Citation Impact
Citing Papers
Nature of the protein universe
2009 StandoutNobel
Single molecules of the bacterial actin MreB undergo directed treadmilling motion in Caulobacter crescentus
2006 StandoutNobel
TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
2008 StandoutScience
A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS
2019 Science
Origins of coevolution between residues distant in protein 3D structures
2017 StandoutNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer
2008 Standout
Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease
2012
Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution
2024 StandoutNobel
A structure‐based benchmark for protein–protein binding affinity
2011
Epithelial-mesenchymal transition and its implications for fibrosis
2003 Standout
Regulation of the l-arabinose operon of Escherichia coli
2000
The structure of the cofactor-binding fragment of the LysR family member, CysB: a familiar fold with a surprising subunit arrangement
1997
Structural mimicry of DH domains by Arfaptin suggests a model for the recognition of Rac–GDP by its guanine nucleotide exchange factors
2001
Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6
2002
Ovarian cancer
2014 Standout
Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1
2010
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Molecular mechanisms in signal transduction at the membrane
2010
Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins
2001
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
2005
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex
2002
Modeling and Studying Proteins with Molecular Dynamics
2004
Domain Rearrangements in Protein Evolution
2005
Oxygen sensing by HIF hydroxylases
2004 StandoutNobel
Regulation of Marginal Zone B Cell Development by MINT, a Suppressor of Notch/RBP-J Signaling Pathway
2003 StandoutNobel
Rab GTPases as coordinators of vesicle traffic
2009 Standout
Engineering an allosteric transcription factor to respond to new ligands
2015 StandoutNobel
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Eukaryotic transcriptional regulatory complexes: cooperativity from near and afar
2003
Rho GTPases in cell biology
2002 StandoutNature
Mechanically Activated Ion Channels
2015 StandoutNobel
Brefeldin A
1999
Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell Cycle
2001
New Approaches and Therapeutics Targeting Apoptosis in Disease
2005
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
A Rho Exchange Factor Mediates Thrombin and Gα12-induced Cytoskeletal Responses
1999
Identification of Potential Mechanisms for Regulation of p115 RhoGEF through Analysis of Endogenous and Mutant Forms of the Exchange Factor
2001
Evolution of functional diversity in the cupin superfamily
2001
Intrinsically disordered proteins in cellular signalling and regulation
2014 Standout
Structure of the Ultra-High-Affinity Colicin E2 DNase–Im2 Complex
2012 StandoutNobel
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
2014 Standout
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Hydrogen bonds with π-acceptors in proteins: frequencies and role in stabilizing local 3D structures11Edited by R. Huber
2001
Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family
2002 StandoutNobel
Network motifs in the transcriptional regulation network of Escherichia coli
2002 Standout
Hyperactive Ras in developmental disorders and cancer
2007
“Click” synthesis of small-molecule inhibitors targeting caspases
2008
Interactions with Aromatic Rings in Chemical and Biological Recognition
2003 Standout
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
2007
Integrating signals from RTKs to ERK/MAPK
2007
Dissociation of GDP Dissociation Inhibitor and Membrane Translocation Are Required for Efficient Activation of Rac by the Dbl Homology-Pleckstrin Homology Region of Tiam
2003
Rho and Rac Take Center Stage
2004 Standout
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
2000 Nature
Golgi Localization of Carbohydrate Sulfotransferases Is a Determinant of L-selectin Ligand Biosynthesis
2003 StandoutNobel
Guanine nucleotide exchange factors for Rho GTPases: turning on the switch
2002
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
2008 Standout
Multifunctional Roles for the PH Domain of Dbs in Regulating Rho GTPase Activation
2003
Structure, Exchange Determinants, and Family-Wide Rab Specificity of the Tandem Helical Bundle and Vps9 Domains of Rabex-5
2004
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
2001
The Pfam protein families database
2011 Standout
The Hydrogen Bond in the Solid State
2002 Standout
Mutational Analysis of Gβγ and Phospholipid Interaction with G Protein-coupled Receptor Kinase 2
2000
Targeting MET in cancer: rationale and progress
2012
How RhoGDI binds Rho
1999
Exhaustive Enumeration of Protein Domain Families
2003
Dosage-Sensitive, Reciprocal Genetic Interactions between the Abl Tyrosine Kinase and the Putative GEF trio Reveal trio 's Role in Axon Pathfinding
2000
Signaling to the Rho GTPases: networking with the DH domain
2002
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Small GTP-Binding Proteins
2001 Standout
Investigating Cell Surface Galectin-Mediated Cross-Linking on Glycoengineered Cells
2012 StandoutNobel
The TetR Family of Transcriptional Repressors
2005
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
XRCC1 Protein Interacts with One of Two Distinct Forms of DNA Ligase III
1997 StandoutNobel
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function
2009 StandoutNobel
Signal-dependent membrane targeting by pleckstrin homology (PH) domains
2000
Rho GTPases and their effector proteins
2000
A growing family of guanine nucleotide exchange factors is responsible for activation of ras-family GTPases
2002
Molecular Cloning and Expression of Human cDNAs Encoding a Novel DNA Ligase IV and DNA Ligase III, an Enzyme Active in DNA Repair and Recombination
1995 StandoutNobel
A Genetic Screen for Novel Components of the Ras/Mitogen-Activated Protein Kinase Signaling Pathway That Interact With the yan Gene of Drosophila Identifies split ends, a New RNA Recognition Motif-Containing Protein
2000
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1
2003
Rho GTPases and their effector proteins
2000 Standout
The protein structures that shape caspase activity, specificity, activation and inhibition
2004
A Self-Assembled Multivalent Pseudopolyrotaxane for Binding Galectin-1
2004 StandoutNobel
Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
GEFs: structural basis for their activation of small GTP-binding proteins
1999
ThreeC. elegansRac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis
2001 StandoutNobel
Progress in Modeling of Protein Structures and Interactions
2005 StandoutScienceNobel
The Guanine Nucleotide-Binding Switch in Three Dimensions
2001 StandoutScience
Ca2+Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase
2003 Standout
Controlling Allosteric Networks in Proteins
2016
A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation
2016 StandoutNobel
Structure of the RGS-like Domain from PDZ-RhoGEF
2001
Arac/XylS family of transcriptional regulators
1997
Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and -10
2006
A mammalian protein complex that repairs double-strand breaks and deletions by recombination
1993 Nobel
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
Single-molecule diffusion measurements of H-Ras at the plasma membrane of live cells reveal microdomain localization upon activation
2005
Signal Strength Dictates Phosphoinositide 3-Kinase Contribution to Ras/Extracellular Signal-Regulated Kinase 1 and 2 Activation via Differential Gab1/Shp2 Recruitment: Consequences for Resistance to Epidermal Growth Factor Receptor Inhibition
2007
AraC Regulatory Protein Mutants with Altered Effector Specificity
2008
Works of S.M. Soisson being referenced
Tandem Histone Folds in the Structure of the N-Terminal Segment of the Ras Activator Son of Sevenless
2003
The 1.6 Å crystal structure of the AraC sugar-binding and dimerization domain complexed with d-fucose
1997
Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless
2004
Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met
2011
Crystal Structure of the Dbl and Pleckstrin Homology Domains from the Human Son of Sevenless Protein
1998
A rapid and quantitave microtiter assay for eukaryotic topisomerase II
1989
Structural Basis for Ligand-Regulated Oligomerization of AraC
1997 Science
Reducing the Peptidyl Features of Caspase-3 Inhibitors: A Structural Analysis
2004
Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation
2008