Citation Impact
Citing Papers
Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment
2018 StandoutNobel
Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix
2009
Estrogen Receptors: How Do They Signal and What Are Their Targets
2007 Standout
Molecular imaging in living subjects: seeing fundamental biological processes in a new light
2003 Standout
β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation
2002 StandoutNobel
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
The Regulation of Chondrocyte Function by Proinflammatory Mediators
2004
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
2004 Standout
Rheumatoid arthritis
2016 Standout
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
2011 StandoutNobel
Signal integration by JNK and p38 MAPK pathways in cancer development
2009 Standout
Prognostic models for outcome following liver resection for colorectal cancer metastases: A systematic review
2011
Cellular senescence in aging and age-related disease: from mechanisms to therapy
2015 Standout
Articular Cartilage Injuries
2002
1,2,3,4-Tetrahydroquinoline-containing αVβ3 integrin antagonists with enhanced oral bioavailability
2004
Intraarticular injection of heparin‐binding insulin‐like growth factor 1 sustains delivery of insulin‐like growth factor 1 to cartilage through binding to chondroitin sulfate
2010
Targeting proteases: successes, failures and future prospects
2006
Control of fibroblast‐like synoviocyte proliferation by macrophage migration inhibitory factor
2003
Mitogen activated protein kinase inhibitors: where are we now and where are we going?
2006
Wnt signaling in osteoblasts and bone diseases
2004
Piperidine-containing β-arylpropionic acids as potent antagonists of αvβ3/αvβ5 integrins
2004
Raloxifene, a Selective Estrogen Receptor Modulator, Reduces Carrageenan-Induced Acute Inflammation in Normal and Ovariectomized Rats
2005
The Pathogenesis of Rheumatoid Arthritis
2011 Standout
The role of synovitis in osteoarthritis pathogenesis
2012
Osteoporosis: now and the future
2011 Standout
Transport of anti-IL-6 antigen binding fragments into cartilage and the effects of injury
2013
Osteoarthritis
2015 Standout
Cathepsin K inhibitors as treatment of bone metastasis
2008
Skeletal remodeling in health and disease
2007 Standout
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
2010 Standout
WNT signaling in bone homeostasis and disease: from human mutations to treatments
2013 Standout
Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis
2010
Intraocular injection of tamoxifen‐loaded nanoparticles: a new treatment of experimental autoimmune uveoretinitis
2004
Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis
2013 StandoutNobel
Differential effects of estrogen in the injured forebrain of young adult and reproductive senescent animals
2003
Phosphorylation and Functional Inactivation of TSC2 by Erk
2005 Standout
Progress and problems in the exploration of therapeutic targets
2006
Evidence that cytokines play a role in rheumatoid arthritis
2008
Intra‐articular depot formulation principles: Role in the management of postoperative pain and arthritic disorders
2008
Gene mediated insulin‐like growth factor‐I delivery to the synovium
2001
Endocrine Regulation of Energy Metabolism by the Skeleton
2007 Standout
Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines
2011
The Involvement of the Apoptosis-Modulating Proteins ERK 1/2, Bcl-xL and Bax in the Resolution of Acute Inflammation in Vivo
2006
Lipoprotein oxidation and gene expression in the artery wall
1993
SAR of 3,4-Dihydropyrido[3,2-d]pyrimidone p38 inhibitors
2003
p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases
2003
Therapeutic strategies for rheumatoid arthritis
2003
Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent
2003
Adipocyte differentiation from the inside out
2006 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Sex differences in immune responses
2016 Standout
Expression of mitogen‐activated protein kinase phosphatase 1, a negative regulator of the mitogen‐activated protein kinases, in rheumatoid arthritis: Up‐regulation by interleukin‐1β and glucocorticoids
2004
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
2009 Standout
Beneficial effects of estrogen treatment in the HLA-B27 transgenic rat model of inflammatory bowel disease
2004
Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints
2005
Structure–activity studies of cyclic ketone inhibitors of the serine protease plasmin: Design, synthesis, and biological activity
2006
Prevention of the onset and progression of collagen‐induced arthritis in rats by the potent p38 mitogen‐activated protein kinase inhibitor FR167653
2003
New developments in osteoarthritis: Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options
2010
Genetic regulation of osteoclast development and function
2003
The Stability of the G Protein-coupled Receptor-β-Arrestin Interaction Determines the Mechanism and Functional Consequence of ERK Activation
2003 StandoutNobel
Time, stress, and location dependent chondrocyte death and collagen damage in cyclically loaded articular cartilage
2003
Post‐traumatic osteoarthritis: The role of accelerated chondrocyte senescence
2004
The Long-term Consequence of Anterior Cruciate Ligament and Meniscus Injuries
2007 Standout
The Complex Role of Estrogens in Inflammation
2007 Standout
The Protective Role of Endogenous Estrogens in Carrageenan-Induced Lung Injury in the Rat
2001
Large-scale synthesis of SB-462795, a cathepsin K inhibitor: the RCM-based approaches
2009
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD): Explanation and Elaboration
2015 Standout
The role of the chondrocyte in osteoarthritis
2000
Adipokines in Arthritis: New Kids on the Block
2009
Diagnosis and Treatment of Hip and Knee Osteoarthritis
2021 Standout
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
2001 Standout
Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease
2011
Estrogen Receptor-β: Recent Lessons from in Vivo Studies
2006
Atherosclerosis: Basic Mechanisms
1995 Standout
Osteoclastogenesis, Bone Resorption, and Osteoclast-Based Therapeutics
2003
New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
2009 Standout
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
MIF Signal Transduction Initiated by Binding to CD74
2003 Standout
The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
2002 StandoutNobel
Trk Receptors: Roles in Neuronal Signal Transduction
2003 Standout
Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
Transition-Metal-Catalyzed C−S, C−Se, and C−Te Bond Formation via Cross-Coupling and Atom-Economic Addition Reactions
2011 Standout
IL-1 mediates TNF-induced osteoclastogenesis
2005 Standout
Identification of Selective, Nonpeptidic Nitrile Inhibitors of Cathepsin S Using the Substrate Activity Screening Method
2006
Microwave-Assisted Synthesis in Water as Solvent
2007 Standout
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
2005 Standout
Secreted Frizzled-Related Protein-1 Inhibits RANKL-Dependent Osteoclast Formation
2004
Early Prediction of Severity in Acute Pancreatitis Using Infrared Spectroscopy of Serum
2007
Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
2011 Standout
Activatable Photosensitizers for Imaging and Therapy
2010 Standout
IFN-γ Induces High Mobility Group Box 1 Protein Release Partly Through a TNF-Dependent Mechanism
2003
Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications
2012 Standout
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Odanacatib, a cathepsin-K inhibitor for osteoporosis: A two-year study in postmenopausal women with low bone density
2009
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Development of a Robust Ring-Closing Metathesis Reaction in the Synthesis of SB-462795, a Cathepsin K Inhibitor
2008
p38 MAP kinase inhibitors: A future therapy for inflammatory diseases
2006
Mice Lacking Cathepsin K Maintain Bone Remodeling but Develop Bone Fragility Despite High Bone Mass
2006
Osteoarthritis: an update with relevance for clinical practice
2011 Standout
Matrix Metalloproteinases: Role In Arthritis
2006
An Efficient Route to 4-Aryl-5-pyrimidinylimidazoles via Sequential Functionalization of 2,4-Dichloropyrimidine
2005
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Micro-CT in small animal and specimen imaging
2002
Works of Simon Blake being referenced
Antifibrotic action of interleukin-1 receptor antagonist in lapine monoarticular arthritis.
1995
A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat
2002
Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis
2000
In Situ Hybridisation for Decorin mRNA in Rabbit Syniovium During Antigen-Induced Arthritis
1993
Disease-modifying activity of SB 273005, an orally active, nonpeptide ?v?3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis
2001
Injurious Mechanical Compression of Bovine Articular Cartilage Induces Chondrocyte Apoptosis
2000
What next for rheumatoid arthritis therapy?
2004
Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13
2008
FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis
2000
Therapeutic potential of cytokine manipulation
1992
Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro
2008
A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys
2006
Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: Interaction with exogenous cytokines
2003
Outcome Analysis of Patients with Acute Pancreatitis by Using an Artificial Neural Network
2002
Mechanical injury potentiates proteoglycan catabolism induced by interleukin‐6 with soluble interleukin‐6 receptor and tumor necrosis factor α in immature bovine and adult human articular cartilage
2009
Idoxifene, a Novel Selective Estrogen Receptor Modulator, Is Effective in a Rat Model of Adjuvant-Induced Arthritis
1999
Azepanone-Based Inhibitors of Human Cathepsin L
2005
Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate
2001