Standout Papers
Citation Impact
Citing Papers
Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants
2001 StandoutScience
ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
2008 Standout
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
2012 StandoutScience
Hallmarks of Cancer: The Next Generation
2011 Standout
β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
2009 StandoutNobel
Prevalence of fatty liver in Japanese children and relationship to obesity
1995
Protein Kinase A and G Protein-coupled Receptor Kinase Phosphorylation Mediates β-1 Adrenergic Receptor Endocytosis through Different Pathways
2003 StandoutNobel
Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
2007
A view on drug resistance in cancer
2019 StandoutNature
Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development
2012
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf
2012
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
2009 StandoutNature
Cell cycle proteins as promising targets in cancer therapy
2017 Standout
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
2011 StandoutNobel
Alternative splicing of Bim and Erk-mediated BimEL phosphorylation are dispensable for hematopoietic homeostasis in vivo
2012
Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche
2007
Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
2016 Standout
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
2014 StandoutNature
Integrating liquid biopsies into the management of cancer
2017
Nonalcoholic Fatty Liver Disease
2002 Standout
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future
2017 Standout
Osimertinib or Platinum–Pemetrexed in EGFR T790M–Positive Lung Cancer
2016 Standout
Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic
2008
Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer
2013 Standout
Delayed expression of apoptotic and cell-cycle control genes in carcinogen-exposed bladders of mice lacking p53.S389 phosphorylation
2007
BCL-2 family antagonists for cancer therapy
2008
Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function
2008
Regulated portals of entry into the cell
2003 StandoutNature
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
Autophagy: Renovation of Cells and Tissues
2011 Standout
Skin Cancer: Lights on Genome Lesions
2005
BIM Mediates EGFR Tyrosine Kinase Inhibitor-Induced Apoptosis in Lung Cancers with Oncogenic EGFR Mutations
2007
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
2011
Blinded by the Light: The Growing Complexity of p53
2009 Standout
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
2007 StandoutNature
Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling
2015
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
2005 Standout
Cell Death
2009
The use of bisphosphonates in multiple myeloma: recommendations of an expert panel on behalf of the European Myeloma Network
2009
Uncertainty in the niches that maintain haematopoietic stem cells
2008
Xeroderma Pigmentosum p48 Gene Enhances Global Genomic Repair and Suppresses UV-Induced Mutagenesis
2000
Non-ATP competitive protein kinase inhibitors as anti-tumor therapeutics
2009
Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development
2010
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
CK2 and GAK/auxilin2 Are Major Protein Kinases in Clathrin‐Coated Vesicles
2002
limma powers differential expression analyses for RNA-sequencing and microarray studies
2015 Standout
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
2003
Autophagy as a target for anticancer therapy
2011
DDB Accumulates at DNA Damage Sites Immediately after UV Irradiation and Directly Stimulates Nucleotide Excision Repair
2002 StandoutNobel
Survey of the year 2003 commercial optical biosensor literature
2004
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Global analysis of protein localization in budding yeast
2003 StandoutNature
The Bcl-2 apoptotic switch in cancer development and therapy
2007 Standout
Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development
2006 StandoutNobel
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
Survey of the year 2005 commercial optical biosensor literature
2006
Upregulation of Flt3 Expression within the Bone Marrow Lin−Sca1+c-kit+ Stem Cell Compartment Is Accompanied by Loss of Self-Renewal Capacity
2001
The p53 pathway: positive and negative feedback loops
2005 Standout
Role of Cyclin G-associated Kinase in Uncoating Clathrin-coated Vesicles from Non-neuronal Cells
2000
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
2009 Standout
Analysis of Ribonucleotide Removal from DNA by Human Nucleotide Excision Repair
2015 StandoutNobel
BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts
2007
Thrombopoietin and the Hematopoietic Stem Cell
2005
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
2009
Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics
2007
Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC
2018 Standout
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)–based mutagenesis screen: high efficacy of drug combinations
2006
Acute Myeloid Leukemia
2015 Standout
Thrombopoietin and the Hematopoietic Stem Cell
1998
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Novel Protein Kinases Ark1p and Prk1p Associate with and Regulate the Cortical Actin Cytoskeleton in Budding Yeast
1999
Identification of Lin–Sca1+kit+CD34+Flt3– short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients
2004
Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells
2010
Aurora A Inhibitor (MLN8237) plus Vincristine plus Rituximab Is Synthetic Lethal and a Potential Curative Therapy in Aggressive B-cell Non-Hodgkin Lymphoma
2012
Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs
2003
Spermidine in health and disease
2018 StandoutScience
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Immature hematopoietic stem cells undergo maturation in the fetal liver
2012
Integrin-linked kinase – essential roles in physiology and cancer biology
2008
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges
2012
Electron Tunneling Pathways and Role of Adenine in Repair of Cyclobutane Pyrimidine Dimer by DNA Photolyase
2012 StandoutNobel
Significance analysis of microarrays applied to the ionizing radiation response
2001 Standout
Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells
2007
Multiple Myeloma
2011 Standout
Quantum dot/antibody conjugates for in vivo cytometric imaging in mice
2015 StandoutNobel
Biological Basket Weaving: Formation and Function of Clathrin-Coated Vesicles
2001
Mcl-1 Down-regulation Potentiates ABT-737 Lethality by Cooperatively Inducing Bak Activation and Bax Translocation
2007
Dynamics and mechanism of cyclobutane pyrimidine dimer repair by DNA photolyase
2011 StandoutNobel
Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML
2014
Physiology of Microglia
2011 Standout
Works of Shinya Kimura being referenced
Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia
2015
Autophagy and autophagic cell death are next targets for elimination of the resistance to tyrosine kinase inhibitors
2008
Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia
2007
Cyclin G1 associates with MDM2 and regulates accumulation and degradation of p53 protein
2002
Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery
2001
Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer
2005
Structure, Expression, and Chromosomal Localization of Human GAK
1997
GAK: a cyclin G associated kinase contains a tensin/auxilin‐like domain1
1997
Expression of a mammalian DNA photolyase confers light-dependent repair activity and reduces mutations of UV-irradiated shuttle vectors in xeroderma pigmentosum cells
1999
Neuroprotective Efficacy of a New Brain-Penetrating C-Abl Inhibitor in a Murine Parkinson’s Disease Model
2013
Application of a Highly Sensitive Detection System for Epidermal Growth Factor Receptor Mutations in Plasma DNA
2012
Rapid quantitation of immunoglobulin G antibodies specific for blood group antigens A and B by surface plasmon resonance
2004
A Noninvasive System for Monitoring Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors with Plasma DNA
2011
Lipopolysaccharide sensitizes microglia toward Ca2+‐induced cell death: Mode of cell death shifts from apoptosis to necrosis
2005
New Tyrosine Kinase Inhibitors in the Treatment of Chronic Myeloid Leukemia
2006
p53‐independent anti‐tumor effects of the nitrogen‐containing bisphosphonate zoledronic acid
2004
Cytokine Production and Function in c-mpl–Deficient Mice: No Physiologic Role for Interleukin-3 in Residual Megakaryocyte and Platelet Production
1998
Effects of daunorubicin on cell growth, cell cycle and induction of apoptosis in HL-60 cells.
1998
CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells
2008
Bim and Bad mediate imatinib-induced killing of Bcr/Abl + leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
2006
Activity of the multitargeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL–positive leukemic cells
2010
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin
1998
Monitoring EGFR T790M with plasma DNA from lung cancer patients in a prospective observational study
2015
NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia
2005
[Epidemiology of fatty liver--ultrasound mass survey in a rural region].
1986