Citation Impact
Citing Papers
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels
2006 StandoutNobel
Tumour-cell invasion and migration: diversity and escape mechanisms
2003 Standout
Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor
2001
NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells
2001
CD44 is required for two consecutive steps in HGF/c-Met signaling
2002
MST/MLK2, a Member of the Mixed Lineage Kinase Family, Directly Phosphorylates and Activates SEK1, an Activator of c-Jun N-terminal Kinase/Stress-activated Protein Kinase
1997
Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis
2002
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase
1998 Standout
Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
1995
Ordering S phase and M phase in the cell cycle
1994 StandoutNobel
Down-regulation of MET, the receptor for hepatocyte growth factor
2001
Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers
2000
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
1997 StandoutNatureNobel
How Tumors Become Angiogenic
1996
Components of a New Human Protein Kinase Signal Transduction Pathway
1995
Translational Control by MAPK Signaling in Long-Term Synaptic Plasticity and Memory
2004 Nobel
A Signaling Adapter Function for α6β4 Integrin in the Control of HGF-Dependent Invasive Growth
2001
High Intensity ERK Signal Mediates Hepatocyte Growth Factor-induced Proliferation Inhibition of the Human Hepatocellular Carcinoma Cell Line HepG2
2001
Calcium's Role in Mechanotransduction during Muscle Development
2014 Standout
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
M-Ras/R-Ras3, a Transforming Ras Protein Regulated by Sos1, GRF1, and p120 Ras GTPase-activating Protein, Interacts with the Putative Ras Effector AF6
1999
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
1995 Standout
Overexpression of a Constitutively Active Form of Phosphatidylinositol 3-Kinase Is Sufficient to Promote Glut 4 Translocation in Adipocytes
1996
Identification of an Atypical Grb2 Carboxyl-terminal SH3 Domain Binding Site in Gab Docking Proteins Reveals Grb2-dependent and -independent Recruitment of Gab1 to Receptor Tyrosine Kinases
2000
Src Homology 2-containing Inositol 5-Phosphatase 1 Binds to the Multifunctional Docking Site of c-Met and Potentiates Hepatocyte Growth Factor-induced Branching Tubulogenesis
2001
Mutation of the c-Cbl TKB Domain Binding Site on the Met Receptor Tyrosine Kinase Converts It into a Transforming Protein
2001
[40] Biological assays for Ras transformation
1995
Nuclear Localization of Mitogen-activated Protein Kinase Kinase 1 (MKK1) Is Promoted by Serum Stimulation and G2-M Progression
1999
TGF-β signaling in tumor suppression and cancer progression
2001 Standout
The N-terminal ERK-binding Site of MEK1 Is Required for Efficient Feedback Phosphorylation by ERK2 in Vitro and ERK Activation in Vivo
1999
Structural basis of oncogenic activation caused by point mutations in the kinase domain of the MET proto‐oncogene: Modeling studies
2001
Cytoplasmic Localization of Mitogen-activated Protein Kinase Kinase Directed by Its NH2-terminal, Leucine-rich Short Amino Acid Sequence, Which Acts as a Nuclear Export Signal
1996
Oncoprotein Networks
1997
MAP Kinase Signaling Specificity Mediated by the LIN-1 Ets/LIN-31 WH Transcription Factor Complex during C. elegans Vulval Induction
1998
The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway
1995 Standout
The Hallmarks of Cancer
2000 Standout
p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast
1995 StandoutNobel
How MAP Kinases Are Regulated
1995 Standout
Potent Blockade of Hepatocyte Growth Factor-stimulated Cell Motility, Matrix Invasion and Branching Morphogenesis by Antagonists of Grb2 Src Homology 2 Domain Interactions
2001
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
1996 StandoutNature
Stimulation of 92-kDa Gelatinase B Promoter Activity by ras Is Mitogen-activated Protein Kinase Kinase 1-independent and Requires Multiple Transcription Factor Binding Sites Including Closely Spaced PEA3/ets and AP-1 Sequences
1996
Dual Leucine Zipper-bearing Kinase (DLK) Activates p46SAPK and p38 but Not ERK2
1996
Structural Analysis of the MAP Kinase ERK2 and Studies of MAP Kinase Regulatory Pathways
1996
Identification of Substrates and Regulators of the Mitogen-activated Protein Kinase ERK5 Using Chimeric Protein Kinases
1998
Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK
1998
Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3
2000
Mechanisms of asymmetric cell division: Two Bs or not two Bs, that is the question
1992 StandoutNobel
Crisscross regulation of cell-type-specific gene expression during development in B. subtilis
1992 Nature
Mechanistic Studies of the Dual Phosphorylation of Mitogen-activated Protein Kinase
1997
Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
1997
Cascade regulation of spore coat gene expression in Bacillus subtilis
1990
Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding.
1999
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism
1999
The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases
1996
Phosphorylation and Functional Inactivation of TSC2 by Erk
2005 Standout
Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation
1997
The MEK1 Proline-rich Insert Is Required for Efficient Activation of the Mitogen-activated Protein Kinases ERK1 and ERK2 in Mammalian Cells
1998
Macrophage Stimulating Protein
1999
Constitutively Active Mutant of the Mitogen-activated Protein Kinase Kinase MEK1 Induces Epithelial Dedifferentiation and Growth Inhibition in Madin-Darby Canine Kidney-C7 Cells
1997
MAP kinase pathways
1999
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
1998
Control of the Cell Morphology and the S Phase Entry by Mitogen-activated Protein Kinase Kinase
1999
Activation of Mitogen-activated Protein Kinase by H2O2
1996
Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase
1997
Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration
1998
MicroReview Cascades of sigma factors revisited
1990
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes
1997
Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cells
1999
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
1994
Hypoxia-driven selection of the metastatic phenotype
2007
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
1999
Met, metastasis, motility and more
2003 Standout
Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.
1997
Processing of a sporulation sigma factor in Bacillus subtilis: How morphological structure could control gene expression
1988
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
Genomic analysis of metastasis reveals an essential role for RhoC
2000 Nature
Contributions of the Mitogen-activated Protein (MAP) Kinase Backbone and Phosphorylation Loop to MEK Specificity
1996
Hepatocyte growth factor, a versatile signal for developing neurons
1999
The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades
1998
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
1994 Standout
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation
1998
Gα12 and Gα13 Regulate Extracellular Signal-regulated Kinase and c-Jun Kinase Pathways by Different Mechanisms in COS-7 Cells
1996
Isolation of MEK5 and Differential Expression of Alternatively Spliced Forms
1995
A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation
1998
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
A Novel Regulatory Mechanism in the Mitogen-activated Protein (MAP) Kinase Cascade
1997
Purification of a 12,020-Dalton Protein That Enhances the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase
1995
K252a inhibits the oncogenic properties of Met, the HGF receptor
2002
Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1
1997
How to make tubes: signaling by the Met receptor tyrosine kinase
2003
MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase.
1995
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
1999 StandoutNobel
The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network.
2000
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
1995 StandoutScience
A Proline-Rich Sequence Unique to MEK1 and MEK2 Is Required for Raf Binding and Regulates MEK Function
1995
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
2001 Standout
Distinct, Constitutively Active MAPK Phosphatases Function inXenopusOocytes: Implications for p42 MAPK Regulation In Vivo
1999
The Gab1 PH Domain Is Required for Localization of Gab1 at Sites of Cell-Cell Contact and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase
1999
Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element
1995 Science
Activation of Cdc42, Rac, PAK, and Rho-Kinase in Response to Hepatocyte Growth Factor Differentially Regulates Epithelial Cell Colony Spreading and Dissociation
2000
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
1985 StandoutNobel
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps
2000
Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death
1995
A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs
1996
Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor
1997
In vivo molecular imaging of met tyrosine kinase growth factor receptor activity in normal organs and breast tumors.
2001
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
The Bacillus subtilis gene for the development transcription factor sigma K is generated by excision of a dispensable DNA element containing a sporulation recombinase gene.
1990
TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.
1994
The Elk-1 ETS-Domain Transcription Factor Contains a Mitogen-Activated Protein Kinase Targeting Motif
1998
14-3-3 Proteins Are Required for Maintenance of Raf-1 Phosphorylation and Kinase Activity
1998
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
Degradation of the Met Tyrosine Kinase Receptor by the Ubiquitin-Proteasome Pathway
1997 StandoutNobel
Inhibition of Ras-Induced DNA Synthesis by Expression of the Phosphatase MKP-1
1994 Science
Bcl-2-mediated alterations in endoplasmic reticulum Ca 2+ analyzed with an improved genetically encoded fluorescent sensor
2004 StandoutNobel
Newly synthesized protein(s) must associate with p34cdc2 to activate MAP kinase and MPF during progesterone-induced maturation of Xenopus oocytes.
1995 StandoutNobel
The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution
1997
Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase
1997 StandoutNobel
Activating mutations for the Met tyrosine kinase receptor in human cancer
1997
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis
2013 StandoutNobel
Megakaryocytic Differentiation Induced by Constitutive Activation of Mitogen-Activated Protein Kinase Kinase
1997
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor
1998 Science
Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH 2 -terminal kinase activation, and defects in AP-1 transcriptional activity
1997
The MKK7 Gene Encodes a Group of c-Jun NH2-Terminal Kinase Kinases
1999
MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.
1995
Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors
1999
Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development
1995
Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2.
1996
Dual specificity phosphatases: a gene family for control of MAP kinase function
2000
Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase
2001
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
Selective response of ternary complex factor Sap1a to different mitogen-activated protein kinase subgroups.
1996
Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models
2001
Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells
1995
Extracellular Signal-Regulated Kinase Activates Topoisomerase IIα through a Mechanism Independent of Phosphorylation
1999
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
2001 StandoutNobel
Essential Role of Gab1 for Signaling by the C-Met Receptor in Vivo
2000
Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses
1996 Science
The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.
1995
Activation of Both MAP Kinase and Phosphatidylinositide 3-Kinase by Ras Is Required for Hepatocyte Growth Factor/Scatter Factor–induced Adherens Junction Disassembly
1998
Radioimmunoscintigraphy of Tumors Autocrine for Human Met and Hepatocyte Growth Factor/Scatter Factor
2002
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.
1996
Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways
2000
A synthetic inhibitor of the mitogen-activated protein kinase cascade.
1995 Standout
Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors
1997
Activation of the Met Receptor by Cell Attachment Induces and Sustains Hepatocellular Carcinomas in Transgenic Mice
2001 Nobel
The von Hippel-Lindau Tumor Suppressor Gene Inhibits Hepatocyte Growth Factor/Scatter Factor-Induced Invasion and Branching Morphogenesis in Renal Carcinoma Cells
1999 StandoutNobel
Regulation of Cell Motility by Mitogen-activated Protein Kinase
1997
A maize cDNA encoding a member of the retinoblastoma protein family: involvement in endoreduplication.
1996 StandoutNobel
The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.
1995 StandoutNobel
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf
2000
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Signal Transduction through MAP Kinase Cascades
1998 Standout
Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions.
1997 Nobel
Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.
1996
Urokinase expression and binding activity associated with the transforming growth factor ?1-induced migratory and invasive phenotype of mouse epidermal keratinocytes
1999
Temporal and spatial control of the mother-cell regulatory gene spoIIID of Bacillus subtilis.
1989
Disruption of epithelial cell-matrix interactions induces apoptosis
1994 Standout
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
1999 StandoutNobel
Works of Sing Rong being referenced
Autocrine hepatocyte growth factor/scatter factor-Met signaling induces transformation and the invasive/metastastic phenotype in C127 cells.
1996
Hepatocyte growth factor/scatter factor—Met signaling in tumorigenicity and invasion/metastasis
1996
The Met-HGF/SF autocrine signaling mechanism is involved in sarcomagenesis
1995
Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase
1994 StandoutScience
Autocrine Mechanism for met Proto-oncogene Tumorigenicity
1994
Met expression and sarcoma tumorigenicity.
1993
Transcriptional control of the Bacillus subtilis spoIID gene
1986
Tumorigenesis induced by coexpression of human hepatocyte growth factor and the human met protooncogene leads to high levels of expression of the ligand and receptor.
1993
Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.
1992
The Met Proto-Oncogene Mesenchymal to Epithelial Cell Conversion
1994 Science
Tumorigenicity of the met Proto-Oncogene and the Gene for Hepatocyte Growth Factor
1992
Met proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients.
1995
Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation.
1994
Enhanced Tumorigenicity and Invasion-Metastasis by Hepatocyte Growth Factor/Scatter Factor-Met Signalling in Human Cells Concomitant with Induction of the Urokinase Proteolysis Network
1996
Transcriptional regulation and structure of the Bacillus subtilis sporulation locus spoIIIC
1988