Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Hypoxia Induces Trimethylated H3 Lysine 4 by Inhibition of JARID1A Demethylase
2010
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
2019 StandoutNobel
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
2011 StandoutNobel
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
2010
The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks
2017 StandoutNobel
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
The DNA-damage response in human biology and disease
2009 StandoutNature
An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes
2017
Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway
2006
PIDD Mediates NF-κB Activation in Response to DNA Damage
2005
Transcriptional regulation by p53: one protein, many possibilities
2006
Mitochondrial Dynamics and Metabolic Regulation
2016
Signals from within: the DNA-damage-induced NF-κB response
2006
Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways
2017
Inflammation and metabolic disorders
2006 StandoutNature
Histone deacetylases and cancer
2007
Regulation of cell death and autophagy by IKK and NF‐κB: critical mechanisms in immune function and cancer
2012
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Inhibition of Aurora-A suppresses epithelial–mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells
2008
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia
2017 StandoutNobel
Shared Principles in NF-κB Signaling
2008 Standout
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
NF-κB, the first quarter-century: remarkable progress and outstanding questions
2012 Standout
DNA damage-induced nuclear factor-kappa B activation and its roles in cancer progression
2017
Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity
2004 Standout
A compendium of proteins that interact with HIF-1α
2017 StandoutNobel
Regulation of immunity and inflammation by hypoxia in immunological niches
2017
ATR: an essential regulator of genome integrity
2008
Differential effects of NF-κB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome
2006
Tyrosine Nitration on p65
2005
Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways
2014 StandoutNobel
Transcriptional regulation by hypoxia inducible factors
2013
Hypoxia and mitochondrial oxidative metabolism
2010
Transcriptional regulation via the NF-κB signaling module
2006
The complexity of NF-κB signaling in inflammation and cancer
2013 Standout
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis
2003
SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation
2014
Blinded by the Light: The Growing Complexity of p53
2009 Standout
The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy
2009
IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy
2005 Standout
Prospective therapeutic applications of p53 inhibitors
2005
Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2
2000
NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy target
2010
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
NF-κB and IKK as therapeutic targets in cancer
2006 Standout
Cyld Inhibits Tumor Cell Proliferation by Blocking Bcl-3-Dependent NF-κB Signaling
2006
Effects of Iron Supplementation and Depletion on Hypoxic Pulmonary Hypertension
2009 StandoutNobel
NF-κB: tumor promoter or suppressor?
2004
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
2010
The NF-κB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease
2006
The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals
2012
Transcriptional Repression of Protein Kinase Cα via Sp1 by Wild Type p53 Is Involved in Inhibition of Multidrug Resistance 1 P-Glycoprotein Phosphorylation
2004
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
NF-κB Is Required for UV-Induced JNK Activation via Induction of PKCδ
2006
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
2009 StandoutNobel
The diverse and complex roles of NF-κB subunits in cancer
2012
Crosstalk in NF-κB signaling pathways
2011 Standout
Signaling to NF-κB
2004 Standout
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways
2016
Anthracycline drug targeting: cytoplasmic versus nuclear – a fork in the road
2001
2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process
2015
Mitochondrial TCA cycle metabolites control physiology and disease
2020 Standout
Nuclear factor-κB, p53, and mitochondria: regulation of cellular metabolism and the Warburg effect
2012
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Inflammation and p53: A Tale of Two Stresses
2011
Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy
2013
Characterization of genome-wide p53-binding sites upon stress response
2008
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
2016 StandoutNobel
Good cop, bad cop: the different faces of NF-κB
2006
Reactive oxygen species mediate crosstalk between NF-κB and JNK
2005
Genetics and biology of pancreatic ductal adenocarcinoma
2006
Expression of the Bcl-3 proto-oncogene suppresses p53 activation
2005
NF-κB, inflammation, immunity and cancer: coming of age
2018 Standout
Sin3: Insight into its transcription regulatory functions
2013
Oxygen homeostasis
2009 StandoutNobel
p53 and the Carcinogenicity of Chronic Inflammation
2016
Integrating cell-signalling pathways with NF-κB and IKK function
2006 Standout
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation
2013 StandoutNobel
Modeling neurodevelopmental disorder-associated humanAGO1mutations inCaenorhabditis elegansArgonautealg-1
2024 StandoutNobel
p65/RelA Modulates BECN1 Transcription and Autophagy
2009
Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection
2009
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
2001 StandoutScience
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
2018 StandoutNobel
Tumor Necrosis Factor Alpha-Mediated Reduction of KLF2 Is Due to Inhibition of MEF2 by NF-κB and Histone Deacetylases
2005
Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors
2005
Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways
2015
A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα
2010 StandoutNobel
IκB Kinase α-Mediated Derepression of SMRT Potentiates Acetylation of RelA/p65 by p300
2005
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL −/− clear cell renal carcinoma
2017 StandoutNobel
NF-κB, an Active Player in Human Cancers
2014
Arf tumor suppressor promoter monitors latent oncogenic signals in vivo
2003
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
Epigenetics: New Questions on the Response to Hypoxia
2011
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia
2015
Hypoxia. 5. Hypoxia and hematopoiesis
2011
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Transient and Selective NF-κB p65 Serine 536 Phosphorylation Induced by T Cell Costimulation Is Mediated by IκB Kinase β and Controls the Kinetics of p65 Nuclear Import
2004
Biology and targeting of the Jumonji-domain histone demethylase family in childhood neoplasia: a preclinical overview
2019
Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation
2014
Identification of prolyl hydroxylation modifications in mammalian cell proteins
2014
Interstitial microdeletion of the 1p34.3p34.2 region
2018
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
2018 Standout
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Ceramide Interaction with the Respiratory Chain of Heart Mitochondria
2000
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
2018 StandoutNobel
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
2009 StandoutNobel
Regulation of cell proliferation by hypoxia-inducible factors
2015 StandoutNobel
Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice
2009 StandoutNobel
The Nuclear Factor κB Subunits RelA/p65 and c-Rel Potentiate but Are Not Required for Ras-Induced Cellular Transformation
2004
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
Targeting Protein–Protein Interactions in the HIF System
2016
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
NF-κB in cancer—a friend turned foe
2004
HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells
2012
Transcription Factor NF-κB Differentially Regulates Death Receptor 5 Expression Involving Histone Deacetylase 1
2005
Works of Sónia Rocha being referenced
Hypoxia induces rapid changes to histone methylation and reprograms chromatin
2019 Science
PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192
2013
Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway
2012
HIF-independent role of prolyl hydroxylases in the cellular response to amino acids
2012
Evolutionary Conserved Regulation of HIF-1β by NF-κB
2011
Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex
2012
The p53-inhibitor Pifithrin-α inhibits Firefly Luciferase activity in vivo and in vitro
2003
HIF-1α depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs
2011
SWI/SNF Regulates the Cellular Response to Hypoxia
2008
Ceramide Induces Cytochrome c Release from Isolated Mitochondria
1999
NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration
2011
IKK and NF‐κB‐mediated regulation of Claspin impacts on ATR checkpoint function
2010
p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor
2003
Regulation of p53 tumour suppressor target gene expression by the p52 NF‐κB subunit
2006
Active Repression of Antiapoptotic Gene Expression by RelA(p65) NF-κB
2004
Gene regulation under low oxygen: holding your breath for transcription
2007
SNIP1 Is a Candidate Modifier of the Transcriptional Activity of c-Myc on E Box-Dependent Target Genes
2006
Chromatin as an oxygen sensor and active player in the hypoxia response
2011
Regulation of ATR-dependent pathways by the FHA domain containing protein SNIP1
2007
Regulation of NF‐κB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor
2005
Cezanne ( OTUD 7B) regulates HIF ‐1α homeostasis in a proteasome‐independent manner
2014
The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C.
2001
The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration
2011
Cisplatin Mimics ARF Tumor Suppressor Regulation of RelA (p65) Nuclear Factor-κB Transactivation
2006
Mechanism of Hypoxia-Induced NF-κB
2010
Chromatin and oxygen sensing in the context of JmjC histone demethylases
2014
Protein kinase C inhibitor and irradiation-induced apoptosis: relevance of the cytochrome c-mediated caspase-9 death pathway.
2000
KDM2 Family Members are Regulated by HIF-1 in Hypoxia
2017
Differential p53-dependent mechanism of radiosensitization in vitro and in vivo by the protein kinase C-specific inhibitor PKC412.
2001
p53 Represses Cyclin D1 Transcription through Down Regulation of Bcl-3 and Inducing Increased Association of the p52 NF-κB Subunit with Histone Deacetylase 1
2003
Regulation of gene expression by hypoxia
2008
2015
Regulation of hypoxia-inducible factor-1α by NF-κB
2008