Citation Impact
Citing Papers
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
2005 StandoutScience
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
2023 StandoutNobel
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Development of a Purine-Scaffold Novel Class of Hsp90 Binders that Inhibit the Proliferation of Cancer Cells and Induce the Degradation of Her2 Tyrosine Kinase
2002
DT-Diaphorase Expression and Tumor Cell Sensitivity to 17-Allylamino,17-demethoxygeldanamycin, an Inhibitor of Heat Shock Protein 90
1999
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts
2004
Tumor-infiltrating lymphocytes and hepatocellular carcinoma: molecular biology
2010
Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine
2001
Proteins regulating Ras and its relatives
1993 StandoutNature
Development of a Fluorescence Polarization Assay for the Molecular Chaperone Hsp90
2004
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Cellular and Gene Expression Responses Involved in the Rapid Growth Inhibition of Human Cancer Cells by RNA Interference-mediated Depletion of Telomerase RNA
2005 StandoutNobel
Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway
2002
Biological functions of fucose in mammals
2017
Novobiocin and Related Coumarins and Depletion of Heat Shock Protein 90-Dependent Signaling Proteins
2000
Synthesis of (−)‐Okilactomycin by a Prins‐Type Fragment‐Assembly Strategy
2011
Selective inhibition of bleomycin-induced G2 cell cycle checkpoint by simaomicin α
2004 StandoutNobel
The FGF family: biology, pathophysiology and therapy
2009 Standout
Bortezomib‐induced apoptosis in mature T‐cell lymphoma cells partially depends on upregulation of Noxa and functional repression of Mcl‐1
2008
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Cell-cycle checkpoints and cancer
2004 StandoutNature
Targeting hypoxia cell signaling for cancer therapy
2007
Prospects for drug screening using the reverse two-hybrid system
1999
Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine)
2002
Twenty years of cell‐penetrating peptides: from molecular mechanisms to therapeutics
2009
Overexpression of hypoxia-inducible factor HIF-1α predicts early relapse in breast cancer: Retrospective study in a series of 745 patients
2005
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 StandoutNature
Hsp90 & Co. – a holding for folding
1999
Regulatory T‐cell function of adult T‐cell leukemia/lymphoma cells
2007
Celastrols as Inducers of the Heat Shock Response and Cytoprotection
2004 Standout
Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes
2003
Heat shock protein 90: The cancer chaperone
2007
17-(Allylamino)-17-demethoxygeldanamycin activity in human melanoma models
2004
HSP90 and the chaperoning of cancer
2005 Standout
A Nucleotide-dependent Molecular Switch Controls ATP Binding at the C-terminal Domain of Hsp90
2002
CCR4 as a novel molecular target for immunotherapy of cancer
2006
Structure, function, and mechanism of the Hsp90 molecular chaperone
2001
The Heat Shock Protein 90 Antagonist Novobiocin Interacts with a Previously Unrecognized ATP-binding Domain in the Carboxyl Terminus of the Chaperone
2000
Sulfotransferases: Structure, Mechanism, Biological Activity, Inhibition, and Synthetic Utility
2004
Binding of ATP to Heat Shock Protein 90
2002
Adenine derived inhibitors of the molecular chaperone HSP90—SAR explained through multiple X-ray structures
2003
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function
2002
The microenvironment of the tumour–host interface
2001 StandoutNature
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
Human memory CCR4+CD8+ T cell subset has the ability to produce multiple cytokines
2009
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
2008
Glycosylation in health and disease
2019
Quantum Chemical Calculations and Mutational Analysis Suggest Heat Shock Protein 90 Catalyzes Trans-Cis Isomerization of Geldanamycin
2004
Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells
2005
Therapeutic and diagnostic implications of Hsp90 activation
2004
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
The 90-kDa Molecular Chaperone Family
1998
Induction of IRF‐3/‐7 kinase and NF‐κB in response to double‐stranded RNA and virus infection: common and unique pathways
2001
ATP citrate lyase inhibition can suppress tumor cell growth
2005
Farnesyltransferase Inhibitors: Preclinical Development
1999
Mechanisms of Suppression of α-Synuclein Neurotoxicity by Geldanamycin in Drosophila
2004
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Mechanisms of gene silencing by double-stranded RNA
2004 StandoutNature
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Targeting the checkpoint kinases: chemosensitization versus chemoprotection
2004
Proteomics to study genes and genomes
2000 StandoutNature
High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity
2004
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy
2004
Immunopathogenesis of lymphoma: Focus on CCR4
2010
Hsp90 isoforms: functions, expression and clinical importance
2004
Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer
2016 Standout
Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives
1992
Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer
2004
BCR-ABL point mutants isolated from patients with imatinib mesylate–resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90
2002
Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains
2013 StandoutNobel
Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity
2004
Benzannulation reactions of Fischer carbene complexes for the synthesis of indolocarbazoles
2001
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976
1993 Standout
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage.
2000
Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3 high regulatory T cells in humans
2015 StandoutNobel
The development of imatinib as a therapeutic agent for chronic myeloid leukemia
2004
Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2.
1995
Coinhibitory Pathways in Immunotherapy for Cancer
2016
A General Catalytic Asymmetric Prins Cyclization
2016 StandoutNobel
Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor.
1996
Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I–driven CD8+ T cell response
2018
Staurosporine and ent-Staurosporine: The First Total Syntheses, Prospects for a Regioselective Approach, and Activity Profiles1
1996
Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma
2012 StandoutNobel
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis.
2001
Inhibitors of HSP90 and other chaperones for the treatment of cancer
2004
Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells
1993 ScienceNobel
The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways
2005
Hsp90 inhibitors deplete key anti‐apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin
2004
Altered Hsp90 function in cancer: A unique therapeutic opportunity
2004
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations
2016 Standout
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein
2002 StandoutScience
In vitro reconstitution of the human RISC-loading complex
2008 StandoutNobel
Phase I Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients With Advanced Cancer
2005
Indolocarbazoles. 1. Total synthesis and protein kinase inhibiting characteristics of compounds related to K-252c.
1993
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
The protein kinase C inhibitor Gö6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints.
2003
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans
2013 StandoutNobel
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Structure−Activity Relationships in a Series of Substituted Indolocarbazoles: Topoisomerase I and Protein Kinase C Inhibition and Antitumoral and Antimicrobial Properties
1996
Synthesis of complex alkoxyamines using a polymer-supported N-hydroxyphthalimide
2004
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors.
2003
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin
1999
Molecular Chaperones: Biology and Prospects for Pharmacological Intervention
1998
Cancer immunotherapy using checkpoint blockade
2018 StandoutScience
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition
2005
Isolation and Synthesis of Biologically Active Carbazole Alkaloids
2002 Standout
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Catalytic Asymmetric Vinylogous Prins Cyclization: A Highly Diastereo- and Enantioselective Entry to Tetrahydrofurans
2016 StandoutNobel
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
2006 StandoutScience
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Works of Shiro Akinaga being referenced
Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.
1991
A Radicicol Derivative, KF58333, Inhibits Expression of Hypoxia‐inducible Factor‐1α and Vascular Endothelial Growth Factor, Angiogenesis and Growth of Human Breast Cancer Xenografts
2001
Antitumor effect of KT6124, a novel derivative of protein kinase inhibitor K-252a and its mechanism of action
1992
Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor, UCN-01
1999
Development of Radicicol Analogues
2003
A neutralizing anti‐fibroblast growth factor (FGF) 8 monoclonal antibody shows anti‐tumor activity against FGF8b‐expressing LNCaP xenografts in androgen‐dependent and ‐independent conditions
2008
Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin
1998
Halohydrin and Oxime Derivatives of Radicicol: Synthesis and Antitumor Activities
2002
Telomerase Inhibitors Identified by a Forward Chemical Genetics Approach Using a Yeast Strain with Shortened Telomere Length
2006
Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells
1994
Radicicol Leads to Selective Depletion of Raf Kinase and Disrupts K-Ras-activated Aberrant Signaling Pathway
1998
UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G2 checkpoint abrogation
2000
Stereospecific antitumor activity of radicicol oxime derivatives
2001
UCN‐01 (7‐Hydoxystaurosporine) Inhibits in vivo Growth of Human Cancer Cells through Selective Perturbation of G1 Phase Checkpoint Machinery
2001
Chrolactomycin, a Novel Antitumor Antibiotic Produced by Streptomyces sp.
2001
Diverse effects of indolocarbazole compounds on the cell cycle progression of ras-transformed rat fibroblast cells.
1993
Oligonucleotide N3′ → P5′ Thio-phosphoramidate Telomerase Template Antagonists as Potential Anticancer Agents
2003
Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C
1993
The CC Chemokine Receptor 4 as a Novel Specific Molecular Target for Immunotherapy in Adult T-Cell Leukemia/Lymphoma
2004
Interaction of Radicicol with Members of the Heat Shock Protein 90 Family of Molecular Chaperones
1999
Multicenter Phase II Study of Mogamulizumab (KW-0761), a Defucosylated Anti-CC Chemokine Receptor 4 Antibody, in Patients With Relapsed Peripheral T-Cell Lymphoma and Cutaneous T-Cell Lymphoma
2014
UCN-01 (7-hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti-cancer agents for the new century?
2000
A Neutralizing Anti–Fibroblast Growth Factor 8 Monoclonal Antibody Shows Potent Antitumor Activity against Androgen-Dependent Mouse Mammary Tumors In vivo
2005
Stevens–Johnson S yndrome associated with mogamulizumab treatment of adult T ‐cell leukemia / lymphoma
2013
G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.
1997
Estrogen sulfotransferase and steroid sulfatase in human breast carcinoma.
2003
Identification of Ras farnesyltransferase inhibitors by microbial screening.
1993
Defucosylated Anti-CCR4 Monoclonal Antibody (KW-0761) for Relapsed Adult T-Cell Leukemia-Lymphoma: A Multicenter Phase II Study
2012
A novel telomerase template antagonist (GRN163) as a potential anticancer agent.
2003
KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.
1999
Synthesis and Antitumor Activity of Novel O-Carbamoylmethyloxime Derivatives of Radicicol
2003
Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer.
2001
Phase I Study of KW-0761, a Defucosylated Humanized Anti-CCR4 Antibody, in Relapsed Patients With Adult T-Cell Leukemia-Lymphoma and Peripheral T-Cell Lymphoma
2010
Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents.
2000
Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.
1998
Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex
2000
Defucosylated Humanized Anti-CCR4 Monoclonal Antibody KW-0761 as a Novel Immunotherapeutic Agent for Adult T-cell Leukemia/Lymphoma
2010