Sofie V. Nielsen

Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

Mechanism and medical implications of mammalian autophagy

Cellular senescence in aging and age-related disease: from mechanisms to therapy

RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling

The increasing complexity of the ubiquitin code

Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis

Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation

The Perseus computational platform for comprehensive analysis of (prote)omics data

2016 update of the PRIDE database and its related tools

PROTAC targeted protein degraders: the past is prologue

Spartan deficiency causes genomic instability and progeroid phenotypes

Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Regulation of PCNA–protein interactions for genome stability

Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation

Natural and Designed Proteins Inspired by Extremotolerant Organisms Can Form Condensates and Attenuate Apoptosis in Human Cells

Accurate proteome-wide missense variant effect prediction with AlphaMissense

Principles of Ubiquitin-Dependent Signaling

Understanding the Origins of Loss of Protein Function by Analyzing the Effects of Thousands of Variants on Activity and Abundance

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations

Multiplexed assays reveal effects of missense variants in MSH2 and cancer predisposition

DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

Toward mechanistic models for genotype–phenotype correlations in phenylketonuria using protein stability calculations

Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

Blocking protein quality control to counter hereditary cancers