Citation Impact
Citing Papers
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
2005 StandoutScience
Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor
2011
Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor
2003 Standout
Proteomic Study Reveals That Proteins Involved in Metabolic and Detoxification Pathways Are Highly Expressed in HER-2/neu-positive Breast Cancer
2005
Structural and Functional Characterization of the Human Protein Kinase ASK1
2007
ERBB receptors and cancer: the complexity of targeted inhibitors
2005 Standout
Involvement of the p38 mitogen‐activated protein kinase cascade in hepatocellular carcinoma
2003
Regulation of cell death by the Abl tyrosine kinase
2000
Gli proteins and Hedgehog signaling: development and cancer
1999
Imatinib Therapy in Clonal Eosinophilic Disorders, Including Systemic Mastocytosis
2004
Mechanisms of type-I- and type-II-interferon-mediated signalling
2005 Standout
Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases
2005 Standout
Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb
2000 Standout
Role of Antioxidants and Natural Products in Inflammation
2016 Standout
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Oncogenic kinase signalling
2001 StandoutNature
Signal integration by JNK and p38 MAPK pathways in cancer development
2009 Standout
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
2007 Standout
Role of platelet-derived growth factors in physiology and medicine
2008 Standout
Epidermal growth factor receptor mutations in lung cancer
2007 Standout
Therapeutic Strategies for Targeting Ras Proteins
2011
The resurgence of platinum-based cancer chemotherapy
2007 Standout
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
2022 Standout
Identification of JTP‐70902, a p15INK4b‐inductive compound, as a novel MEK1/2 inhibitor
2007
Golgi stress mediates redox imbalance and ferroptosis in human cells
2018
Susceptibility of HIV-1-TAT transfected cells to undergo apoptosis. Biochemical mechanisms
1999
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
2012 Standout
Tyrosine kinases as targets in cancer therapy – successes and failures
2003
Endoplasmic reticulum stress: cell life and death decisions
2005 Standout
The ASK1-MAP Kinase Cascades in Mammalian Stress Response
2004
p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-κB activity and Fas expression
2000
IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy
2005 Standout
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
Role of Oxidative Modifications in Atherosclerosis
2004 Standout
More than one way to die: apoptosis, necrosis and reactive oxygen damage
1999
Linking the growth inhibition response from the National Cancer Institute's anticancer screen to gene expression levels and other molecular target data
2003
The Sonic Hedgehog–Patched–Gli Pathway in Human Development and Disease
2000
Panel of human cancer cell lines provides valuable database for drug discovery and bioinformatics
2003
Identification of genes associated with platinum drug sensitivity and resistance in human ovarian cancer cells
2005
Mitogen-activated protein kinases in apoptosis regulation
2004
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence
2010 StandoutNobel
Apoptosis
2002 Standout
Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug
2002
Physicochemical properties and membrane interactions of anti-apoptotic derivatives 2-(4-fluorophenyl)-3-(pyridin-4-yl)imidazo[1,2-a]pyridine depending on the hydroxyalkylamino side chain length and conformation: An NMR and ESR study
2009
IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage
2013 StandoutNobel
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cells
2003
Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome
2001 Standout
The immune contexture in human tumours: impact on clinical outcome
2012 Standout
Tumor immunosurveillance in human cancers
2011
Molecular mechanisms of necroptosis: an ordered cellular explosion
2010 Standout
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Antitumor Activity of ZSTK474, a New Phosphatidylinositol 3-Kinase Inhibitor
2006
Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles
2005
Targeting Immunosupportive Cancer Therapies: Accentuate the Positive, Eliminate the Negative
2007 StandoutNobel
The PI3K Pathway in Human Disease
2017 Standout
Reversal of experimental pulmonary hypertension by PDGF inhibition
2005
Transition‐Metal‐Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage
2009 Standout
Glyoxalase I Is Critical for Human Retinal Capillary Pericyte Survival under Hyperglycemic Conditions
2006
Distinct and regulated activities of human Gli proteins in Drosophila
1999
Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer
2016
The NCI60 human tumour cell line anticancer drug screen
2006 Standout
A novel protein overexpressed in hepatoma accelerates export of NF-κB from the nucleus and inhibits p53-dependent apoptosis
2002
Glycosylation in cancer: mechanisms and clinical implications
2015 Standout
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
2008 Standout
Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats
2010
From seeing to believing: labelling strategies for in vivo cell-tracking experiments
2013
Redox Control of Cell Death
2002
AI and computational chemistry-accelerated development of an alotaketal analogue with conventional PKC selectivity
2022
The development of imatinib as a therapeutic agent for chronic myeloid leukemia
2004
Apoptosis: A Review of Programmed Cell Death
2007 Standout
Improving Prospects for Targeting RAS
2015
Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element
2003
Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1
2001
DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition
2009 Standout
Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins
1999
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Trk Receptors: Roles in Neuronal Signal Transduction
2003 Standout
Gli proteins encode context-dependent positive and negative functions: implications for development and disease
1999
Polyproline-Rod Approach to Isolating Protein Targets of Bioactive Small Molecules: Isolation of a New Target of Indomethacin
2007
Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor
2004 StandoutScience
Regulation of G Protein–Coupled Receptor Signaling by Scaffold Proteins
2002 StandoutNobel
PubChem 2023 update
2022 Standout
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
2007 Standout
Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy
2015 Standout
A novel pyridopyrimidine inhibitor of abl kinase is a picomolar inhibitor of Bcr-abl-driven K562 cells and is effective against STI571-resistant Bcr-abl mutants.
2003
Mechanisms of Diabetic Complications
2013 Standout
Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance
2000
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism
2001
c-Abl: activation and nuclear targets
2000
Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL–transformed hematopoietic cell lines
2000
Apoptotic Death of β Cells after Optic Nerve Transection in Adult Cats
2003 StandoutNobel
Cellular stress response and apoptosis in cancer therapy
2001
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
2001 Standout
Map kinase signaling pathways and hematologic malignancies
2003
c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and Ubiquitination
2001 StandoutNobel
ARG tyrosine kinase activity is inhibited by STI571
2001
Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE
2002
Metal-Free Multicomponent Syntheses of Pyridines
2014 Standout
Works of Shingo Dan being referenced
Correlating Phosphatidylinositol 3-Kinase Inhibitor Efficacy with Signaling Pathway Status: In silico and Biological Evaluations
2010
In vitro multifaceted activities of a specific group of novel phosphatidylinositol 3-kinase inhibitors on hotspot mutant PIK3CA
2014
Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR–ABL tyrosine kinase, CGP 57148
1998
Repression of Cyclin B1 Expression after Treatment with Adriamycin, but Not Cisplatin in Human Lung Cancer A549 Cells
2001
Activation of c-Abl tyrosine kinase requires caspase activation and is not involved in JNK/SAPK activation during apoptosis of human monocytic leukemia U937 cells
1999
ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo
2011
Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but G0/G1 arrest
2008
IVSE, isolated from Inula japonica,suppresses LPS-induced NO production via NF-κB and MAPK inactivation in RAW264.7 cells
2015
ASK1 mediates apoptotic cell death induced by genotoxic stress
1999
AMF-26, a Novel Inhibitor of the Golgi System, Targeting ADP-ribosylation Factor 1 (Arf1) with Potential for Cancer Therapy
2011
Effects of side chain length of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, on PKC binding, anti-proliferative, and pro-inflammatory activities
2021
Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis
2000
An integrated database of chemosensitivity to 55 anticancer drugs and gene expression profiles of 39 human cancer cell lines.
2002
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays
2005
Cloning of Novel Isoforms of the Human Gli2 Oncogene and Their Activities To Enhance Tax-Dependent Transcription of the Human T-Cell Leukemia Virus Type 1 Genome
1998
Interaction of Gli2 with CREB Protein on DNA Elements in the Long Terminal Repeat of Human T-Cell Leukemia Virus Type 1 Is Responsible for Transcriptional Activation by Tax Protein
1999