Citation Impact
Citing Papers
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
Identification of a Primary Target of Thalidomide Teratogenicity
2010 StandoutScience
Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine activation
2005
Wnt5a–Ror–Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis
2012
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
2007 StandoutNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Structural Basis of Wnt Recognition by Frizzled
2012 Science
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
2017 Standout
Hallmarks of Cancer: The Next Generation
2011 Standout
Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling
2001 Standout
β-arrestins: traffic cops of cell signaling
2004 StandoutNobel
Global Interactomics Uncovers Extensive Organellar Targeting by Zika Virus
2018
A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer
2006
Pharmacological Onomastics: What's in a name?
2007
Homo- and Hetero-oligomerization of β-Arrestins in Living Cells
2005
Distinct Signaling Profiles of β1 and β2 Adrenergic Receptor Ligands toward Adenylyl Cyclase and Mitogen-Activated Protein Kinase Reveals the Pluridimensionality of Efficacy
2006
Yes-associated protein regulates the hepatic response after bile duct ligation
2012
Allosteric interactions between GB1 andGB2 subunits are required for optimalGABAB receptor function
2001
Can we safely target the WNT pathway?
2014
Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma
2012
A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer
2014
G-protein-coupled Receptor Kinase Specificity for β-Arrestin Recruitment to the β2-Adrenergic Receptor Revealed by Fluorescence Resonance Energy Transfer
2006 StandoutNobel
G protein coupled receptor structure and activation
2006 StandoutNobel
Downregulation of G protein-coupled receptors
2000
Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation
2006 StandoutNobel
Structure of rhodopsin and the metarhodopsin I photointermediate
2005
Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway
2014
Heterozygous Loss-of-Function Mutations in YAP1 Cause Both Isolated and Syndromic Optic Fissure Closure Defects
2014
Structure-based Analysis of GPCR Function: Evidence for a Novel Pentameric Assembly between the Dimeric Leukotriene B4 Receptor BLT1 and the G-protein
2003
Genetic interaction networks in cancer cells
2019
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
Analysis of receptor oligomerization by FRAP microscopy
2009
β-Arrestin-biased Agonism at the β2-Adrenergic Receptor
2007 StandoutNobel
Structure and Conformational Changes in the C-terminal Domain of the β2-Adrenoceptor
2007 StandoutNobel
Lessons from constitutively active mutants of G protein-coupled receptors
2002
Real-time monitoring of receptor and G-protein interactions in living cells
2005
A Cyclic Peptide Mimicking the Third Intracellular Loop of the V2 Vasopressin Receptor Inhibits Signaling through Its Interaction with Receptor Dimer and G Protein
2004
A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors
2016
Probing the β2 Adrenoceptor Binding Site with Catechol Reveals Differences in Binding and Activation by Agonists and Partial Agonists
2005 StandoutNobel
GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling
2006 StandoutNobel
Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer
2009 StandoutNobel
Dimerization and Phosphorylation of Thyrotropin-releasing Hormone Receptors Are Modulated by Agonist Stimulation
2002
β1/β2-Adrenergic Receptor Heterodimerization Regulates β2-Adrenergic Receptor Internalization and ERK Signaling Efficacy
2002
Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells
2010
A CRISPR toolbox to study virus–host interactions
2017
The Human Transcription Factors
2018 Standout
Identification of a serotonin/glutamate receptor complex implicated in psychosis
2008 Nature
Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation
2004 StandoutNobel
Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking
2001
Global Genetic Networks and the Genotype-to-Phenotype Relationship
2019
The Fourth Transmembrane Segment Forms the Interface of the Dopamine D2 Receptor Homodimer
2003
Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling
2008 Nobel
Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration
2014
Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex
2012
Agonist Binding: A Multistep Process
2004 StandoutNobel
Novel β2-adrenergic receptor signaling pathways
2002
Inactivation of a Gαs–PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis
2015
The molecular acrobatics of arrestin activation
2004
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Agonist Actions of “β-Blockers” Provide Evidence for Two Agonist Activation Sites or Conformations of the Human β1-Adrenoceptor
2003
G protein coupled receptor dimerization: implications in modulating receptor function
2001
Newly Synthesized Human δ Opioid Receptors Retained in the Endoplasmic Reticulum Are Retrotranslocated to the Cytosol, Deglycosylated, Ubiquitinated, and Degraded by the Proteasome
2001
Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification
2010
Constitutive Dimerization of the G-Protein Coupled Receptor, Neurotensin Receptor 1, Reconstituted into Phospholipid Bilayers
2009
Telomerase modulates Wnt signalling by association with target gene chromatin
2009 Nature
Historical review: A brief history and personal retrospective of seven-transmembrane receptors
2004 StandoutNobel
Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization
2002
Mammalian Sweet Taste Receptors
2001 Standout
C5a Receptor Oligomerization
2003
Receptor-Mediated Activation of Heterotrimeric G-Proteins: Current Structural Insights
2007
Kinetic Analysis of G Protein–Coupled Receptor Signaling Using Fluorescence Resonance Energy Transfer in Living Cells
2007
The Hippo Signaling Pathway in Development and Cancer
2010 Standout
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Filopodia-based Wnt transport during vertebrate tissue patterning
2015
Evidence for Negative Binding Cooperativity within CCR5-CCR2b Heterodimers
2004
The coming of age of de novo protein design
2016 StandoutNatureNobel
Wnt/β-Catenin Signaling and Disease
2012 Standout
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
2009 Standout
Heterodimerization with β2-Adrenergic Receptors Promotes Surface Expression and Functional Activity of α1D-Adrenergic Receptors
2005
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Disorder-associated mutations lead to functional inactivation of neuroligins
2004
Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals
2016
The Hippo pathway: regulators and regulations
2013
Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling
2009
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Methods to monitor the quaternary structure of G protein‐coupled receptors
2005
A Membrane-proximal Basic Domain and Cysteine Cluster in the C-terminal Tail of CCR5 Constitute a Bipartite Motif Critical for Cell Surface Expression
2001 StandoutNobel
Ligand-dependent Inhibition of Oligomerization at the Human Thyrotropin Receptor
2002
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
Differential Desensitization, Receptor Phosphorylation, β-Arrestin Recruitment, and ERK1/2 Activation by the Two Endogenous Ligands for the CC Chemokine Receptor 7
2004
Conformational complexity of G-protein-coupled receptors
2007 StandoutNobel
Monitoring Receptor Oligomerization Using Time-resolved Fluorescence Resonance Energy Transfer and Bioluminescence Resonance Energy Transfer
2001
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
“Induced-Fit” Mechanism for Catecholamine Binding to the β2-Adrenergic Receptor
2004
The Ants Go Marching Two by Two: Oligomeric Structure of G-Protein-Coupled Receptors
2004
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
The selectivity of β‐adrenoceptor agonists at human β1‐, β2‐ and β3‐adrenoceptors
2010
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Alternative Wnt Signaling Activates YAP/TAZ
2015
Homo- and Heterodimerization of Somatostatin Receptor Subtypes
2001
Homo- and Hetero-oligomerization of Thyrotropin-releasing Hormone (TRH) Receptor Subtypes
2002 StandoutNobel
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Reduced Cell Surface Expression of CCR5 in CCR5Δ32 Heterozygotes Is Mediated by Gene Dosage, Rather Than by Receptor Sequestration
2002 StandoutNobel
G‐protein‐coupled receptors: past, present and future
2006
Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation
2005
Seven-transmembrane receptors
2002 StandoutNobel
Oligomerization of G-protein-coupled transmitter receptors
2001
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Receptor activity‐independent recruitment of βarrestin2 reveals specific signalling modes
2004
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Allosteric Effects of G Protein Overexpression on the Binding of β-Adrenergic Ligands with Distinct Inverse Efficacies
2001
Morphine-like Opiates Selectively Antagonize Receptor-Arrestin Interactions
2010
The selectivity of β‐adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors
2005
Update on Wnt signaling in bone cell biology and bone disease
2011
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation
2011
Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation
2011
Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes
2010
New Roles for β-Arrestins in Cell Signaling: Not Just for Seven-Transmembrane Receptors
2006 StandoutNobel
Monitoring agonist‐promoted conformational changes of β‐arrestin in living cells by intramolecular BRET
2005
G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology
2004
β-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
2001 StandoutNobel
Roles of G‐protein‐coupled receptor dimerization
2004
Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors
2008 StandoutNobel
Structural aspects of M 3 muscarinic acetylcholine receptor dimer formation and activation
2011
Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.
2000
G Protein–Coupled Receptor Rhodopsin
2006
Ror2/Frizzled Complex Mediates Wnt5a-Induced AP-1 Activation by Regulating Dishevelled Polymerization
2010
G Protein–Coupled Receptor Oligomerization
2004
The Basic and Clinical Pharmacology of Nonpeptide Vasopressin Receptor Antagonists
2001
Hippo Pathway Regulation of Gastrointestinal Tissues
2014
β-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
2006 StandoutNobel
Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size
2011
β-Arrestins and Cell Signaling
2007 StandoutNobel
The evasive nature of drug efficacy: implications for drug discovery
2007
Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor
2005 StandoutNobel
beta -Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
2001
Functional reconstitution of β2-adrenergic receptors utilizing self-assembling Nanodisc technology
2006
Seven-Transmembrane Receptor Signaling Through β-Arrestin
2005 StandoutNobel
Chemokine Signaling and Functional Responses: The Role of Receptor Dimerization and TK Pathway Activation
2001
Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells
2005
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Heterodimerization of μ and δ Opioid Receptors: A Role in Opiate Synergy
2000
Exosomes in developmental signalling
2016
β-Arrestin-biased ligands at seven-transmembrane receptors
2007 StandoutNobel
Genomic Screening with RNAi: Results and Challenges
2010
Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction
2007
Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation
2004 StandoutNobel
Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences
2002
Constitutive and Agonist-dependent Homo-oligomerization of the Thyrotropin-releasing Hormone Receptor
2001
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
Oligomerization of opioid receptors with beta 2-adrenergic receptors: A role in trafficking and mitogen-activated protein kinase activation
2000
Two-signal requirement for growth-promoting function of Yap in hepatocytes
2015
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Membrane Trafficking of G Protein–Coupled Receptors
2004
Negative regulation of Wnt signaling mediated by CK1‐phosphorylated Dishevelled via Ror2
2010
The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans
2014
Genome-wide CRISPR screen for Zika virus resistance in human neural cells
2019
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
2016
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Works of Stéphane Angers being referenced
Wilms Tumor Suppressor WTX Negatively Regulates WNT/ß-Catenin Signaling
2007 Science
β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
2003
BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates*
2015
Proximal events in Wnt signal transduction
2009
High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
2015
Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer
2002
The KLHL12–Cullin-3 ubiquitin ligase negatively regulates the Wnt–β-catenin pathway by targeting Dishevelled for degradation
2006
Functional Significance of Oligomerization of G-protein-coupled Receptors
2000
Constitutive Agonist-independent CCR5 Oligomerization and Antibody-mediated Clustering Occurring at Physiological Levels of Receptors
2002
Monitoring of Ligand-independent Dimerization and Ligand-induced Conformational Changes of Melatonin Receptors in Living Cells by Bioluminescence Resonance Energy Transfer
2002
Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants
2000
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation
2009
THE BRET2/ARRESTIN ASSAY IN STABLE RECOMBINANT CELLS: A PLATFORM TO SCREEN FOR COMPOUNDS THAT INTERACT WITH G PROTEIN-COUPLED RECEPTORS (GPCRS)*
2002
Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
2016
Homodimerization of the β2-Adrenergic Receptor as a Prerequisite for Cell Surface Targeting
2004
Molecular architecture and assembly of the DDB1–CUL4A ubiquitin ligase machinery
2006 Nature
β2-Adrenergic Receptor Down-regulation
1999
Visualization of a short-range Wnt gradient in the intestinal stem-cell niche
2016 Nature
G Protein βγ Subunits Regulate Cell Adhesion through Rap1a and Its Effector Radil
2010
Oligomeric Size of the M2 Muscarinic Receptor in Live Cells as Determined by Quantitative Fluorescence Resonance Energy Transfer
2010
Biochemical and biophysical demonstration of GPCR oligomerization in mammalian cells
2001
Modulation of the β-Catenin Signaling Pathway by the Dishevelled-Associated Protein Hipk1
2009
Recovery of Oligomers and Cooperativity When Monomers of the M2Muscarinic Cholinergic Receptor Are Reconstituted into Phospholipid Vesicles
2007
New Regulators of Wnt/β-Catenin Signaling Revealed by Integrative Molecular Screening
2008
Reply: beyond receptor dimerization
2000
The Ubiquitin-Specific Protease USP34 Regulates Axin Stability and Wnt/β-Catenin Signaling
2011
Detection of β 2 -adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)
2000
Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function
2002
Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)
2000