Standout Papers
Citation Impact
Citing Papers
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
2002 StandoutScienceNobel
Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS
2018 StandoutNobel
Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy
2012 StandoutScienceNobel
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
Identification of a Primary Target of Thalidomide Teratogenicity
2010 StandoutScience
TOR Complex 2 Integrates Cell Movement during Chemotaxis and Signal Relay in Dictyostelium
2005
Architecture of human mTOR complex 1
2015 Science
Biochemical, Cellular, and In vivo Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin
2009
Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2
2010
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Inhibition of Target of Rapamycin Signaling by Rapamycin in the Unicellular Green Alga Chlamydomonas reinhardtii
2005
TOR Signaling in Growth and Metabolism
2006 Standout
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells
2008
Hallmarks of Cancer: The Next Generation
2011 Standout
mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide
2016 Nature
Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk
2016
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
2008
Orientation of the protonated retinal Schiff base group in bacteriorhodopsin from absorption linear dichroism
1989
Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
2020 StandoutNobel
mTOR Signaling in Growth Control and Disease
2012 Standout
PRAS40 and PRR5-Like Protein Are New mTOR Interactors that Regulate Apoptosis
2007
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
2011
Control of repeat-protein curvature by computational protein design
2015 StandoutNobel
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
A Central Role for mTOR in Lipid Homeostasis
2013
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
2010 Standout
Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
2012
Growing roles for the mTOR pathway
2005
hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase
2005
The expanding TOR signaling network
2005
mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
2011
The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht
1999 Standout
Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy
1990 StandoutNobel
p53 — a Jack of all trades but master of none
2009
A comparison of successful and failed protein interface designs highlights the challenges of designing buried hydrogen bonds
2012
Atomic structures of amyloid cross-β spines reveal varied steric zippers
2007 StandoutNature
Protein–protein interaction and quaternary structure
2008
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity
2013
Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly
2010
Tor forms a dimer through an N-terminal helical solenoid with a complex topology
2016
Accurate design of co-assembling multi-component protein nanomaterials
2014 StandoutNatureNobel
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
2007
A role for Raptor phosphorylation in the mechanical activation of mTOR signaling
2013
Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
2013
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
2017 StandoutNature
Specificity in protein-protein interactions: the structural basis for dual recognition in endonuclease colicin-immunity protein complexes
2000
Restricted sidechain plasticity in the structures of native proteins and complexes
2011 StandoutNobel
sgRNAcas9: A Software Package for Designing CRISPR sgRNA and Evaluating Potential Off-Target Cleavage Sites
2014
Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
2009
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Structure of the cross-β spine of amyloid-like fibrils
2005 StandoutNature
Hydration of protein–protein interfaces
2005
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Sequence-specific inhibition of microRNA via CRISPR/CRISPRi system
2014
On/off blinking and switching behaviour of single molecules of green fluorescent protein
1997 StandoutNatureNobel
Nuclear magnetic resonance study of the Schiff base in bacteriorhodopsin: counterion effects on the nitrogen-15 shift anisotropy
1989
The coming of age of de novo protein design
2016 StandoutNatureNobel
CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing
2014
mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion
2010
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12
2012
Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 IsMediated by p70S6 Kinase
2005
Rheb Binds and Regulates the mTOR Kinase
2005
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
2006
Redox Regulation of the Nutrient-sensitive Raptor-mTOR Pathway and Complex
2005
Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis
2011
SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity
2006
Vibrational spectroscopy of bacteriorhodopsin mutants: light-driven proton transport involves protonation changes of aspartic acid residues 85, 96, and 212
1988
Kemp elimination catalysts by computational enzyme design
2008 StandoutNatureNobel
CRISPR-Cas systems for editing, regulating and targeting genomes
2014 Standout
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
2006 Standout
Hotspot-Centric De Novo Design of Protein Binders
2011 StandoutNobel
The Two TORCs and Akt
2007
The Neurology of mTOR
2014
PatchDock and SymmDock: servers for rigid and symmetric docking
2005 Standout
Molecular Organization of Target of Rapamycin Complex 2
2005
Activation of mTORC2 by Association with the Ribosome
2011
Design of multi-scale protein complexes by hierarchical building block fusion
2021 StandoutNobel
Genome-wide profiling of adenine base editor specificity by EndoV-seq
2019
Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model
2001
Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2
2012
Foxo Transcription Factors Control Regulatory T Cell Development and Function
2010
Crystal Structure at 2.8 Å of an FcRn/Heterodimeric Fc Complex
2001
Chromophore structure in bacteriorhodopsin's N intermediate: implications for the proton-pumping mechanism
1988
AKT/PKB Signaling: Navigating the Network
2017 Standout
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Regulation of TORC1 by Rag GTPases in nutrient response
2008
Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability
2006
Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR–Cas9 system
2014
mTOR kinase structure, mechanism and regulation
2013 Nature
The TNF and TNF Receptor Superfamilies
2001 Standout
PRR5, a Novel Component of mTOR Complex 2, Regulates Platelet-derived Growth Factor Receptor β Expression and Signaling
2007
Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis
2003 StandoutNature
Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase
2011
PP2AT61ɛ Is an Inhibitor of MAP4K3 in Nutrient Signaling to mTOR
2010
Signaling pathways controlling skeletal muscle mass
2013
Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
2008
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging
2015
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
2009 StandoutNobel
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
2006
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
1998 StandoutNatureNobel
Molecular mechanisms of mTOR-mediated translational control
2009 Standout
Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model
2016
The molecular architecture of protein–protein binding sites
2007
The molecular structure of green fluorescent protein
1996
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging
2010
Vibrational spectroscopy of bacteriorhodopsin mutants: chromophore isomerization perturbs trytophan-86
1989
Vibrational spectroscopy of bacteriorhodopsin mutants: I. Tyrosine‐185 protonates and deprotonantes during the photocycle
1988
Accurate design of megadalton-scale two-component icosahedral protein complexes
2016 StandoutScienceNobel
Computational design of a leucine-rich repeat protein with a predefined geometry
2014
Nutrients Suppress Phosphatidylinositol 3-Kinase/Akt Signaling via Raptor-Dependent mTOR-Mediated Insulin Receptor Substrate 1 Phosphorylation
2005
GT-Scan: identifying unique genomic targets
2014
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
2005
The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction
2010 StandoutNobel
Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1
2010
Disruption of Tsc2 in pancreatic β cells induces β cell mass expansion and improved glucose tolerance in a TORC1-dependent manner
2008
The coordinate regulation of the p53 and mTOR pathways in cells
2005
Residue frequencies and pairing preferences at protein-protein interfaces
2001
Computational design of a homotrimeric metalloprotein with a trisbipyridyl core
2016 StandoutNobel
Directed and Systematic Differentiation of Cardiovascular Cells From Mouse Induced Pluripotent Stem Cells
2008 StandoutNobel
Detection of targeted GFP - Hox gene fusions during mouse embryogenesis
1998 StandoutNobel
THE GREEN FLUORESCENT PROTEIN
1998 StandoutNobel
Neurons Expressing the Highest Levels of γ-Synuclein Are Unaffected by Targeted Inactivation of the Gene
2003
Of Flies and Fishes
1994 StandoutScienceNobel
The Pleckstrin Homology Domain Proteins Slm1 and Slm2 Are Required for Actin Cytoskeleton Organization in Yeast and Bind Phosphatidylinositol-4,5-Bisphosphate and TORC2
2005
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Photoisomerization in bacteriorhodopsin studied by FTIR, linear dichroism and photoselection experiments combined with quantum chemical theoretical analysis
1989
Analysis and minimization of cellular RNA editing by DNA adenine base editors
2019
Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control
2011
Regulation of TFEB and V-ATPases by mTORC1
2011
Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology
2013
Pushing the Envelope in the mTOR Pathway: The Second Generation of Inhibitors
2011
Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice
2013
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
2008
Structure-function studies on bacteriorhodopsin. V. Effects of amino acid substitutions in the putative helix F.
1987
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
2008 Standout
Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism
2010
Trapping a transition state in a computationally designed protein bottle
2015 StandoutScienceNobel
Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development.
1996
Recombineering: a powerful new tool for mouse functional genomics
2001
Decreased IRS Signaling Impairs β-Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in β-Cells
2010
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
2009
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Design of a hyperstable 60-subunit protein icosahedron
2016 StandoutNatureNobel
Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
2009
Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1
2009
Computational design of a pH-sensitive IgG binding protein
2013 StandoutNobel
Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue
2010
Structural origins of efficient proton abstraction from carbon by a catalytic antibody
2005
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
2007
mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases
2014
Specific Covalent Labeling of Recombinant Protein Molecules Inside Live Cells
1998 StandoutScienceNobel
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
2013
Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney
2011
Muscle-Specific Deletion of Rictor Impairs Insulin-Stimulated Glucose Transport and Enhances Basal Glycogen Synthase Activity
2007
Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces
2015 StandoutScienceNobel
Works of Shuo Lin being referenced
Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy
2013
Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system
2017
A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo
2011
Shape complementarity at protein–protein interfaces
1994
Protein binding versus protein folding: the role of hydrophilic bridges in protein associations 1 1Edited by B. Honig
1997
TALEN-mediated precise genome modification by homologous recombination in zebrafish
2013
Requirements for green fluorescent protein detection in transgenic zebrafish embryos
1996
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
2004 Standout
Deprotonation of tyrosines in bacteriorhodopsin as studied by Fourier transform infrared spectroscopy with deuterium and nitrate labeling
1987
Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
2008
Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy
2013
Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish
2013
The Aequorea victoria Green Fluorescent Protein Can Be Used as a Reporter in Live Zebrafish Embryos
1995
Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish
2000
Precise A•T to G•C base editing in the zebrafish genome
2018
Zebrafish as a Developmental Model Organism for Pediatric Research
2008
p53 family in development
2008
Inactivation of mTORC1 in the Developing Brain Causes Microcephaly and Affects Gliogenesis
2013
ER71 Acts Downstream of BMP, Notch, and Wnt Signaling in Blood and Vessel Progenitor Specification
2008
Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family
2008
GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene
1997
CasOT: a genome-wide Cas9/gRNA off-target searching tool
2014
Neuropathology in Mice Expressing Human α-Synuclein
2000
Neuropathology in mice expressing human alpha-synuclein
2000
FTIR difference studies on apoproteins. Protonation states of aspartic and glutamic acid residues during the photocycle of bacteriorhodopsin
1987
Fourier transform infrared difference spectroscopy of bacteriorhodopsin and its photoproducts regenerated with deuterated tyrosine
1986
Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2
1997
Syntheses of Fused Tetracyclic Quinolines via Ugi-Variant MCR and Pd-Catalyzed Bis-annulation
2013
Integration and Germ-Line Transmission of a Pseudotyped Retroviral Vector in Zebrafish
1994 Science
Modification of bacterial artificial chromosomes through Chi-stimulated homologous recombination and its application in zebrafish transgenesis
1998