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A New Substrate Specificity for Acyl Transferase Domains of the Ascomycin Polyketide Synthase in Streptomyces hygroscopicus
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High-Throughput Mutagenesis to Evaluate Models of Stereochemical Control in Ketoreductase Domains from the Erythromycin Polyketide Synthase
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Cytochrome P450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2)
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Catalysis, Specificity, and ACP Docking Site of Streptomyces coelicolor Malonyl-CoA:ACP Transacylase
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Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor
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Optimal Determination of Particle Orientation, Absolute Hand, and Contrast Loss in Single-particle Electron Cryomicroscopy
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Organocatalytic Enantioselective Decarboxylative Aldol Reaction of Malonic Acid Half Thioesters with Aldehydes
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Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699
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Building-block selectivity of polyketide synthases
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Alternative modular polyketide synthase expression controls macrolactone structure
2000 Nature
Metabolic diversity in myxobacteria: identification of the myxalamid and the stigmatellin biosynthetic gene cluster of Stigmatella aurantiaca Sg a15 and a combined polyketide-(poly)peptide gene cluster from the epothilone producing strain Sorangium cellulosum So ce90
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Analysis of the Tetronomycin Gene Cluster: Insights into the Biosynthesis of a Polyether Tetronate Antibiotic
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Protein–Protein Interactions in Multienzyme Megasynthetases
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Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters
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Overexpression of the Nocardia lactamduransα‐Aminoadipyl‐Cysteinyl‐Valine Synthetase in Streptomyces lividans
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Characterization of the Mupirocin Biosynthesis Gene Cluster from Pseudomonas fluorescens NCIMB 10586
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Taking dendritic cells into medicine
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Organizational and Mutational Analysis of a Complete FR-008/Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex
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Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase
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Presence of an acyl carrier protein in NADH:ubiquinone oxidoreductase from bovine heart mitochondria
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bryA
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Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis
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Autophagy and Aging
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Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis
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Biochemistry and molecular cell biology of diabetic complications
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Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15
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Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
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Engineering specificity of starter unit selection by the erythromycin‐producing polyketide synthase
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The contentious nature of soil organic matter
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The Hidden Steps of Domain Skipping
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Gene Knockout Reveals a Novel Gene Cluster for the Synthesis of a Class of Cell Wall Lipids Unique to Pathogenic Mycobacteria
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Cryptosporidium parvum: the first protist known to encode a putative polyketide synthase
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New Lessons for Combinatorial Biosynthesis from Myxobacteria
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The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90
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Leinamycin Biosynthesis Revealing Unprecedented Architectural Complexity for a Hybrid Polyketide Synthase and Nonribosomal Peptide Synthetase
2004
Mechanism of Thioesterase-Catalyzed Chain Release in the Biosynthesis of the Polyether Antibiotic Nanchangmycin
2008
Structure and Biosynthesis of the Jamaicamides, New Mixed Polyketide-Peptide Neurotoxins from the Marine Cyanobacterium Lyngbya majuscula
2004
Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice
2002 StandoutNobel
The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid
1997
The type I fatty acid and polyketide synthases: a tale of two megasynthases
2007
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
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Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation
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Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum
2001
Spiroketal Polyketide Formation in Sorangium: Identification and Analysis of the Biosynthetic Gene Cluster for the Highly Cytotoxic Spirangienes
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Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems
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The Biosynthetic Logic of Polyketide Diversity
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Differential Impact of Blood Pressure–Lowering Drugs on Central Aortic Pressure and Clinical Outcomes
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Biosynthesis of fatty acids and related metabolites
1997
Evolution of protein function by Domain swapping
2001
Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties
2007 StandoutNobel
Novel Enzymatic Mechanisms in Carbohydrate Metabolism
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Can a Ketone Be More Reactive than an Aldehyde? Catalytic Asymmetric Synthesis of Substituted Tetrahydrofurans
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Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide–polyketide synthetase system
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Effect of non-invasive calibration of radial waveforms on error in transfer-function-derived central aortic waveform characteristics
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Harnessing the Biosynthetic Code: Combinations, Permutations, and Mutations
1998 Science
Die Vancomycin-Antibiotica und der Kampf gegen resistente Bakterien
1999
Ribosomal Synthesis of N-Methyl Peptides
2008 StandoutNobel
Retro-Diels−Alder Femtosecond Reaction Dynamics
1996 StandoutNobel
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
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Genetic Contributions to Understanding Polyketide Synthases
1997
Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms
2006
Evolution of polyketide synthases in bacteria
2008
Cloning and sequencing of a gene encoding carminomycin 4-O-methyltransferase from Streptomyces peucetius and its expression in Escherichia coli
1993
Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice
2002 StandoutNobel
Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone
2007
On the Biosynthetic Origin of Methoxymalonyl-Acyl Carrier Protein, the Substrate for Incorporation of “Glycolate” Units into Ansamitocin and Soraphen A
2006
Engineering enzymes for noncanonical amino acid synthesis
2018 StandoutNobel
Elucidating the Substrate Specificity and Condensation Domain Activity of FkbP, the FK520 Pipecolate-Incorporating Enzyme
2005
Tolerance and Specificity of Polyketide Synthases
1999
The candicidin gene cluster from Streptomyces griseus IMRU 3570 The GenBank accession numbers for the sequences reported in this paper are AJ300302 and AJ300303.
2002
Polyketide Double Bond Biosynthesis. Mechanistic Analysis of the Dehydratase-Containing Module 2 of the Picromycin/Methymycin Polyketide Synthase
2005
Tetrahydrofuran-Containing Macrolides: A Fascinating Gift from the Deep Sea
2013
Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlH, A Non-Heme Iron Dioxygenase of Streptomyces avermitilis
2006 StandoutNobel
Combinatorial Biosynthesis of Natural Products
2008
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
2010 StandoutNobel
Identification of the Putative Bryostatin Polyketide Synthase Gene Cluster from “Candidatus Endobugula sertula”, the Uncultivated Microbial Symbiont of the Marine Bryozoan Bugula neritina
2006
Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase
2001
A Self-Complexing [2]Catenane
2000 StandoutNobel
Biosynthetic Pathway and Gene Cluster Analysis of Curacin A, an Antitubulin Natural Product from the Tropical Marine Cyanobacterium Lyngbya majuscula
2004
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
2017 StandoutNobel
Elucidation of the Kijanimicin Gene Cluster: Insights into the Biosynthesis of Spirotetronate Antibiotics and Nitrosugars
2007
Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement
1993
Enzymatic Chemistry of Cyclopropane, Epoxide, and Aziridine Biosynthesis
2011
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Genetic Modifiers of Atherosclerosis in Mice
2000
Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units
2006
Structural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine Selectivity
2010 StandoutNobel
Avermectin Biosynthesis
1997 StandoutNobel
Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering
1998
Forty years of genetics with Streptomyces: from in vivo through in vitro to in silico
1999
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes
2016 StandoutNobel
The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase
1997
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlI, a Cytochrome P450 of Streptomyces avermitilis
2006 StandoutNobel
Modification of post-PKS tailoring steps through combinatorial biosynthesis
2002
A multifunctional polyketide–peptide synthetase essential for albicidin biosynthesis in Xanthomonas albilineans The GenBank accession number for the sequence determined in this work is AF239749.
2001
EngineeredStreptomyces avermitilisHost for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites
2013 StandoutNobel
Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes
1999
IDPi Catalysis
2019 StandoutNobel
Identification and Characterization of a Gene Cluster for Synthesis of the Polyketide Antibiotic 2,4-Diacetylphloroglucinol fromPseudomonas fluorescensQ2-87
1999
Genome Sequence of the Streptomycin-Producing MicroorganismStreptomyces griseusIFO 13350
2008
Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase
2006
Stereospecific Acyl Transfers on the Erythromycin-Producing Polyketide Synthase
1994 Science
Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450 BM3 demethylases
2009 StandoutNobel
Swinging Arms and Swinging Domains in Multifunctional Enzymes: Catalytic Machines for Multistep Reactions
2000
Involvement of a Cytochrome P450 Monooxygenase in Thaxtomin A Biosynthesis by Streptomyces acidiscabies
2002
Systems biology of cyanobacterial secondary metabolite production and its role in drug discovery
2008
Activation of olefins via asymmetric Brønsted acid catalysis
2018 StandoutScienceNobel
A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae
2008
Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling
2007 StandoutNobel
Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus
2010 Standout
New Rapamycin Derivatives by Precursor‐Directed Biosynthesis
2004
Engineering of modular polyketide synthases to produce novel polyketides
1998
Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse
2017
Terpene synthases are widely distributed in bacteria
2014 StandoutNobel
Direct transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesis
2008
Genetics of Zwittermicin A Production by Bacillus cereus
2004
Hydroxymethylfurfural, A Versatile Platform Chemical Made from Renewable Resources
2013 Standout
Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase
2001
Mutasynthesis of Rapamycin Analogues through the Manipulation of a Gene Governing Starter Unit Biosynthesis
2005
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis
1999
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Sequential Asymmetric Polyketide Heterocyclization Catalyzed by a Single Cytochrome P450 Monooxygenase (AurH)
2008
Works of Stephen Haydock being referenced
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans
2004
Double-blind, placebo-controlled crossover comparison of five classes of antihypertensive drugs
2002
Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of the enzymatic domains in the modular polyketide synthase
1996
The putative elaiophylin biosynthetic gene cluster in Streptomyces sp. DSM4137 is adjacent to genes encoding adenosylcobalamin-dependent methylmalonyl CoA mutase and to genes for synthesis of cobalamin
2004
Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea
1998
The Gene Cluster for Fluorometabolite Biosynthesis in Streptomyces cattleya: A Thioesterase Confers Resistance to Fluoroacetyl-Coenzyme A
2006
Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases
1991
Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid–type III polyketide synthase
2006
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338
2007
Prediction and Manipulation of the Stereochemistry of Enoylreduction in Modular Polyketide Synthases
2008
Biosynthetic Gene Cluster of the Glycopeptide Antibiotic Teicoplanin
2004
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea
1990 Nature
Pathoaetiology, Epidemiology and Diagnosis of Hypertension
2000
6‐Deoxyerythronolide‐B synthase 2 from Saccharopolyspora erythraea
1992
Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of genes flanking the polyketide synthase
1996
Insights into Polyether Biosynthesis from Analysis of the Nigericin Biosynthetic Gene Cluster in Streptomyces sp. DSM4137
2007
Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl‐CoA:acyl carrier protein transacylase domains in modular polyketide synthases
1995
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.
1995
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449
2005
Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin
2006
Influence of drugs and gender on the arterial pulse wave and natriuretic peptide secretion in untreated patients with essential hypertension
2002
A Common Variant of the Endothelial Nitric Oxide Synthase (Glu298→Asp) Is a Major Risk Factor for Coronary Artery Disease in the UK
1999