Citation Impact
Citing Papers
Phase separation of signaling molecules promotes T cell receptor signal transduction
2016 Science
Lipid Rafts As a Membrane-Organizing Principle
2009 StandoutScience
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ
2013 StandoutNobel
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
2009 StandoutNobel
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
2012
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
RIAM Links the ADAP/SKAP-55 Signaling Module to Rap1, Facilitating T-Cell-Receptor-Mediated Integrin Activation
2007
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
2013 StandoutNobel
Fast molecular tracking maps nanoscale dynamics of plasma membrane lipids
2010 StandoutNobel
Phase coexistence and connectivity in the apical membrane of polarized epithelial cells
2006
The Proline-Rich Sequence of CD3ε as an Amplifier of Low-Avidity TCR Signaling
2008
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
The kinetic-segregation model: TCR triggering and beyond
2006
Three-dimensional tracking of single mRNA particles in Saccharomyces cerevisiae using a double-helix point spread function
2010 StandoutNobel
Single-Molecule Microscopy Reveals Plasma Membrane Microdomains Created by Protein-Protein Networks that Exclude or Trap Signaling Molecules in T Cells
2005
Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation
2008
Lipid Rafts
2003
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
The reverse stop-signal model for CTLA4 function
2008
Oncogenic kinase signalling
2001 StandoutNature
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway
1998
Death by TNF: a road to inflammation
2022
Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor
2003
Vav1 Acidic Region Tyrosine 174 Is Required for the Formation of T Cell Receptor-induced Microclusters and Is Essential in T Cell Development and Activation
2006
Chemical ligation of unprotected peptides directly from a solid support
1998
CD28-mediated co-stimulation: a quantitative support for TCR signalling
2003
Mechanisms for T cell receptor triggering
2010
Interaction of SLP adaptors with the SH2 domain of Tec family kinases
1999
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Cyclophilin A Regulates TCR Signal Strength in CD4+ T Cells via a Proline-Directed Conformational Switch in Itk
2004
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
2006 StandoutNatureNobel
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Spatiotemporal Basis of CTLA-4 Costimulatory Molecule-Mediated Negative Regulation of T Cell Activation
2010
Signaling at neuro/immune synapses
2012
The molecular machinery of regulated cell death
2019 Standout
PD‐1 signaling in primary T cells
2009
Signaling clusters in the cell membrane
2011
Rewiring T-cell responses to soluble factors with chimeric antigen receptors
2018
Upstream-Downstream: CD28 Cosignaling Pathways and T Cell Function
1996
Targeting apoptosis in cancer therapy
2020 Standout
Regulation of T-cell activation by the cytoskeleton
2007
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
2005
Molecular Details of Itk Activation by Prolyl Isomerization and Phospholigand Binding: The NMR Structure of the Itk SH2 Domain Bound to a Phosphopeptide
2006
T Cell Receptor-Proximal Signals Are Sustained in Peripheral Microclusters and Terminated in the Central Supramolecular Activation Cluster
2006
Itk/Emt/Tsk Activation in Response to CD3 Cross-linking in Jurkat T Cells Requires ZAP-70 and Lat and Is Independent of Membrane Recruitment
1999
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
2006
Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils
2003
Revitalizing membrane rafts: new tools and insights
2010
Signals involved in thymocyte positive and negative selection
1999
Selected glimpses into the activation and function of Src kinase
2000
Direct observation of the nanoscale dynamics of membrane lipids in a living cell
2008 StandoutNatureNobel
Biophysical mechanism of T-cell receptor triggering in a reconstituted system
2012 Nature
CD28 and CTLA‐4 coreceptor expression and signal transduction
2009
T-cell regulation by CD28 and CTLA-4
2001
Jurkat T cells and development of the T-cell receptor signalling paradigm
2004
Complementation In Trans of Altered Thymocyte Development in Mice Expressing Mutant Forms of the Adaptor Molecule SLP76
2008
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
Dual Role of SLP-76 in Mediating T Cell Receptor-induced Activation of Phospholipase C-γ1
2006
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Lucky Imaging: Improved Localization Accuracy for Single Molecule Imaging
2009
Tailoring T-cell receptor signals by proximal negative feedback mechanisms
2008
The CD28 Signaling Pathway Regulates Glucose Metabolism
2002
HS1 Functions as an Essential Actin-Regulatory Adaptor Protein at the Immune Synapse
2006
Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement
2007
T-cell-antigen recognition and the immunological synapse
2003
Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation
2002
Temporal and Spatial Regulation of Chemotaxis
2002
The WAVE2 Complex Regulates Actin Cytoskeletal Reorganization and CRAC-Mediated Calcium Entry during T Cell Activation
2006
Formins Regulate the Actin-Related Protein 2/3 Complex-Independent Polarization of the Centrosome to the Immunological Synapse
2007
Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse
2005
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
2005 StandoutNature
Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice
2008 StandoutNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
2001 StandoutNobel
Regulation of the Jak2 Tyrosine Kinase by Its Pseudokinase Domain
2000
Computational design of a synthetic PD-1 agonist
2021 StandoutNobel
A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity
2008 StandoutNobel
Control of the Molecular Orientation of Membrane-Anchored Biomimetic Glycopolymers
2009 StandoutNobel
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Bee1, a Yeast Protein with Homology to Wiscott-Aldrich Syndrome Protein, Is Critical for the Assembly of Cortical Actin Cytoskeleton
1997
NK T Cell Precursors Exhibit Differential Cytokine Regulation and Require Itk for Efficient Maturation
2002
The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor
2013
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
The CD3ε Proline-Rich Sequence, and Its Interaction with Nck, Is Not Required for T Cell Development and Function
2005
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Fluorescence Imaging of Membrane Dynamics
2008
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
1997 StandoutNobel
Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation
2000 StandoutNobel
T cell receptor for antigen induces linker for activation of T cell–dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2
2006
SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation
2004
Synthetic Analogues of Glycosylphosphatidylinositol-Anchored Proteins and Their Behavior in Supported Lipid Bilayers
2007 StandoutNobel
A novel pathway down-modulating T cell activation involves HPK-1–dependent recruitment of 14-3-3 proteins on SLP-76
2007
Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation.
2003 StandoutNobel
c-Cbl-Mediated Regulation of LAT-Nucleated Signaling Complexes
2007
CARMA1 Is Required for Akt-Mediated NF-κB Activation in T Cells
2006
The Actin Cytoskeleton in T Cell Activation
2008
Autoinhibition of Jak2 Tyrosine Kinase Is Dependent on Specific Regions in Its Pseudokinase Domain
2003
Dynamics of putative raft-associated proteins at the cell surface
2004
The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells
2009
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Rho GTPases and the Actin Cytoskeleton
1998 StandoutScience
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Anatomy and Dynamics of a Supramolecular Membrane Protein Cluster
2007 StandoutScienceNobel
Keeping the (Kinase) Party Going: SLP-76 and ITK Dance to the Beat
2007
Cutting Edge: Itk Is Not Essential for CD28 Signaling in Naive T Cells
2005
ADAP–SLP-76 Binding Differentially Regulates Supramolecular Activation Cluster (SMAC) Formation Relative to T Cell–APC Conjugation
2004
SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK
2007
The receptor deformation model of TCR triggering
2007
Physiological Functions of Pten in Mouse Tissues.
2003 StandoutNobel
Kinase-Independent Functions for Itk in TCR-Induced Regulation of Vav and the Actin Cytoskeleton
2005
TEC FAMILY KINASES IN T LYMPHOCYTE DEVELOPMENT AND FUNCTION
2004
Polarized sorting in epithelial cells: raft clustering and the biogenesis of the apical membrane
2004
TCR Triggering by the pMHC Complex: Valency, Affinity, and Dynamics
2008
Fmoc-Based Synthesis of Peptide-αThioesters: Application to the Total Chemical Synthesis of a Glycoprotein by Native Chemical Ligation
1999 StandoutNobel
Three-dimensional localization of T-cell receptors in relation to microvilli using a combination of superresolution microscopies
2016
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways
2002
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
Single dose of anti–CTLA-4 enhances CD8 + T-cell memory formation, function, and maintenance
2010 StandoutNobel
Antigen Receptor–Induced Activation and Cytoskeletal Rearrangement Are Impaired in Wiskott-Aldrich Syndrome Protein–Deficient Lymphocytes
1999
The ADAP/SKAP55 Signaling Module Regulates T-Cell Receptor-Mediated Integrin Activation through Plasma Membrane Targeting of Rap1
2006
Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signaling
2005
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Antigen Recognition Is Facilitated by Invadosome-like Protrusions Formed by Memory/Effector T Cells
2012
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
The Pten/PI3K pathway governs the homeostasis of Vα14iNKT cells
2006 StandoutNobel
T Cell Activation
2009 Standout
The Role of B7‐1/B7‐2:CD28/CLTA‐4 Pathways in the Prevention of Anergy, Induction of Productive Immunity and Down‐Regulation of the Immune Response
1996
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
2012 StandoutNobel
SLP-76 Coordinates Nck-Dependent Wiskott-Aldrich Syndrome Protein Recruitment with Vav-1/Cdc42-Dependent Wiskott-Aldrich Syndrome Protein Activation at the T Cell-APC Contact Site
2003
Works of Stephen C. Bunnell being referenced
Dynamic Actin Polymerization Drives T Cell Receptor–Induced Spreading
2001
Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function
2004
Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton
2004
PTEN permits acute increases in D3‐phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt
2004
Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade
2000
Lck Phosphorylates the Activation Loop Tyrosine of the Itk Kinase Domain and Activates Itk Kinase Activity
1997
Multiple Microclusters: Diverse Compartments Within the Immune Synapse
2009
Identification of Itk/Tsk Src Homology 3 Domain Ligands
1996
Signal initiation in T‐cell receptor microclusters
2008
Gelsolin overexpression alters actin dynamics and tyrosine phosphorylation of lipid raft-associated proteins in Jurkat T cells
2006
T‐Cell Antigen Receptor‐Induced Signaling Complexes: Internalization Via a Cholesterol‐Dependent Endocytic Pathway
2006
T Cell Costimulation via the Integrin VLA-4 Inhibits the Actin-Dependent Centralization of Signaling Microclusters Containing the Adaptor SLP-76
2008
Role for the Abi/Wave Protein Complex in T Cell Receptor-Mediated Proliferation and Cytoskeletal Remodeling
2006
Regulatory intramolecular association in a tyrosine kinase of the Tec family
1997 Nature
Persistence of Cooperatively Stabilized Signaling Clusters Drives T-Cell Activation
2006
p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.
1995
Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation
2000
T Cell Receptor–initiated Calcium Release Is Uncoupled from Capacitative Calcium Entry in Itk-deficient T Cells
1998
Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection
2018
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
2002