Citation Impact
Citing Papers
Removing T-cell epitopes with computational protein design
2014 StandoutNobel
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
Cation–π interactions in ligand recognition and catalysis
2002
Hyperleptinemia of Pregnancy Associated with the Appearance of a Circulating Form of the Leptin Receptor
1997
Estrogen Receptors: How Do They Signal and What Are Their Targets
2007 Standout
Structural Basis for Cytokine Hormone-Receptor Recognition and Receptor Activation
1998
Contemporary strategies for the stabilization of peptides in the α-helical conformation
2008
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
1994 Standout
Self-Assembling Drugs: A New Approach to Biochemical Modulation in Cancer Chemotherapy
1994
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Enzyme-Catalyzed Activation of Anticancer Prodrugs
2004
Dynamic Covalent Chemistry
2002 StandoutNobel
Combination of threading potentials and sequence profiles improves fold recognition 1 1Edited by B. Honig
2000
Congenital leptin deficiency is associated with severe early-onset obesity in humans
1997 StandoutNature
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
2001 StandoutNature
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
2006
The metabolic syndrome
2010 Standout
Cysteine Promoted C‐Terminal Hydrazinolysis of Native Peptides and Proteins
2013 StandoutNobel
Rationally Designed Chemical Modulators Convert a Bacterial Channel Protein into a pH‐Sensory Valve
2006 StandoutNobel
The weight of leptin in immunity
2004
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
Inhibition of α-helix-mediated protein–protein interactions using designed molecules
2013
Structural Insight into the Mode of Action of a Direct Inhibitor of Coregulator Binding to the Thyroid Hormone Receptor
2007
Selective activation of anticancer prodrugs by monoclonal antibody–enzyme conjugates
2001
Polymeric anticancer drugs with pH-controlled activation
2004
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
Assessing Kidney Function — Measured and Estimated Glomerular Filtration Rate
2006 Standout
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Ectopic Expression of Nonliganded Retinoic Acid Receptor β Abrogates AP-1 Activity by Selective Degradation of c-Jun in Cervical Carcinoma Cells
2004 StandoutNobel
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
The metabolic syndrome
2005 Standout
Synergism through direct covalent bonding between agents: A strategy for rational design of chemotherapeutic combinations
1990
Constraining Cyclic Peptides To Mimic Protein Structure Motifs
2014
Central nervous system control of food intake
2000 StandoutNature
Recommendations for Improving Serum Creatinine Measurement: A Report from the Laboratory Working Group of the National Kidney Disease Education Program
2005
Lessons learnt from structural studies of the oestrogen receptor
2006
NMR structure of human erythropoietin and a comparison with its receptor bound conformation
1998
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
1998 StandoutNature
Homology modeling using parametric alignment ensemble generation with consensus and energy-based model selection
2006 StandoutNobel
Origin and physiological roles of inflammation
2008 StandoutNature
The biology of leptin: a review.
1998
Immunological functions of leptin and adiponectin
2012
What We Talk About When We Talk About Fat
2014 Standout
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
1998 StandoutNature
Obesity and the Regulation of Energy Balance
2001 Standout
Tumor-activated Prodrugs—A New Approach to Cancer Therapy
2004
The active conformation of human glucokinase is not altered by allosteric activators
2011
Retinoic acid nuclear receptor β inhibits breast carcinoma anchorage independent growth
1995
Leptin and the regulation of body weight in mammals
1998 StandoutNature
Inhibitors of HIV‐1 Protease by Using In Situ Click Chemistry
2006 StandoutNobel
Leptin, Leptin Receptors, and the Control of Body Weight
2009
In Situ Click Chemistry: Enzyme‐Generated Inhibitors of Carbonic Anhydrase II
2004 StandoutNobel
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
Cancer of the Ovary
2004 Standout
The adipoinsular axis: effects of leptin on pancreatic β-cells
2000
Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
1998
Cyanogen Bromide Cleavage Generates Fragments Suitable for Expressed Protein and Glycoprotein Ligation
2004 StandoutNobel
The Role of SOCS-3 in Leptin Signaling and Leptin Resistance
1999
In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications
2004 StandoutNobel
From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions
2011 StandoutNobel
Clinical evaluation of intraperitoneal Pseudomonas exotoxin immunoconjugate OVB3-PE in patients with ovarian cancer.
1991
Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice
2002 StandoutNobel
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Restoration of leptin responsiveness in diet‐induced obese mice using an optimized leptin analog in combination with exendin‐4 or FGF21
2012
Physiological Increase in Plasma Leptin Markedly Inhibits Insulin Secretion In Vivo
2001
A Transgenic Model of Visceral Obesity and the Metabolic Syndrome
2001 StandoutScience
Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template
2012 StandoutNobel
Hydrogen Bond Surrogate Stabilization of β-Hairpins
2018
Macrocyclic Control in Helix Mimetics
2019
Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B: Evidence that directed migration is mediated by βγ dimers released by activation of Gαi-coupled receptors
1997
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
Leptin
2000
Synthesis of an organoinsulin molecule that can be activated by antibody catalysis
2001 StandoutNobel
Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix
2004 Science
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
2004 StandoutNobel
Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate
2013 StandoutNobel
Enzyme-Responsive Snap-Top Covered Silica Nanocontainers
2008 StandoutNobel
Peptide stapling techniques based on different macrocyclisation chemistries
2014
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation
2001
In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors
2005 StandoutNobel
Constrained Peptides as Miniature Protein Structures
2012
Antibody-directed enzyme prodrug therapy (ADEPT): a review
1997
Multiple event activation of a generic prodrug trigger by antibody catalysis
1999 StandoutNobel
Plasma pharmacokinetics of vinblastine and the investigational Vinca alkaloid N-(deacetyl-O-4-vinblastoyl-23)-L-ethyl isoleucinate in mice as determined by high-performance liquid chromatography.
1993
Stapled β-Hairpins Featuring 4-Mercaptoproline
2021 StandoutNobel
Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus
1998
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis
1997 StandoutScienceNobel
A β-lactamase with reduced immunogenicity for the targeted delivery of chemotherapeutics using antibody-directed enzyme prodrug therapy
2005
Development of α-Helical Calpain Probes by Mimicking a Natural Protein–Protein Interaction
2012
Works of Steve Briggs being referenced
New antitumor monoclonal antibody-vinca conjugates LY203725 and related compounds: design, preparation, and representative in vivo activity
1989
Crystal structure of the obese protein Ieptin-E100
1997 Nature
The crystal structures of human α‐thrombin complexed with active site‐directed diamino benzo[b] thiophene derivatives: A binding mode for a structurally novel class of inhibitors
2000
Positive interference with the Jaffé reaction by cephalosporin antibiotics.
1977
Antitumor activity of the monoclonal antibody-Vinca alkaloid immunoconjugate LY203725 (KS1/4-4-desacetylvinblastine-3-carboxhydrazide) in a nude mouse model of human ovarian cancer.
1990
Isolation of three separate anaphylatoxins from complement-activated human serum
1981
Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor–coactivator interactions
2003
A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor β
2006
Isolation of three separate anaphylatoxins from complement-activated human serum
1981
Site-specific prodrug activation by antibody-beta-lactamase conjugates: regression and long-term growth inhibition of human colon carcinoma xenograft models.
1993
Long-term growth suppression of human glioma xenografts by chemoimmunoconjugates of 4-desacetylvinblastine-3-carboxyhydrazide and monoclonal antibody 9.2.27.
1992
A Novel Glucokinase Activator Modulates Pancreatic Islet and Hepatocyte Function
2005