Citation Impact
Citing Papers
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
2011 Standout
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
2007 StandoutNobel
PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5
2009
The Tpl2 Mutation Sluggish Impairs Type I IFN Production and Increases Susceptibility to Group B Streptococcal Disease
2009 StandoutNobel
Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes
2010
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses
2017
The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo
2015
Affinity purification of ARE-binding proteins identifies poly(A)-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization
2003
β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation
2002 StandoutNobel
Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor
2004 StandoutNobel
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
2011 Standout
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Signal integration by JNK and p38 MAPK pathways in cancer development
2009 Standout
The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia
2017 StandoutNobel
Knockout of ERK5 causes multiple defects in placental and embryonic development
2003
Mechanism of p38 MAP kinase activation in vivo
2003
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
2012 StandoutNature
p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype
2011
Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity
2021 Standout
Controlling gene expression in response to stress
2011
MAPKAP kinases — MKs — two's company, three's a crowd
2006
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways
2007
HSP27 Multimerization Mediated by Phosphorylation-sensitive Intermolecular Interactions at the Amino Terminus
1999
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
1999
The p38 signal transduction pathway Activation and function
2000
MK2 and MK3 - a pair of isoenzymes?
2008
Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation
2013
VEGF receptor signalling ? in control of vascular function
2006 Standout
Evolving concepts of rheumatoid arthritis
2003 StandoutNature
Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology
2009
β-Arrestin2 Is Critically Involved in CXCR4-mediated Chemotaxis, and This Is Mediated by Its Enhancement of p38 MAPK Activation
2002
A central role for JNK in obesity and insulin resistance
2002 StandoutNature
MAPKAP Kinase 2 Phosphorylates Tristetraprolin on in Vivo Sites Including Ser178, a Site Required for 14-3-3 Binding
2004
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
Tracking and Elucidating Alphavirus-Host Protein Interactions
2006 StandoutNobel
Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif
2009
Post‐transcriptional regulation of gene expression by mitogen‐activated protein kinase p38
2003
Serine/Threonine Kinases 3pK and MAPK-activated Protein Kinase 2 Interact with the Basic Helix-Loop-Helix Transcription Factor E47 and Repress Its Transcriptional Activity
2000
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
2010 StandoutNature
The splicing factor ASF/SF2 is associated with TIA‐1‐related/TIA‐1‐containing ribonucleoproteic complexes and contributes to post‐transcriptional repression of gene expression
2010
Phase transitions in the assembly of multivalent signalling proteins
2012 StandoutNature
The MEK/ERK cascade: From signaling specificity to diverse functions
2006
Specificity of signaling from MAPKs to MAPKAPKs: Kinases' Tango Nuevo
2008
Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells
1999
The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)
2008
Fluorescence‐based quantitative scratch wound healing assay demonstrating the role of MAPKAPK‐2/3 in fibroblast migration
2009
Geldanamycin inhibits migration of glioma cells in vitro: A potential role for hypoxia‐inducible factor (HIF‐1α) in glioma cell invasion
2003
Mammalian MAP kinase signalling cascades
2001 StandoutNature
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
The PSF·p54nrb Complex Is a Novel Mnk Substrate That Binds the mRNA for Tumor Necrosis Factor α
2007
A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration
1999
The role of senescent cells in ageing
2014 StandoutNature
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
2001
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy
2015
Mitogen‐activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment
2006
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Substrate Discrimination among Mitogen-activated Protein Kinases through Distinct Docking Sequence Motifs
2008
P66ShcA interacts with MAPKAP kinase 2 and regulates its activity
2004
Inflammatory networks during cellular senescence: causes and consequences
2010
Modulation of F-actin Rearrangement by the Cyclic AMP/cAMP-dependent Protein Kinase (PKA) Pathway Is Mediated by MAPK-activated Protein Kinase 5 and Requires PKA-induced Nuclear Export of MK5
2007
Inflammasomes in health and disease
2012 StandoutNature
The Stability of the G Protein-coupled Receptor-β-Arrestin Interaction Determines the Mechanism and Functional Consequence of ERK Activation
2003 StandoutNobel
Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis
2000
p38 mitogen-activated protein kinase is required for TGFβ-mediated fibroblastic transdifferentiation and cell migration
2002
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα
2010 StandoutNobel
Characterization of the activity of human MAP kinase-interacting kinase Mnk1b
2007
Characterization of Mouse Rsk4 as an Inhibitor of Fibroblast Growth Factor-RAS-Extracellular Signal-Regulated Kinase Signaling
2004
Inflammation and its genesis in cystic fibrosis
2015
ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions
2004 Standout
Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects
2002
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Transforming Growth Factor β1 (TGF-β1) Promotes Endothelial Cell Survival during In Vitro Angiogenesis via an Autocrine Mechanism Implicating TGF-α Signaling
2001
Heat shock protein 27 kDa expression and phosphorylation regulates endothelial cell migration
1998
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
2001 Standout
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
MAP Kinases
2001
Essential role of B-Raf in ERK activation during extraembryonic development
2006
Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa
2016
Mechanisms and functions of p38 MAPK signalling
2010
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals.
2001
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
2004
Regulation of Sprouty Stability by Mnk1-Dependent Phosphorylation
2006
MSK activation and physiological roles
2008
TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells
2009
Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Regulates Tumor Necrosis Factor mRNA Stability and Translation Mainly by Altering Tristetraprolin Expression, Stability, and Binding to Adenine/Uridine-Rich Element
2006
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
2010 StandoutNobel
The tumor vascular targeting agent combretastatin A–4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells
2002
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2
2003
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Antimicrobial Resistance in ESKAPE Pathogens
2020 Standout
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference
2003 StandoutNobel
Works of Simon Rousseau being referenced
The Mnks Are Novel Components in the Control of TNFα Biosynthesis and Phosphorylate and Regulate hnRNP A1
2005
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs
2002
CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway
2006
Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Enhances Activation of p38 and ERK MAPKs, Increasing Interleukin-6 Synthesis in Airway Epithelial Cells Exposed to Pseudomonas aeruginosa
2010
IL-17 primes airway epithelial cells lacking functional Cystic Fibrosis Transmembrane conductance Regulator (CFTR) to increase NOD1 responses
2009
p38 MAP-Kinases pathway regulation, function and role in human diseases
2007
p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
1997 Standout
Primary tumors induce neutrophil extracellular traps with targetable metastasis-promoting effects
2019
Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
1999
Deleterious impact of Pseudomonas aeruginosa on cystic fibrosis transmembrane conductance regulator function and rescue in airway epithelial cells
2015
Vascular Endothelial Growth Factor (VEGF)-driven Actin-based Motility Is Mediated by VEGFR2 and Requires Concerted Activation of Stress-activated Protein Kinase 2 (SAPK2/p38) and Geldanamycin-sensitive Phosphorylation of Focal Adhesion Kinase
2000
Distinct intracellular signaling pathways control the synthesis of IL-8 and RANTES in TLR1/TLR2, TLR3 or NOD1 activated human airway epithelial cells
2008
SAPK2/p38-dependent F-Actin Reorganization Regulates Early Membrane Blebbing during Stress-induced Apoptosis
1998
NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein
2014
TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNFα in LPS-stimulated macrophages
2008
Neutrophil extracellular traps sequester circulating tumor cells via β1-integrin mediated interactions
2017
Cystic fibrosis–adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses
2015