Citation Impact
Citing Papers
Expression and amplification of the N-myc gene in primary retinoblastoma
1984 Nature
Mechanism of met oncogene activation
1986
Small GTP-Binding Proteins
1992
RAS oncogenes: the first 30 years
2003
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans
2009 StandoutNobel
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice
1988 StandoutNobel
Isolation and characterization of kirsten murine sarcoma virus‐transformed mouse keratinocytes resistant to transforming growth factor beta
1990
RAS Is Regulated by the let-7 MicroRNA Family
2005 Standout
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
1989 StandoutNatureNobel
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein
1990
Identification of genes expressed in C. elegans touch receptor neurons
2002 StandoutNatureNobel
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
Purification of component A of Rab geranylgeranyl transferase: Possible identity with the choroideremia gene product
1992 StandoutNobel
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites
1995 StandoutNobel
Swaying is a mutant allele of the proto-oncogene Wnt-1
1991 StandoutNobel
The role of Rab3A in neurotransmitter release
1994 StandoutNatureNobel
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
1994 StandoutNobel
Activation of C. elegans cell death protein CED-9 by an ammo-acid substitution in a domain conserved in Bcl-2
1994 StandoutNatureNobel
Ras-dependent carbon metabolism and transformation in mouse fibroblasts
2006
Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations
1983 Nature
Transformation of quail embryo fibroblasts by a retrovirus carrying a normal human c-myc gene.
1986
Homologies Between Signal Transducing G Proteins and ras Gene Products
1984 StandoutScienceNobel
Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21
1988 Science
Cellular Oncogenes and Multistep Carcinogenesis
1983 Science
Malignant transformation of early passage rodent cells by a single mutated human oncogene
1984 Nature
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
1983 StandoutNature
Three different activated ras genes in mouse tumours; evidence for oncogene activation during progression of a mouse lymphoma.
1984
Small GTP-Binding Proteins
2001 Standout
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
1989 StandoutScienceNobel
Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus
1984 StandoutNatureNobel
Analysis of dominant-negative mutations of the Caenorhabditis elegans let-60 ras gene.
1991
Two human c-onc genes are located on the long arm of chromosome 8.
1982
Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
1983 Nature
Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene
1983 Nature
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
THE MOLECULAR GENETICS OF CELLULAR ONCOGENES
1984
Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage
1984 StandoutScienceNobel
Locus of the α-Chain of the T-Cell Receptor Is Split by Chromosome Translocation in T-Cell Leukemias
1985 Science
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA
1983 StandoutNobel
Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas
1982
Biological properties of human c-Ha-ras1 genes mutated at codon 12
1984 Nature
Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation
1989 StandoutScienceNobel
The protein products of the myc and myb oncogenes and adenovirus E1a are structurally related
1983 StandoutNatureNobel
The Chromosomal Basis of Human Neoplasia
1983 Science
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1
1983 Nature
Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.
1988
Fission yeast Schizosaccharomyces pombe correctly excises a mammalian RNA transcript intervening sequence
1985 StandoutNatureNobel
New human transforming genes detected by a tumorigenicity assay.
1984
A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene
1982 Nature
A human gastric carcinoma contains a single mutated and an amplified normal allele of the Ki-rasoncogene
1986
Ha-ras proteins exhibit GTPase activity: point mutations that activate Ha-ras gene products result in decreased GTPase activity.
1985
The N-rasoncogene assigned to the short arm of human chromosome 1
1983
Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels
1991 StandoutScienceNobel
Oncogenes: Yeast aids cancer research
1985 StandoutNatureNobel
A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells
1983 StandoutNatureNobel
A novel ras-related gene family
1985 StandoutNobel
Identification of nuclear proteins encoded by viral and cellular myc oncogenes
1983 StandoutNatureNobel
Oncogene amplification during tumorigenesis of established rat fibroblasts reversibly transformed by activated human ras oncogenes.
1986
Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies
1985
Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src
1984 StandoutNobel
Activation of a cellular oncogene by DNA rearrangement: possible involvement of an IS-like element
1982 Nature
A product of yeast RAS2 gene is a guanine nucleotide binding protein.
1984
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo
1987
Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia
1983 Nature
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour
1983 StandoutNatureNobel
Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc
1984 StandoutNatureNobel
A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene.
1984
Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.
1984
Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumour cells
1985 StandoutNatureNobel
A novel transforming gene in a human malignant melanoma cell line
1984 Nature
Analysis of viral and somatic activations of the cHa-ras gene
1985
Structure and activation of the human N-ras gene
1983
Retinoblastoma: Clues to Human Oncogenesis
1984 Science
Harvey ras genes transform without mutant codons, apparently activated by truncation of a 5' exon (exon -1).
1986
Three human transforming genes are related to the viral ras oncogenes.
1983
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
1986 StandoutNatureNobel
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
1985 StandoutNobel
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
1982
Mechanism of activation of a human oncogene
1982 Nature
Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene
1983 Nature
Cellular Transforming Genes
1982 Science
Yeast and mammalian ras proteins have conserved biochemical properties
1985 Nature
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas
1984 Nature
The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity
1984 Nature
NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice.
1985
Suppression of tumorigenicity with continued expression of the c-Ha-ras oncogene in EJ bladder carcinoma-human fibroblast hybrid cells.
1986
Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change
1982 Nature
Transformation and stimulation of DNA synthesis in NIH-3T3 cells are a titratable function of normal p21N-ras expression.
1986
Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats
1985 Nature
Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue
1983 Nature
A cellular gene encodes scrapie PrP 27-30 protein
1985 StandoutNobel
Homology between human bladder carcinoma oncogene product and mitochondrial ATP-synthase
1983 StandoutNatureNobel
The drosophila ras oncogenes: Structure and nucleotide sequence
1984
Molecular cloning and nucleotide sequence of a transforming gene detected by transfection of chicken B-cell lymphoma DNA
1983 Nature
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1
1983 Nature
Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor
1984 StandoutNobel
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene
1986 StandoutNobel
Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line.
1983
Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus
1982 Nature
Concerted DNA rearrangements in Moloney murine leukemia virus-induced thymomas: a potential synergistic relationship in oncogenesis
1985
The HL-60 transforming sequence: A ras oncogene coexisting with altered myc genes in hematopoietic tumors
1983
Expression of N-myc in teratocarcinoma stem cells and mouse embryos
1985 StandoutNatureNobel
Activation of a c-K- ras Oncogene by Somatic Mutation in Mouse Lymphomas Induced by Gamma Radiation
1984 Science
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Identification of a provirally activated c-Ha-ras oncogene in an avian nephroblastoma via a novel procedure: cDNA cloning of a chimaeric viral-host transcript.
1986
Activation of ras genes in human tumors does not affect localization, modification, or nucleotide binding properties of p21
1984
Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene
1983 Nature
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Molecular cloning and sequence analysis of a ras gene from Schizosaccharomyces pombe.
1985
The human c-Ha-ras2 is a processed pseudogene inactivated by numerous base substitutions
1984
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
1982 Nature
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture
1985 StandoutNatureNobel
Works of Simonetta Pulciani being referenced
Spontaneous activation of a human proto-oncogene.
1983
A Transforming ras Gene in Tumorigenic Guinea Pig Cell Lines Initiated by Diverse Chemical Carcinogens
1984 Science
T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes
1982 Nature
Transforming genes in human tumors
1982
ras gene Amplification and Malignant Transformation
1985
Oncogenes in solid human tumours
1982 Nature
ras gene Amplification and malignant transformation.
1985
Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells.
1982