Citation Impact
Citing Papers
Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity
2013 StandoutNobel
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Ten things you should know about protein kinases: IUPHAR R eview 14
2015
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Unified Synthesis of Polycyclic Alkaloids by Complementary Carbonyl Activation**
2021 StandoutNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
ClassyFire: automated chemical classification with a comprehensive, computable taxonomy
2016
Confab - Systematic generation of diverse low-energy conformers
2011
PubChem3D: Conformer generation
2011
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
2024 StandoutNobel
The re-emergence of natural products for drug discovery in the genomics era
2015 Standout
Structural Basis for Gating and Activation of RyR1
2016 StandoutNobel
Imaging beyond the proteome
2012 StandoutNobel
1,4‐Thienodiazepine‐2,5‐diones via MCR (II): Scaffold Hopping by Gewald and Ugi‐Deprotection‐Cyclization Strategy
2010
Parallel synthesis of potent dopaminergic N-phenyltriazole carboxamides applying a novel click chemistry based phenol linker
2009
Graph mining: procedure, application to drug discovery and recent advances
2012
Biology‐Oriented Synthesis
2011
Diversity Through a Branched Reaction Pathway: Generation of Multicyclic Scaffolds and Identification of Antimigratory Agents
2010
The application of in silico drug-likeness predictions in pharmaceutical research
2015
Open Babel: An open chemical toolbox
2011 Standout
DOCK 6: Combining techniques to model RNA–small molecule complexes
2009
Synthesis of Small Molecules with High Scaffold Diversity: Exploitation of Metathesis Cascades in Combination with Inter‐ and Intramolecular Diels–Alder Reactions
2010
Marine natural products
1990 Standout
Scaffold‐Hopping Cascade Yields Potent Inhibitors of 5‐Lipoxygenase
2008
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
2010 Standout
Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo
2012 Standout
Machine learning for molecular and materials science
2018 StandoutNature
The Pictet–Spengler Reaction in Nature and in Organic Chemistry
2011 Standout
Biostructural Features of Additional Jasplakinolide (Jaspamide) Analogues
2011
Screening for Inhibitors of Tau Protein Aggregation into Alzheimer Paired Helical Filaments: A Ligand Based Approach Results in Successful Scaffold Hopping
2007
Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation
2010
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
2017 StandoutNobel
Similar interactions of natural products with biosynthetic enzymes and therapeutic targets could explain why nature produces such a large proportion of existing drugs
2011
Simple indole alkaloids and those with a nonrearranged monoterpenoid unit
2010 Standout
Effects of multiple conformers per compound upon 3-D similarity search and bioassay data analysis
2012
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Neutrophil extracellular traps in immunity and disease
2017 Standout
Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases
2015
PubChem Substance and Compound databases
2015 Standout
When analoging is not enough: scaffold discovery in medicinal chemistry
2010
Biology‐Oriented Combined Solid‐ and Solution‐Phase Synthesis of a Macroline‐Like Compound Collection
2009
Regulating the regulator: post-translational modification of RAS
2011
A concise asymmetric synthesis of (−)-rasfonin
2011 StandoutNobel
PROTAC targeted protein degraders: the past is prologue
2022 Standout
Pharmacological Inhibition of Protein Lipidation
2015
The ChEMBL database in 2017
2016 Standout
Multicomponent synthesis of 2,3-dihydrochromeno[4,3-d]pyrazolo[3,4-b]pyridine-1,6-diones: a novel heterocyclic scaffold with antibacterial activity
2011
Fluorogenic probes for live-cell imaging of the cytoskeleton
2014 StandoutNobel
Global profiling of dynamic protein palmitoylation
2011
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Chondramide C: Synthesis, Configurational Assignment, and Structure–Activity Relationship Studies
2008
PubChem3D: conformer ensemble accuracy
2013
Synthesis and Testing of a Focused Phenothiazine Library for Binding to HIV-1 TAR RNA
2006
Enhancements of screening collections to address areas of unmet medical need: an industry perspective
2010
Drugging the undruggable RAS: Mission Possible?
2014
Quantitative Super-Resolution Microscopy of the Mammalian Glycocalyx
2019 StandoutNobel
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
The Golden Age of Transfer Hydrogenation
2015 Standout
New Structures and Bioactivity Properties of Jasplakinolide (Jaspamide) Analogues from Marine Sponges
2010
Catalytic Asymmetric Reductive Condensation of N–H Imines: Synthesis of C2‐Symmetric Secondary Amines
2016 StandoutNobel
Macrocycles in Drug Discovery─Learning from the Past for the Future
2023
pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures
2015 Standout
Bioactivity-Guided Navigation of Chemical Space
2010
Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations
2018
A Searchable Map of PubChem
2010
The conjugate addition of enantiomerically pure lithium amides as chiral ammonia equivalents part II: 2005−2011
2012
On the Mechanism of Cu-Catalyzed Enantioselective Extended Conjugate Additions: A Structure-Based Approach
2014 StandoutNobel
Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments
2020
Toward a Global Understanding of Chemical Pollution: A First Comprehensive Analysis of National and Regional Chemical Inventories
2020 Standout
Exploring Protein Lipidation with Chemical Biology
2011
Gerüstdiversitätsbasierte Synthese und ihre Anwendung bei der Sonden‐ und Wirkstoffsuche
2016
Phosphine Organocatalysis
2018 Standout
Chemical space as a source for new drugs
2010
ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization
2015
Targeting protein palmitoylation: selective inhibitors and implications in disease
2014
Palladium-Catalyzed Transformations of Alkyl C–H Bonds
2016 Standout
SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules
2019 Standout
Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
2015 Standout
Click-Chemistry Based High Throughput Screening Platform for Modulators of Ras Palmitoylation
2017 StandoutNobel
Liganding Functional Tyrosine Sites on Proteins Using Sulfur–Triazole Exchange Chemistry
2020
Azine Activation via Silylium Catalysis
2021 StandoutNobel
Recent applications of multicomponent reactions in medicinal chemistry
2012
Small Molecule Modulators of Protein–Protein Interactions: Selected Case Studies
2014
Microwave-Assisted Synthesis in Water as Solvent
2007 Standout
Discovery and Synthesis of Namalide Reveals a New Anabaenopeptin Scaffold and Peptidase Inhibitor
2011
SwissSimilarity: A Web Tool for Low to Ultra High Throughput Ligand-Based Virtual Screening
2016
Shaping the interaction landscape of bioactive molecules
2013
Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies
2018
Regio- and Stereospecific Synthesis of C-3 Functionalized Proline Derivatives by Palladium Catalyzed Directed C(sp3)–H Arylation
2014
Neural‐Symbolic Machine Learning for Retrosynthesis and Reaction Prediction
2017
Charting, Navigating, and Populating Natural Product Chemical Space for Drug Discovery
2012
The intracellular dynamic of protein palmitoylation
2010
Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
2014 Standout
Natural Products as Sources of New Drugs from 1981 to 2014
2016 Standout
Enantioselective Organocatalytic Partial Transfer Hydrogenation of Lactone-Fused Quinolines
2014
ChatGPT Chemistry Assistant for Text Mining and the Prediction of MOF Synthesis
2023 StandoutNobel
Natural Product Biosynthesis Inspired Concise and Stereoselective Synthesis of Benzopyrones and Related Scaffolds
2011
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?
2015
Chemistry: Chemical con artists foil drug discovery
2014 StandoutNature
Scaffold Diversity Synthesis and Its Application in Probe and Drug Discovery
2016
Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signalling
2013
Design and synthesis of analogues of natural products
2015
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Metal-Free Multicomponent Syntheses of Pyridines
2014 Standout
Selective Chemical Imaging of Static Actin in Live Cells
2012
Modulators of Protein–Protein Interactions
2014
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
2019 Standout
Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues
2011 StandoutNobel
Works of Steffen Renner being referenced
Total Synthesis of Chondramide C and Its Binding Mode to F‐Actin
2008
Natural-product-derived fragments for fragment-based ligand discovery
2012
New Inhibitors of the Tat–TAR RNA Interaction Found with a “Fuzzy” Pharmacophore Model
2005
Searching for Drug Scaffolds with 3D Pharmacophores and Neural Network Ensembles
2007
Synthesis and Structure–Activity Correlation of a Brunsvicamide‐Inspired Cyclopeptide Collection
2009
Interactive exploration of chemical space with Scaffold Hunter
2009
Bioactivity-guided mapping and navigation of chemical space
2009
The Scaffold Tree: An Efficient Navigation in the Scaffold Universe
2010
New Allosteric Modulators of Metabotropic Glutamate Receptor 5 (mGluR5) Found by Ligand‐Based Virtual Screening
2005
Scaffold‐Hopping Potential of Ligand‐Based Similarity Concepts
2005
A Scaffold‐Tree‐Merging Strategy for Prospective Bioactivity Annotation of γ‐Pyrones
2010
Small-molecule inhibition of APT1 affects Ras localization and signaling
2010
Anticancer Properties of an Important Drug Lead Podophyllotoxin Can Be Efficiently Mimicked by Diverse Heterocyclic Scaffolds Accessible via One-Step Synthesis
2011
Development of Highly Potent Inhibitors of the Ras‐Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design
2011
Virtual Screening for Selective Allosteric mGluR1 Antagonists and Structure–Activity Relationship Investigations for Coumarine Derivatives
2007
Impact of Conformational Flexibility on Three-Dimensional Similarity Searching Using Correlation Vectors
2006
Totalsynthese von Chondramid C und Bindung an F‐Aktin
2008
A Collection of Robust Organic Synthesis Reactions for In Silico Molecule Design
2011
A Scaffold‐Tree‐Merging Strategy for Prospective Bioactivity Annotation of γ‐Pyrones
2010
Scaffold‐Hopping: How Far Can You Jump?
2006