Standout Papers
Citation Impact
Citing Papers
[6] Use of T7 RNA polymerase to direct expression of cloned genes
1990 Standout
Active Site Tightness and Substrate Fit in DNA Replication
2002
Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations
2003
Recognition of Cognate Transfer RNA by the 30 S Ribosomal Subunit
2001 StandoutScienceNobel
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
DnaG interacts with a linker region that joins the N- and C-domains of DnaB and induces the formation of 3-fold symmetric rings
2004
Structural Basis of Transcription
2004 StandoutNobel
Inhibition of the ω-conotoxin-sensitive calcium current by distinct G proteins
1992 StandoutNobel
A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein
1989
Bacillus subtilis Bacteriophage SPP1 G40P Helicase Lacking the N-terminal Domain Unwinds DNA Bidirectionally
2005
DnaB from Thermus aquaticus Unwinds Forked Duplex DNA with an Asymmetric Tail Length Dependence
1999 StandoutNobel
Primer Terminus Stabilization at the φ29 DNA Polymerase Active Site
1995
Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation
1998
Crystal Structures of the Bacillus stearothermophilus CCA-Adding Enzyme and Its Complexes with ATP or CTP
2002 StandoutNobel
An aspartic acid residue in TPR-1, a specific region of protein-priming DNA polymerases, is required for the functional interaction with primer terminal protein
2000
DNA polymerase of the T4-related bacteriophages
2000
A Conserved Insertion in Protein-primed DNA Polymerases is Involved in Primer Terminus Stabilisation
2003
Quaternary Polymorphism of Replicative Helicase G40P: Structural Mapping and Domain Rearrangement
2006
Roles of the helicase and primase domain of the gene 4protein of bacteriophage T7 in accessing the primase recognition site
1998
The Bacterial Helicase-Primase Interaction: A Common Structural/Functional Module
2005
Structure of the Replicating Complex of a Pol α Family DNA Polymerase
2001 StandoutNobel
Identification of a Region of Escherichia coli DnaB Required for Functional Interaction with DnaG at the Replication Fork
2000
Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.
2001
Structural basis for initiation of transcription from an RNA polymerase–promoter complex
1999 StandoutNatureNobel
Replication of non-hydrogen bonded bases by DNA polymerases: A mechanism for steric matching
1998
Side Chains That Influence Fidelity at the Polymerase Active Site of Escherichia coli DNA Polymerase I (Klenow Fragment)
1999
Yeast RNA Polymerase II at 5 Å Resolution
1999 StandoutNobel
Building a Replisome from Interacting Pieces
1999 StandoutNobel
Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal
1998 Nature
Structures of Mismatch Replication Errors Observed in a DNA Polymerase
2004
An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics
1991
A single tyrosine prevents insertion of ribonucleotides in the eukaryotic-type φ29 DNA polymerase 1 1Edited by A. R. Fersht
1999
The 3′-tail of a forked-duplex sterically determines whether one or two DNA strands pass through the central channel of a replication-fork helicase
2000
Translational regulation of tra-2 by its 3′ untranslated region controls sexual identity in C. elegans
1993
Mitochondrial DNA sequences from a 7000-year old brain
1988 StandoutNobel
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7
2003
The Structure of T. aquaticus DNA Polymerase III Is Distinct from Eukaryotic Replicative DNA Polymerases
2006 StandoutNobel
Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes
1998 StandoutNobel
DNA Structure and Aspartate 276 Influence Nucleotide Binding to Human DNA Polymerase β
2001
Crystal structure of DNA polymerase from hyperthermophilic archaeon Pyrococcus kodakaraensis KOD111Edited by R. Huber
2001
Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis
1989 StandoutNobel
Role of the first aspartate residue of the “YxDTDS” motif of ø29 DNA polymerase as a metal ligand during both TP-primed and DNA-primed DNA synthesis
1998
Structure of Taq polymerase with DNA at the polymerase active site
1996 StandoutNatureNobel
Insights into Strand Displacement and Processivity from the Crystal Structure of the Protein-Primed DNA Polymerase of Bacteriophage φ29
2004 StandoutNobel
Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant
1991
Crystal structure of a thermostable Bacillus DNA polymerase l large fragment at 2.1 Å resolution
1997
Crystal structure of an archaebacterial DNA polymerase
1999
How E. coli DNA polymerase I (klenow fragment) distinguishes between deoxy- and dideoxynucleotides
1998
Structure and Function of Transcription-Repair Coupling Factor
1995 StandoutNobel
Low Fidelity Mutants in the O-Helix of Thermus aquaticus DNA Polymerase I
1997
Human Transcription-Repair Coupling Factor CSB/ERCC6 Is a DNA-stimulated ATPase but Is Not a Helicase and Does Not Disrupt the Ternary Transcription Complex of Stalled RNA Polymerase II
1997 StandoutNobel
Purification and characterization of Escherichia coli endonuclease III from the cloned nth gene
1989
An open and closed case for all polymerases
1999
Asymmetric Interactions of Hexameric Bacteriophage T7 DNA Helicase with the 5′- and 3′-Tails of the Forked DNA Substrate
1997
The crystal structure of the Thermus aquaticus DnaB helicase monomer
2007 StandoutNobel
DNA substrate structural requirements for the exonuclease and polymerase activities of prokaryotic and phage DNA polymerases
1989
Ribozyme-mediated repair of defective mRNA by targeted trans-splicing
1994 NatureNobel
A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase
2018 StandoutNobel
Structural analysis of a eukaryotic sliding DNA clamp–clamp loader complex
2004 Nature
Acyclic and dideoxy terminator preferences denote divergent sugar recognition by archaeon and Taq DNA polymerases
2002
Structure and Function of Transcription-Repair Coupling Factor
1995 StandoutNobel
Crystal Structure of T7 Gene 4 Ring Helicase Indicates a Mechanism for Sequential Hydrolysis of Nucleotides
2000
DNA Polymerases: Structural Diversity and Common Mechanisms
1999 StandoutNobel
Crystal structure of a pol α family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp . 9°N-7 1 1Edited by D. Rees
2000
Receptor-effector coupling by G proteins
1990
Structure and function of Escherichia coli DnaB protein: Role of the N-terminal domain in helicase activity
1994
Vectors for selective expression of cloned DNAs by T7 RNA polymerase
1987
Crystal and Solution Structures of the Helicase-binding Domain of Escherichia coli Primase
2005
DNA-Thumb Interactions and Processivity of T7 DNA Polymerase in Comparison to Yeast Polymerase η
2004
Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius
1999 Nobel
Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
1988
Extensive unwinding of the plasmid template during staged enzymatic initiation of DNA replication from the origin of the Escherichia coli chromosome
1986
Kinetic Analysis of an Efficient DNA-Dependent TNA Polymerase
2005 StandoutNobel
Codon catalog usage is a genome strategy modulated for gene expressivity
1981
cDNA-derived primary structure of the glycoprotein component of canine microsomal signal peptidase complex.
1988 StandoutNobel
A specific subdomain in φ29 DNA polymerase confers both processivity and strand-displacement capacity
2005 StandoutNobel
Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.
1987 StandoutNobel
Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli.
1990 StandoutNobel
Characterization of steady state, single-turnover, and binding kinetics of the TaqI restriction endonuclease.
1992
Bacteriophage T7 helicase/primase proteins form rings around single-stranded DNA that suggest a general structure for hexameric helicases.
1995
Green Fluorescent Protein as a Marker for Gene Expression
1994 StandoutScienceNobel
DNA Polymerase-Mediated DNA Synthesis on a TNA Template
2002 StandoutNobel
Newly Identified Brain Potassium Channels Gated by the Guanine Nucleotide Binding Protein G o
1988 Science
Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure
1989 StandoutScienceNobel
The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain.
1991 StandoutNobel
A Structural Basis for Metal Ion Mutagenicity and Nucleotide Selectivity in Human DNA Polymerase β,
1996
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Expression of Gsα in Escherichia coli
1989 StandoutNobel
A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides
1998
Highly Efficient DNA Synthesis by the Phage ϕ 29 DNA Polymerase
1989
Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution
2001 StandoutScienceNobel
Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance
1998 StandoutScience
Computer Simulation of the Chemical Catalysis of DNA Polymerases: Discriminating between Alternative Nucleotide Insertion Mechanisms for T7 DNA Polymerase
2003 StandoutNobel
Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase
1997 StandoutNobel
Determinants of nucleotide sugar recognition in an archaeon DNA polymerase
1999
E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins.
1996 StandoutNobel
Getting a grip on how DNA polymerases function.
2001
Interaction of adjacent primase domains within the hexameric gene 4 helicase-primase of bacteriophage T7
2002
The arginine finger of bacteriophage T7 gene 4 helicase: Role in energy coupling
2004
A Reexamination of the Nucleotide Incorporation Fidelity of DNA Polymerases
2002
Isolation and sequencing of NOP1. A yeast gene encoding a nucleolar protein homologous to a human autoimmune antigen.
1990 StandoutNobel
Overproduction and dissection of proteins by the expression-cassette polymerase chain reaction.
1990
Bacteriophage T4 gene 41 protein, required for the synthesis of RNA primers, is also a DNA helicase.
1982
Computer simulations of protein functions: Searching for the molecular origin of the replication fidelity of DNA polymerases
2005 StandoutNobel
Activation of yeast RNA polymerase II transcription by a thymidine-rich upstream element in vitro.
1989 StandoutNobel
DNA Replication Fidelity
2000
DNA- and RNA-dependent DNA polymerases
1993 StandoutNobel
Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template
2007 StandoutNobel
Splice Variants of the α Subunit of the G Protein G s Activate Both Adenylyl Cyclase and Calcium Channels
1989 StandoutScienceNobel
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
2000 StandoutScienceNobel
Isolation, Characterization, and Expression in Escherichia coli of the DNA Polymerase Gene from Thermus aquaticus
1989
DNA sequencing with Thermus aquaticus DNA polymerase and direct sequencing of polymerase chain reaction-amplified DNA.
1988
Primer-terminus stabilization at the psi 29 DNA polymerase active site. Mutational analysis of conserved motif TX2GR.
1994
Structural and functional analysis of temperature-sensitive mutants of the phage phi 29 DNA polymerase.
1990
Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase
2002 StandoutScienceNobel
Fidelity of phi 29 DNA polymerase. Comparison between protein-primed initiation and DNA polymerization.
1993
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Structure of Hexameric DnaB Helicase and Its Complex with a Domain of DnaG Primase
2007 StandoutScienceNobel
The bacterial replicative helicase DnaB evolved from a RecA duplication.
2000
The negative charge of Glu-111 is required to activate the cleavage center of EcoRI endonuclease
1989 StandoutNobel
A DNA binding protein that recognizes oligo(dA).oligo(dT) tracts.
1989
TNA Synthesis by DNA Polymerases
2003 StandoutNobel
Characterization of the bacteriophage T4 gene 41 DNA helicase
1989
Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas
1989 StandoutScience
The Escherichia coli dnaB replication protein is a DNA helicase.
1986
Molecular Dynamics Free-Energy Simulations of the Binding Contribution to the Fidelity of T7 DNA Polymerase
2002 StandoutNobel
A comprehensive set of sequence analysis programs for the VAX
1984 StandoutNobel
Recombinant αi-3 Subunit of G Protein Activates Gk-gated K+ Channels
1989
Works of Stanley Tabor being referenced
A Complex of the Bacteriophage T7 Primase-Helicase and DNA Polymerase Directs Primer Utilization
2001
Formation of a DNA Loop at the Replication Fork Generated by Bacteriophage T7 Replication Proteins
1998
Coordination of leading and lagging strand DNA synthesis at the replication fork of bacteriophage T7
1994
Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution
1998 Nature
The Linker Region between the Helicase and Primase Domains of the Bacteriophage T7 Gene 4 Protein Is Critical for Hexamer Formation
1999
Crystal Structure of the Helicase Domain from the Replicative Helicase-Primase of Bacteriophage T7
1999
The gene 4 protein of bacteriophage T7. Characterization of helicase activity.
1983
Escherichia coli thioredoxin stabilizes complexes of bacteriophage T7 DNA polymerase and primed templates.
1987
DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. Effect of pyrophosphorolysis and metal ions.
1990
Effect of manganese ions on the incorporation of dideoxynucleotides by bacteriophage T7 DNA polymerase and Escherichia coli DNA polymerase I.
1989
DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.
1987 Standout
Template recognition sequence for RNA primer synthesis by gene 4 protein of bacteriophage T7.
1981
A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.
1985 Standout
The thioredoxin binding domain of bacteriophage T7 DNA polymerase confers processivity on Escherichia coli DNA polymerase I
1997
Distinguishing between mechanisms of eukaryotic transcriptional activation with bacteriophage T7 RNA polymerase
1987
A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides.
1995
Purification and characterization of the bacteriophage T7 gene 2.5 protein. A single-stranded DNA-binding protein.
1992
Selective oxidation of the exonuclease domain of bacteriophage T7 DNA polymerase.
1987
Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7.
1987
Selective Inactivation of the Exonuclease Activity of Bacteriophage T7 DNA Polymerase by in Vitro Mutagenesis
1989
Nucleotide sequence of the primary origin of bacteriophage T7 DNA replication: relationship to adjacent genes and regulatory elements.
1980