Citation Impact
Citing Papers
Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages
2005 StandoutNobel
Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding
2009 StandoutNobel
Activation of Ras Signaling Pathway by 8-Oxoguanine DNA Glycosylase Bound to Its Excision Product, 8-Oxoguanine
2012
Differential Membrane Localization of ERas and Rheb, Two Ras-related Proteins Involved in the Phosphatidylinositol 3-Kinase/mTOR Pathway
2005 StandoutNobel
Rapid identification of functionally critical amino acids in a G protein–coupled receptor
2007
Early endosome localization and activity of RasGEF1b, a toll-like receptor-inducible Ras guanine-nucleotide exchange factor
2010
Prediction and validation of the distinct dynamics of transient and sustained ERK activation
2005
RAS oncogenes: the first 30 years
2003
Structure-based Mutagenesis Reveals Distinct Functions for Ras Switch 1 and Switch 2 in Sos-catalyzed Guanine Nucleotide Exchange
2001
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
2013 StandoutNature
Crystal Structure of ARF1•Sec7 Complexed with Brefeldin A and Its Implications for the Guanine Nucleotide Exchange Mechanism
2003
Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing
2002
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
M-Ras/R-Ras3, a Transforming Ras Protein Regulated by Sos1, GRF1, and p120 Ras GTPase-activating Protein, Interacts with the Putative Ras Effector AF6
1999
Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ
2000
Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex.
2001
GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes
2004 StandoutNobel
Capturing cyclic nucleotides in action: snapshots from crystallographic studies
2006
Conformational Changes in Rhodopsin
1999
Molecular mechanisms in signal transduction at the membrane
2010
The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coli
2005 StandoutNobel
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
2005
A computationally engineered RAS rheostat reveals RAS–ERK signaling dynamics
2016 StandoutNobel
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
2010
Structural Basis for Guanine Nucleotide Exchange on Ran by the Regulator of Chromosome Condensation (RCC1)
2001
Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
2004 Standout
RAS Is Regulated by the let-7 MicroRNA Family
2005 Standout
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
Brefeldin A
1999
Discovery of Small Molecules that Bind to K‐Ras and Inhibit Sos‐Mediated Activation
2012
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Multiple Residues in the Second Extracellular Loop Are Critical for M3 Muscarinic Acetylcholine Receptor Activation
2007
Structural Basis for Activation of ARF GTPase
1998
Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI
2000
The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.
2000
Signaling—2000 and Beyond
2000 Standout
Sar1p N-Terminal Helix Initiates Membrane Curvature and Completes the Fission of a COPII Vesicle
2005 StandoutNobel
8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1
2013
Ras and relatives—job sharing and networking keep an old family together
2002
β2-Adrenergic Receptor Signaling and Desensitization Elucidated by Quantitative Modeling of Real Time cAMP Dynamics
2007 StandoutNobel
bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila
2003 Standout
Activation of the Luteinizing Hormone Receptor Following Substitution of Ser-277 with Selective Hydrophobic Residues in the Ectodomain Hinge Region
2000 StandoutNobel
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
2007
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
2000 Nature
Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp
1999 StandoutNatureNobel
Golgi Localization of Carbohydrate Sulfotransferases Is a Determinant of L-selectin Ligand Biosynthesis
2003 StandoutNobel
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Combinatorial protein design: strategies for screening protein libraries
1997 StandoutNobel
Pheromone signalling and polarized morphogenesis in yeast
1997
Structure and dynamics of the M3 muscarinic acetylcholine receptor
2012 StandoutNatureNobel
Structures of modified eEF2·80S ribosome complexes reveal the role of GTP hydrolysis in translocation
2007 StandoutNobel
RIM1α is required for presynaptic long-term potentiation
2002 StandoutNatureNobel
Sequential Binding of Agonists to the β2 Adrenoceptor
2003 StandoutNobel
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins
2000 Nature
Dynamics of the Upper 50-kDa Domain of Myosin V Examined with Fluorescence Resonance Energy Transfer
2005 StandoutNobel
GTP Hydrolysis Mechanism of Ras-like GTPases
2004
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Protein Kinase A-mediated Phosphorylation of the β2-Adrenergic Receptor Regulates Its Coupling to Gs and Gi
2002 StandoutNobel
ERK Plays a Regulatory Role in Induction of LTP by Theta Frequency Stimulation and Its Modulation by β-Adrenergic Receptors
1999 StandoutNobel
Putative Reaction Intermediates in Crm1-mediated Nuclear Protein Export
1999 StandoutNobel
Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair
2013
When protein folding is simplified to protein coiling: the continuum of solenoid protein structures
2000
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
Detecting cAMP‐induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator
2004
Discovery of Small Molecules that Bind to K‐Ras and Inhibit Sos‐Mediated Activation
2012
Investigating Cell Surface Galectin-Mediated Cross-Linking on Glycoengineered Cells
2012 StandoutNobel
An Anionic Residue at Position 564 Is Important for Maintaining the Inactive Conformation of the Human Lutropin/Choriogonadotropin Receptor
1998
On the Mechanism of Hydrolysis of Phosphate Monoesters Dianions in Solutions and Proteins
2006 StandoutNobel
Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis
2009 StandoutNobel
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function
2009 StandoutNobel
Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM
2008 StandoutNobel
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
2012
Fast structural responses of gap junction membrane domains to AB5 toxins
2013 StandoutNobel
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
1998 StandoutNature
Agonist-induced conformational changes in the G-protein-coupling domain of the β 2 adrenergic receptor
2001 StandoutNobel
Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein
2002 StandoutScience
Electrostatics of nanosystems: Application to microtubules and the ribosome
2001 Standout
Rho GTPases and the Actin Cytoskeleton
1998 StandoutScience
GEFs: structural basis for their activation of small GTP-binding proteins
1999
Computer Simulation of Protein−Protein Interactions
2001
The Guanine Nucleotide-Binding Switch in Three Dimensions
2001 StandoutScience
Structure of a Bag/Hsc70 Complex: Convergent Functional Evolution of Hsp70 Nucleotide Exchange Factors
2001 Science
Cryo-EM structure of the mammalian eukaryotic release factor eRF1–eRF3-associated termination complex
2012 StandoutNobel
The Karyopherin Kap122p/Pdr6p Imports Both Subunits of the Transcription Factor Iia into the Nucleus
1999 StandoutNobel
The process of mRNA–tRNA translocation
2007 StandoutNobel
Nuclear Import of the TATA-binding Protein: Mediation by the Karyopherin Kap114p and a Possible Mechanism for Intranuclear Targeting
1999 StandoutNobel
Structural Mechanism of Muscle Contraction
1999
Works of S.M. Margarit being referenced
Structural Evidence for Feedback Activation by Ras·GTP of the Ras-Specific Nucleotide Exchange Factor SOS
2003
The structural basis of the activation of Ras by Sos
1998 Nature
Regulation of Sos Activity by Intramolecular Interactions
1998
Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor.
1996