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Citing Papers
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1999
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Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
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Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
1998
Genetic variability of the AIDS virus: Nucleotide sequence analysis of two isolates from African patients
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Essential role of mouse telomerase in highly proliferative organs
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Synergistic Regulation of the Human Interleukin-12 p40 Promoter by NFκB and Ets Transcription Factors in Epstein-Barr Virus-transformed B Cells and Macrophages
1998
The paradigm of IL-6: from basic science to medicine.
2002
Regulation of Experimental Autoimmune Encephalomyelitis by Interleukin‐12
1996
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2002
The generation of diversity and pattern in animal development
1992 StandoutNobel
Structure and chromosomal location of the mouse interleukin‐12 p35 and p40 subunit genes
1996
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
1993 StandoutNobel
De novo design of luciferases using deep learning
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CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
1992 StandoutNatureNobel
Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β
1995
The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells
1989 StandoutNature
Enhancement of Memory-Related Long-Term Facilitation by ApAF, a Novel Transcription Factor that Acts Downstream from Both CREB1 and CREB2
2000 StandoutNobel
Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
1991 Nature
Interleukin-18: A Novel Cytokine That Augments Both Innate and Acquired Immunity
1998
Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.
1998
IL-12 in Autoimmunity
1998
Neuronal differentiation factors/cytokines and synaptic plasticity
1993
Induction of interferon-γ production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation
1999
Biology of Natural Killer Cells
1989 Standout
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
IL-12 Acts Directly on DC to Promote Nuclear Localization of NF-κB and Primes DC for IL-12 Production
1998
Role of Oxidative Modifications in Atherosclerosis
2004 Standout
Interleukin-12 Induces Tyrosine Phosphorylation of an 85-kDa Protein Associated with the Interleukin-12 Receptor β1 Subunit
1998
Taking dendritic cells into medicine
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Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability.
1996
Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice
1995
Atherosclerosis — An Inflammatory Disease
1999 Standout
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
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Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Membrane Proteins Involved in Phagocyte Adherence to Endothelium
1990
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
1997 Standout
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
1994 StandoutNobel
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
1996 Nature
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Regulation by HIV Rev depends upon recognition of splice sites
1989 StandoutNobel
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
Recent advances in the growth and isolation of primitive human haemopoietic progenitor cells
1992
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist
1995
Natural killer cell stimulatory factor (NKSF) or interleukin-12 is a key regulator of immune response and inflammation
1992
Hypermutability and mismatch repair deficiency in RER+ tumor cells
1993 StandoutNobel
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture
1994 StandoutScienceNobel
Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.
1996
Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes
1995
Macrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes.
1990
Molecular cloning and expression of cDNAs for the human interleukin-2 receptor
1984 Nature
Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration.
1995
T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression
1987
Genome organization and transactivation of the human immunodeficiency virus type 2
1987 StandoutNatureNobel
1997
Interferon-γ–Dependent Inducible Expression of the Human Interleukin-12 p35 Gene in Monocytes Initiates From a TATA-Containing Promoter Distinct From the CpG-Rich Promoter Active in Epstein-Barr Virus-Transformed Lymphoblastoid Cells
1998
Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF.
1992
A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits
1996
Expression and function of the interleukin 7 receptor in murine lymphocytes.
1993
Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site
1995
Interleukin-12–Activated Natural Killer Cells Recognize B7 Costimulatory Molecules on Tumor Cells and Autologous Dendritic Cells
1998
Roles of Interleukin-12 and Gamma Interferon in MurineChlamydia pneumoniaeInfection
2000
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.
1995
Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.
1994
Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.
1990
Role of Interleukin-12 in Primary Influenza Virus Infection
1998
Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)
1985 Science
Negative regulation of early B lymphopoiesis by interleukin 3 and interleukin 1 alpha.
1994
Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.
1993
IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages
2007 Standout
Mice Lacking Bioactive IL-12 Can Generate Protective, Antigen-Specific Cellular Responses to Mycobacterial Infection Only if the IL-12 p40 Subunit Is Present
2002
Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells
2002 StandoutNobel
Indications for Cardiac Catheterization and Intervention in Pediatric Cardiac Disease
2011 Standout
Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon.
1985
Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse
1993 StandoutNobel
Regulation of gamma interferon production by natural killer cells in scid mice: roles of tumor necrosis factor and bacterial stimuli
1991
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.
1993 Standout
Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
1993 StandoutScience
HUMAN TUMOR SUPPRESSOR GENES
1990
Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes.
1987
Extracellular Matrix Modulates Macrophage Functions Characteristic to Atheroma
1998
Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.
1995
Cachectin: More Than a Tumor Necrosis Factor
1987 StandoutNobel
IL-12 Is Dysregulated in Macrophages from IRF-1 and IRF-2 Knockout Mice
1999
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.
1995
Expression of Murine IL-12 Is Regulated by Translational Control of the p35 Subunit
1999
Expression and Function of IL-12 and IL-18 Receptors on Human Tonsillar B Cells
2000
Molecular Mechanisms of the Induction of IL-12 and Its Inhibition by IL-10
1998
Regulation of IL-12 p40 Promoter Activity in Primary Human Monocytes: Roles of NF-κB, CCAAT/Enhancer-Binding Protein β, and PU.1 and Identification of a Novel Repressor Element (GA-12) That Responds to IL-4 and Prostaglandin E2
2001
Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate
2012
Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.
1994
Interleukin 6: A Multifunctional Cytokine Regulating Immune Reactions and the Acute Phase Protein Response
1990
IL-12 Is Required to Maintain a Th1 Response DuringLeishmania majorInfection
2000
Stimulation of oligodendroglial proliferation and maturation by interleukin-2
1986 Nature
Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival.
1991
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
1985 StandoutNobel
Cloning of the γ Chain of the Human IL-2 Receptor
1992 Science
Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.
1990
Molecular Cloning and Characterization of NF-IL3A, a Transcriptional Activator of the Human Interleukin-3 Promoter
1995
Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice
1998
In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression.
1994
Viruses in Human Cancers
1991 StandoutScienceNobel
B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.
1994
Expression of functional human interleukin-2 receptor in mouse T cells by cDNA transfection
1986 StandoutNatureNobel
Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.
1992
Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia.
1992
Interleukin 12: A key modulator of immune function
1994
The Unstable Atheroma
1997
Interferon-γ–Dependent Inducible Expression of the Human Interleukin-12 p35 Gene in Monocytes Initiates From a TATA-Containing Promoter Distinct From the CpG-Rich Promoter Active in Epstein-Barr Virus-Transformed Lymphoblastoid Cells
1998
Antibodies Against IL-12 Prevent Superantigen-Induced and Spontaneous Relapses of Experimental Autoimmune Encephalomyelitis
1998
The same exhaustible multilineage precursor produces both myeloid and lymphoid cells as early as 3-4 weeks after marrow transplantation.
1992
A Protective and Agonistic Function of IL-12p40 in Mycobacterial Infection
2001
Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.
1996
Requirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors
1997 Science
Cytokine dysregulation and acute graft-versus-host disease
1992
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.
1993
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.
1996
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.
1993
Regulation of interleukin-12 production in antigen-presenting cells
2001
Antitumor and antimetastatic activity of interleukin 12 against murine tumors.
1993
The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major
1994 Science
A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum
1987 StandoutNobel
Regulation of Matrix Metalloproteinase Expression in Human Vascular Smooth Muscle Cells by T Lymphocytes
1997
Negative regulation of early T lymphopoiesis by interleukin-3 and interleukin-1 alpha
1995
Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression.
1991
Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.
1994
Enhancement of Antitumor Immunity by CTLA-4 Blockade
1996 StandoutScienceNobel
Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-β in ANA-1 cells
1998
An IFN-γ-Inducible Transcription Factor, IFN Consensus Sequence Binding Protein (ICSBP), Stimulates IL-12 p40 Expression in Macrophages
2000
Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor
1994 StandoutScience
Chlamydial Heat Shock Protein 60 Localizes in Human Atheroma and Regulates Macrophage Tumor Necrosis Factor-α and Matrix Metalloproteinase Expression
1998 Standout
Properties of lymph-borne (veiled) dendritic cells in culture. I. Modulation of phenotype, survival and function: partial dependence on GM-CSF.
1989
Regulation of Nuclear Gamma Interferon Gene Expression by Interleukin 12 (IL-12) and IL-2 Represents a Novel Form of Posttranscriptional Control
2002
NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines
1999 Standout
Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production.
1995
Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12
1998
Biosynthesis and Posttranslational Regulation of Human IL-12
2000
Molecular Bases of the Acute Coronary Syndromes
1995 Standout
Works of Stephen Clark being referenced
Effect of WBC reduction of transfused RBCs on postoperative infection rates in cardiac surgery
2002
Vascular complications of lung transplantation
1996
Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture.
1991
The murine Il-6 gene maps to the proximal region of chromosome 5.
1989
Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival.
1986
Human T-cell growth factor: partial amino acid sequence, cDNA cloning, and organization and expression in normal and leukemic cells.
1984
Clonal proliferation of murine lymphohemopoietic progenitors in culture.
1992
Response of resting human peripheral blood natural killer cells to interleukin 2.
1984
Recombinant human macrophage colony-stimulating factor (M-CSF) requires subliminal concentrations of granulocyte/macrophage (GM)-CSF for optimal stimulation of human macrophage colony formation in vitro.
1987
Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases.
1995
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.
1991
Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.
1987
Production of hematopoietic colony-stimulating factors by human natural killer cells.
1989
Establishment of a novel heterotransplantable acute lymphoblastic leukemia cell line with a t(17;19) chromosomal translocation the growth of which is inhibited by interleukin-3.
1991
Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides.
1991
Interleukin 6: identification as a hematopoietic colony-stimulating factor.
1988
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.
1989 Standout
Growth of human hemopoietic colonies in response to recombinant gibbon interleukin 3: comparison with human recombinant granulocyte and granulocyte-macrophage colony-stimulating factor.
1987
The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q.
1987
Stimulation of murine hemopoietic colony formation by human IL-6.
1988