Standout Papers

Histone deacetylases (HDACs): characterization of the classical HDAC family 2003 2026 2010 2018 2.4k
  1. Histone deacetylases (HDACs): characterization of the classical HDAC family (2003)
    Albert H. Gennip, Huib N. Caron et al. Biochemical Journal

Citation Impact

Citing Papers

Lipid Rafts As a Membrane-Organizing Principle
2009 StandoutScience
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
2013 StandoutScience
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
A "Silent" Polymorphism in the MDR 1 Gene Changes Substrate Specificity
2006 StandoutScience
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels
2006 StandoutNobel
Functional Proteomics Establishes the Interaction of SIRT7 with Chromatin Remodeling Complexes and Expands Its Role in Regulation of RNA Polymerase I Transcription
2012
A phytol-enriched diet induces changes in fatty acid metabolism in mice both via PPARα-dependent and -independent pathways
2005
Brawn for Brains: The Role of MEF2 Proteins in the Developing Nervous System
2005
Crucial Role for the Myelin‐associated Glycoprotein in the Maintenance of Axon‐Myelin Integrity
1995
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes
2009
The functional purification of P-glycoprotein is dependent on maintenance of a lipid–protein interface
1997
Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon
2008
Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice
2011 StandoutNobel
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia
2017 StandoutNobel
Dying for a cause: invertebrate genetics takes on human neurodegeneration
2003
Structure of Human Phytanoyl-CoA 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease*
2005
A Vast Repertoire of Dscam Binding Specificities Arises from Modular Interactions of Variable Ig Domains
2007 StandoutNobel
Shared Principles in NF-κB Signaling
2008 Standout
Hepatitis C virus NS5A as a potential viral Bcl‐2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma
2003
Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization
2007 StandoutNobel
The multifaceted roles of fatty acid synthesis in cancer
2016
When Checkpoints Fail
1997 StandoutNobel
Heat shock proteins as gatekeepers of proteolytic pathways—Implications for age-related macular degeneration (AMD)
2009
The Epigenomics of Cancer
2007 Standout
Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses
2005
Mitochondria: In Sickness and in Health
2012 Standout
Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents
2010
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel
2002 StandoutNatureNobel
Mitochondria, Oxidants, and Aging
2005 Standout
The Role of HDAC6 in Cancer
2010
Metazoan MicroRNAs
2018 Standout
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
The biology of the P-glycoproteins
1995
Molecular Evolution of the Histone Deacetylase Family: Functional Implications of Phylogenetic Analysis
2004
HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?
2013
A gene mutated in X–linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast
1996
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Deoxyribonucleoside triphosphate levels: A critical factor in the maintenance of genetic stability
1994
Histone Deacetylase 7 Associates with Hypoxia-inducible Factor 1α and Increases Transcriptional Activity
2004
Light‐Controlled Histone Deacetylase (HDAC) Inhibitors: Towards Photopharmacological Chemotherapy
2015 StandoutNobel
Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer
2011
Drug Insight: histone deacetylase inhibitor-based therapies for cutaneous T-cell lymphomas
2008
The Human ATP-Binding Cassette (ABC) Transporter Superfamily
2001
Axonal Transection in the Lesions of Multiple Sclerosis
1998 Standout
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
EMT: 2016
2016 Standout
Mitochondrial disorders caused by mutations in respiratory chain assembly factors
2011
Down-regulation of Histone Deacetylases Stimulates Adipocyte Differentiation
2006
Functional Characterization of Glycosylation-Deficient Human P-Glycoprotein Using A Vaccinia Virus Expression System
2000
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
2003 Standout
Crystal Structure of the Non-heme Iron Dioxygenase PtlH in Pentalenolactone Biosynthesis
2007 StandoutNobel
Dietarytrans10,cis12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver
2007
Fibrate induction of the adrenoleukodystrophy‐related gene (ABCD2)
2001
The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote TH17 cell–dependent emphysema
2015
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
Connexin 26 mutations in hereditary non-syndromic sensorineural deafness
1997 StandoutNature
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Sirtuins: Sir2-related NAD-dependent protein deacetylases.
2004
The NS5A Protein of Hepatitis C Virus Is a Zinc Metalloprotein
2004 StandoutNobel
Regulation of cardiac hypertrophy by intracellular signalling pathways
2006 Standout
The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice
2009
Peroxisome biogenesis disorders
2006
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
2011 StandoutNature
Crystal Structure of the Extracellular Domain from P0, the Major Structural Protein of Peripheral Nerve Myelin
1996
SIRT1 Regulates HIV Transcription via Tat Deacetylation
2005
Histone deacetylase inhibitors in hematological malignancies and solid tumors
2015
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
2012 Standout
IκB Kinase α-Mediated Derepression of SMRT Potentiates Acetylation of RelA/p65 by p300
2005
Regulation of HIF-1α activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia
2011
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
Deracemization of α-Aryl Hydrocoumarins via Catalytic Asymmetric Protonation of Ketene Dithioacetals
2012 StandoutNobel
Characterisation of tumour‐derived microvesicles in cancer patients' blood and correlation with clinical outcome
2017
A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum
2010 StandoutNobel
Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs.
2011
Peroxisome biogenesis disorders: Biological, clinical and pathophysiological perspectives
2013
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance.
1994 StandoutNobel
Modulation of antigen‐presenting cells by HDAC inhibitors: implications in autoimmunity and cancer
2011
Spermidine in health and disease
2018 StandoutScience
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
2011 Standout
Mammalian ABC Transporters in Health and Disease
2002
Altered expression of ALDP in X-linked adrenoleukodystrophy.
1995
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
2009 StandoutScience
A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels
1998 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Emerging Targets in Photopharmacology
2016 StandoutNobel
Asparagine-linked oligosaccharides are localized to single extracytosolic segments in multi-span membrane glycoproteins
1994
Histone deacetylase 10 promotes autophagy-mediated cell survival
2013
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
2015 StandoutNobel
Role of ALDP (ABCD1) and Mitochondria in X-Linked Adrenoleukodystrophy
2003
Connexin Mutations in X-Linked Charcot-Marie-Tooth Disease
1993 StandoutScience
Targeting HDACs: A Promising Therapy for Alzheimer's Disease
2011
Genetics of Sensory Mechanotransduction
2002 StandoutNobel

Works of Stephan Kemp being referenced

Contiguous gene deletion of ELOVL7, ERCC8 and NDUFAF2 in a patient with a fatal multisystem disorder
2009
Evidence for two enzymatic pathways for ω-oxidation of docosanoic acid in rat liver microsomes
2005
Identification of a Two Base Pair Deletion in Five Unrelated Families with Adrenoleukodystrophy: A Possible Hot Spot for Mutations
1994
Analysis of very long-chain fatty acids using electrospray ionization mass spectrometry
2003
The gene for X-linked myotubular myopathy is located in an 8 Mb region at the border of Xq27.3 and Xq28
1994
Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification
2015
Gene redundancy and pharmacological gene therapy: Implications for X-linked adrenoleukodystrophy
1998
X-linked adrenoleukodystrophy: Very long-chain fatty acid metabolism, ABC half-transporters and the complicated route to treatment
2006
ABCD1 mutations and the X-linked adrenoleukodystrophy mutation database: Role in diagnosis and clinical correlations
2001
Role of very-long-chain acyl-coenzyme A synthetase in X-linked adrenoleukodystrophy
1999
X-Linked Adrenoleukodystrophy: Genes, Mutations, and Phenotypes
1999
Deletion of the serine 34 codon from the major peripheral myelin protein P0 gene in Charcot–Marie–Tooth disease type 1B
1993
N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein.
1993
Histone deacetylases (HDACs): characterization of the classical HDAC family
2003 Standout
Pharmacological induction of peroxisomes in peroxisome biogenesis disorders
2000
THYMINELESS DEATH IN BACILLUS MEGATERIUM
1964
Spectrum of mutations in the gene encoding the adrenoleukodystrophy protein.
1995
Rankless by CCL
2026