Citation Impact
Citing Papers
On the relationship between folding and chemical landscapes in enzyme catalysis
2008 StandoutNobel
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 StandoutNobel
CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes
2007 StandoutScience
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Origins of catalysis by computationally designed retroaldolase enzymes
2010 StandoutNobel
Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease
2010 StandoutScienceNobel
Computational Thermostabilization of an Enzyme
2005 StandoutScienceNobel
Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
2011 StandoutNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Structure⧸Function Correlations of Proteins using MM, QM⧸MM, and Related Approaches: Methods, Concepts, Pitfalls, and Current Progress
2003 StandoutNobel
Examining the case for the effect of barrier compression on tunneling, vibrationally enhanced catalysis, catalytic entropy and related issues
2010 StandoutNobel
Computer Simulation of Primary Kinetic Isotope Effects in the Proposed Rate-limiting Step of the Glyoxalase I Catalyzed Reaction
2000
Thermophilic Adaptation of Proteins
2001
Dynamic activation of protein function: a view emerging from NMR spectroscopy.
2001
Choreographing an enzyme's dance
2010
Hydrogen tunneling in biology
1999
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Renal Effects of Ibuprofen, Piroxicam, and Sulindac in Patients with Asymptomatic Renal Failure
1990
A putative viral defence mechanism in archaeal cells
2006
An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling
2009
Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited
2005
Nested cooperativity and salt dependence of the ATPase activity of the archaeal chaperonin Mm‐cpn
2003
The EVB as a quantitative tool for formulating simulations and analyzing biological and chemical reactions
2009 StandoutNobel
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
Induction of gene amplification by 5-aza-2′-deoxycytidine
1992
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Environmentally coupled hydrogen tunneling
2002
Barrier Compression and Its Contribution to Both Classical and Quantum Mechanical Aspects of Enzyme Catalysis
2010
Temperature adaptation of enzymes: Lessons from laboratory evolution
2001 StandoutNobel
Characterization of the endonuclease SSO2001 from Sulfolobus solfataricus P2
2009
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Extreme catalysts from low-temperature environments
2004
Domain rotations between open, closed and bullet-shaped forms of the thermosome, an archaeal chaperonin 1 1Edited by A. R. Fersht
2000
Hyperthermophilic Enzymes: Sources, Uses, and Molecular Mechanisms for Thermostability
2001 Standout
Molecular chaperones in cellular protein folding
1996 StandoutNature
Modelling enzyme reaction mechanisms, specificity and catalysis
2005
Crystal Structure of the Thermosome, the Archaeal Chaperonin and Homolog of CCT
1998
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
1995 StandoutNobel
Dynamics of biochemical and biophysical reactions: insight from computer simulations
2001 StandoutNobel
The sequence of a subtilisin‐type protease (aerolysin) from the hyperthermophilic archaeum Pyrobaculum aerophilum reveals sites important to thermostability
1994
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Mechanism of folding chamber closure in a group II chaperonin
2010 StandoutNatureNobel
Improving the carboligase activity of benzoylformate decarboxylase from Pseudomonas putida by a combination of directed evolution and site-directed mutagenesis
2002
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Primary Structure of the Thermosome fromThermoplasma acidophilum
1995
The contentious nature of soil organic matter
2015 StandoutNature
Regulation of CRISPR–Cas adaptive immune systems
2017
The thermosome: archetype of group II chaperonins
1998
X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 Å resolution: determinants of thermostability revealed from structural comparisons
2001
At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?
2009 StandoutNobel
Inhibition of Type III CRISPR-Cas Immunity by an Archaeal Virus-Encoded Anti-CRISPR Protein
2019
Structural bases of hydrogen tunneling in enzymes: progress and puzzles
2004
Reply to Karplus: Conformational dynamics have no role in the chemical step
2010 StandoutNobel
23S rRNA base pair 2057–2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A→G
2005 StandoutNobel
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
On the Relationship between Thermal Stability and Catalytic Power of Enzymes
2007 StandoutNobel
A novel interference mechanism by a type IIIB CRISPR ‐Cmr module in S ulfolobus
2013
Converting structural information into an allosteric-energy-based picture for elongation factor Tu activation by the ribosome
2011 StandoutNobel
Comment on “Effect of Active Site Mutation Phe93 → Trp in the Horse Liver Alcohol Dehydrogenase Enzyme on Catalysis: A Molecular Dynamics Study”
2003 StandoutNobel
Evidence To Support the Hypothesis That Promoting Vibrations Enhance the Rate of an Enzyme Catalyzed H-Tunneling Reaction
2009
Energetics and Dynamics of Enzymatic Reactions
2001 StandoutNobel
Solute Solvent Dynamics and Energetics in Enzyme Catalysis: The SN2 Reaction of Dehalogenase as a General Benchmark
2004 StandoutNobel
Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair
2004
Ketosteroid isomerase provides further support for the idea that enzymes work by electrostatic preorganization
2010 StandoutNobel
A new paradigm for electrostatic catalysis of radical reactions in vitamin B 12 enzymes
2007 StandoutNobel
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
2013 StandoutScienceNobel
A 21st century revisionist's view at a turning point in enzymology
2009
Donor−Acceptor Distance and Protein Promoting Vibration Coupling to Hydride Transfer: A Possible Mechanism for Kinetic Control in Isozymes of Human Lactate Dehydrogenase
2003
Temperature-Dependent Isotope Effects in Soybean Lipoxygenase-1: Correlating Hydrogen Tunneling with Protein Dynamics
2002
The First Experimental Test of the Hypothesis that Enzymes Have Evolved To Enhance Hydrogen Tunneling
2003
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
Amino Acid Biosynthesis in the Halophilic Archaeon Haloarcula hispanica
1999 StandoutNobel
Sensing cooperativity in ATP hydrolysis for single multisubunit enzymes in solution
2011 StandoutNobel
By chance, or by design?
2004 Nature
Promoting Modes and Demoting Modes in Enzyme-Catalyzed Proton Transfer Reactions: A Study of Models and Realistic Systems
2002
Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects
2007
Challenges in Enzyme Mechanism and Energetics
2003
Effects of a Distal Mutation on Active Site Chemistry
2006
Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling
2012 StandoutNobel
Perspective: Defining and quantifying the role of dynamics in enzyme catalysis
2016 Nobel
Glomalin-related soil protein contains non-mycorrhizal-related heat-stable proteins, lipids and humic materials
2010
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Fluctuating Enzymes: Lessons from Single-Molecule Studies
2005
Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed βα protein
2019 StandoutNobel
New directions in single-molecule imaging and analysis
2007 StandoutNobel
Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase
2006
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
Functional and nonfunctional mutations distinguished by random recombination of homologous genes
1997 StandoutNobel
Enzyme catalysis: over-the-barrier or through-the-barrier?
2000
Redox cycling and kinetic analysis of single molecules of solution-phase nitrite reductase
2011 StandoutNobel
The Role of Dynamics in Enzyme Activity
2003
Enzyme millisecond conformational dynamics do not catalyze the chemical step
2009 StandoutNobel
Identification of Transcription Complexes that Contain the Double Bromodomain Protein Brd2 and Chromatin Remodeling Machines
2006
Protein Flexibility Correlates with Degree of Hydrogen Tunneling in Thermophilic and Mesophilic Alcohol Dehydrogenases
2000
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
2001 StandoutNobel
Enzyme engineering reaches the boiling point
1998 StandoutNobel
Network of coupled promoting motions in enzyme catalysis
2002
A Theoretical Analysis of the Proton and Hydride Transfer in Liver Alcohol Dehydrogenase (LADH)
2002
A Computational Method to Identify Residues Important in Creating a Protein Promoting Vibration in Enzymes
2002
Exploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase
2010 StandoutNobel
Quantum Mechanics/Molecular Mechanics Studies of Triosephosphate Isomerase-Catalyzed Reactions: Effect of Geometry and Tunneling on Proton-Transfer Rate Constants
2002
Role of 16S rRNA Helix 44 in Ribosomal Resistance to Hygromycin B
2003
Works of Simonetta Bartolucci being referenced
New virus isolates from Italian hydrothermal environments underscore the biogeographic pattern in archaeal virus communities
2020
5-Aza-2′-deoxycytidine as inducer of differentiation and growth inhibition in mouse neuroblastoma cells
1989
Stability and activity of a thermostable malic enzyme in denaturants and water‐miscible organic solvents
1989
Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase
1999 Nature
Characterization of the Sulfolobus host–SSV2 virus interaction
2006
A protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus contains two thioredoxin fold units
1998
Transcriptome analysis of Sulfolobus solfataricus infected with two related fuselloviruses reveals novel insights into the regulation of CRISPR-Cas system
2015
The chaperonin from the archaeon Sulfolobus solfataricus promotes correct refolding and prevents thermal denaturation in vitro
1994
Analysis of piroxicam in plasma by high-performance liquid chromatography
1980
Extremophiles 2002
2003
Malic enzyme from archaebacterium Sulfolobus solfataricus. Purification, structure, and kinetic properties.
1987
Stabilization of Enzymes against Thermal Stress and Freeze-Drying by Mannosylglycerate
1997
pIT3, a cryptic plasmid isolated from the hyperthermophilic crenarchaeon Sulfolobus solfataricus IT3
2006
Characterization of redox proteins from extreme thermophilic archaebacteria: studies on alcohol dehydrogenase and thioredoxins
1995
The Purification, Cloning, and High Level Expression of a Glutaredoxin-like Protein from the Hyperthermophilic Archaeon Pyrococcus furiosus
1995
Cloning and overexpression in Escherichia coli of the genes encoding NAD-dependent alcohol dehydrogenase from two Sulfolobus species
1996
An Autonomously Replicating Transforming Vector for Sulfolobus solfataricus
1998