Standout Papers
Citation Impact
Citing Papers
Atomic-Level Characterization of the Structural Dynamics of Proteins
2010 StandoutScienceNobel
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
Origins of Specificity in Protein-DNA Recognition
2010
Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å
1991 StandoutScience
Generation of protein-derived redoxcofactors by posttranslational modification
2010
Copper—A “Modern” Bioelement
1996
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Improving the antigen affinity of an antibody Fv-fragment by protein design
1992
Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid
1988 Nature
Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling
2005
Cu(I)-dependent Biogenesis of the Galactose Oxidase Redox Cofactor
2003
Peptide-binding specificity of the molecular chaperone BiP
1991 StandoutNatureNobel
Copper-containing amine oxidases. Biogenesis and catalysis; a structural perspective
2004
Copper-tyrosyl radical enzymes
2003
Three-dimensional structures of the free and the antigen-complexed Fab from monoclonal anti-lysozyme antibody D44.1
1994
Reticular synthesis and the design of new materials
2003 StandoutNatureNobel
NMR structure of the mouse prion protein domain PrP(121–231)
1996 StandoutNatureNobel
Crystal structure of myoglobin form a synthetic gene
1990
Identification of Catalytic Residues in Glyoxal Oxidase by Targeted Mutagenesis
1999
Interior and surface of monomeric proteins
1987
Structural Characterization of the Copper Site in Galactose Oxidase Using X-ray Absorption Spectroscopy
1994
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Exploring Molecular Oxygen Pathways in Hansenula polymorpha Copper-containing Amine Oxidase
2007
Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli
1989 StandoutNatureNobel
Crystallographic investigations of the tryptophan‐derived cofactor in the quinoprotein methylamine dehydrogenase
1991
Three‐dimensional structure of a fluorescein–Fab complex crystallized in 2‐methyl‐2,4‐pentanediol
1989
Identification of the residues in human CD4 critical for the binding of HIV
1989 StandoutNobel
The 1.23 Å structure ofPichia pastorislysyl oxidase reveals a lysine–lysine cross-link
2006
Mechanism of post-translational quinone formation in copper amine oxidases and its relationship to the catalytic turnover
2004
Structural basis for initiation of transcription from an RNA polymerase–promoter complex
1999 StandoutNatureNobel
Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution
2001 StandoutNatureNobel
Predicting antibody hypervariable loop conformations II: Minimization and molecular dynamics studies of MCPC603 from many randomly generated loop conformations
1986
A surface expression vector for antibody screening
1991
Solution structure of the single-strand break repair protein XRCC1 N-terminal domain.
1999
Synthetic models of the active site of catechol oxidase: mechanistic studies
2006
Complexes of the copper-containing amine oxidase fromArthrobacter globiformiswith the inhibitors benzylhydrazine and tranylcypromine
2008
Expression of an antibody Fv fragment in myeloma cells
1988 StandoutNobel
Crystal structure of the human vascular adhesion protein‐1: Unique structural features with functional implications
2005
Reshaping human antibodies for therapy
1988 StandoutNatureNobel
Crystal structure of a plant catechol oxidase containing a dicopper center
1998
Glyoxal Oxidase from Phanerochaete chrysosporium Is a New Radical-Copper Oxidase
1996
Less Symmetrical Dicopper(II ) Complexes as Catechol Oxidase Models—An Adjacent Thioether Group Increases Catecholase Activity
2004
Antibody framework residues affecting the conformation of the hypervariable loops
1992 StandoutNobel
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
Electrostatic calculations of side-chain pKa values in myoglobin and comparison with NMR data for histidines
1993
Modeling of loops in protein structures
2000 Standout
Structural studies of protein–nucleic acid interaction: the sources of sequence-specific binding
1990 StandoutNobel
Accurate modeling of protein conformation by automatic segment matching
1992
Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3Å resolution
1985 StandoutNatureNobel
DNA recognition by β-sheets in the Arc represser–operator crystal structure
1994 Nature
THE ROLE OF REDOX‐ACTIVE AMINO ACIDS IN THE PHOTOSYNTHETIC WATER‐OXIDIZING COMPLEX
1993
Crystal structure of the Hhal DNA methyltransferase complexed with S-adenosyl-l-methionine
1993 StandoutNobel
Canonical structures for the hypervariable regions of immunoglobulins
1987
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Searching protein structure databases has come of age
1994
The structure of the G protein heterotrimer Giα1β1γ2
1995 Nobel
Systematic development of computational models for the catalytic site in galactose oxidase: impact of outer-sphere residues on the geometric and electronic structures
2007
Biogenesis of Novel Quinone Coenzymes1
1995
[21] Tyrosyl radicals in photosystem II
1995
Crystal Structure of Amine Oxidase from Bovine Serum
2005
T-cell antigen receptor genes and T-cell recognition
1988 StandoutNature
A new crystal form of human vascular adhesion protein 1
2010
Conformations of immunoglobulin hypervariable regions
1989 StandoutNatureNobel
Biomimetic modeling of copper oxidase reactivity
2000
The copper-containing amine oxidase fromArthrobacter globiformis: refinement at 1.55 and 2.20 Å resolution in two crystal forms
2006
Biomimetic metal-radical reactivity: aerial oxidation of alcohols, amines, aminophenols and catechols catalyzed by transition metal complexes
2005
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 å resolution
1996
Aerobic oxidation of primary alcohols catalyzed by copper complexes of 1,10-phenanthroline-derived ligands
2012
A new method for building protein conformations from sequence alignments with homologues of known structure
1991
Neutron diffraction study of carbonmonoxymyoglobin
1991
Using Xenon as a Probe for Dioxygen-binding Sites in Copper Amine Oxidases
2004
RF3 Induces Ribosomal Conformational Changes Responsible for Dissociation of Class I Release Factors
2007 StandoutNobel
Three-Dimensional Structure of Antibodies
1988
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
1994 Standout
Phage antibodies: filamentous phage displaying antibody variable domains
1990 StandoutNatureNobel
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Oxygen Binding, Activation, and Reduction to Water by Copper Proteins
2001
A robust bulk-solvent correction and anisotropic scaling procedure
2005
A novel type of catalytic copper cluster in nitrous oxide reductase.
2000
Calculating three‐dimensional changes in protein structure due to amino‐acid substitutions: The variable region of immunoglobulins
1986
Co-crystal structure of TBP recognizing the minor groove of a TATA element
1993 Nature
Neutron Laue diffractometry with an imaging plate provides an effective data collection regime for neutron protein crystallography
1997
Crystal Structure of Agaricus bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone
2011
Structure of human semicarbazide-sensitive amine oxidase/vascular adhesion protein-1
2005
Enzymes and associated electron transport systems that catalyse the respiratory reduction of nitrogen oxides and oxyanions
1995
Structure of antibody hypervariable loops reproduced by a conformational search algorithm
1988 Nature
Making antibody fragments using phage display libraries
1991 StandoutNatureNobel
Nucleases: diversity of structure, function and mechanism
2010
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Galactose Oxidase Model: Biomimetic Enantiomer‐Differentiating Oxidation of Alcohols by a Chiral Copper Complex
2008
Oxygen-18 kinetic isotope effects in the dopamine .beta.-monooxygenase reaction: Evidence for a new chemical mechanism in non-heme, metallomonooxygenase
1994
Copper amine oxidase: a novel use for a tyrosine
1995
Ligand interactions with galactose oxidase: mechanistic insights
1993
X-ray snapshots of quinone cofactor biogenesis in bacterial copper amine oxidase
2002
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
Trapping of a Dopaquinone Intermediate in the TPQ Cofactor Biogenesis in a Copper-Containing Amine Oxidase fromArthrobacterglobiformis
2007
Knowledge-based prediction of protein structures and the design of novel molecules
1987 Nature
Modelling of the combining sites of three anti-lysozyme monoclonal antibodies and of the complex between one of the antibodies and its epitope.
1986
Mutation at a Strictly Conserved, Active Site Tyrosine in the Copper Amine Oxidase Leads to Uncontrolled Oxygenase Activity
2010
Reshaping Human Antibodies: Grafting an Antilysozyme Activity
1988 StandoutScienceNobel
Dioxygen Binds End-On to Mononuclear Copper in a Precatalytic Enzyme Complex
2004 Science
Copper K-extended x-ray absorption fine structure studies of oxidized and reduced dopamine beta-hydroxylase. Confirmation of a sulfur ligand to copper(I) in the reduced enzyme.
1991
Tyrosine codon corresponds to topa quinone at the active site of copper amine oxidases.
1992
Three-dimensional structure of Fab R19.9, a monoclonal murine antibody specific for the p-azobenzenearsonate group.
1989
Spectroscopic and Electronic Structure Studies of Phenolate Cu(II) Complexes: Phenolate Ring Orientation and Activation Related to Cofactor Biogenesis
2008
Volume changes in protein evolution
1994
Side-On Copper-Nitrosyl Coordination by Nitrite Reductase
2004 Science
Antibody–antigen flexibility
1987 StandoutNatureNobel
Multicopper Oxidases and Oxygenases
1996 Standout
Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex.
1989
Oxidations by copper metalloenzymes and some biomimetic approaches
1998
Structure and Spectroscopy of Copper−Dioxygen Complexes
2004 Standout
Copper Active Sites in Biology
2014 Standout
Detecting Subtle Sequence Signals: a Gibbs Sampling Strategy for Multiple Alignment
1993 Science
Enhanced visibility of hydrogen atoms by neutron crystallography on fully deuterated myoglobin
2000 StandoutNobel
Second Generation Light-Driven Molecular Motors. Unidirectional Rotation Controlled by a Single Stereogenic Center with Near-Perfect Photoequilibria and Acceleration of the Speed of Rotation by Structural Modification
2002 StandoutNobel
Aerobic Oxidation of Primary Alcohols (Including Methanol) by Copper(II)− and Zinc(II)−Phenoxyl Radical Catalysts
1999
Assignment of resonances in the 1H nuclear magnetic resonance spectrum of the carbon monoxide complex of sperm whale myoglobin by phase-sensitive two-dimensional techniques
1987
Structure of bovine pancreatic trypsin inhibitor
1984 StandoutNobel
Quality Control by DNA Repair
1999 StandoutScienceNobel
Structural and Functional Aspects of Metal Sites in Biology
1996 Standout
The Role of Protein Crystallography in Defining the Mechanisms of Biogenesis and Catalysis in Copper Amine Oxidase
2012
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Mapping epitopes and antigenicity by site-directed masking
2006 StandoutNobel
Cloning, sequencing, expression, and regulation of the structural gene for the copper/topa quinone-containing methylamine oxidase from Arthrobacter strain P1, a gram-positive facultative methylotroph
1993
Synthetic Models of the Inactive Copper(II)−Tyrosinate and Active Copper(II)−Tyrosyl Radical Forms of Galactose and Glyoxal Oxidases
1997
Crystal structure of a quinoenzyme: copper amine oxidase of Escherichia coli at 2 å resolution
1995
Kinetic and Structural Analysis of Substrate Specificity in Two Copper Amine Oxidases from Hansenula polymorpha
2010
Enantiomer-Specific Binding of Ruthenium(II) Molecular Wires by the Amine Oxidase of Arthrobacter globiformis
2008
An enantiopure galactose oxidase model: synthesis of chiral amino alcohols through oxidative kinetic resolution catalyzed by a chiral copper complex
2009
Spectro-electrochemical and DFT studies of a planar Cu(II)–phenolate complex active in the aerobic oxidation of primary alcohols
2011
Role of Copper Ion in Bacterial Copper Amine Oxidase: Spectroscopic and Crystallographic Studies of Metal-Substituted Enzymes
2003
Mechanisms of Antibody Binding to a Protein
1987 Science
Three-dimensional structure of an antibody-antigen complex.
1987
Copper(I)−Dioxygen Reactivity of [(L)CuI]+ (L = Tris(2-pyridylmethyl)amine): Kinetic/Thermodynamic and Spectroscopic Studies Concerning the Formation of Cu−O2 and Cu2−O2 Adducts as a Function of Solvent Medium and 4-Pyridyl Ligand Substituent Variations
2003
Functional Analogues of Cytochrome c Oxidase, Myoglobin, and Hemoglobin
2003
Ten Years of a Biomimetic Approach to the Copper(II) Radical Site of Galactose Oxidase
2007
Making Antibodies by Phage Display Technology
1994 StandoutNobel
Binding of CO to Myoglobin from a Heme Pocket Docking Site to Form Nearly Linear Fe-C-O
1995 Science
Isotopic Probing of Molecular Oxygen Activation at Copper(I) Sites
2007
Evidence Against Reduction of Cu2+ to Cu+ during Dioxygen Activation in a Copper Amine Oxidase from Yeast
2000
Aerobic Copper-Catalyzed Organic Reactions
2013 Standout
Intramolecular electron transfer rate between active-site copper and topa quinone in pea seedling amine oxidase.
1993
The role of the α-helix dipole in protein function and structure
1985
Identification of Two Imidazole Binding Sites and Key Residues for Substrate Specificity in Human Primary Amine Oxidase AOC3
2011
Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°
1991 StandoutScienceNobel
"Diabodies": small bivalent and bispecific antibody fragments.
1993 StandoutNobel
Protein Structure Prediction and Structural Genomics
2001 StandoutScienceNobel
Supramolecular chemistry ? Scope and perspectives: Molecules ? Supermolecules ? Molecular devices
1988 Nobel
Crystal Structures of an Antibody to a Peptide and Its Complex with Peptide Antigen at 2.8 Å
1990 Science
The Structure of Bound Water and Refinement of Acid Metmyoglobin
1984
Intrigues and Intricacies of the Biosynthetic Pathways for the Enzymatic Quinocofactors: PQQ, TTQ, CTQ, TPQ, and LTQ
2013
Mechanisms Whereby Mononuclear Copper Proteins Functionalize Organic Substrates
1996 Standout
Dioxygen Activation at a Single Copper Site: Structure, Bonding, and Mechanism of Formation of 1:1 Cu−O2 Adducts
2004
Aerial oxidation of primary alcohols and amines catalyzed by Cu(ii ) complexes of 2,2′-selenobis(4,6-di-tert-butylphenol) providing [O,Se,O]-donor atoms
2004
Synthetic Models for Heme−Copper Oxidases
2004
Post-Translational His-Cys Cross-Linkage Formation in Tyrosinase Induced by Copper(II)−Peroxo Species
2011
Structure and Inhibition of Human Diamine Oxidase
2009
Differential Reactivity between Two Copper Sites in Peptidylglycine α-Hydroxylating Monooxygenase
2010
Selective Light Supported Oxidation of Hexoses Using Air as Oxidant – Synthesis of Tetrahydroxyazepanes
2007
Catalytic Galactose Oxidase Models: Biomimetic Cu(II)-Phenoxyl-Radical Reactivity
1998 Science
Structure and Activity of Aspergillus nidulans Copper Amine Oxidase
2011
Structure of the Oxidized Active Site of Galactose Oxidase from Realistic In Silico Models
2006
Catalytic oxidations mediated by metal ions and nitroxyl radicals
2006
Catalytic Mechanism of Galactose Oxidase: A Theoretical Study
2000
Three-dimensional structure of a complex of antibody with influenza virus neuraminidase
1987 Nature
Catalytic Reaction Profile for Alcohol Oxidation by Galactose Oxidase
2001
A New Cofactor in a Prokaryotic Enzyme: Tryptophan Tryptophylquinone as the Redox Prosthetic Group in Methylamine Dehydrogenase
1991 Science
Mononuclear Cu–O2 Complexes: Geometries, Spectroscopic Properties, Electronic Structures, and Reactivity
2007
Structure of Escherichia coli ribosomal protein L25 complexed with a 5S rRNA fragment at 1.8-Å resolution
2000 StandoutNobel
Correlation of Active Site Metal Content in Human Diamine Oxidase with Trihydroxyphenylalanine Quinone Cofactor Biogenesis,
2010
Protein Radicals in Enzyme Catalysis
1998 Standout
Phosphocholine binding immunoglobulin Fab McPC603
1986
Tyrosine-Derived Quinone Cofactors
2004
Kinetics and Spectroscopic Evidence That the Cu(I)−Semiquinone Intermediate Reduces Molecular Oxygen in the Oxidative Half-Reaction of Arthrobacter globiformis Amine Oxidase
2008
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic β2-microglobulin variant
2011
Free Radical Catalysis by Galactose Oxidase
2003
Structure of bacteriophage T4 lysozyme refined at 1.7 Å resolution
1987
The relation between the divergence of sequence and structure in proteins.
1986 Standout
The Formation of Lysine Tyrosylquinone (LTQ) Is a Self-Processing Reaction. Expression and Characterization of a Drosophila Lysyl Oxidase
2005
Antigen specificity and cross-reactivity of monoclonal anti-lysozyme antibodies
1987
Galactose Oxidase Pro-Sequence Cleavage and Cofactor Assembly Are Self-Processing Reactions
2000
Molecular evolution of proteins on filamentous phage. Mimicking the strategy of the immune system.
1992 StandoutNobel
A Theoretical Study of the Mechanism for the Biogenesis of Cofactor Topaquinone in Copper Amine Oxidases
2004
Dioxygen Activation by Copper Complexes. Mechanistic Insights into Copper Monooxygenases and Copper Oxidases
2002
Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response.
1990 Nobel
Crystallographic refinement of the three-dimensional structure of the FabD1.3-lysozyme complex at 2.5-A resolution
1991
Works of Simon E. V. Phillips being referenced
The Stacking Tryptophan of Galactose Oxidase: A Second-Coordination Sphere Residue that Has Profound Effects on Tyrosyl Radical Behavior and Enzyme Catalysis ,
2007
Crystal structure of restriction endonuclease BglI bound to its interrupted DNA recognition sequence
1998
Polyanionic Inhibitors of Phosphoglycerate Mutase: Combined Structural and Biochemical Analysis
1999
Novel thioether bond revealed by a 1.7 Å crystal structure of galactose oxidase
1991 Nature
Galactose oxidase: Molecular analysis and mutagenesis studies
1993
Amine Oxidases and Galactose Oxidase
2000
Structure of a xenon derivative ofEscherichia colicopper amine oxidase: confirmation of the proposed oxygen-entry pathway
2008
Three-dimensional crystal structures of Escherichia coli met repressor with and without corepressor
1989 Nature
Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography
1992 Nature
Crystal Structure of Intact Elongation Factor EF-Tu from Escherichia coli in GDP Conformation at 2.05Å Resolution
1999
Medical implications from the crystal structure of a copper‐containing amine oxidase complexed with the antidepressant drug tranylcypromine
2004
The structural basis of Holliday junction resolution by T7 endonuclease I
2007 Nature
Three-dimensional structure of galactose oxidase: an enzyme with a built-in secondary cofactor
1992
Crystal structure of the met represser–operator complex at 2.8 Å resolution reveals DNA recognition by β-strands
1992 Nature
Enhanced Fructose Oxidase Activity in a Galactose Oxidase Variant
2004
Cooperative tandem binding of met repressor of Escherichia coli
1989 Nature
Crystal Structure of a Free Radical Enzyme, Galactose Oxidase
1994
Cofactor processing in galactose oxidase
2003
The Predicted Structure of Immunoglobulin D1.3 and Its Comparison with the Crystal Structure
1986 StandoutScienceNobel
Visualization of Dioxygen Bound to Copper During Enzyme Catalysis
1999 Science
Conserved Tyrosine-369 in the Active Site ofEscherichia coliCopper Amine Oxidase Is Not Essential,
2001
Cross-Link Formation of the Cysteine 228−Tyrosine 272 Catalytic Cofactor of Galactose Oxidase Does Not Require Dioxygen
2008
Crystal structure of the precursor of galactose oxidase: An unusual self-processing enzyme
2001
Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution
1986 Science
Crystal structure of monomeric human β-2-microglobulin reveals clues to its amyloidogenic properties
2002
Catalytic Mechanism of the Quinoenzyme Amine Oxidase from Escherichia coli: Exploring the Reductive Half-Reaction,
1997
Specific β-sheet interactions
1991
Structure and refinement of oxymyoglobin at 1·6 Å resolution
1980
Tyrosine 495 is a key residue in the active site of Galactose oxidase
1995
Three-dimensional structure of an antigen–antibody complex at 6 Å resolution
1985 Nature
Structure and mechanism of galactose oxidase: catalytic role of tyrosine 495
1997
Structure and mechanism of galactose oxidase. The free radical site.
1994
Neutron diffraction reveals oxygen–histidine hydrogen bond in oxymyoglobin
1981 Nature
Preliminary studies of two active site mutants of galactose oxidase
1993
Active Site Rearrangement of the 2-Hydrazinopyridine Adduct in Escherichia coli Amine Oxidase to an Azo Copper(II) Chelate Form: A Key Role for Tyrosine 369 in Controlling the Mobility of the TPQ−2HP Adduct
2005
The CO bond angle of carboxymyoglobin determined by angular-resolved XANES spectroscopy
1985 Nature
Probing the catalytic mechanism of Escherichia coli amine oxidase using mutational variants and a reversible inhibitor as a substrate analogue
2002
Investigation into the mechanism of λmax shifts and their dependence on pH for the 2-hydrazinopyridine derivatives of two copper amine oxidases
2000
Role of the Interactions between the Active Site Base and the Substrate Schiff Base in Amine Oxidase Catalysis. Evidence from Structural and Spectroscopic Studies of the 2-Hydrazinopyridine Adduct of Escherichia coli Amine Oxidase
2005
The Active Site Base Controls Cofactor Reactivity inEscherichia coliAmine Oxidase: X-ray Crystallographic Studies with Mutational Variants,
1999
Exploring the Roles of the Metal Ions in Escherichia coli Copper Amine Oxidase,
2010