Standout Papers
- A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo (1989)
- cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos (1991)
- The functional domains of the Drosophila morphogen dorsal: evidence from the analysis of mutants. (1992)
Citation Impact
Citing Papers
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
A Function for Kinesin I in the Posterior Transport of oskar mRNA and Staufen Protein
2000 Science
IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System
1993
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
In Vivo Regulation of the IκB Homologue cactus during the Immune Response of Drosophila
1998 StandoutNobel
Direct and continuous assessment by cells of their position in a morphogen gradient
1995 StandoutNatureNobel
Drosophila Immunity: A Comparative Analysis of the Rel Proteins Dorsal and Dif in the Induction of the Genes Encoding Diptericin and Cecropin
1996
Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation
1999
Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA
1999
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
2010 Standout
Widespread mRNA Association with Cytoskeletal Motor Proteins and Identification and Dynamics of Myosin-Associated mRNAs in S. cerevisiae
2012 StandoutNobel
Robustness of the BMP morphogen gradient in Drosophila embryonic patterning
2002 Nature
Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg
1992 StandoutNobel
Ventralizing signal determined by protease activation in Drosophila embryogenesis
1994 Nature
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
1997 StandoutNatureNobel
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs
1990 Nature
Extracellular proteases and embryonic pattern formation
1992
Drosophila gurken (TGFα) mRNA Localizes as Particles that Move within the Oocyte in Two Dynein-Dependent Steps
2003
Dynein Anchors Its mRNA Cargo after Apical Transport in the Drosophila Blastoderm Embryo
2005
NEW EMBO MEMBER'S REVIEW: Nuclear interpretation of Dpp signaling in Drosophila
2001
Dpp Gradient Formation in the Drosophila Wing Imaginal Disc
2000
DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide
1991
Regulation of Organ Growth by Morphogen Gradients
2009
Krapfen/dMyd88 is required for the establishment of dorsoventral pattern in the Drosophila embryo
2003 Nobel
Mutational analysis of the Drosophila snake protease: an essential role for domains within the proenzyme polypeptide chain.
1994
Morphogen gradients: new insights from DPP
1999
decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo
1992
The Rel Protein DIF Mediates the Antifungal but Not the Antibacterial Host Defense in Drosophila
2000 StandoutNobel
Drosophila Squid/hnRNP Helps Dynein Switch from a gurken mRNA Transport Motor to an Ultrastructural Static Anchor in Sponge Bodies
2007
The Expanding Social Network of Ionotropic Glutamate Receptors: TARPs and Other Transmembrane Auxiliary Subunits
2011
The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in drosophila
1991
IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: A new member of the IκB family
1992
The Cytoplasmic Dynein and Kinesin Motors Have Interdependent Roles in Patterning the Drosophila Oocyte
2002
The dorsal protein enhances the biosynthesis and stability of theDrosophilaIkB homologue cactus
1995
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
1996 StandoutNobel
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
Direct and Long-Range Action of a Wingless Morphogen Gradient
1996
Multiple Kinesin Motors Coordinate Cytoplasmic RNA Transport on a Subpopulation of Microtubules in Xenopus Oocytes
2008
2 Dorsal—Ventral Pattern Formation in the Drosophila Embryo: The Role of Zygotically Active Genes
1991
Activin signalling and response to a morphogen gradient
1994 StandoutNatureNobel
A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
1999
Molecular genetics of Drosophila immunity
1994
A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila
1996 Nobel
Cytoplasmic factors determining anteroposterior polarity in Drosophila embryos
1990
The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein 1
1991
The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila
1989
Cactus-independent regulation of Dorsal nuclear import by the ventral signal
2000
Morphogen gradients
2000
Drosophila innate immunity: an evolutionary perspective
2002 StandoutNobel
Structure of the Drosophila BicaudalD protein and its role in localizing the posterior determinant nanos
1989
The immune response of Drosophila
2003 StandoutNatureNobel
Weckle Is a Zinc Finger Adaptor of the Toll Pathway in Dorsoventral Patterning of the Drosophila Embryo
2006
The drosophila gastrulation gene concertina encodes a Gα-like protein
1991 StandoutNobel
Spatially localized rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis
1993 StandoutNobel
In Vivo Imaging of oskar mRNA Transport Reveals the Mechanism of Posterior Localization
2008
Control of development and immunity by Rel transcription factors in Drosophila
1999
Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox geneHox-#150;1.6
1992 StandoutNatureNobel
Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen
1993
Learning about cancer genes through invertebrate genetics
1992
Moving messages: the intracellular localization of mRNAs
2005
Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins
1992
The anaphase-promoting complex: it's not just for mitosis any more
2002
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections
2007 StandoutNobel
Wingless Repression of Drosophila frizzled 2 Expression Shapes the Wingless Morphogen Gradient in the Wing
1998
Dif, a dorsal-related gene that mediates an immune response in Drosophila
1993
Signal transduction by a protease cascade
1999
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
Proteolytic processing of the Drosophila Spätzle protein by Easter generates a dimeric NGF-like molecule with ventralising activity
1998
The inhibitory ankyrin and activator Rel proteins
1992 Nobel
The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo
1994
Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal
1990 Nobel
Problems and paradigms: Morphogens and pattern formation
1997
Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product
1991
Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity
1992 StandoutNobel
Dorsal-ventral polarity in the Drosophila embryo
1993
Postembryonic Hematopoiesis in Drosophila
2001
Regulated nuclear import of Rel proteins in the Drosophila immune response
1998 Nature
pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo
1993
mRNA Localization: Gene Expression in the Spatial Dimension
2009
Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons
1988
Dorsoventral pattern formation in Drosophila: signal transduction and nuclear targeting
1991
Cut2 proteolysis required for sister-chromatid separation in fission yeast
1996 StandoutNatureNobel
Synaptic AMPA receptor composition in development, plasticity and disease
2016
Dual Roles for Patched in Sequestering and Transducing Hedgehog
1996 Standout
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates
1992 StandoutNobel
Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo.
1993
Responses of embryonic xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm
1992
Dominant and recessive alleles of the Drosophila easter gene are point mutations at conserved sites in the serine protease catalytic domain
1990
The torso receptor localizes as well as transduces the spatial signal specifying terminal body pattern in Drosophila
1993 Nature
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis.
1992
The NF-kappa B p50 precursor, p105, contains an internal I kappa B-like inhibitor that preferentially inhibits p50.
1992 Nobel
Kap104p: A Karyopherin Involved in the Nuclear Transport of Messenger RNA Binding Proteins
1996 StandoutScienceNobel
Activation of the easter zymogen is regulated by five other genes to define dorsal-ventral polarity in the Drosophila embryo
1992
Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.
1996
The Drosophila membrane receptor Toll can function to promote cellular adhesion.
1990
Interactions of a Rel protein with its inhibitor.
1995
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1998 StandoutScienceNobel
Cactus protein degradation mediates Drosophila dorsal-ventral signaling.
1995
Separable and redundant regulatory determinants in Cactus mediate its dorsal group dependent degradation
2001
Specificity of Rel-Inhibitor Interactions in Drosophila Embryos
1995
The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo
1992 StandoutNobel
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Dpp signaling thresholds in the dorsal ectoderm of the Drosophila embryo
2000
bicoid and the terminal system activate tailless expression in the early Drosophila embryo
1992
PER Protein Interactions and Temperature Compensation of a Circadian Clock in Drosophila
1995 StandoutScienceNobel
A processed form of the Spätzle protein defines dorsal-ventral polarity in the Drosophila embryo
1994
An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo
1993
Spatial regulation of the gap gene giant during Drosophila development
1991
A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-kappa B.
1993
Rel/NF-κB double mutants reveal that cellular immunity is central to Drosophila host defense
2006
The future of cloning
1999 StandoutNatureNobel
A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis
1998
A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway
1996
Amino acids conserved in interleukin-1 receptors (IL-1Rs) and the Drosophila toll protein are essential for IL-1R signal transduction.
1992
A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast.
1992
A Spätzle-Processing Enzyme Required for Toll Signaling Activation in Drosophila Innate Immunity
2006
A General Mechanism for Network-Dosage Compensation in Gene Circuits
2010 StandoutScienceNobel
Multiple steps in the localization of bicoid RNA to the anterior pole of the Drosophila oocyte
1989 StandoutNobel
Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.
1995
The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos.
1991
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube
1998
Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila.
1995 StandoutNobel
The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product
1990
An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators
1997
Are Adult Learning Mechanisms Also Used for Development?
1992 StandoutScienceNobel
In vivo self-association of the Drosophila rel-protein dorsal.
1992
Plasma membrane localization of the Toll protein in the syncytial Drosophila embryo: importance of transmembrane signaling for dorsal–ventral pattern formation
1991
Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.
1991
DrosophilaWntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo
2005
Cell shape changes during gastrulation in Drosophila
1990
Similarities between trunk and spätzle, putative extracellular ligands specifying body pattern in Drosophila.
1995
Functional analysis of the Drosophila twist promoter reveals a dorsal-binding ventral activator region.
1991
cdc12p, a Protein Required for Cytokinesis in Fission Yeast, Is a Component of the Cell Division Ring and Interacts with Profilin
1997 StandoutNobel
Dissociation of the dorsal-cactus complex and phosphorylation of the dorsal protein correlate with the nuclear localization of dorsal.
1993
Adhesion molecules and the hierarchy of neural development
1988
Disulfide cross-linking in crude embryonic lysates reveals three complexes of the Drosophila morphogen dorsal and its inhibitor cactus.
1994 StandoutNobel
Biphasic activation of the BMP pathway patterns the Drosophila embryonic dorsal region
2001
Multiple pathways in nuclear transport: the import of U2 snRNP occurs by a novel kinetic pathway.
1991
Role of nonhistone proteins in the chromosomal events of mitosis
1994
The Dorsal-related immunity factor (Dif) can define the dorsal-ventral axis of polarity in the Drosophila embryo
1998
Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.
1991
Thermal waves in NH3 oxidation on a Pt wire
1989
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation
1997 StandoutScienceNobel
Cell intercalation during Drosophila germband extension and its regulation by pair-rule segmentation genes
1994 StandoutNobel
Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes
1998 StandoutNobel
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
1994 StandoutNatureNobel
The control of cell fate along the dorsal-ventral axis of the Drosophila embryo
1991 StandoutNobel
A multimeric complex and the nuclear targeting of the Drosophila Rel protein Dorsal
1997
Effects of Boundaries on Pattern Formation: Catalytic Oxidation of CO on Platinum
1994 StandoutScienceNobel
Morphogen gradient interpretation
2001 StandoutNatureNobel
Modulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia
1992 StandoutScienceNobel
Works of Siegfried Roth being referenced
Drosophila Cornichon acts as cargo receptor for ER export of the TGFα-like growth factor Gurken
2006
Axis Determination in Insect Embryos
2007 Nobel
Axis Determination: Proteolytic generation of a morphogen
1994
Polar Transport in the Drosophila Oocyte Requires Dynein and Kinesin I Cooperation
2002
Stable Anterior Anchoring of the Oocyte Nucleus Is Required to Establish Dorsoventral Polarity of the Drosophila Egg
2001
The polarity of the dorsoventral axis in the drosophila embryo is defined by an extracellular signal
1991
Dorsoventral Axis Formation in the Drosophila Embryo—Shaping and Transducing a Morphogen Gradient
2005
cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila
1995
A Serpin Regulates Dorsal-Ventral Axis Formation in the Drosophila Embryo
2003
Biochemical characterization of polypeptide components involved in neurite fasciculation and elongation
1987
The Drosophila Gene brinker Reveals a Novel Mechanism of Dpp Target Gene Regulation
1999 Nobel
A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo
1989 StandoutNobel
Drosophila development: The secrets of delayed induction
1998
The maternal NF-κB/Dorsal gradient of Tribolium castaneum: dynamics of early dorsoventral patterning in a short-germ beetle
2000
Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos
1993
cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos
1991 StandoutNobel
The relationship between ovarian and embryonic dorsoventral patterning in Drosophila
1994
The role ofbrinkerin mediating the graded response to Dpp in earlyDrosophilaembryos
1999
Chaotic dynamics of two coupled biochemical oscillators
1987
The functional domains of the Drosophila morphogen dorsal: evidence from the analysis of mutants.
1992 StandoutNobel
The origin of dorsoventral polarity inDrosophila
2003