Standout Papers
Citation Impact
Citing Papers
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Structure of a Synaptic γδ Resolvase Tetramer Covalently Linked to Two Cleaved DNAs
2005 StandoutScienceNobel
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
Principles for designing proteins with cavities formed by curved β sheets
2017 StandoutScienceNobel
The lac Repressor Displays Facilitated Diffusion in Living Cells
2012 Science
De novo design of self-assembling helical protein filaments
2018 StandoutScienceNobel
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
Hallucinating symmetric protein assemblies
2022 StandoutScienceNobel
Probing the target search of DNA-binding proteins in mammalian cells using TetR as model searcher
2015
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Crystal structure of the site-specific recombinase γδ resolvase complexed with a 34 by cleavage site
1995 StandoutNobel
Site-specific recombination by Tn3 resolvase: Topological changes in the forward and reverse reactions
1989
Assessment of the optimization of affinity and specificity at protein–DNA interfaces
2009 StandoutNobel
Specific binding by EcoRV endonuclease to its DNA recognition site GATATC
1997
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Making and Breaking Nucleic Acids: Two-Mg2+-Ion Catalysis and Substrate Specificity
2006
Substrate recognition by the EcoRI endonuclease
1990
Magnesium(2+) confers DNA binding specificity to the EcoRV restriction endonuclease
1992
Installing hydrolytic activity into a completely de novo protein framework
2016
Sequence-specific DNA binding by theMspl DNA methyltransferase
1992 StandoutNobel
Control of NF- B-dependent Transcriptional Responses by Chromatin Organization
2009
Towards a molecular view of transcriptional control
2012
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Structure and function of restriction endonucleases
1995
Transcription Dynamics
2009
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
On the Divalent Metal Ion Dependence of DNA Cleavage by Restriction Endonucleases of the EcoRI Family
2009
Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
2014 StandoutNobel
Crystal structure of Thermus aquaticus DNA polymerase
1995 StandoutNatureNobel
DNAase I footprinting of restriction enzymes
1988
Structural and energetic origins of indirect readout in site-specific DNA cleavage by a restriction endonuclease.
1999
Reaction mechanism of alkaline phosphatase based on crystal structures
1991 Standout
Crystal structure of the Hhal DNA methyltransferase complexed with S-adenosyl-l-methionine
1993 StandoutNobel
Massively parallel determination and modeling of endonuclease substrate specificity
2014 StandoutNobel
The coming of age of de novo protein design
2016 StandoutNatureNobel
The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion
2012
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
Restriction enzymes and their isoschizomers
1990 StandoutNobel
Design, Activity, and Structure of a Highly Specific Artificial Endonuclease
2002 StandoutNobel
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Structural analysis of a mutational hot-spot in the Eco RV restriction endonuclease: a catalytic role for a main chain carbonyl group
1999
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
2011 StandoutNatureNobel
Probing the Indirect Readout of the Restriction Enzyme EcoRV
1996
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Towards the design of rare cutting restriction endonucleases: using directed evolution to generate variants of EcoRV differing in their substrate specificity by two orders of magnitude
1998
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Tumor Suppressor p53 Slides on DNA with Low Friction and High Stability
2008
Specificity of restriction endonucleases and DNA modification methyltransferases — a review (edition 3)
1990
Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin lattice
2010
Uncoupling of the recombination and topoisomerase activities of the γδ resolvase by a mutation at the crossover point
1988 Nature
Nucleases: diversity of structure, function and mechanism
2010
Architecture of the γδ Resolvase Synaptosome
1998
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System
2015 StandoutNobel
Exploitation of binding energy for catalysis and design
2009 StandoutNatureNobel
Transient cleavage kinetics of the Eco RI restriction endonuclease measured in a pulsed quenchflow apparatus: enzyme concentration-dependent activity change
1981
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Characterization of steady state, single-turnover, and binding kinetics of the TaqI restriction endonuclease.
1992
Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells.
1982
McsB Is a Protein Arginine Kinase That Phosphorylates and Inhibits the Heat-Shock Regulator CtsR
2009 StandoutScienceNobel
OPTICAL DETECTION OF SINGLE MOLECULES
1997
Computational design of water-soluble α-helical barrels
2014 Science
How a protein searches for its site on DNA: the mechanism of facilitated diffusion
2009
Single-molecule imaging reveals target-search mechanisms during DNA mismatch repair
2012
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
The enfolding arms of EcoRI endonuclease: Role in DNA binding and cleavage
1986
Bacterial Resistance to β-Lactam Antibiotics: Compelling Opportunism, Compelling Opportunity
2005 Standout
DNA determinants important in sequence recognition by Eco RI endonuclease.
1981 StandoutNobel
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
Phosphorus-31 NMR as a Probe for Phosphoprotein
1985
Linear diffusion of restriction endonucleases on DNA.
1985
Specificity of restriction endonucleases and methylases — a review (edition 2)
1986
Structure of the DNA-Eco RI Endonuclease Recognition Complex at 3 Å Resolution
1986 Science
Structure and function of restriction endonucleases
1991
Coordinate ion pair formation between EcoRI endonuclease and DNA.
1983
The Chemistry of Self-Splicing RNA and RNA Enzymes
1987 StandoutScienceNobel
Rational Design of Helical Nanotubes from Self-Assembly of Coiled-Coil Lock Washers
2013
3D imaging of Sox2 enhancer clusters in embryonic stem cells
2014 StandoutNobel
Change in synaptic channel gating during neuromuscular development
1978 StandoutNatureNobel
The Kinetic Mechanism of EcoRI Endonuclease
1999 StandoutNobel
Alkaline Phosphatase, Solution Structure, and Mechanism
1983
Illuminating Single Molecules in Condensed Matter
1999 StandoutScienceNobel
A comparison of DNA cleavage by the restriction enzymes SalPI and PstI
1980
Progress in Modeling of Protein Structures and Interactions
2005 StandoutScienceNobel
Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°
1991 StandoutScienceNobel
CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea
2013
Leaving group dependence in the phosphorylation of Escherichia coli alkaline phosphatase by monophosphate esters
1986
Thermodynamic parameters governing interaction of EcoRI endonuclease with specific and nonspecific DNA sequences.
1983 StandoutNobel
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Modular Design of Self-Assembling Peptide-Based Nanotubes
2015
CCBuilder: an interactive web-based tool for building, designing and assessing coiled-coil protein assemblies
2014
Diverse Functions of Restriction-Modification Systems in Addition to Cellular Defense
2013
Recognition sequences of restriction endonucleases and methylases — a review
1985
Kinked DNA in crystalline complex with EcoRI endonuclease
1984 Nature
Analysis of gamma delta resolvase mutants in vitro: evidence for an interaction between serine-10 of resolvase and site I of res.
1986
The Energetic Basis of Specificity in the Eco RI Endonuclease—DNA Interaction
1990 Science
Cell-type-specific contacts to immunoglobulin enhancers in nuclei
1985 StandoutNatureNobel
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene
1986 StandoutNobel
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
A quantitative description of end‐plate currents
1972
Glu-111 is required for activation of the DNA cleavage center of EcoRI endonuclease
1989 StandoutNobel
Linear diffusion of the restriction endonuclease EcoRV on DNA is essential for the in vivo function of the enzyme.
1996
Studies on Sequence Recognition By Type II Restriction and Modification Enzyme
1982 StandoutNobel
Works of Stephen E. Halford being referenced
Site-specific DNA transesterification catalyzed by a restriction enzyme
2007
Measurement of the contributions of 1D and 3D pathways to the translocation of a protein along DNA
2005
The Gel Shift Assay for the Analysis of DNA–Protein Interactions
2003
Structure–function correlation for the EcoRV restriction enzyme: from non‐specific binding to specific DNA cleavage
1993
A novel mechanism for the scission of double-stranded DNA: BfiI cuts both 3′–5′ and 5′–3′ strands by rotating a single active site
2010
DNA cleavage by the EcoRV restriction endonuclease: roles of divalent metal ions in specificity and catalysis
1999
The cloning, purification and characterization of theEcoRV modification methylase
1988
Divalent Metal Ions at the Active Sites of the EcoRV and EcoRI Restriction Endonucleases
1995
Characterization of Monomeric L1 Metallo-β-lactamase and the Role of the N-terminal Extension in Negative Cooperativity and Antibiotic Hydrolysis
2002
EcoRV restriction endonuclease: communication between DNA recognition and catalysis
1992
Reactions of Type II Restriction Endonucleases with 8-Base Pair Recognition Sites
1999
Discrimination between DNA sequences by the EcoRV restriction endonuclease
1989
Rapid Reaction Analysis of the Catalytic Cycle of the EcoRV Restriction Endonuclease
1995
The Metal-independent Type IIs Restriction Enzyme BfiI is a Dimer that Binds Two DNA Sites but has Only One Catalytic Centre
2003
How do site-specific DNA-binding proteins find their targets?
2004
Interactions of the EcoRV restriction endonuclease with fluorescent oligodeoxynucleotides
1995
How to get from A to B: strategies for analysing protein motion on DNA
2002
Specific DNA Recognition by EcoRV Restriction Endonuclease Induced by Calcium Ions
1995
EcoRV restriction endonuclease: communication between catalytic metal ions and DNA recognition
1992
Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway
2010
The activity of the EcoRV restriction endonuclease is influenced by flanking DNA sequences both inside and outside the DNA-protein complex
1992
Reactions of the Eco RV restriction endonuclease with fluorescent oligodeoxynucleotides: identical equilibrium constants for binding to specific and non-specific DNA 1 1Edited by A. R. Fersht
1998
Differences between Ca 2+ and Mg 2+ in DNA binding and release by the SfiI restriction endonuclease: implications for DNA looping
2009
Fidelity of DNA recognition by the EcoRV restriction/modification system in vivo
1990
Modes of DNA cleavage by the EcoRV restriction endonuclease
1988
EcoRV restriction endonuclease binds all DNA sequences with equal affinity
1991
Random Mutagenesis Targeted to the Active Site of the EcoRV Restriction Endonuclease
1996
The EcoRI restriction endonuclease with bacteriophage λ DNA. Equilibrium binding studies
1980
Phosphorus-31 nuclear magnetic resonance study of alkaline phosphatase: the role of inorganic phosphate in limiting the enzyme turnover rate at alkaline pH
1976
The resolvase protein from the transposon Tn21
1985
Relaxed specificity of the EcoRV restriction endonuclease
1986
Rapid-Reaction Analysis of Plasmid DNA Cleavage by the EcoRV Restriction Endonuclease
1997
Kinetic Analysis of a Mutational Hot Spot in the EcoRV Restriction Endonuclease
1997
A New Method for Determining the Stereochemistry of DNA Cleavage Reactions: Application to the SfiI and HpaII Restriction Endonucleases and to the MuA Transposase
1999
How does EcoRI cleave its recognition site on DNA?
1983
The reactions of the EcoRi and other restriction endonucleases
1979
A substrate-induced conformation change in the reaction of alkaline phosphatase from Escherichia coli
1969
The EcoRI restriction endonuclease with bacteriophage λ DNA. Kinetic studies
1980
Single turnovers of the EcoRI restriction endonuclease
1983
Accessibility, Reactivity, and Selectivity of Side Chains within a Channel of de Novo Peptide Assembly
2013
Site-specific Recombination atresSites Containing DNA-binding Sequences for both Tn21 and Tn3 Resolvases
1995
The EcoR V restriction endonuclease.
1987
Site-specific recombination and topoisomerization by Tn21resolvase: role of metal ions
1986
The SalGI restriction endonuclease. Purification and properties
1982
An end to 40 years of mistakes in DNA–protein association kinetics?
2009