Citation Impact
Citing Papers
Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization
2004 StandoutScienceNobel
TRP channel activation by reversible covalent modification
2006 StandoutNobel
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Developmental Decline in Neuronal Regeneration by the Progressive Change of Two Intrinsic Timers
2013 StandoutScienceNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Long-term cigarette smoke exposure increases uncoupling protein expression but reduces energy intake
2008
Hallmarks of Cancer: The Next Generation
2011 Standout
MEX-5 and MEX-6 Function to Establish Soma/Germline Asymmetry in Early C. elegans Embryos
2000
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Systems Biology of Growth Factor‐Induced Receptor Endocytosis
2008
Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway
1996
Specificity in Signal Transduction
2004
A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate
2007 Nature
MicroRNAs
2004 Standout
Huntingtin Is Ubiquitinated and Interacts with a Specific Ubiquitin-conjugating Enzyme
1996
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
U Box Proteins as a New Family of Ubiquitin-Protein Ligases
2001
E2–c-Cbl Recognition Is Necessary but not Sufficient for Ubiquitination Activity
2008
Derailed endocytosis: an emerging feature of cancer
2008
Calcium's Role in Mechanotransduction during Muscle Development
2014 Standout
Suppressor of Cytokine Signaling-1 Inhibits VAV Function through Protein Degradation
2000
Receptor downregulation and multivesicular-body sorting
2002
Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States
1999
The role of autophagy in neurodegenerative disease
2013 Standout
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
ER protein quality control and proteasome-mediated protein degradation
1999
nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans
2009 StandoutNobel
Protein regulation by monoubiquitin
2001
Highwire Regulates Synaptic Growth in Drosophila
2000
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Inactivation of the HR6B Ubiquitin-Conjugating DNA Repair Enzyme in Mice Causes Male Sterility Associated with Chromatin Modification
1996
RING Finger Proteins
2000
Molecular Insights into Polyubiquitin Chain Assembly
2001
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
1993 Standout
Monoubiquitin carries a novel internalization signal that is appended to activated receptors
2000
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases
2000
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
2000 StandoutNatureNobel
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
Proteolysis and the cell cycle: with this RING I do thee destroy
2000
Recognition and Ubiquitination of Notch by Itch, a Hect-type E3 Ubiquitin Ligase
2000
Ubiquitin Ligase Activity of TFIIH and the Transcriptional Response to DNA Damage
2005 StandoutNobel
A protein conjugation system essential for autophagy
1998 StandoutNatureNobel
Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling
2008
Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-α signaling
2001
ERK-dependent threonine phosphorylation of EGF receptor modulates receptor downregulation and signaling
2008
MicroRNA Pathways in Flies and Worms
2003 StandoutNobel
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation
2000
Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing
2001 StandoutNobel
Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins
2007
Accuracy and reliability of apical S3 gallop detection
1995
Themes and variations on ubiquitylation
2001
Membrane Topology and Function of Der3/Hrd1p as a Ubiquitin-Protein Ligase (E3) Involved in Endoplasmic Reticulum Degradation
2001
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
The Chaperone Protein BiP Binds to a Mutant Prion Protein and Mediates Its Degradation by the Proteasome
2000
Prognostic Importance of Elevated Jugular Venous Pressure and a Third Heart Sound in Patients with Heart Failure
2001 Standout
The human ubiquitin‐conjugating enzyme UbcH1 is involved in the repair of UV‐damaged, alkylated and cross‐linked DNA
1994
The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation
2001
Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction
2004
Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme Isomerization
2001
NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer
2000 Standout
Implications of Third Heart Sounds in Patients with Valvular Heart Disease
1992
The lin-41 RBCC Gene Acts in the C. elegans Heterochronic Pathway between the let-7 Regulatory RNA and the LIN-29 Transcription Factor
2000 StandoutNobel
Novel Multiubiquitin Chain Linkages Catalyzed by the Conjugating Enzymes E2EPF and RAD6 Are Recognized by 26 S Proteasome Subunit 5
1996
Structure of a c-Cbl–UbcH7 Complex
2000
Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53
2000
Chaperone-mediated autophagy: a unique way to enter the lysosome world
2012
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways
2006 StandoutNobel
Structure of a β-TrCP1-Skp1-β-Catenin Complex
2003
CHIP Is a U-box-dependent E3 Ubiquitin Ligase
2001
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
E3 ubiquitin ligases as T cell anergy factors
2004
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
2000 Standout
RING domains: master builders of molecular scaffolds?
2000
The BCL-2 protein family: opposing activities that mediate cell death
2007 Standout
Autophagy and related mechanisms of lysosome-mediated protein degradation
1994
The Accuracy and Interobserver Agreement in Detecting the ‘Gallop Sounds’ by Cardiac Auscultation
1998
microRNAs
2001 StandoutNobel
The functions of animal microRNAs
2004 StandoutNatureNobel
COP9 signalosome revisited: a novel mediator of protein degradation
2001
Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
2013 StandoutNobel
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
Identification of a Family of Closely Related Human Ubiquitin Conjugating Enzymes
1995
Protein S-nitrosylation: purview and parameters
2005 Standout
Targeted destabilization of HY5 during light-regulated development of Arabidopsis
2000 Nature
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Degradation of Myogenic Transcription Factor MyoD by the Ubiquitin Pathway In Vivo and In Vitro: Regulation by Specific DNA Binding
1998 StandoutNobel
Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli
2000 Science
A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition
2001
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
2001
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.
1990
In Vivo Action of the HRD Ubiquitin Ligase Complex: Mechanisms of Endoplasmic Reticulum Quality Control and Sterol Regulation
2001
Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases
2005 Nobel
The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis
2009
The APC11 RING-H2 Finger Mediates E2-Dependent Ubiquitination
2000
Mechanisms Underlying Ubiquitination
2001 Standout
RING Domain E3 Ubiquitin Ligases
2009 Standout
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Assembly of Cell Regulatory Systems Through Protein Interaction Domains
2003 Science
A Tale of Two Cbls: Interplay of c-Cbl and Cbl-b in Epidermal Growth Factor Receptor Downregulation
2008
UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior.
1997
Proteasomes play an essential role in thymocyte apoptosis.
1996
A major ubiquitin conjugation system in wheat germ extracts involves a 15-kDa ubiquitin-conjugating enzyme (E2) homologous to the yeast UBC4/UBC5 gene products.
1993
Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-“N-end rule” protein substrates
1994 StandoutNobel
Regulation of Presynaptic Terminal Organization by C. elegans RPM-1, a Putative Guanine Nucleotide Exchanger with a RING-H2 Finger Domain
2000
Endoplasmic Reticulum Degradation Requires Lumen to Cytosol Signaling
2000
Structural Mechanisms Underlying Posttranslational Modification by Ubiquitin-Like Proteins
2007
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex
2003
2001
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
2000
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex
2002
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses
2011
Works of Simon S. Wing being referenced
The UPS in diabetes and obesity
2008
Increase in levels of polyubiquitin and proteasome mRNA in skeletal muscle during starvation and denervation atrophy
1995
BH3‐ligand regulates access of MCL‐1 to its E3 ligase
2005
Endocrine regulation of protein breakdown in skeletal muscle
1988
Proparathyroid Hormone-related Protein Is Associated with the Chaperone Protein BiP and Undergoes Proteasome-mediated Degradation
1998
Ataxin-3 Deubiquitination Is Coupled to Parkin Ubiquitination via E2 Ubiquitin-conjugating Enzyme
2011
Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2
2006
Activation of a UBC4-Dependent Pathway of Ubiquitin Conjugation during Postnatal Development of the Rat Testis
1999
Proteins containing peptide sequences related to Lys-Phe-Glu-Arg-Gln are selectively depleted in liver and heart, but not skeletal muscle, of fasted rats
1991
The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase
1999 Science
Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting
1993
Interobserver Agreement by Auscultation in the Presence of a Third Heart Sound in Patients with Congestive Heart Failure
1987
S-Nitrosylation of IRP2 Regulates Its Stability via the Ubiquitin-Proteasome Pathway
2003
Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation
1995
A rabbit reticulocyte ubiquitin carrier protein that supports ubiquitin-dependent proteolysis (E214k) is homologous to the yeast DNA repair gene RAD6.
1992
14-kDa ubiquitin-conjugating enzyme: structure of the rat gene and regulation upon fasting and by insulin
1994
Activation of the ubiquitin-ATP-dependent proteolytic system in skeletal muscle during fasting and denervation atrophy.
1991
Molecular cloning, expression and characterization of a ubiquitin conjugation enzyme (E217kB) highly expressed in rat testis
1995