Standout Papers
- Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. (2000)
Citation Impact
Citing Papers
Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass
2004
Cdc42, Rac1, and Rac2 Display Distinct Patterns of Activation during Phagocytosis
2004
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions
2012 StandoutNobel
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
2003
Single molecules of the bacterial actin MreB undergo directed treadmilling motion in Caulobacter crescentus
2006 StandoutNobel
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
2017 StandoutNobel
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Structure of Arp2/3 Complex in Its Activated State and in Actin Filament Branch Junctions
2001 Science
Identification of a tight junction–associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability
2003
Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment
2005
Sequential Binding of Cytosolic Phox Complex to Phagosomes through Regulated Adaptor Proteins: Evaluation Using the Novel Monomeric Kusabira-Green System and Live Imaging of Phagocytosis
2008
Therapeutic siRNA: state of the art
2020
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
2011 StandoutNobel
The HIV-1 Nef Protein and Phagocyte NADPH Oxidase Activation
2002
Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity
2000
Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex
2000
Periodic Lamellipodial Contractions Correlate with Rearward Actin Waves
2004
Profilins as regulators of actin dynamics
1997
Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein
1999
Activation of Arp2/3 Complex by Wiskott-Aldrich Syndrome Protein Is Linked to Enhanced Binding of ATP to Arp2
2001
Multimodal Nonlinear Optical Microscopy and Applications to Central Nervous System Imaging
2008
Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization
2005
Biomaterials and bone mechanotransduction
2001
The presynaptic cytomatrix of brain synapses
2001
Rac1 and Rac2 GTPases in haematopoiesis
2004
The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly
1999
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
2006 Standout
The role of Rac1 and Rac2 in bacterial killing
2005
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment
2004 Standout
Plant and Animal Pathogen Recognition Receptors Signal through Non-RD Kinases
2006
Activation of the Arp2/3 Complex by the Listeria ActA Protein
2001
p40 : The last NADPH oxidase subunit
2005
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
2006 StandoutNatureNobel
Classification of Surgical Complications
2004 Standout
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
Regulation of Actin Dynamics in Rapidly Moving Cells:A Quantitative Analysis
2002
Genetic Deletion of Rac1 GTPase Reveals Its Critical Role in Actin Stress Fiber Formation and Focal Adhesion Complex Assembly
2006
Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis
2006
Structure and function of the Arp2/3 complex
1999
Leukocytes navigate by compass: roles of PI3Kγ and its lipid products
2000
The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization
2006
Cell type-specific functions of Rho GTPases revealed by gene targeting in mice
2006
Annexin V disruption impairs mechanically induced calcium signaling in osteoblastic cells
2004
Rho GTPases in cancer cell biology
2008
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Spatial and Temporal Analysis of Rac Activation during Live Neutrophil Chemotaxis
2002
Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation
2003
Rho GTPases in cell biology
2002 StandoutNature
Putting tumours in context
2001 Standout
Fibrillar β-Amyloid-stimulated Intracellular Signaling Cascades Require Vav for Induction of Respiratory Burst and Phagocytosis in Monocytes and Microglia
2006
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Mammalian Rho GTPases: new insights into their functions from in vivo studies
2008 Standout
Nap1 Regulates Dictyostelium Cell Motility and Adhesion through SCAR-Dependent and -Independent Pathways
2006
Rac2 Specificity in Macrophage Integrin Signaling
2003
Uncertainty in the niches that maintain haematopoietic stem cells
2008
Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-β during the process of epithelial to mesenchymal transition in rat proximal epithelial cells
2007
Local force and geometry sensing regulate cell functions
2006 Standout
The stem cell niche: theme and variations
2004
Directional Sensing Requires Gβγ-Mediated PAK1 and PIXα-Dependent Activation of Cdc42
2003
Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities
2001
Dynamic Actin Patterns and Arp2/3 Assembly at the Substrate-Attached Surface of Motile Cells
2004
Rho signaling and mechanical control of vascular development
2008
Intravital Imaging of the Kidney Using Multiparameter Multiphoton Microscopy
2003
Rac1 Controls the Formation of Midline Commissures and the Competency of Tangential Migration in Ventral Telencephalic Neurons
2007
Two-Photon Microscopy for Imaging of the (Atherosclerotic) Vascular Wall: A Proof of Concept Study
2004
GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo
2007
Regulation of neutrophil function by Rac GTPases
2003
Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
1998
Rac1 Is Essential for Platelet Lamellipodia Formation and Aggregate Stability under Flow
2005
RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development
2006
Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins
2000 Nature
Rac1 GTPase Regulates Cell Genomic Stability and Senescence
2006
A case-control analysis of readmissions to the cardiac surgical intensive care unit
2002
Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility
2004
Identification of stem cells in small intestine and colon by marker gene Lgr5
2007 StandoutNature
Matrix Elasticity Directs Stem Cell Lineage Specification
2006 Standout
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
The plant immune system
2006 StandoutNature
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
2003 Standout
Targeting and Regulation of Reactive Oxygen Species Generation by Nox Family NADPH Oxidases
2009
Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors
2015 StandoutNobel
Two Components of Actin-based Retrograde Flow in Sea Urchin Coelomocytes
1999
Folate-Receptor-Mediated Delivery of InP Quantum Dots for Bioimaging Using Confocal and Two-Photon Microscopy
2005
A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity
2008 StandoutNobel
Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor
2007
Size-Dependent Charge Collection in Junctions Containing Single-Size and Multi-Size Arrays of Colloidal CdSe Quantum Dots
2007 StandoutNobel
Vav1 and Rac Control Chemokine-promoted T Lymphocyte Adhesion Mediated by the Integrin α4β1
2005
Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia
1999
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Activation by Cdc42 and Pip2 of Wiskott-Aldrich Syndrome Protein (Wasp) Stimulates Actin Nucleation by Arp2/3 Complex
2000
Subsecond Luminescence Intensity Fluctuations of Single CdSe Quantum Dots
2005
Rho kinase mediates serum-induced contraction in fibroblast fibers independent of myosin LC20 phosphorylation
2003
Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration
2004
Interaction of Human Arp2/3 Complex and the Listeria monocytogenes ActA Protein in Actin Filament Nucleation
1998 Science
Chemoattractant-Stimulated Rac Activation in Wild-Type and Rac2-Deficient Murine Neutrophils: Preferential Activation of Rac2 and Rac2 Gene Dosage Effect on Neutrophil Functions
2002
RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation, survival, migration, and engraftment of hematopoietic progenitor cells
2004
Regulatory and Signaling Properties of the Vav Family
2000
Two-Photon Microscopy of Cells and Tissue
2004
Regulation of Actin Filament Network Formation Through ARP2/3 Complex: Activation by a Diverse Array of Proteins
2001
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Probing the Cytotoxicity of Semiconductor Quantum Dots
2003 Standout
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
2005 StandoutScience
Crystal Structure of Arp2/3 Complex
2001 Science
SalmonellaInteractions with Host Cells: Type III Secretion at Work
2001
Interactions of Acanthamoeba Profilin with Actin and Nucleotides Bound to Actin
1998
Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells
2007
RhoG Regulates the Neutrophil NADPH Oxidase
2006
Molecular Mechanisms Controlling Actin Filament Dynamics in Nonmuscle Cells
2000
Generation and Characterization of Rac3 Knockout Mice
2005
Ultrafast Dynamics of Resonance Energy Transfer in Cryptochrome
2005 StandoutNobel
SIGNALING TO THE ACTIN CYTOSKELETON
1998
Rho GTPases and their effector proteins
2000 Standout
Hydrodynamic Dimensions, Electrophoretic Mobility, and Stability of Hydrophilic Quantum Dots
2006
Rho GTPases and cell migration
2001
An essential role for Rac1 in endothelial cell function and vascular development
2008
Rac2-Deficient Hematopoietic Stem Cells Show Defective Interaction with the Hematopoietic Microenvironment and Long-Term Engraftment Failure
2005
Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity
2004
Vav GEFs are required for β2 integrin-dependent functions of neutrophils
2004
Tensegrity II. How structural networks influence cellular information processing networks
2003
The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes
2005 StandoutNobel
Identifying the Relative Contributions of Rac1 and Rac2 to Osteoclastogenesis
2007
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function
2003
Actin Binding Proteins: Regulation of Cytoskeletal Microfilaments
2003
Near-Complete Suppression of Quantum Dot Blinking in Ambient Conditions
2004
Cellular Control of Actin Nucleation
2002
ThreeC. elegansRac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis
2001 StandoutNobel
Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins
2002
Role of the Guanosine Triphosphatase Rac2 in T Helper 1 Cell Differentiation
2000 Science
The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments
1998
Multiphoton Absorbing Materials: Molecular Designs, Characterizations, and Applications
2008 Standout
Requirement of Rac1 and Rac2 Expression by Mature Dendritic Cells for T Cell Priming
2004 Science
Rac2 Is an Essential Regulator of Neutrophil Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Response to Specific Signaling Pathways
2001
Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs
2012 StandoutScience
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Tracking Individual Kinesin Motors in Living Cells Using Single Quantum-Dot Imaging
2006
Ca2+Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase
2003 Standout
Profilin is predominantly associated with monomeric actin in Acanthamoeba
1999
Rac1 and Rac2 regulate macrophage morphology but are not essential for migration
2006
New directions in single-molecule imaging and analysis
2007 StandoutNobel
Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks
2000
Two-Photon Absorbing Nanocrystal Sensors for Ratiometric Detection of Oxygen
2009 StandoutNobel
Influence of the C Terminus of Wiskott-Aldrich Syndrome Protein (WASp) and the Arp2/3 Complex on Actin Polymerization
1999
A dendrimer-based platform for simultaneous dual fluorescence imaging of hydrogen peroxide and pH gradients produced in living cells
2011
Deficiency of Small Gtpase Rac2 Affects T Cell Activation
2001
Analysis of the Actin–Myosin II System in Fish Epidermal Keratocytes: Mechanism of Cell Body Translocation
1997
Critical Roles for Rac1 and Rac2 GTPases in B Cell Development and Signaling
2003 Science
cdc12p, a Protein Required for Cytokinesis in Fission Yeast, Is a Component of the Cell Division Ring and Interacts with Profilin
1997 StandoutNobel
Neutrophils from p40phox−/− mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing
2006
A Cell's Sense of Direction
1999 Science
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Quantum dot/antibody conjugates for in vivo cytometric imaging in mice
2015 StandoutNobel
Invited Review: Focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle
2001
Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow
2007
Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis
2000 Science
Compact Biocompatible Quantum Dots Functionalized for Cellular Imaging
2008 StandoutNobel
The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.
1995
Arp2/3 complex requires hydrolyzable ATP for nucleation of new actin filaments
2001
Rac2 is critical for neutrophil primary granule exocytosis
2004
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Free Radicals in the Physiological Control of Cell Function
2002 Standout
A New Approach to Mineralization of Biocompatible Hydrogel Scaffolds: An Efficient Process toward 3-Dimensional Bonelike Composites
2003 StandoutNobel
Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins
2002
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Rac1 Deletion in Mouse Neutrophils Has Selective Effects on Neutrophil Functions
2003
Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis
2007
Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton
2006
RhoA is required for monocyte tail retraction during transendothelial migration
2001
Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex
1999
Works of Simon J. Atkinson being referenced
Rac GTPase Isoform-specific Regulation of NADPH Oxidase and Chemotaxis in Murine Neutrophils in Vivo
2004
Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis
2001
Rac Activation Induces NADPH Oxidase Activity in Transgenic COS Cells, and the Level of Superoxide Production Is Exchange Factor-dependent
2002
Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense
1999
aPKC-PAR complex dysfunction and tight junction disassembly in renal epithelial cells during ATP depletion
2006
Myosin II Light Chain Phosphorylation Regulates Membrane Localization and Apoptotic Signaling of Tumor Necrosis Factor Receptor-1
2001
Identification of futility in intensive care
1994
siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury
2009
Loop 6 of RhoA Confers Specificity for Effector Binding, Stress Fiber Formation, and Cellular Transformation
1999
Rac2 Regulates Neutrophil Chemotaxis, Superoxide Production, and Myeloid Colony Formation through Multiple Distinct Effector Pathways
2005
FcγR-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome
2008
The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcγIIA receptor–induced phagocytosis
2006
Role for p40phox in Fcγ-Receptor-Induced NADPH Oxidase Activation.
2004
Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.
2000 StandoutNobel
Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose.
1994
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization
2001
Functional studies of the kidney of living animals using multicolor two-photon microscopy
2002
Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases
2003 Science
Sequences, structural models, and cellular localization of the actin-related proteins Arp2 and Arp3 from Acanthamoeba.
1995
Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils
2006
Role of Rho in Ca2+-insensitive contraction and paxillin tyrosine phosphorylation in smooth muscle
2000
Rac2-Deficient Murine Macrophages Have Selective Defects in Superoxide Production and Phagocytosis of Opsonized Particles
2004
Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion
1998
The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization
2002
Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions
1998