Citation Impact
Citing Papers
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
2012 StandoutScience
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
2012 StandoutScience
Control of Epstein-Barr virus infection in vitro by T helper cells specific for virion glycoproteins
2006
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
2015 StandoutScience
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly
2013
Arresting a Transient Receptor Potential (TRP) Channel
2010 StandoutNobel
UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
2015 StandoutNobel
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
2013
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
2011
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA
2013
Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment
2013
Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS
2013
Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor
2012
Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation
2013
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
2013 StandoutNature
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
2010 Standout
Mitochondrion: an emerging platform critical for host antiviral signaling
2011
When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction
2008
A guide to immunometabolism for immunologists
2016 Standout
What the Myddosome structure tells us about the initiation of innate immunity
2011
Structural mechanism of cytosolic DNA sensing by cGAS
2013 Nature
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
Activation and regulation of the inflammasomes
2013 Standout
Cytosolic Sensing of Viruses
2013
Shared and Distinct Functions of Type I and Type III Interferons
2019
The Latent Membrane Protein 1 of Epstein-Barr Virus Establishes an Antiviral State via Induction of Interferon-stimulated Genes
2004
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
2014
Pattern Recognition Receptors and Inflammation
2010 Standout
Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2
2008
Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses
2014
The molecular machinery of regulated cell death
2019 Standout
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
2014 Standout
Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING
2012
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus
2014 StandoutNobel
Intracellular Toll-like Receptors
2010 StandoutNobel
Mitochondria: In Sickness and in Health
2012 Standout
AIM2 Facilitates the Apoptotic DNA-induced Systemic Lupus Erythematosus via Arbitrating Macrophage Functional Maturation
2013
Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children
2016 Standout
IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection
2011
Regulation of innate immune cell function by mTOR
2015
Regulation of inflammasome signaling
2012
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
2010 Standout
Autophagy in Human Health and Disease
2013 Standout
The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses
2014
TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88–independent TLR4 pathway
2009
Immune Sensing of DNA
2013
Inflammasomes: mechanism of assembly, regulation and signalling
2016 Standout
Genetic variation in Toll-like receptors and disease susceptibility
2012
Regulation of Signaling by Non-degradative Ubiquitination
2008
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Autophagy and Aging
2011 Standout
Hypersusceptibility to Vesicular Stomatitis Virus Infection in Dicer1-Deficient Mice Is Due to Impaired miR24 and miR93 Expression
2007 StandoutNobel
Sterile inflammation: sensing and reacting to damage
2010 Standout
LPS/TLR4 signal transduction pathway
2008 Standout
Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome
2011
Mechanisms and Functions of Inflammasomes
2014 Standout
The broad-spectrum antiviral functions of IFIT and IFITM proteins
2012
AKT/PKB Signaling: Navigating the Network
2017 Standout
Newly described pattern recognition receptors team up against intracellular pathogens
2013
Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
2013
Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing
2013
The PI3K Pathway in Human Disease
2017 Standout
TIR-containing adaptors in Toll-like receptor signalling
2009
Interleukin-18 up-regulates amino acid transporters and facilitates amino acid–induced mTORC1 activation in natural killer cells
2019
Tumor-derived exosomes antagonize innate antiviral immunity
2018
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
2012
Intrinsic antiviral immunity
2012
Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis
2008
STING is a direct innate immune sensor of cyclic di-GMP
2011 Nature
Inflammasomes in health and disease
2012 StandoutNature
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
2020 Standout
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
2009 Standout
Identification and transcriptome analysis of erythroblastic island macrophages
2019 StandoutNobel
Viral evasion and subversion of pattern-recognition receptor signalling
2008
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
2014
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking
2013
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
2011 StandoutNobel
IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV
2013 Science
STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
2012
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy
2013
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
A Virological View of Innate Immune Recognition
2012
Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation
2017
Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid
2013
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
2012
Priming of protective T cell responses against virus-induced tumors in mice with human immune system components
2009 StandoutNobel
AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity
2015
cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response to Francisella Infection
2015
Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses
2008 StandoutNobel
Inflammation and metabolism in tissue repair and regeneration
2017 StandoutScience
MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP
2011
Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense
2013
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
N‐Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen‐Presenting Cells through Dectin‐1 and Dectin‐2
2018 StandoutNobel
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
2013 Science
Cellular Responses to Viral Infection in Humans: Lessons from Epstein-Barr Virus
2007
Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways
2017
Works of Sinéad E. Keating being referenced
A novel anti-viral role for STAT3 in IFN-α signalling responses
2016
IRAK-2 Participates in Multiple Toll-like Receptor Signaling Pathways to NFκB via Activation of TRAF6 Ubiquitination
2007
Role of Non-degradative Ubiquitination in Interleukin-1 and Toll-like Receptor Signaling
2008
IFI16 is an innate immune sensor for intracellular DNA
2010
Epstein-Barr Virus gp42 Is Posttranslationally Modified To Produce Soluble gp42 That Mediates HLA Class II Immune Evasion
2004
Cytosolic DNA sensors regulating type I interferon induction
2011
Latent Membrane Protein 1 Inhibits Epstein-Barr Virus Lytic Cycle Induction and Progress via Different Mechanisms
2003
mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function
2014
The Lytic Cycle of Epstein-Barr Virus Is Associated with Decreased Expression of Cell Surface Major Histocompatibility Complex Class I and Class II Molecules
2002