Standout Papers
Citation Impact
Citing Papers
K + Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension
2011 Science
Case Detection, Diagnosis, and Treatment of Patients with Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline
2008 Standout
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
2006 StandoutNobel
Structure of the human epithelial sodium channel by cryo-electron microscopy
2018
Finishing the euchromatic sequence of the human genome
2004 StandoutNature
Cytochromes P-450 and the regulation of steroid synthesis
1986
Activation of Store-Operated Ca2+ Current in Xenopus Oocytes Requires SNAP-25 but Not a Diffusible Messenger
1999 StandoutNobel
The regulation of aldosterone synthase expression
2003
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Molecular genetics of human hypertension
1998
Primary aldosteronism—careful investigation is essential and rewarding
2003
Glucocorticoid-Remediable Aldosteronism
2003
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
A novel genetic locus for low renin hypertension: familial hyperaldosteronism type II maps to chromosome 7 (7p22)
2000
Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21
1997
Prospects for Cardiovascular Research
2001 StandoutNobel
Hypertension caused by a truncated epithelial sodium channel γ subunit: genetic heterogeneity of Liddle syndrome
1995
Laboratory challenges in primary aldosteronism screening and diagnosis
2015
Molecular Mechanisms of Human Hypertension
2001 Standout
Glucocorticoid-remediable Aldosteronism
2011
Molecular basis of human hypertension: Role of angiotensinogen
1992 Standout
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
1999
Evidence for Abnormal Left Ventricular Structure and Function in Normotensive Individuals with Familial Hyperaldosteronism Type I
2005
Glucocorticoid-remediable aldosteronism is associated with severe hypertension in early childhood
2001
Deletion Hybrid Genes, due to Unequal Crossing Over betweenCYP11B1(11β-Hydroxylase) andCYP11B2(Aldosterone Synthase) Cause Steroid 11β-Hydroxylase Deficiency and Congenital Adrenal Hyperplasia1
2001
Molecular basis of the Cd36 chromosomal deletion underlying SHR defects in insulin action and fatty acid metabolism
2002
Familial hyperaldosteronism type II is linked to the chromosome 7p22 region but also shows predicted heterogeneity
2005
Molecular Biology of Steroid Hormone Synthesis*
1988
Expression of 11β-Hydroxysteroid Dehydrogenase Using Recombinant Vaccinia Virus
1990
Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes.
1997 StandoutNobel
Roles of the C Termini of α-, β-, and γ-Subunits of Epithelial Na+ Channels (ENaC) in Regulating ENaC and Mediating Its Inhibition by Cytosolic Na+
2001
18-Oxocortisol Measurement in Adrenal Vein Sampling as a Biomarker for Subclassifying Primary Aldosteronism
2011
Primary Hyperaldosteronism in Essential Hypertensives: Prevalence, Biochemical Profile, and Molecular Biology1
2000
Gitelman's variant of Barter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na–Cl cotransporter
1996
Examination of Genotype and Phenotype Relationships in 14 Patients with Apparent Mineralocorticoid Excess1
1998
MINERALOCORTICOID ACTIVITY OF LIQUORICE: 11-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY COMES OF AGE
1987
Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination
2000
Microarray, qPCR, andKCNJ5Sequencing of Aldosterone-Producing Adenomas Reveal Differences in Genotype and Phenotype between Zona Glomerulosa- and Zona Fasciculata-Like Tumors
2012
Genetic Susceptibility for Human Familial Essential Hypertension in a Region of Homology with Blood Pressure Linkage on Rat Chromosome 10
1997 StandoutNobel
Primary aldosteronism
1995
The Nedd4-like Protein KIAA0439 Is a Potential Regulator of the Epithelial Sodium Channel
2001
Role of gammaENaC subunit in lung liquid clearance and electrolyte balance in newborn mice. Insights into perinatal adaptation and pseudohypoaldosteronism.
1998
Severe autosomal dominant hypertension and brachydactyly in a unique Turkish kindred maps to human chromosome 12
1996
H+-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels
1998
Mineralocorticoid hypertension
1994
RecombinantCYP11BGenes Encode Enzymes that Can Catalyze Conversion of 11-Deoxycortisol to Cortisol, 18-Hydroxycortisol, and 18-Oxocortisol1
1998
CD36 is a sensor of diacylglycerides
2005 StandoutNatureNobel
TRP channels as cellular sensors
2003 StandoutNature
A novel spice–site mutation in the γ subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 families
1996
A Di-leucine Signal in the Ubiquitin Moiety
2000
Liddle's Syndrome Revisited -- A Disorder of Sodium Reabsorption in the Distal Tubule
1994
Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel
1995
A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro.
1997
The Activity of the Epithelial Sodium Channel Is Regulated by Clathrin-mediated Endocytosis
1997
A Novel Form of Human Mendelian Hypertension Featuring Nonglucocorticoid-Remediable Aldosteronism
2008
Exploration of the pore structure of a peptide-gated Na+ channel
2001
Male–female differences in fertility and blood pressure in ACE-deficient mice
1995 StandoutNatureNobel
Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na+ channel cell surface expression
2001
Liddle’s Syndrome
1998
Familial hyperaldosteronism
2001
Importance of quantitative genetic variations in the etiology of hypertension
2000 StandoutNobel
A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel
2002
Hypertension and the Cortisol-Cortisone Shuttle
2003
Apparent mineralocorticoid excess
2001
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination
1997
Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease
1998
Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome
1999
Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1
1996
Atherosclerosis
2000 StandoutNature
Cloning and tissue distribution of the human 1 lβ-hydroxysteroid dehydrogenase type 2 enzyme
1994
Regulation of the epithelial sodium channel (ENaC) by accessory proteins
2000
Type 1 Aldosterone Synthase Deficiency Presenting in a Middle-Aged Man1
2001
Early death due to defective neonatal lung liquid clearance in αENaC-deficient mice
1996
Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension
1992
Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system.
1998
New Target Regions for Human Hypertension via Comparative Genomics
2000
Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na–K–2CI cotransporter NKCC2
1996
Human hypertension caused by mutations in the kidney isozyme of 11β–hydroxysteroid dehydrogenase
1995
Association of hypertension with T594M mutation in β subunit of epithelial sodium channels in black people resident in London
1998
HIGH INCIDENCE OF PRIMARY ALDOSTERONISM IN 199 PATIENTS REFERRED WITH HYPERTENSION
1994
THE GENETICS, PATHOPHYSIOLOGX, AND MANAGEMENT OF HUMAN DEFICIENCIES OF P450c17
2001
Genome Duplications and Other Features in 12 Mb of DNA Sequence from Human Chromosome 16p and 16q
1999
Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I
1998
Apparent mineralocorticoid excess syndrome: an overview
2004
The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.
1991
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
1993 StandoutNobel
Molecular Genetics of Human Blood Pressure Variation
1996 Science
Mineralocorticoid Action: Target Tissue Specificity Is Enzyme, Not Receptor, Mediated
1988 StandoutScience
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
2006 StandoutNobel
Immunohistochemical localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme in human kidney and placenta.
1995
11β-Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid Excess*
1997
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na + channels
2004 StandoutNobel
WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.
1996
Acid potentiation of the capsaicin receptor determined by a key extracellular site
2000 StandoutNobel
Steroid disorders in children: Congenital adrenal hyperplasia and apparent mineralocorticoid excess
1999
A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system.
1995
Familial Incomplete Male Pseudohermaphroditism, Type 2
1974 StandoutNobel
A novel mouse Nedd4 protein suppresses the activity of the epithelial Na + channel
2001
Familial Incomplete Male Pseudohermaphroditism, Type 1
1974 StandoutNobel
Clinical and Biochemical Variability of Congenital Adrenal Hyperplasia Due to llβ-Hydroxylase Deficiency, A Study of 25 Patients*
1983
Glucocorticoid-Remediable Aldosteronism
1999
Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males
2007 StandoutNobel
Genome-Wide Linkage Analyses of Systolic Blood Pressure Using Highly Discordant Siblings
1999
Estrogen receptor variant and hypertension in women.
1993
Amino acid substitution R384P in aldosterone synthase causes corticosterone methyloxidase type I deficiency.
1995
The Significance of Elevated Levels of Plasma 18-Hydroxycorticosterone in Patients with Primary Aldosteronism*
1979
Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.
1992
Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro
2005 StandoutNobel
Nedd4 mediates control of an epithelial Na + channel in salivary duct cells by cytosolic Na +
1998
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
2002 StandoutScienceNobel
Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor
2004 StandoutNobel
Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency*
2000
Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse
2001 StandoutNobel
Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene
2004 StandoutNobel
Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.
1992
Inborn Error in the Terminal Step of Aldosterone Biosynthesis
1980
Signals for Sorting of Transmembrane Proteins to Endosomes and Lysosomes
2003 Standout
Genetic Analysis of Inherited Hypertension in the Rat
2000
Functional mapping of disease susceptibility loci using cell biology
2006 StandoutNobel
Congenital Adrenal Hyperplasia
1987
Mutation T318M in the CYP11B2 gene encoding P450c11AS (aldosterone synthase) causes corticosterone methyl oxidase II deficiency.
1995
Disorders of Adrenal Steroid Biogenesis
1967
Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the β-subunit of the amiloride-sensitive epithelial sodium channel
1999
Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency.
1992
Isolated Aldosterone Synthase Deficiency Caused by Simultaneous E198D and V386A Mutations in the CYP11B2 Gene1
1998
Intracranial Aneurysm and Hemorrhagic Stroke in Glucocorticoid-remediable Aldosteronism
1998
Hereditary Defect in Biosynthesis of Aldosterone: Aldosterone Synthase Deficiency 1964–19971
1997
Hypokalemia in the Hypertensive Patient
1967
Primary Aldosteronism
1988
17-hydroxylation deficiency in man.
1966
Evaluation of the Dexamethasone Suppression Test for the Diagnosis of Glucocorticoid-Remediable Aldosteronism1
1997
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
2011 Standout
A genetically clamped renin transgene for the induction of hypertension
2002 StandoutNobel
In VivoStructure–Function Analyses ofCaenorhabditis elegansMEC-4, a Candidate Mechanosensory Ion Channel Subunit
2000
The role of individual Nedd4–2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels
2002
Evidence for a Gene Influencing Blood Pressure on Chromosome 17
2000
AFFINITY OF LIQUORICE DERIVATIVES FOR MINERALOCORTICOID AND GLUCOCORTICOID RECEPTORS
1983
The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline
2016 Standout
Genetic Analysis of Aldosterone Synthase in Patients with Idiopathic Hyperaldosteronism1
1999
Captopril Suppression Versus Salt Loading in Confirming Primary Aldosteronism
2001
Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner
1998 StandoutNobel
Genetic Dissection of Complex Traits
1994 StandoutScience
Seven Lessons From Two Candidate Genes in Human Essential Hypertension
1999
18-Hydroxycorticosterone, 18-Hydroxycortisol, and 18-Oxocortisol in the Diagnosis of Primary Aldosteronism and Its Subtypes
2012
Epithelial Sodium Channel and the Control of Sodium Balance: Interaction Between Genetic and Environmental Factors
2002
Gene Targeting Approaches to Analyzing Hypertension
1999 StandoutNobel
Adaptation of nitrogen metabolism to hyperosmotic environment in Amphibia
1981
Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to Eag and cyclic nucleotide-gated channels
1997 StandoutNobel
Genetic control of blood pressure and the angiotensinogen locus.
1995 StandoutNobel
The Mechanism of Mineralocorticoid Action of Carbenoxolone*
1982
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury
2007 StandoutNobel
A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity.
1995
Measurement of Peripheral Plasma 18-Oxocortisol Can Discriminate Unilateral Adenoma From Bilateral Diseases in Patients With Primary Aldosteronism
2015
Incidence of primary aldosteronism uncomplicated "essential" hypertension. A prospective study with elevated aldosterone secretion and suppressed plasma renin activity used as diagnostic criteria
1968
Genetic variation in P450c11AS in Chilean patients with low renin hypertension.
1996
Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice.
1994 StandoutNobel
In vivo phosphorylation of the epithelial sodium channel
1998
Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome.
1996
The Natural History of Salt-Wasting Disorders of Adrenal and Renal Origin*
1984
Oxoreductase and Dehydrogenase Activities of the Human and Rat 11β-Hydroxysteroid Dehydrogenase Type 2 Enzyme*
1997
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Minireview: Primary Aldosteronism—Changing Concepts in Diagnosis and Treatment
2003
Essential Hypertension: Renin and Aldosterone, Heart Attack and Stroke
1972
All Three WW Domains of Murine Nedd4 Are Involved in the Regulation of Epithelial Sodium Channels by Intracellular Na+
1999
Uncompensated polyuria in a mouse model of Bartter's syndrome
2000 StandoutNobel
Neuronal Plasticity: Increasing the Gain in Pain
2000 StandoutScience
Normokalemic hyperaldosteronism in patients with resistant hypertension.
2002
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
Living with Water Stress: Evolution of Osmolyte Systems
1982 StandoutScience
Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension.
1995 StandoutNobel
Renin-angiotensin system in genetically hypertensive mice.
1984
Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5
2012
Hypertension, increased aldosterone secretion and low plasma renin activity relieved by dexamethasone.
1966
Structure and function of the hepatic form of 11 beta-hydroxysteroid dehydrogenase in the squirrel monkey, an animal model of glucocorticoid resistance.
1993
Reduced growth, abnormal kidney structure, and type 2 (AT 2 ) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT 1A and AT 1B receptors for angiotensin II
1998 StandoutNobel
Prevalence and Characteristics of Familial Hyperaldosteronism
2011
Cloning and Expression of Rat cDNA Encoding Corticosteroid 11β-Dehydrogenase
1989
Genetic Study of Patients with Dexamethasone-Suppressible Aldosteronism without the Chimeric CYP11B1/CYP11B2 Gene
2001
Molecular phenotyping for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration
2002 StandoutNobel
Works of Stanley Ulick being referenced
Evidence for the Secretion of an Antimineralocorticoid in Congenital Adrenal Hyperplasia*
1986
Isolation and identification of an endogenous metabolite of 18-oxocortisol from human urine
1987
Apparent mineralocorticoid excess type II
1994
Anomalous oxidative cleavage of the side chain of 18-oxocortisol and its tetrahydro metabolite
1989
Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel
1994
Defective Fasciculata Zone Function as the Mechanism of Glucocorticoid-Remediable Aldosteronism*
1990
Glucocorticoid-remediable Aldosteronism in a Large Kindred: Clinical Spectrum and Diagnosis Using a Characteristic Biochemical Phenotype
1992
Pathogenesis of the Type 2 Variant of the Syndrome of Apparent Mineralocorticoid Excess*
1990
Inborn errors of aldosterone biosynthesis in humans
1995
Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase
1992
Congenitally Defective Aldosterone Biosynthesis in Humans: Inactivation of the P450C18 Gene (CYP11B2) Due to Nucleotide Deletion in CMO I-Deficient Patients
1993
A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension
1992 StandoutNature
Evidence for Cortisol as the mineralocorticoid in the syndrome of apparent mineralocorticoid excess
1992
A new form of the syndrome of apparent mineralocorticoid excess
1989
Mineralocorticoid Unresponsiveness with Severe Neonatal Hyponatremia and Hyperkalemia
1980
Defective ring A reduction of cortisol as the major metabolic error in the syndrome of apparent mineralocorticoid excess
1992
Amplification of the Action of Aldosterone by 5α-Dihydrocortisol*
1978
Metabolic and Blood Pressure Responses to Hydrocortisone in the Syndrome of Apparent Mineralocorticoid Excess*
1983
Biosynthesis of 18-oxocortisol by aldosterone-producing adrenal tissue.
1983
Evidence for an Unidentified Steroid in a Child with Apparent Mineralocorticoid Hypertension
1977
The biochemical phenotypes of two inborn errors in the biosynthesis of aldosterone.
1992
Metabolism and rate of secretion of aldosterone in the bullfrog
1968
ELECTROLYTE METABOLISM AND ALDOSTERONE SECRETION IN BENIGN AND MALIGNANT HYPERTENSION
1960
A Syndrome of Apparent Mineralocorticoid Excess Associated with Defects in the Peripheral Metabolism of Cortisol*
1979
Hypersecretion of a New Corticosteroid, 18–Hydroxycortisol in Two Types of Adrenocortical Hypertension
1982
Liddle's syndrome: heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel
1996
The biochemical phenotypes of two inborn errors in the biosynthesis of aldosterone
1993
Adrenocortical factors in hypertension
1976
Isolation and identification of 18-hydroxycortisol from the urine of patients with primary aldosteronism.
1982
Identification of Two C18 Oxygenated Corticosteroids Isolated from Human Urine
1962
An Aldosterone Biosynthetic Defect in a Salt-Losing Disorder
1964
ALDOSTERONE SECRETION AND PRIMARY AND MALIGNANT HYPERTENSION *
1960
Cortisol inactivation overload: a mechanism of mineralocorticoid hypertension in the ectopic adrenocorticotropin syndrome.
1992
Control of aldosterone secretion in the spontaneously hypertensive rat.
1975
Defective ring A reduction of cortisol as the major metabolic error in the syndrome of apparent mineralocorticoid excess.
1992
The Etiology of a Syndrome of Factitious Mineralocorticoid Excess: A Steroid-Containing Nasal Spray*
1979
AN ABNORMALITY IN STEROID REDUCTIVE METABOLISM IN A HYPERTENSIVE SYNDROME
1977
The Nature of the Defect in a Salt-Wasting Disorder in Jews of Iran12
1977
[45] Isolation and synthesis of the major metabolites of aldosterone and 18-hydroxycorticosterone
1975
Metabolic Responses to the Administration of Angiotensin II, K and ACTH in Two Salt-Wasting Syndromes
1977
The isolation of a urinary metabolite of aldosterone and its use to measure the rate of secretion of aldosterone by the adrenal cortex of man.
1958
Congenitally defective aldosterone biosynthesis in humans: The involvement of point mutations of the P-450C18 gene (CYP11B2) in CMO II deficient patients
1992
The molecular basis of glucocorticoid-remediable aldosteronism, a Mendelian cause of human hypertension.
1992
Diagnosis and Nomenclature of the Disorders of the Terminal Portion of the Aldosterone Biosynthetic Pathway
1976
The unique steroidogenesis of the aldosteronoma in the differential diagnosis of primary aldosteronism.
1993
Simultaneous Measurement of Secretory Rates of Aldosterone and 18-Hydroxycorticosterone
1965