Citation Impact
Citing Papers
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
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Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
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Electrically monitoring DNA repair by photolyase
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DNA Lesion Recognition by the Bacterial Repair Enzyme MutM
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Enforced Presentation of an Extrahelical Guanine to the Lesion Recognition Pocket of Human 8-Oxoguanine Glycosylase, hOGG1
2012
Hallmarks of Cancer: The Next Generation
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Nakijiquinones J−R, Sesquiterpenoid Quinones with an Amine Residue from Okinawan Marine Sponges
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Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase
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Structural studies of human alkyladenine glycosylase and E. coli 3-methyladenine glycosylase
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Crystal Structure of a Human Alkylbase-DNA Repair Enzyme Complexed to DNA
1998
Base-excision repair of oxidative DNA damage
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Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase
2008 Nature
Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells
2003
Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis
2006
DNA repair: Caretakers of the genome?
1997
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA
1998
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)
2004
Flipping Duplex DNA Inside Out
2002
PKS and NRPS release mechanisms
2009
Cofactor-independent oxidases and oxygenases
2010
Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome
1999 StandoutNobel
Marine natural products
1990 Standout
8-hydroxyguanine (7,8-dihydro-8-oxoguanine) DNA glycosylase and AP lyase activities of hOGG1 protein and their substrate specificity
1997
Engineering of an enantioselective tyrosine aminomutase by mutation of a single active site residue in phenylalanine aminomutase
2010 StandoutNobel
Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA
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Structural Characterization of Human 8-Oxoguanine DNA Glycosylase Variants Bearing Active Site Mutations
2006
Requirement of RSF and FACT for Transcription of Chromatin Templates in Vitro
1998
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 StandoutNature
Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage
1998
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily
1998
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Structure and function in the uracil-DNA glycosylase superfamily
2000
Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA
2005 Nature
Activation of Human MutS Homologs by 8-Oxo-guanine DNA Damage
2002
Infrequent Mutations of the hOGG1 Gene, That Is Involved in the Excision of 8‐Hydroxyguanine in Damaged DNA, in Human Gastric Cancer
1998
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
The Ogg1 protein of Saccharomyces cerevisiae: a 7,8-dihydro-8- oxoguanine DNA glycosylase/AP lyase whose lysine 241 is a critical residue for catalytic activity
1997
Inactivation of OGG1 increases the incidence of G · C→T · A transversions in Saccharomyces cerevisiae : evidence for endogenous oxidative damage to DNA in eukaryotic cells
1997
Conformational Changes That Occur during an RNA-editing Adenosine Deamination Reaction
2001
Genomic basis for natural product biosynthetic diversity in the actinomycetes
2009
Repair of Endogenous DNA Damage
2000 StandoutNobel
The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation
1998
DNA repair: How yeast repairs radical damage
1996
Base excision repair enzyme family portrait: integrating the structure and chemistry of an entire DNA repair pathway
1997
The critical active-site amine of the human 8-oxoguanine DNA glycosylase, hOgg1: direct identification, ablation and chemical reconstitution
1997
A proteome chip approach reveals new DNA damage recognition activities in Escherichia coli
2007
Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites
1997
Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme
2009 Nature
Structural Basis for the Excision Repair of Alkylation-Damaged DNA
1996
DNA-Protein Cross-link Formation Mediated by Oxanine
2003
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant
2011 StandoutNatureNobel
Differential Specificity of Human and Escherichia coli Endonuclease III and VIII Homologues for Oxidative Base Lesions
2004
DNA base damage recognition and removal: New twists and grooves
2005
Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2
2003
Clue to damage recognition by UvrB: residues in the beta-hairpin structure prevent binding to non-damaged DNA
2001
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
The mechanism of action of DNA photolyases
2001
Gene regulation and DNA damage in the ageing human brain
2004 Nature
A designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue
2018
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Identification and Characterization of a Novel Human DNA Glycosylase for Repair of Cytosine-derived Lesions
2002
Mechanism‐Inspired Engineering of Phenylalanine Aminomutase for Enhanced β‐Regioselective Asymmetric Amination of Cinnamates
2011 StandoutNobel
The intricate structural chemistry of base excision repair machinery: Implications for DNA damage recognition, removal, and repair
2007
Substrate specificity of the Ogg1 protein of Saccharomyces cerevisiae: excision of guanine lesions produced in DNA by ionizing radiation- or hydrogen peroxide/metal ion-generated free radicals
1998
Insights from the sea: Structural biology of marine polyketide synthases
2012
Poly(ADP-ribose) Polymerase-1 (PARP-1) Is Required in Murine Cell Lines for Base Excision Repair of Oxidative DNA Damage in the Absence of DNA Polymerase β
2003
Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity
2016
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
DNA glycosylases
1997
A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer
1997
Involvement of mammalian OGG1(MMH) in excision of the 8-hydroxyguanine residue in DNA1,2 1Guest Editor: Miral Dizdaroglu 2This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal.
2002
Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer
2004
A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage
2002
Lessons learned from structural results on uracil-DNA glycosylase
2000
The enigma of endonuclease VIII
2003
Substrate specificities of the Ntg1 and Ntg2 proteins of Saccharomyces cerevisiae for oxidized DNA bases are not identical
1998
Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2
2004
Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice
2001
Base Excision Repair
2004
MSH2 and MSH6 Are Required for Removal of Adenine Misincorporated Opposite 8-Oxo-Guanine in S. cerevisiae
1999
Site-Specific DNA Damage Recognition by Enzyme-Induced Base Flipping
2004
The Dermatomyositis-Specific Autoantigen Mi2 Is a Component of a Complex Containing Histone Deacetylase and Nucleosome Remodeling Activities
1998
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans
2002 StandoutNobel
Distinct Repair Activities of Human 7,8-Dihydro-8-oxoguanine DNA Glycosylase and Formamidopyrimidine DNA Glycosylase for Formamidopyrimidine and 7,8-Dihydro-8-oxoguanine
2000 StandoutNobel
Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli
2001
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
Protein Engineering for Improving and Diversifying Natural Product Biosynthesis
2020
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
1999 StandoutNobel
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
2001 StandoutNobel
The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexes
1998
DNA-mediated charge transport for DNA repair
2003
New mechanistic studies on the proline-catalyzed aldol reaction
2004 StandoutNobel
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Cloning and characterization of hOGG1 , a human homolog of the OGG1 gene of Saccharomyces cerevisiae
1997
A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex
2006
Phenylalanine Aminomutase-Catalyzed Addition of Ammonia to Substituted Cinnamic Acids: a Route to Enantiopure α- and β-Amino Acids
2009 StandoutNobel
The Origin of Stereoselectivity in Proline-Catalyzed Intramolecular Aldol Reactions
2001
Directed Evolution of a Designer Enzyme Featuring an Unnatural Catalytic Amino Acid
2018
DNA REPAIR MECHANISMS FOR THE RECOGNITION AND REMOVAL OF DAMAGED DNA BASES
1999
Requirement for human AP endonuclease 1 for repair of 3′-blocking damage at DNA single-strand breaks induced by reactive oxygen species
2000
Quality Control by DNA Repair
1999 StandoutScienceNobel
The C-Terminal Domain of the Adenine-DNA Glycosylase MutY Confers Specificity for 8-Oxoguanine·Adenine Mispairs and May Have Evolved from MutT, an 8-Oxo-dGTPase
1999
Crystal structures of proline-derived enamines
2010 StandoutNobel
Efficient Repair of Abasic Sites in DNA by Mitochondrial Enzymes
1998
ATP-independent diffusion of double-stranded RNA binding proteins
2012 StandoutNobel
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
BASE FLIPPING
1998 Nobel
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
2010 StandoutNobel
Transition States of Amine-Catalyzed Aldol Reactions Involving Enamine Intermediates: Theoretical Studies of Mechanism, Reactivity, and Stereoselectivity
2001
Chemistry of Glycosylases and Endonucleases Involved in Base-Excision Repair
1998
Stereoselective Synthesis of (+)-Avarol, (+)-Avarone, and Some Nonracemic Analogues
1996
Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells
2004 StandoutNobel
Molecular dynamics and protein function
2005
Biochemical Properties and Crystal Structure of a β-Phenylalanine Aminotransferase from Variovorax paradoxus
2012 StandoutNobel
Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination
2009 StandoutNobel
Vanchrobactin and Anguibactin Siderophores Produced by Vibrio sp. DS40M4
2010
A direct intramolecular asymmetric catalytic aldol cyclodehydration of meso-3,4-disubstituted-1,6-dialdehydes
2004
Requirement for human AP endonuclease 1 for repair of 3′-blocking damage at DNA single-strand breaks induced by reactive oxygen species
2000
DNA glycosylases in the base excision repair of DNA
1997
Structural Investigations into the Stereochemistry and Activity of a Phenylalanine-2,3-aminomutase from Taxus chinensis
2014 StandoutNobel
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III
1997 StandoutNobel
Cultivation-independent approaches to investigate the chemistry of marine symbiotic bacteria
2009
Augmented Expression of a Human Gene for 8-oxoguanine DNA Glycosylase (MutM) in B Lymphocytes of the Dark Zone in Lymph Node Germinal Centers
1997
Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase
1997 StandoutNobel
Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples
2012 StandoutNobel
Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA
2002
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
2011 Standout
How Enzymes Work: Analysis by Modern Rate Theory and Computer Simulations
2004 Science
Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase
1997
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Asymmetric Enamine Catalysis
2007 StandoutNobel
DNA glycosylase recognition and catalysis
2004
In Vitro Reconstitution of Formylglycine‐Generating Enzymes Requires Copper(I)
2015
Repair of DNA–polypeptide crosslinks by human excision nuclease
2006 StandoutNobel
A Chemoenzymatic Approach to Glycopeptide Antibiotics
2004
Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.
1997
Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors
2003 StandoutNobel
Structure of a DNA Glycosylase Searching for Lesions
2006 Science
Works of Steven D. Bruner being referenced
Engineered P450 biocatalysts show improved activity and regio-promiscuity in aromatic nitration
2017
Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily
1996
Type II Thioesterase Restores Activity of a NRPS Module Stalled with an Aminoacyl‐S‐enzyme that Cannot Be Elongated
2004
Structural Basis for the Cyclization of the Lipopeptide Antibiotic Surfactin by the Thioesterase Domain SrfTE
2002
DpgC Is a Metal- and Cofactor-Free 3,5-Dihydroxyphenylacetyl-CoA 1,2-Dioxygenase in the Vancomycin Biosynthetic Pathway
2004
How do DNA repair proteins locate damaged bases in the genome?
1997
Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM
2007
Selective Inhibition of Herpes Simplex Virus Type-1 Uracil-DNA Glycosylase by Designed Substrate Analogs
2000
Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
2000 Nature
Structural and Mechanistic Studies on Repair of 8-Oxoguanine in Mammalian Cells
2000
Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis
2007 Nature
Product-assisted catalysis in base-excision DNA repair
2003
Repair of oxidatively damaged guanine in Saccharomyces cerevisiae by an alternative pathway
1998
Structure and chemistry of 4-methylideneimidazole-5-one containing enzymes
2009
Probing the active site of MIO‐dependent aminomutases, key catalysts in the biosynthesis of β‐amino acids incorporated in secondary metabolites
2010
Total Synthesis of (-)-Ilimaquinone
1995
Characterization of the Surfactin Synthetase C-Terminal Thioesterase Domain as a Cyclic Depsipeptide Synthase
2002
The Structure of l -Tyrosine 2,3-Aminomutase from the C-1027 Enediyne Antitumor Antibiotic Biosynthetic Pathway,
2007
The Mechanism of MIO-Based Aminomutases in β-Amino Acid Biosynthesis
2007
New Tools for Studying Vesicular-Mediated Protein Trafficking: Synthesis and Evaluation of Ilimaquinone Analogs in a Non-Radioisotope-Based Antisecretory Assay
1997
An artificial self‐sufficient cytochrome P450 directly nitrates fluorinated tryptophan analogs with a different regio‐selectivity
2016
Substrate Recognition and Catalysis by the Cofactor-Independent Dioxygenase DpgC,
2007
Structure elucidation and biosynthesis of fuscachelins, peptide siderophores from the moderate thermophile Thermobifida fusca
2008