Citation Impact
Citing Papers
In Situ Visualization of the pKM101-Encoded Type IV Secretion System Reveals a Highly Symmetric ATPase Energy Center
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Epigenetic Repression of DNA Mismatch Repair by Inflammation and Hypoxia in Inflammatory Bowel Disease–Associated Colorectal Cancer
2009 StandoutNobel
Structural bases for F plasmid conjugation and F pilus biogenesis in Escherichia coli
2019
Activation of β-catenin by carcinogenic Helicobacter pylori
2005
SHP-2 Tyrosine Phosphatase as an Intracellular Target of Helicobacter pylori CagA Protein
2002 Science
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
The Cell Biology of Phagocytosis
2011
CD8+CD205+ Splenic Dendritic Cells Are Specialized to Induce Foxp3+ Regulatory T Cells
2008 StandoutNobel
Structural analysis of the Legionella pneumophila Dot/Icm type IV secretion system core complex
2020
Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex
2020
Nucleotide Oligomerization Binding Domain-Like Receptor Signaling Enhances Dendritic Cell-Mediated Cross-Priming In Vivo
2009 StandoutNobel
From conjugation to T4S systems in Gram‐negative bacteria: a mechanistic biology perspective
2019
Gastric cancer
2016 Standout
A Double-Barrel Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) System to Quantify 96 Interactomes per Day*
2015
2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion
2014
Role of the AlpAB proteins and lipopolysaccharide in adhesion of Helicobacter pylori to human gastric tissue
2002
Modulation of Integrin Activation by an Entropic Spring in the β-Knee
2010 StandoutNobel
Malignant Helicobacter pylori-Associated Diseases: Gastric Cancer and MALT Lymphoma
2019
The role of the neutrophil and phagocytosis in infection caused by Helicobacter pylori
2001
An Acquired and Endogenous Glycocalyx Forms a Bidirectional “Don’t Eat” and “Don’t Eat Me” Barrier to Phagocytosis
2020 StandoutNobel
Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by the Brucella type IV secretion system
2008
Helicobacter pylori persistence: biology and disease
2004
A De Novo Protein Binding Pair By Computational Design and Directed Evolution
2011 StandoutNobel
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
2002 Standout
Helicobacter pylorienter and survive within multivesicular vacuoles of epithelial cells
2002
Investigation of the biological relevance ofHelicobacter pylori cagElocus diversity, presence of CagA tyrosine phosphorylation motifs and vacuolating cytotoxin genotype on IL-8 induction in gastric epithelial cells
2003
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
2007 StandoutNobel
Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants
2010 Standout
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility
2016 Standout
The Agrobacterium VirB/VirD4 T4SS: Mechanism and Architecture Defined Through In Vivo Mutagenesis and Chimeric Systems
2018
Host and microbial constituents influence helicobacter pylori-induced cancer in a murine model of hypergastrinemia
2003
Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5
2003
Mouse Models of Colon Cancer
2009
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Helicobacter pyloriFlagellin Evades Toll‐Like Receptor 5–Mediated Innate Immunity
2004
GeSeq – versatile and accurate annotation of organelle genomes
2017 Standout
Crystal Structure of the Hexameric Traffic ATPase of the Helicobacter pylori Type IV Secretion System
2000
High-resolution structure of the Shigella type-III secretion needle by solid-state NMR and cryo-electron microscopy
2014 StandoutNobel
Molecular mechanisms of phagocytic uptake in mammalian cells
2008
Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin‐8
2001
Pathogenic mechanisms of the oncoprotein CagA in H. pylori-induced gastric cancer
2016
Show me the substrates: modulation of host cell function by type IV secretion systems
2003
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
2004 Standout
Helicobacter pylori in Health and Disease
2009
Rab GTPases as coordinators of vesicle traffic
2009 Standout
What are the consequences of the disappearing human microbiota?
2009
Intracellular Toll-like Receptors
2010 StandoutNobel
Metastatic transcriptional pattern revealed by gene expression profiling in primary colorectal carcinoma
2005
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Analysis of the type IV secretion system-dependent cell motility of Helicobacter pylori-infected epithelial cells
2004
Pathogenic trickery: deception of host cell processes
2001
Persistent bacterial infections: the interface of the pathogen and the host immune system
2004
Metalloproteinases and their natural inhibitors in inflammation and immunity
2013
Bacterial Adhesins in Host-Microbe Interactions
2009
Pyroptosis: mechanisms and diseases
2021 Standout
Oncogenic mechanisms of the Helicobacter pylori CagA protein
2004
The Perseus computational platform for comprehensive analysis of (prote)omics data
2016 Standout
OrganellarGenomeDRAW (OGDRAW): a tool for the easy generation of high-quality custom graphical maps of plastid and mitochondrial genomes
2007
Helicobacter pylori cag-Type IV Secretion System Facilitates Corpus Colonization to Induce Precancerous Conditions in Mongolian Gerbils
2005
Helicobacter pylori-induced gastric inflammation and gastric cancer
2013
The biofilm matrix
2010 Standout
Pathogenicity island-dependent effects of on intracellular signal transduction in epithelial cells
2005
NOD1 and NOD2 signalling links ER stress with inflammation
2016 StandoutNature
The Impact of the Gut Microbiota on Human Health: An Integrative View
2012 Standout
Remodelling the extracellular matrix in development and disease
2014 Standout
The CagA Protein ofHelicobacter pyloriIs Translocated into Epithelial Cells and Binds to SHP‐2 in Human Gastric Mucosa
2003
Structure of the outer membrane complex of a type IV secretion system
2009 Nature
The primary transcriptome of the major human pathogen Helicobacter pylori
2010 StandoutNature
Dynamic Evolution of Pathogenicity Revealed by Sequencing and Comparative Genomics of 19 Pseudomonas syringae Isolates
2011
A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system
2003
c‐Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs
2002
Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori
2004
Helicobacter pylori CagA Containing ITAM‐Like Sequences Localized to Lipid Rafts Negatively Regulates VacA‐Induced Signaling In Vivo
2003
CagA tyrosine phosphorylation and interleukin-8 induction by Helicobacter pylori are independent from AlpAB, HopZ and Bab group outer membrane proteins
2002
Coadaptation of Helicobacter pylori and humans: ancient history, modern implications
2009
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
T Cell Surveillance of Oncogene-Induced Prostate Cancer Is Impeded by T Cell-Derived TGF-β1 Cytokine
2011 StandoutNobel
Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori
2005
Gastric cancer
2020 Standout
Duodenal ulcer promoting gene of Helicobacter pylori
2005
Helicobacter pyloriInfection
2002 Standout
Survey of the year 2003 commercial optical biosensor literature
2004
Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions
2015 Standout
A microbial symbiosis factor prevents intestinal inflammatory disease
2008 StandoutNature
Attenuation of Helicobacter pylori CagA·SHP-2 Signaling by Interaction between CagA and C-terminal Src Kinase
2003
Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice
2007 Nature
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy
2017 Standout
Interaction of Helicobacter pylori with professional phagocytes: role of the cag pathogenicity island and translocation, phosphorylation and processing of CagA
2001
The versatile bacterial type IV secretion systems
2003
Impact of biofilm matrix components on interaction of commensal Escherichia coli with the gastrointestinal cell line HT-29
2006
Cryo-EM structure of a type IV secretion system
2022 StandoutNatureNobel
Correlation between Variation of the 3′ Region of thecagAGene inHelicobacter pyloriand Disease Outcome in Japan
2002
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
2005 Standout
The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation
2003
Anti-apoptotic signalling by the Dot/Icm secretion system ofL. pneumophila
2006
The gut microbiota shapes intestinal immune responses during health and disease
2009 Standout
Innate immune recognition of the extracellular mucosal pathogen, Helicobacter pylori
2005
Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
2010 Standout
Gut Microbiota in Health and Disease
2010 Standout
Growth Phase-Dependent Response ofHelicobacter pylorito Iron Starvation
2003
Molecular Pathogenesis ofShigellaspp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion
2008
Pivoting the Plant Immune System from Dissection to Deployment
2013 StandoutScience
Phenotypic characterization of human colorectal cancer stem cells
2007 Standout
Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system
2012
Helicobacter pyloriInduces Apoptosis of Macrophages in Association with Alterations in the Mitochondrial Pathway
2004
Type IV secretion systems: Advances in structure, function, and activation
2020
Helicobacter pylori-host cell interactions mediated by type IV secretion
2005
Structural Biology of Bacterial Type IV Secretion Systems
2015
The VirB5 protein localizes to the T-pilus tips in Agrobacterium tumefaciens
2007
Helicobacter pyloriVacA cytotoxin interacts with fibronectin and alters HeLa cell adhesion and cytoskeletal organization in vitro
2004
Bacterial Resistance to β-Lactam Antibiotics: Compelling Opportunism, Compelling Opportunity
2005 Standout
Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after laser-capture microdissection of tumor tissues and normal epithelia.
2001
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
2008 Standout
The Helicobacter pylori vacuoloating cytotoxin: from cellular vacuolation to immunosuppressive activities
2004
Structure of a Type IV Secretion System Core Complex
2009 Science
Pathogenesis ofHelicobacter pyloriInfection
2006 Standout
Gastrointestinal Malignancy and the Microbiome
2014
Contributions of Amino Acid Side Chains to the Kinetics and Thermodynamics of the Bivalent Binding of Protein L to Ig κ Light Chain
2004 StandoutNobel
Crystal structure of CagV, the Helicobacter pylori homologue of the T4SS protein VirB8
2019
Helicobacter pylori Resists Phagocytosis by Macrophages: Quantitative Assessment by Confocal Microscopy and Fluorescence-Activated Cell Sorting
2001
Mitochondrial Reactive Oxygen Species. Contribution to Oxidative Stress and Interorganellar Signaling
2006
One ring to rule them all? Genome sequencing provides new insights into the ‘master circle’ model of plant mitochondrial DNA structure
2013
Helicobacter pylori VacA Toxin Promotes Bacterial Intracellular Survival in Gastric Epithelial Cells
2006
Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors
2008 Science
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Proteases and protease inhibitors in infectious diseases
2017
Plasticity of Repetitive DNA Sequences within a Bacterial (Type IV) Secretion System Component
2003
Evaluation of Phosphatidylinositol-4-Kinase IIIα as a Hepatitis C Virus Drug Target
2012
Gene Expression Profiling of Helicobacter pylori Reveals a Growth-Phase-Dependent Switch in Virulence Gene Expression
2003
Importance and regulation of the colonic mucus barrier in a mouse model of colitis
2010
pH-Regulated Gene Expression of the Gastric PathogenHelicobacter pylori
2003
Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
2002
Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii
2007 Standout
Identification of strain-specific genes located outside the plasticity zone in nine clinical isolates of Helicobacter pylori b bThe GenBank accession numbers for the H. pylori sequences reported in this paper are AF326599–AF326607 for region A, AF326608–AF326616 for region B, AF326617–AF326625 for region C, AF326626–AF326634 for region D, AF327212–AF327220 for region E, AF328909–AF328916 and AF328924 for region F, and AF32917–AF32923 for region G.
2002
The gut flora as a forgotten organ
2006 Standout
Works of Steffen Backert being referenced
Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E‐cadherin to disrupt intercellular adhesion
2010
Importance of EGF receptor, HER2/Neu and Erk1/2 kinase signalling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: antagonistic effects of the vacuolating cytotoxin VacA
2008
A Small Fibronectin-mimicking Protein from Bacteria Induces Cell Spreading and Focal Adhesion Formation
2010
Role of type IV secretion inHelicobacter pyloripathogenesis
2008
Distinct Roles of Secreted HtrA Proteases from Gram-negative Pathogens in Cleaving the Junctional Protein and Tumor Suppressor E-cadherin
2012
Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori
2011
DNA Binding Specificity of the Replication Initiator Protein, DnaA from Helicobacter pylori
2003
Helicobacter pylori type IV secretion, host cell signalling and vaccine development
2002
Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus
2000
Helicobacter exploits integrin for type IV secretion and kinase activation
2007 Nature
A Helical RGD Motif Promoting Cell Adhesion: Crystal Structures of the Helicobacter pylori Type IV Secretion System Pilus Protein CagL
2013
Phage T4-like intermediates of DNA replication and recombination in the mitochondria of the higher plant Chenopodium album (L.)
2000
Tyrosine-phosphorylated bacterial effector proteins: the enemies within
2005
Identification of a tyrosine-phosphorylated 35 kDa carboxy-terminal fragment (p35CagA) of theHelicobacter pylori CagA protein in phagocytic cells: Processing or breakage?
2001
Differential gene expression in colon carcinoma cells and tissues detected with a cDNA array
1999
Type IV secretion systems and their effectors in bacterial pathogenesis
2006
Role of Abl and Src family kinases in actin-cytoskeletal rearrangements induced by the Helicobacter pylori CagA protein
2011
Biochemical and functional characterization ofHelicobacter pylorivesicles
2010
Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells
2001
Use of a novel coinfection system reveals a role for Rac1, H-Ras, and CrkII phosphorylation inHelicobacter pylori-induced host cell actin cytoskeletal rearrangements
2007
c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains
2012
Host Cell Interactome of Tyrosine-Phosphorylated Bacterial Proteins
2009
The Helicobacter pylori CagA protein induces tyrosine dephosphorylation of ezrin
2004
A Specific A/T Polymorphism in Western Tyrosine Phosphorylation B-Motifs Regulates Helicobacter pylori CagA Epithelial Cell Interactions
2015
Helicobacter pylori CagL Activates ADAM17 to Induce Repression of the Gastric H, K-ATPase α Subunit
2010
Src Is the Kinase of the Helicobacter pylori CagA Protein in Vitro and in Vivo
2002
Activation of Abl by Helicobacter pylori: A Novel Kinase for CagA and Crucial Mediator of Host Cell Scattering
2007
VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems?
2008
Cortactin: an Achilles' heel of the actin cytoskeleton targeted by pathogens
2005
Functional Analysis of thecagPathogenicity Island inHelicobacter pyloriIsolates from Patients with Gastritis, Peptic Ulcer, and Gastric Cancer
2004
The Versatility of the Helicobacter pylori Vacuolating Cytotoxin VacA in Signal Transduction and Molecular Crosstalk
2010
Helicobacter pyloridownregulates expression of human β-defensin 1 in the gastric mucosa in a type IV secretion-dependent fashion
2013
Type IV Secretion and Signal Transduction of Helicobacter pylori CagA through Interactions with Host Cell Receptors
2017
Functional Analysis of theHelicobacter pylori cagPathogenicity Island Reveals Both VirD4-CagA-Dependent and VirD4-CagA-Independent Mechanisms
2002
Type IV secretion in Gram‐negative and Gram‐positive bacteria
2017
Prevalence and Spread of Enterohepatic Helicobacter Species in Mice Reared in a Specific-Pathogen-Free Animal Facility
2006
The mystery of the rings: structure and replication of mitochondrial genomes from higher plants
1997
NF-κB activation and potentiation of proinflammatory responses by theHelicobacter pyloriCagA protein
2005
Specific Entry ofHelicobacter pyloriinto Cultured Gastric Epithelial Cells via a Zipper-Like Mechanism
2002
Helicobacter pylori Induces AGS Cell Motility and Elongation via Independent Signaling Pathways
2004
The Cag pathogenicity island and interaction between TLR 2/NOD 2 and NLRP 3 regulate IL ‐1β production in Helicobacter pylori infected dendritic cells
2013
Composition, Structure and Function of the Helicobacter Pylori cag Pathogenicity Island Encoded type IV Secretion System
2015
Helicobacter pylori inhibits phagocytosis by professional phagocytes involving type IV secretion components
2000
EnteropathogenicEscherichia coliSubverts Phosphatidylinositol 4,5-Bisphosphate and Phosphatidylinositol 3,4,5-Trisphosphate upon Epithelial Cell Infection
2008