coenzyme A:Cholesterol Acyltransferase Expressed in Chinese Hamster Ovary Cells: Membrane Topology and Active Site Location
2003
Intestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial Triglycerides
2012
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
2011 Standout
GENETIC MODELS OF OBESITY AND ENERGY BALANCE IN THE MOUSE
2000
Total synthesis of pyripyropene A
2011 StandoutNobel
Effect of tumor necrosis factor administration in vivo on lipoprotein lipase activity in various tissues of the rat.
1989
Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption
2004 StandoutScience
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
2003 Standout
Cholesterol Sensing, Trafficking, and Esterification
2006
Acyl coenzyme A : cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis
2001
Works of Steven R. Lear being referenced
A rapid calcium precipitation method of recovering large amounts of highly pure hepatocyte rough endoplasmic reticulum
1999
Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice
2003
Key regulatory oxysterols in liver: analysis as Δ4-3-ketone derivatives by HPLC and response to physiological perturbations
2001
ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase
1998
Role of CYP27A in cholesterol and bile acid metabolism
2004
De novo sterologenesis in the intact rat
1983
Localization of De Novo Sterologenesis in Mammalian Skin
1983
The Disappearance from the Circulation of Chylomicrons Obtained from Control and Diabetic Rats*
1987
De novo cholesterogenesis in pregnancy.
1983
Functional sizes of hepatic enzymes of cholesteryl ester metabolism determined by radiation inactivation.
1994
The Effect of Diabetes Mellitus on Sterol Synthesis in the Intact Rat
1982
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
1998
Developmental expression of elements of hepatic cholesterol metabolism in the rat.
1995
The effect of diabetes mellitus on sterol synthesis in the intact rat
1982
Effect of pregnancy and lactation on lipoprotein and cholesterol metabolism in the rat
1998