Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Functional Characterization of an Isoform-Selective Inhibitor of PI3K-p110β as a Potential Anticancer Agent
2012
Akt1 and Akt2 promote peripheral B-cell maturation and survival
2009
Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)
2010 StandoutNobel
Surveying Saccharomyces Genomes to Identify Functional Elements by Comparative DNA Sequence Analysis
2001
Combined Inhibition of Both p110α and p110β Isoforms of Phosphatidylinositol 3-Kinase Is Required for Sustained Therapeutic Effect in PTEN-Deficient, ER+ Breast Cancer
2016
Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization
2007 StandoutScience
Key role of the p110δ isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110δ function in B cells
2005
Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation
2009 Science
Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity
2016
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
2004 StandoutScience
Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo
2009
Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1
2017
Isoform-Specific Phosphoinositide 3-Kinase Inhibitors Exert Distinct Effects in Solid Tumors
2010
Klf4 reverts developmentally programmed restriction of ground state pluripotency
2009
PTEN-deficient cancers depend on PIK3CB
2008
The p110δ Isoform of Phosphoinositide 3-Kinase Controls Clonal Expansion and Differentiation of Th Cells
2006
Regulation of phosphoinositide 3-kinase expression in health and disease
2009
Mutant G-protein-coupled receptors as a cause of human diseases
2004
Pathogenesis of Osteoarthritis
1970
MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis
2011
Impaired CD4 and CD8 Effector Function and Decreased Memory T Cell Populations in ICOS-Deficient Patients
2009
Expression of ICOS on Human Melanoma-Infiltrating CD4+CD25highFoxp3+ T Regulatory Cells: Implications and Impact on Tumor-Mediated Immune Suppression
2008
MAPK, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Pathways Converge at the Level of Ribosomal Protein S6 Phosphorylation to Control Metabolic Signaling in CD8 T Cells
2009
PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling
2015
Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer
2014
Nanog Is the Gateway to the Pluripotent Ground State
2009 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The PI3K/AKT Pathway as a Target for Cancer Treatment
2015
Finishing the euchromatic sequence of the human genome
2004 StandoutNature
Opportunities and challenges in the development of kinase inhibitor therapy for cancer
2003
The Regulation of Class IA PI 3-Kinases by Inter-Subunit Interactions
2010
Multiple Molecular Interactions Determine the Clustering of Caspr2 and Kv1 Channels in Myelinated Axons
2008
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
Role of the phosphoinositide 3‐kinase p110δ in generation of type 2 cytokine responses and allergic airway inflammation
2007
Naive and Primed Pluripotent States
2009
PI3Kδ and primary immunodeficiencies
2016
A role for phosphoinositol 3–kinase δ in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease
2010
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
2005 StandoutNobel
Angiogenesis: A Team Effort Coordinated by Notch
2009
Akt and mTOR in B Cell Activation and Differentiation
2012
Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase
2016
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
2006 Standout
PI3K signalling in inflammation
2014
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Class I Phosphoinositide 3-Kinase p110β Is Required for Apoptotic Cell and Fcγ Receptor-mediated Phagocytosis by Macrophages
2003
Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents
2003
Vascularized and functional human liver from an iPSC-derived organ bud transplant
2013 StandoutNature
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
β-Arrestin-dependent Regulation of the Cofilin Pathway Downstream of Protease-activated Receptor-2
2007
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Class I PI3K in oncogenic cellular transformation
2008
Generation of Rat Pancreas in Mouse by Interspecific Blastocyst Injection of Pluripotent Stem Cells
2010
Chromosomal Abnormalities in Embryonic and Somatic Stem Cells
2015
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Validated germline-competent embryonic stem cell lines from nonobese diabetic mice
2009
Synergy in activating class I PI3Ks
2015
PI3K pathway alterations in cancer: variations on a theme
2008
PI3K in lymphocyte development, differentiation and activation
2003
Gene Model 129 (Gm129) Encodes a Novel Transcriptional Repressor That Modulates Circadian Gene Expression
2014 StandoutNobel
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
2005
The Pathogenesis of Rheumatoid Arthritis
2011 Standout
Protease‐activated receptors in hemostasis, thrombosis and vascular biology
2005
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
1997 StandoutNature
Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice
2007
Targeting phosphoinositide 3-kinase—Moving towards therapy
2007
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
2005 Standout
Targeting the phosphoinositide 3-kinase pathway in cancer
2009 Standout
Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ
2014
Phosphoinositide 3‐kinases in cell migration
2008
Specific Roles of the p110α Isoform of Phosphatidylinsositol 3-Kinase in Hepatic Insulin Signaling and Metabolic Regulation
2010
The Rise and Fall of the Chemoattractant Receptor GPR33
2005 StandoutNobel
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis
2010 Nature
Constitutive Protease-activated Receptor-2-mediated Migration of MDA MB-231 Breast Cancer Cells Requires Both β-Arrestin-1 and -2
2004 StandoutNobel
PI3Kγ inhibition: towards an 'aspirin of the 21st century'?
2006
Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues
2010
Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
2014 Nature
The immunoglobulin superfamily of neuronal cell adhesion molecules: Lessons from animal models and correlation with human disease
2008
2-Furoyl-LIGRLO-amide: A Potent and Selective Proteinase-Activated Receptor 2 Agonist
2004
Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity
2016
Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
2005
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
2004 Nature
Fugu: a compact vertebrate reference genome
2000 StandoutNobel
Regulation of Class-Switch Recombination and Plasma Cell Differentiation by Phosphatidylinositol 3-Kinase Signaling
2006
Signalling by insulin and IGF receptors: supporting acts and new players
2011
Structure of the Novel C-terminal Domain of Vacuolar Protein Sorting 30/Autophagy-related Protein 6 and Its Specific Role in Autophagy
2012 StandoutNobel
The Effects of Hemodynamic Force on Embryonic Development
2010
Neural stem cell systems: physiological players or in vitro entities?
2010
p110γ and p110δ Phosphoinositide 3-Kinase Signaling Pathways Synergize to Control Development and Functions of Murine NK Cells
2007
Signalling by PI3K isoforms: insights from gene-targeted mice
2005
The emerging mechanisms of isoform-specific PI3K signalling
2010
Targeting proteinase-activated receptors: therapeutic potential and challenges
2012
Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia
2016
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Origin and physiological roles of inflammation
2008 StandoutNature
Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises
2008
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
2014
Estimate of human gene number provided by genome-wide analysis using Tetraodon nigroviridis DNA sequence
2000
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function
2003
AKT/PKB Signaling: Navigating the Network
2017 Standout
Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold
2004
The Hallmarks of Aging
2013 Standout
Points of control in inflammation
2002 StandoutNature
PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model
2014
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
2008
The PI3K Pathway in Human Disease
2017 Standout
Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis
2008 Nature
mTOR and cancer: insights into a complex relationship
2006
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
2009 Standout
Organization of Myelinated Axons by Caspr and Caspr2 Requires the Cytoskeletal Adapter Protein 4.1B
2010
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
2004
Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
2009
A selective inhibitor of the p110δ isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16
2006
Phosphoinositide 3-kinase signalling – which way to target?
2003
Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)
2010 StandoutNobel
Distinct signaling mechanisms activate the target of rapamycin in response to different B‐cell stimuli
2007
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
2012
Zebrafish Comparative Genomics and the Origins of Vertebrate Chromosomes
2000
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock
2012
A conditional knockout resource for the genome-wide study of mouse gene function
2011 Nature
MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development
2012 StandoutNobel
A Case for Regulatory B Cells
2006
The regulation and function of Class III PI3Ks: novel roles for Vps34
2008
Inhibition of class IA PI3K enzymes in non-small cell lung cancer cells uncovers functional compensation among isoforms
2015
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development
2010
Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry
2006
Phosphatidylinositol 3-Kinase Regulates the CD4/CD8 T Cell Differentiation Ratio
2003
PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances
2012
PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context
2014
PI3K p110δ regulates T-cell cytokine production during primary and secondary immune responses in mice and humans
2010
Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex
2002
Essential role of PI3Kδ and PI3Kγ in thymocyte survival
2005
Inhibition of Class I Phosphoinositide 3-Kinase Activity Impairs Proliferation and Triggers Apoptosis in Acute Promyelocytic Leukemia without Affecting Atra-Induced Differentiation
2009
Phosphoinositide 3-Kinase Activity in T Cells Regulates the Magnitude of the Germinal Center Reaction
2010
Organogenesis in a dish: Modeling development and disease using organoid technologies
2014 StandoutScience
Critical Roles of Pten in B Cell Homeostasis and Immunoglobulin Class Switch Recombination
2003 StandoutNobel
Therapeutic potential of phosphoinositide 3-kinase inhibitors
2004
Conserved regulation of the lymphocyte-specific expression oflckin the Fugu and mammals
2002 StandoutNobel
Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors
2011
Phosphoproteomic Analysis Implicates the mTORC2-FoxO1 Axis in VEGF Signaling and Feedback Activation of Receptor Tyrosine Kinases
2013
A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition
2008
Germinal Centers
2012
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation
2006
Long‐term p110α PI3K inactivation exerts a beneficial effect on metabolism
2013
The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion
2007
Metabolic reprogramming and cancer progression
2020 StandoutScience
PI3 Kinases in Cancer: From Oncogene Artifact to Leading Cancer Target
2006
Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells
2013
Simultaneous precise editing of multiple genes in human cells
2019 StandoutNobel
Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase
2009
Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development
2012 StandoutNobel
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state
2010
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Phosphoinositide 3-Kinase : Diverse Roles in Immune Cell Activation
2004
Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy
2016
Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation
2013 StandoutNobel
Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta.
2003
Cutting Edge: The Phosphoinositide 3-Kinase p110δ Is Critical for the Function of CD4+CD25+Foxp3+ Regulatory T Cells
2006
The p110α Isoform of Phosphatidylinositol 3-Kinase Is Essential for Polyomavirus Middle T Antigen-Mediated Transformation
2007
Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody
2020 StandoutNobel
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
The p110δ of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation
2008
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
2016
Peroxisome proliferator-activated receptor γ agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity
2009
Regulation and cellular functions of class II phosphoinositide 3-kinases
2012
Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer
2018
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
The Pten/PI3K pathway governs the homeostasis of Vα14iNKT cells
2006 StandoutNobel
Cutting Edge: T Cell Development Requires the Combined Activities of the p110γ and p110δ Catalytic Isoforms of Phosphatidylinositol 3-Kinase
2005
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates
2014
Works of Stephen Meek being referenced
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
2008
Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice
2002 Science
The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells
2007
Isolation and characterisation of the retinoic acid receptor-α gene in the Japanese pufferfish, F. rubripes
1999 StandoutNobel
Neurofascins Are Required to Establish Axonal Domains for Saltatory Conduction
2005
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
2008 Nature
An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment
2011
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
2006 Nature
Effect of Protease-Activated Receptor-2 Deficiency on Allergic Dermatitis in the Mouse Ear
2002
Capture of Authentic Embryonic Stem Cells from Rat Blastocysts
2008
Generation and Analysis of 25 Mb of Genomic DNA from the Pufferfish Fugu rubripes by Sequence Scanning
1999 StandoutNobel
Essential role for proteinase-activated receptor-2 in arthritis
2003
Essential role for proteinase-activated receptor-2 in arthritis
2003