Standout Papers
Citation Impact
Citing Papers
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila
2006 StandoutNobel
MiR-33 Contributes to the Regulation of Cholesterol Homeostasis
2010 Science
Requirement of bic/microRNA-155 for Normal Immune Function
2007 StandoutScience
miR-221 Silencing Blocks Hepatocellular Carcinoma and Promotes Survival
2011
Characterization of a canine homolog of hepatitis C virus
2011 StandoutNobel
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis
2016 StandoutNobel
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review
2012
MicroRNA-122 Inhibits Tumorigenic Properties of Hepatocellular Carcinoma Cells and Sensitizes These Cells to Sorafenib
2009
UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
2015 StandoutNobel
Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response
2012
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
2002 StandoutNature
MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles
2012
Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model
2009
Systematic Identification of mRNAs Recruited to Argonaute 2 by Specific microRNAs and Corresponding Changes in Transcript Abundance
2008
LNA-mediated microRNA silencing in non-human primates
2008 Nature
Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference
2002
Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure
2013 StandoutNobel
Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics
2010 StandoutNobel
Integration of microRNA miR-122 in hepatic circadian gene expression
2009
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
2004 StandoutNature
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Evolutionarily Conserved Roles of the Dicer Helicase Domain in Regulating RNA Interference Processing
2014 StandoutNobel
MicroRNA-122 Modulates the Rhythmic Expression Profile of the Circadian Deadenylase Nocturnin in Mouse Liver
2010
The changing landscape of atherosclerosis
2021 StandoutNature
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
2011 StandoutNatureNobel
Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit
2013 StandoutNatureNobel
Mammalian microRNAs predominantly act to decrease target mRNA levels
2010 StandoutNature
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model
2010
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
miR-122 is a Unique Molecule with Great Potential in Diagnosis, Prognosis of Liver Disease, and Therapy Both as miRNA Mimic and Antimir
2015
The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development
2000
Therapeutic targeting of microRNAs: current status and future challenges
2014
The biochemistry of apoptosis
2000 StandoutNature
Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation
2013 StandoutNobel
Decoding ALS: from genes to mechanism
2016 StandoutNature
Triplet repeat expansion in neuromuscular disease
2000
MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma #
2008
Protein degradation and protection against misfolded or damaged proteins
2003 StandoutNature
Epigenetic Modulation of miR-122 Facilitates Human Embryonic Stem Cell Self-Renewal and Hepatocellular Carcinoma Proliferation
2011
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
Protein folding and misfolding
2003 StandoutNature
Fragment-based lead discovery: a chemical update
2006
Natural RNA circles function as efficient microRNA sponges
2013 StandoutNature
An efficient and sensitive method for preparing cDNA libraries from scarce biological samples
2014 StandoutNobel
MicroRNAs as a Selective Channel of Communication between Competing RNAs: a Steady-State Theory
2013
MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer
2007 Standout
Repeat expansion disease: progress and puzzles in disease pathogenesis
2010
Dual regulation of hepatitis C viral RNA by cellular RNAi requires partitioning of Ago2 to lipid droplets and P-bodies
2011
Caspase structure, proteolytic substrates, and function during apoptotic cell death
1999
Widespread changes in protein synthesis induced by microRNAs
2008 StandoutNature
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties
2009
miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression
2012
Polyglutamine Pathogenesis
2002
Evidence that microRNAs are associated with translating messenger RNAs in human cells
2006
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
2017 Standout
Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer
2017 StandoutNobel
A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor
2000
Crystal Structure of the HCV IRES Central Domain Reveals Strategy for Start-Codon Positioning
2011 StandoutNobel
Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver
2013
RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries
2011
The utility of LNA in microRNA-based cancer diagnostics and therapeutics
2008
MicroRNAs in Human Cancer
2012
MicroRNA-29c Is a Signature MicroRNA under High Glucose Conditions That Targets Sprouty Homolog 1, and Its in Vivo Knockdown Prevents Progression of Diabetic Nephropathy
2011
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Highly Complementary Target RNAs Promote Release of Guide RNAs from Human Argonaute2
2013
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver
2007
MicroRNA‐29, a key regulator of collagen expression in systemic sclerosis
2010
Hepatitis C virus 3′UTR regulates viral translation through direct interactions with the host translation machinery
2013 StandoutNobel
Points of control in inflammation
2002 StandoutNature
Competition between Small RNAs: A Quantitative View
2012
MicroRNAs: A new class of regulatory genes affecting metabolism
2006
Position-Dependent Function for a Tandem MicroRNA miR-122-Binding Site Located in the Hepatitis C Virus RNA Genome
2008
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
2012
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice
2011
Cellular Defenses against Unfolded Proteins
2001
Micro-Managing the Circadian Clock: The Role of microRNAs in Biological Timekeeping
2012
The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis
1999
Assessing the ceRNA Hypothesis with Quantitative Measurements of miRNA and Target Abundance
2014
Selective Neuronal Degeneration in Huntington's Disease
2006
A decade of caspases
2003
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
2008 Standout
Treatment of HCV Infection by Targeting MicroRNA
2013 Standout
Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state
2007
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis
2012
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Development of micro RNA therapeutics is coming of age
2014
microRNA‐122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma
2010
In Vitro Antiviral Activity and Preclinical and Clinical Resistance Profile of Miravirsen, a Novel Anti-Hepatitis C Virus Therapeutic Targeting the Human Factor miR-122
2014
RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
2010
Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease
2000
Regulation of Hepatitis C Virus Translation and Infectious Virus Production by the MicroRNA miR-122
2010
Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches
2012
Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma
2012
Modulation of Hepatitis C Virus RNA Abundance and the Isoprenoid Biosynthesis Pathway by MicroRNA miR-122 Involves Distinct Mechanisms
2009
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Characterization of nonprimate hepacivirus and construction of a functional molecular clone
2015 StandoutNobel
miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling
2011
mir-276a strengthens Drosophila circadian rhythms by regulating timeless expression
2016 StandoutNobel
Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice
2018
MicroRNA‐122 regulates polyploidization in the murine liver
2016
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
MicroRNA Regulation of Atherosclerosis
2016
Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic mice
2006
microRNAs in Vertebrate Physiology and Human Disease
2007
Nascent-Seq analysis of Drosophila cycling gene expression
2013 StandoutNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
microRNA Functions
2007 Standout
Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets
2009 StandoutNobel
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
2004 StandoutNobel
Works of Stephanie Propp being referenced
G1 arrest and high expression of cyclin kinase and apoptosis inhibitors in accumulated activated/memory phenotype CD4+ cells of older lupus mice
1997
Cleavage of Atrophin-1 at Caspase Site Aspartic Acid 109 Modulates Cytotoxicity
1999
Kennedy's Disease
1999
Potent inhibition of microRNA in vivo without degradation
2008
Proteolytic Cleavage of Ataxin-7 by Caspase-7 Modulates Cellular Toxicity and Transcriptional Dysregulation
2007
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
2006 Standout
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease
2004
Competition for RISC binding predicts in vitro potency of siRNA
2006
SAR by MS: Discovery of a New Class of RNA-Binding Small Molecules for the Hepatitis C Virus: Internal Ribosome Entry Site IIA Subdomain
2005