Citation Impact
Citing Papers
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59
2012 StandoutNobel
Navigating the protein fitness landscape with Gaussian processes
2012 StandoutNobel
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
Protein stability promotes evolvability
2006 StandoutNobel
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution
2007 StandoutNobel
“Allosterism” in the Elementary Steps of the Cytochrome P450 Reaction Cycle
2004
Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450
2006 StandoutNobel
Metal-Substituted Protein MRI Contrast Agents Engineered for Enhanced Relaxivity and Ligand Sensitivity
2010 StandoutNobel
MECHANISTIC ENZYMOLOGY OF OXYGEN ACTIVATION BY THE CYTOCHROMES P450
2002
Dynamic Covalent Chemistry
2002 StandoutNobel
Cytochrome P450: taming a wild type enzyme
2011 StandoutNobel
Regioselective o‐Hydroxylation of Monosubstituted Benzenes by P450 BM3
2013
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Thermostabilization of a Cytochrome P450 Peroxygenase
2003 StandoutNobel
Direct Conversion of Ethane to Ethanol by Engineered Cytochrome P450 BM3
2005 StandoutNobel
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
Nitric oxide synthases: structure, function and inhibition
2001 Standout
Unusual Cytochrome P450 Enzymes and Reactions
2013
Genetically programmed chiral organoborane synthesis
2017 StandoutNatureNobel
Functional Evolution and Structural Conservation in Chimeric Cytochromes P450
2004 StandoutNobel
Practical issues in the application of oxygenases
2003
Enzymatic activation of nitro-aryl fluorogens in live bacterial cells for enzymatic turnover-activated localization microscopy
2012 StandoutNobel
Redox properties of cytochrome P450BM3 measured by direct methods
2003
Enhancing the Efficiency and Regioselectivity of P450 Oxidation Catalysts by Unnatural Amino Acid Mutagenesis
2014
P450BM3(CYP102A1): connecting the dots
2011
Enantioselective Epoxidation of Terminal Alkenes to (R)‐ and (S)‐Epoxides by Engineered Cytochromes P450 BM‐3
2005 StandoutNobel
Protein engineering of Bacillus megaterium CYP102
2001
Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine
2010 StandoutNobel
A hydrogen bond network in the active site of Anabaena ferredoxin-NADP+ reductase modulates its catalytic efficiency
2013
Structure?function studies on nitric oxide synthases
2004
What makes a P450 tick?
2013
Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran
2014 StandoutNobel
The thermodynamics and kinetics of electron transfer in the cytochrome P450cam enzyme system
1999
Fatty acid metabolism, conformational change, and electron transfer in cytochrome P-450BM-3
1999
Microbial P450 enzymes in biotechnology
2004
Scanning chimeragenesis: the approach used to change the substrate selectivity of fatty acid monooxygenase CYP102A1 to that of terpene ω-hydroxylase CYP4C7
2009
A Structural Role for Tryptophan 188 of Inducible Nitric Oxide Synthase
2001
Unusually Broad Substrate Profile of Self‐Sufficient Cytochrome P450 Monooxygenase CYP116B4 from Labrenzia aggregata
2014
Models and mechanisms of O‐O bond activation by cytochrome P450
2004
Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants
2005
Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties
2007 StandoutNobel
Electron transfer in the ruthenated heme domain of cytochrome P450BM‐3
2000
Enantioselective α-Hydroxylation of 2-Arylacetic Acid Derivatives and Buspirone Catalyzed by Engineered Cytochrome P450 BM-3
2006 StandoutNobel
Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran
2014 StandoutNobel
In the light of directed evolution: Pathways of adaptive protein evolution
2009 StandoutNobel
Expression, Purification, and Characterization of Bacillus subtilis Cytochromes P450 CYP102A2 and CYP102A3: Flavocytochrome Homologues of P450 BM3 from Bacillus megaterium
2004
Photoswitchable Intramolecular H-Stacking of Perylenebisimide
2010 StandoutNobel
Electron Transfer in Flavocytochrome P450 BM3: Kinetics of Flavin Reduction and Oxidation, the Role of Cysteine 999, and Relationships with Mammalian Cytochrome P450 Reductase
2003
Tuning P450 Enzymes as Oxidation Catalysts
2012
Rewiring the “Push-Pull” Catalytic Machinery of a Heme Enzyme Using an Expanded Genetic Code
2020
Undirected, Homogeneous C–H Bond Functionalization: Challenges and Opportunities
2016
Dynamic determination of the functional state in photolyase and the implication for cryptochrome
2013 StandoutNobel
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes
2009
Theoretical Insights into the Mechanism and Stereoselectivity of Olefin Cyclopropanation Catalyzed by Two Engineered Cytochrome P450 Enzymes
2018
Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer
2014 StandoutNobel
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
2017 StandoutNobel
General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH
2013 StandoutNobel
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Artificial Molecular Machines
2000 StandoutNobel
Small-Molecule Labeling of Live Cell Surfaces for Three-Dimensional Super-Resolution Microscopy
2014 StandoutNobel
Protein−Surfactant Film Voltammetry of Wild-Type and Mutant Cytochrome P450 BM3
2005 StandoutNobel
A family of thermostable fungal cellulases created by structure-guided recombination
2009 StandoutNobel
Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties
2007 StandoutNobel
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes
2016 StandoutNobel
Trapping a transition state in a computationally designed protein bottle
2015 StandoutScienceNobel
Engineering Cytochrome P450 BM3 for Terminal Alkane Hydroxylation
2006 StandoutNobel
Heme Protein Assemblies
2004
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
On the conservative nature of intragenic recombination
2005 StandoutNobel
Structure of a cytochrome P450–redox partner electron-transfer complex
1999
Bioinspired Metal–Organic Framework Catalysts for Selective Methane Oxidation to Methanol
2018 StandoutNobel
Reduction of Dioxygen Catalyzed by Pyrene-Wired Heme Domain Cytochrome P450 BM3 Electrodes
2004 StandoutNobel
Rate-Limiting Steps in Cytochrome P450 Catalysis
2002
Interaction of NADP(H) with Oxidized and Reduced P450 Reductase during Catalysis. Studies with Nucleotide Analogues
2000
Roles of key active-site residues in flavocytochrome P450 BM3
1999
Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design
2015 StandoutNobel
Methane-Oxidizing Enzymes: An Upstream Problem in Biological Gas-to-Liquids Conversion
2016
Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3
2003 StandoutNobel
Redox Function of Tetrahydrobiopterin and Effect of l -Arginine on Oxygen Binding in Endothelial Nitric Oxide Synthase
2004
Flavocytochrome P450 BM3: an update on structure and mechanism of a biotechnologically important enzyme
2005
Thermodynamic and Biophysical Characterization of Cytochrome P450 BioI from Bacillus subtilis
2004
Expanding the toolbox of organic chemists: directed evolution of P450 monooxygenases as catalysts in regio- and stereoselective oxidative hydroxylation
2014
Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions
2018 StandoutNobel
Phenylalanine 393 Exerts Thermodynamic Control over the Heme of Flavocytochrome P450 BM3
2001
Determining complete electron flow in the cofactor photoreduction of oxidized photolyase
2013 StandoutNobel
What Makes the Difference between a Cryptochrome and DNA Photolyase? A Spectroelectrochemical Comparison of the Flavin Redox Transitions
2008
Phe393 Mutants of Cytochrome P450 BM3 with Modified Heme Redox Potentials Have Altered Heme Vinyl and Propionate Conformations
2004
Functional Interactions in Cytochrome P450BM3. Evidence That NADP(H) Binding Controls Redox Potentials of the Flavin Cofactors
2000
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins
2017 StandoutNobel
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
2017 StandoutNobel
Structure and Chemistry of Cytochrome P450
2005 Standout
From Enzyme to Molecular Device. Exploring the Interdependence of Redox and Molecular Recognition
1998
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of Simon Daff being referenced
The unusual redox properties of flavocytochrome P450 BM3 flavodoxin domain
2004
4-Cyanopyridine, a Versatile Spectroscopic Probe for Cytochrome P450 BM3
2004
CO binding studies of nitric oxide synthase: effects of the substrate, inhibitors and tetrahydrobiopterin
1998
Aromatic Residues and Neighboring Arg414 in the (6R)-5,6,7,8-Tetrahydro-l-Biopterin Binding Site of Full-length Neuronal Nitric-oxide Synthase Are Crucial in Catalysis and Heme Reduction with NADPH
2000
Calmodulin Activates Electron Transfer through Neuronal Nitric-oxide Synthase Reductase Domain by Releasing an NADPH-dependent Conformational Lock
2002
Marked Enhancement in the Reductive Dehalogenation of Hexachloroethane by a Thr319Ala Mutation of Cytochrome P450 1A2
1998
Crucial Role of Lys423 in the Electron Transfer of Neuronal Nitric-oxide Synthase
1999
Roles of the heme proximal side residues tryptophan409 and tryptophan421 of neuronal nitric oxide synthase in the electron transfer reaction
2000
The 42-Amino Acid Insert in the FMN Domain of Neuronal Nitric-oxide Synthase Exerts Control over Ca2+/Calmodulin-dependent Electron Transfer
1999
Probing Electron Transfer in Flavocytochrome P‐450 BM3 and Its Component Domains
1996
P450 BM3: the very model of a modern flavocytochrome
2002
The role of Thr268 and Phe393 in cytochrome P450 BM3
2006
Flavocytochrome P-450 BM3: a paradigm for the analysis of electron transfer and its control in the P-450s
1999
Flavin to haem electron transfer in flavocytochrome b2
1994
Potentiometric Analysis of the Flavin Cofactors of Neuronal Nitric Oxide Synthase
1999
95 Probing inter-domain electron transfer in a model flavocytochrome P-450
1997
An Appraisal of Multiple NADPH Binding-Site Models Proposed for Cytochrome P450 Reductase, NO Synthase, and Related Diflavin Reductase Systems
2004
Steady-State and Stopped-Flow Kinetic Studies of Three Escherichia coli NfsB Mutants with Enhanced Activity for the Prodrug CB1954
2009
Determination of the Redox Properties of Human NADPH-Cytochrome P450 Reductase
2001
Redox Control of the Catalytic Cycle of Flavocytochrome P-450 BM3
1997
Oxygen Activation and Electron Transfer in Flavocytochrome P450 BM3
2003