Citation Impact
Citing Papers
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
The DNA-damage response in human biology and disease
2009 StandoutNature
Glucocorticoid-induced DNA demethylation and gene memory during development
2001
Suppression of sterol 12α-hydroxylase transcription by the short heterodimer partner: insights into the repression mechanism
2001
Apoptosis in the nervous system
2000 StandoutNature
Recent applications of protein crystallography and structure-guided drug design
2005
Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane
2002
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
1998 Standout
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
2009 StandoutNature
A Mouse Model for the Basal Transcription/DNA Repair Syndrome Trichothiodystrophy
1998
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
2006 StandoutNature
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
2000
The conserved nuclear receptor Ftz‐F1 is required for embryogenesis, moulting and reproduction in Caenorhabditis elegans
2000
Activation of the Promoter of the Orphan Receptor SHP by Orphan Receptors That Bind DNA as Monomers
1999
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system
1997
A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
2000 Standout
Bcl-2-family proteins: the role of the BH3 domain in apoptosis
1998
X-linked IAP is a direct inhibitor of cell-death proteases
1997 StandoutNature
Nuclear receptor regulation of cholesterol and bile acid metabolism
1999
Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease
1992
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
2005 StandoutNature
The biochemistry of apoptosis
2000 StandoutNature
The Involvement of DNA-Damage and -Repair Defects in Neurological Dysfunction
2008
Gene regulatory factors in pancreatic development
2003
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
2008 StandoutNature
nhr-25, the Caenorhabditis elegans Ortholog of ftz-f1, Is Required for Epidermal and Somatic Gonad Development
2000
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Diet–microbiota interactions as moderators of human metabolism
2016 StandoutNature
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
1997 Standout
Two CD95 (APO-1/Fas) signaling pathways
1998 Standout
De novo design of bioactive protein switches
2019 StandoutNatureNobel
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors
1998 Standout
α1-Fetoprotein Transcription Factor Is Required for the Expression of Sterol 12α-Hydroxylase, the Specific Enzyme for Cholic Acid Synthesis
2000
Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
2010
A model for p53-induced apoptosis
1997 StandoutNature
Design and Evolution of a Miniature Bcl-2 Binding Protein
2001
Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation
2008
Features and development of Coot
2010 Standout
HOSPITAL MANAGEMENT OF DIABETES
2000
Molecular characterization of mitochondrial apoptosis-inducing factor
1999 StandoutNature
Dual Mechanisms for Repression of the Monomeric Orphan Receptor Liver Receptor Homologous Protein-1 by the Orphan Small Heterodimer Partner
2002
The PI3K Pathway in Human Disease
2017 Standout
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
1999 StandoutNature
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
2002
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?
1999
Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling
1999
Intensive Insulin Therapy in Critically Ill Patients
2001 Standout
Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers
1998
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
2001 StandoutScience
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
2002 StandoutNobel
Molecular Determinants of Bim(BH3) Peptide Binding to Pro-Survival Proteins
2012
The Pathophysiology of Mitochondrial Cell Death
2004 StandoutScience
CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene
1999
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
Bcl-2: Prolonging Life in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis
1997 Science
Substrate and Temperature Dependence of DNA Photolyase Repair Activity Examined with Ultrafast Spectroscopy
1997 StandoutNobel
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
2003 Standout
Quality Control by DNA Repair
1999 StandoutScienceNobel
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
Intracellular Delivery of a Proapoptotic Peptide via Conjugation to a RAFT Synthesized Endosomolytic Polymer
2009
Human ERCC5 cDNA-cosmid complementation for excision repair and bipartite amino acid domains conserved with RAD proteins of Saccharomyces cerevisiae and Schizosaccharomyces pombe.
1993
Epigenetic Reprogramming in Mammalian Development
2001 StandoutScience
Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition.
1999
NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation
1998 StandoutScience
Death Receptors: Signaling and Modulation
1998 StandoutScience
Differential Repair of the Two Major UV-Induced Photolesions in Trichothiodystrophy Fibroblasts
2004
Biochemical Pathways of Caspase Activation During Apoptosis
1999 Standout
Mitochondrial Diseases in Man and Mouse
1999 StandoutScience
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
1997 StandoutScience
Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
2000 StandoutScience
Gene- and strand-specific repair in vitro: partial purification of a transcription-repair coupling factor.
1991 StandoutNobel
Ischemic Cell Death in Brain Neurons
1999 Standout
Seven genes for three diseases
1991 Nature
Mitochondria and Apoptosis
1998 StandoutScience
Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process
1999
THE BIOLOGY OF THE (6–4) PHOTOPRODUCT
1989
The Mitochondrion in Cell Death Control: Certainties and Incognita
2000
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria
1998
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
A new nucleotide-excision-repair gene associated with the disorder trichothiodystrophy.
1993
Works of Stephen Green being referenced
AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
2008
AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules
2015
First-in-Human Pharmacokinetic and Pharmacodynamic Study of the Dual m-TORC 1/2 Inhibitor AZD2014
2015
Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA -Dependent Breast Cancers
2016
Effects of morbid obesity and diabetes mellitus on risk of coronary artery bypass grafting
1992
Bcl-2 regulates activation of apoptotic proteases in a cell-free system
1996
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: identification and optimisation of substituted 2,4-bis anilino pyrimidines
2003
Regulation of apoptosis by BH3 domains in a cell-free system
1997
Imidazo[1,2-a]pyridines: A potent and selective class of cyclin-Dependent kinase inhibitors identified through structure-Based hybridisation
2003
Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-Bis anilino pyrimidines
2003
The α1-Fetoprotein Locus Is Activated by a Nuclear Receptor of the Drosophila FTZ-F1 Family
1996
Early prediction of mortality in patients with acute myocardial infarction: a prospective study of clinical and radionuclide risk factors
1986
Trichothiodystrophy, a human DNA repair disorder with heterogeneity in the cellular response to ultraviolet light.
1988