Citation Impact
Citing Papers
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Computational Thermostabilization of an Enzyme
2005 StandoutScienceNobel
A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours
2002
No health without mental health
2007 Standout
Depressive Symptomatology and Hypertension-Associated Morbidity and Mortality in Older Adults
1995
Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains
1991 StandoutNobel
2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT
2004
By-passing immunization
1991 StandoutNobel
Targeting hypoxia in cancer therapy
2011 Standout
Marriage and health: His and hers.
2001 Standout
Inference of Macromolecular Assemblies from Crystalline State
2007 Standout
The Role of β-Glucuronidase in Drug Disposition and Drug Targeting in Humans
1997
Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vλ repertoire
1999 StandoutNobel
Cancer Statistics, 2006
2006 Standout
Man-made antibodies
1991 NatureNobel
Design and development of polymers for gene delivery
2005 Standout
Selective activation of anticancer prodrugs by monoclonal antibody–enzyme conjugates
2001
Mimicking Somatic Hypermutation: Affinity Maturation of Antibodies Displayed on Bacteriophage Using a Bacterial Mutator Strain
1996 StandoutNobel
Single‐Triggered Trimeric Prodrugs
2005
Novel growth regulatory factors and tumour angiogenesis
1991
Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy
1997
Bioreductive therapies: an overview of drugs and their mechanisms of action
1998
The Impact of Poststroke Depression on Recovery in Activities of Daily Living Over a 2-Year Follow-up
1990
Exploiting tumour hypoxia in cancer treatment
2004 Standout
Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis
2001 Standout
The importance of selenium to human health
2000 Standout
Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family‐specific oligonucleotide probes
1991 StandoutNobel
Gene therapy in pancreatic cancer
2014
Gene directed enzyme/prodrug therapy of cancer: Historical appraisal and future prospectives
2001
By-passing immunisation
1992 StandoutNobel
Polyphenols: food sources and bioavailability
2004 Standout
Molecular and functional characterisation of a fusion protein suited for tumour specific prodrug activation
1992
Natural Product Hybrids as New Leads for Drug Discovery
2003 Standout
Building Antibodies from their Genes
1992 StandoutNobel
Strategies in the design of nanoparticles for therapeutic applications
2010 Standout
Clinical development of gene therapy for colorectal cancer
2003
By–Passing Immunization: Building High Affinity Human Antibodies by Chain Shuffling
1992 StandoutNobel
Recent developments in the field of antitumour anthracyclines
2001
Human Antibody Fragments Specific for Human Blood Group Antigens from a Phage Display Library
1993 StandoutNobel
Selection of phage antibodies by binding affinity
1992 StandoutNobel
Targeting tumors with hypoxia-activated cytotoxins
2007
The repertoire of human germline vH sequences reveals about fifty groups of VH segments with different hypervariable loops
1992 StandoutNobel
Liposomal drug delivery systems: From concept to clinical applications
2012 Standout
Bringing chemistry to life
2011 StandoutNobel
The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT)
1993
Designing dendrimers for biological applications
2005 Standout
Humanized antibodies
1993 StandoutNobel
Making antibody fragments using phage display libraries
1991 StandoutNatureNobel
Open sandwich ELISA: A novel immunoassay based on the interchain interaction of antibody variable region
1996 StandoutNobel
Modifying an immunogenic epitope on a therapeutic protein: a step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT)
2004
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Synthetic human antibodies and a strategy for protein engineering
1998 StandoutNobel
In-cell PCR from mRNA: amplifying and linking the rearranged immunoglobulin heavy and light chain V-genes within single cells
1992 StandoutNobel
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
2014 Standout
Synthesis of Heterobifunctional Protein Fusions Using Copper‐Free Click Chemistry and the Aldehyde Tag
2012 StandoutNobel
A strategy for the isolation of catalytic activities from repertoires of enzymes displayed on phage 1 1Edited by J. Karn
1999 StandoutNobel
Guidelines for the Early Management of Patients With Acute Ischemic Stroke
2013 Standout
Post-stroke depression: relationships to functional impairment, coping strategies, and rehabilitation outcome.
1986
Polymeric nanovehicles for anticancer drugs with triggering release mechanisms
2007
Ligand-Binding Proteins: Their Potential for Application in Systems for Controlled Delivery and Uptake of Ligands
2000
Tumor-selective prodrug activation by fusion protein-mediated catalysis.
1994
Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures.
2002
Antibody fragments from a ‘single pot’ phage display library as immunochemical reagents.
1994 StandoutNobel
Strategies for enzyme/prodrug cancer therapy.
2001
Complications After Acute Stroke
1996
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer
2023 StandoutNobel
Prodrugs of Anthracyclines for Use in Antibody-Directed Enzyme Prodrug Therapy
1998
Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: a phase I and pharmacokinetic study of its prodrug, CB1954.
2001
Making Antibodies by Phage Display Technology
1994 StandoutNobel
Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial
1997
Synthesis of an organoinsulin molecule that can be activated by antibody catalysis
2001 StandoutNobel
"Diabodies": small bivalent and bispecific antibody fragments.
1993 StandoutNobel
Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.
1991
Sustained Tumor Regression of Human Colorectal Cancer Xenografts Using a Multifunctional Mannosylated Fusion Protein in Antibody-Directed Enzyme Prodrug Therapy
2005
Fluorescent Chemosensors Based on Spiroring-Opening of Xanthenes and Related Derivatives
2011 Standout
Antibody–Enzyme Fusion Proteins for Cancer Therapy
2011
The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke
1997 Standout
Single‐Triggered Trimeric Prodrugs
2005
Antibody-directed enzyme prodrug therapy (ADEPT): a review
1997
Medical Complications After Stroke
2000
Poststroke Depression Among the Chinese Elderly in a Rural Community
1997
Improved Recovery in Activities of Daily Living Associated With Remission of Poststroke Depression
2001
Regressions and cures of melanoma xenografts following treatment with monoclonal antibody beta-lactamase conjugates in combination with anticancer prodrugs.
1995
Multiple event activation of a generic prodrug trigger by antibody catalysis
1999 StandoutNobel
Toward antibody-directed "abzyme" prodrug therapy, ADAPT: carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing.
1996
Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1
1994 StandoutScience
Predicting length of stay, functional outcome, and aftercare in the rehabilitation of stroke patients. The dominant role of higher-order cognition.
1993 StandoutNobel
Molecular evolution of proteins on filamentous phage. Mimicking the strategy of the immune system.
1992 StandoutNobel
Works of Springer Cj being referenced
Disposition of the prodrug 4-(bis (2-chloroethyl) amino) benzoyl-L-glutamic acid and its active parent drug in mice
1990
Anti-tumour effects of an antibody-carboxypeptidase G2 conjugate in combination with phenol mustard prodrugs
1995
A cytotoxic agent can be generated selectively at cancer sites
1988
Antibody-directed enzyme prodrug therapy (ADEPT) with mustard prodrugs.
1995
Section Review: Biologicals & Immunologicals: Development of prodrugs for ADEPT (antibody-directed enzyme prodrug therapy)
1996
Antibody directed enzyme prodrug therapy (ADEPT): a three phase system.
1992
Depression and failure to resume social activities after stroke.
1982
Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene.
1997