Citation Impact
Citing Papers
Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1
2008
TRP channel activation by reversible covalent modification
2006 StandoutNobel
Pathophysiology of Migraine: A Disorder of Sensory Processing
2017 Standout
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
2011 StandoutNobel
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007 StandoutNobel
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
2005 StandoutScience
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
2002 Standout
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Desensitization of Capsaicin-activated Currents in the Vanilloid Receptor TRPV1 Is Decreased by the Cyclic AMP-dependent Protein Kinase Pathway
2003
CGRP and migraine: neurogenic inflammation revisited
2005
Protease-Activated Receptor 2 Sensitizes the Capsaicin Receptor Transient Receptor Potential Vanilloid Receptor 1 to Induce Hyperalgesia
2004
Ethanol dilates coronary arteries and increases coronary flow via transient receptor potential vanilloid 1 and calcitonin gene-related peptide
2006
Increased capsaicin receptor TRPV1 nerve fibres in the inflamed human oesophagus
2004
The transient receptor potential vanilloid 1: Role in airway inflammation and disease
2006
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Molecular, pharmacological and functional diversity of 5-HT receptors
2002 Standout
TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia
2004
A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea‐pig bronchus
2001
Structure‐activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens
2001
The TRPV4 channel: structure-function relationship and promiscuous gating behaviour
2003
Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α
2007 StandoutNobel
The Hypothalamic Orexinergic System: Pain and Primary Headaches
2007
More than cool: Promiscuous relationships of menthol and other sensory compounds
2006 StandoutNobel
Orexin-A-induced Ca2+ Entry
2004
ThermoTRP channels and beyond: mechanisms of temperature sensation
2003 StandoutNobel
Opposite thermosensor in fruitfly and mouse
2003 StandoutNatureNobel
β-Arrestin-biased Agonism at the β2-Adrenergic Receptor
2007 StandoutNobel
Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane
2009 StandoutNobel
Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)
2005
Anandamide and vanilloid TRPV1 receptors
2003
The hypocretins: Setting the arousal threshold
2002
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
2008 StandoutNature
Targeting TRP channels for pain relief
2013
Comparison of intracellular calcium signals evoked by heat and capsaicin in cultured rat dorsal root ganglion neurons and in a cell line expressing the rat vanilloid receptor, VR1
2001
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
Biochemistry and pharmacology of endovanilloids
2007
From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs
2007 StandoutNobel
4-(2-Pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists
2003
Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild‐type and TRPV1–/– mice
2003
Rho GTPases in cell biology
2002 StandoutNature
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
Mechanically Activated Ion Channels
2015 StandoutNobel
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
2011 StandoutNatureNobel
The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice
2006
Interaction between the Corticotropin-Releasing Factor System and Hypocretins (Orexins): A Novel Circuit Mediating Stress Response
2004
Characterization of the mouse cold‐menthol receptor TRPM8 and vanilloid receptor type‐1 VR1 using a fluorometric imaging plate reader (FLIPR) assay
2004
Neocortical excitation/inhibition balance in information processing and social dysfunction
2011 StandoutNature
Target validation of G-protein coupled receptors
2002
Gating of TRP channels: a voltage connection?
2005
Analysis of the Native Quaternary Structure of Vanilloid Receptor 1
2001
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
Extracellular Cations Sensitize and Gate Capsaicin Receptor TRPV1 Modulating Pain Signaling
2005
Temperature-dependent activation of recombinant rat vanilloid VR1 receptors expressed in HEK293 cells by capsaicin and anandamide
2001
Regulation of neurotrophin‐induced axonal responses via Rho GTPases
2001
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Neural substrates of awakening probed with optogenetic control of hypocretin neurons
2007 Nature
A TRP Channel that Senses Cold Stimuli and Menthol
2002 StandoutNobel
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
Orexin receptors as therapeutic drug targets
2012
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
2004 StandoutNobel
The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior
2015
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002 StandoutNobel
Endovanilloids
2004
Multiple types of sensory neurons respond to irritating volatile organic compounds (VOCs): Calcium fluorimetry of trigeminal ganglion neurons
2005
Systemic and Site-Specific Effects of A-425619, a Selective TRPV1 Receptor Antagonist, on Wide Dynamic Range Neurons in CFA-Treated and Uninjured Rats
2005
Cannabinoid receptors and their ligands
2002
Ethanol Causes Inflammation in the Airways by a Neurogenic and TRPV1-Dependent Mechanism
2004
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
The hypocretin/orexin ligand–receptor system: implications for sleep and sleep disorders
2000
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Phosphorylation-Dependent Desensitization by Anandamide of Vanilloid Receptor-1 (TRPV1) Function in Rat Skeletal Muscle Arterioles and in Chinese Hamster Ovary Cells Expressing TRPV1
2005
Calcium Signaling
2007 Standout
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
2006 StandoutNobel
Transient Receptor Potential Cation Channels in Disease
2007 Standout
A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating
2008 StandoutNobel
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development
2000
Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development
2006
Modulation of nociceptive dural input to the trigeminal nucleus caudalis via activation of the orexin 1 receptor in the rat
2006
The Super-Cooling Agent Icilin Reveals a Mechanism of Coincidence Detection by a Temperature-Sensitive TRP Channel
2004 StandoutNobel
Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives
2002
Identification of Species-specific Determinants of the Action of the Antagonist Capsazepine and the Agonist PPAHV on TRPV1
2004
Pharmacology of Vanilloid Transient Receptor Potential Cation Channels
2009
Differential effects of anandamide on acetylcholine release in the guinea‐pig ileum mediated via vanilloid and non‐CB1 cannabinoid receptors
2001
Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function
2004
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
Substance P expression in TRPV1 and trkA-positive dorsal root ganglion neurons innervating the mouse lung
2004
Gastrointestinal pain in functional bowel disorders: sensory neurons as novel drug targets
2004
Nicotine Inhibits Voltage-Dependent Sodium Channels and Sensitizes Vanilloid Receptors
2004
A Major Role for Perifornical Orexin Neurons in the Control of Glucose Metabolism in Rats
2009
Pungent products from garlic activate the sensory ion channel TRPA1
2005 StandoutNobel
TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids
2013 StandoutNobel
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis
2013 StandoutNobel
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
2005 StandoutScienceNobel
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4
2009 StandoutNobel
Identification of an Aspartic Residue in the P-loop of the Vanilloid Receptor That Modulates Pore Properties
2000
Cannabinoids and the gastrointestinal tract
2001
AN INTRODUCTION TO TRP CHANNELS
2005 Standout
The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway
2001 StandoutNobel
A TRPV2–PKA Signaling Module for Transduction of Physical Stimuli in Mast Cells
2004
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
The Role of Hypocretins (Orexins) in Sleep Regulation and Narcolepsy
2002
Emerging Targets in Photopharmacology
2016 StandoutNobel
To Eat or to Sleep? Orexin in the Regulation of Feeding and Wakefulness
2001
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
TRP Channels
2007 Standout
Works of Stephen Brough being referenced
The anandamide transport inhibitor AM404 is an agonist at the rat vanilloid receptor (VR1)
2000
The endogenous lipid anandamide is an agonist AT rat and human vanilloid (VR1) receptors.
2000
Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology
2001
Structure–activity analysis of truncated orexin-A analogues at the orexin-1 receptor
2001
Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology
2000
Characterisation of the binding of [3H]‐SB‐674042, a novel nonpeptide antagonist, to the human orexin‐1 receptor
2004
Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX 1 ) receptors, with downstream 5-HT 2C receptor involvement
2001
Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell‐line using FLIPR
1999
1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor
2001
Discovery of small molecule antagonists of TRPV1
2004
Comparison of effects of anandamide at recombinant and endogenous rat vanilloid receptors
2002
The hypocretins are weak agonists at recombinant human orexin‐1 and orexin‐2 receptors
2000
Pharmacological characterisation of human 5-HT2 receptor subtypes
2001
Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1
2002
Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1
2002
SB‐334867‐A: the first selective orexin‐1 receptor antagonist
2001