Citation Impact
Citing Papers
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Fragment-Based Deconstruction of Bcl-x L Inhibitors
2010
ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
2008 Standout
Unified Synthesis of Polycyclic Alkaloids by Complementary Carbonyl Activation**
2021 StandoutNobel
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor
2014
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Synthesis of triazole-linked β-C-glycosyl dimers as inhibitors of PTP1B
2008
Modular click chemistry libraries for functional screens using a diazotizing reagent
2019 StandoutNatureNobel
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Small‐Molecule Affinity Ligands for Protein Purification: Combined Computational Enrichment and Automated In‐line Screening of an Optically Encoded Library
2010 StandoutNobel
Synthetic Molecular Motors and Mechanical Machines
2006 Standout
Copper-catalyzed phosphorylation of sp2C–H bonds
2014
Lipid phosphatases as drug discovery targets for type 2 diabetes
2006
Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1
2008
Efficient and regioselective synthesis of functionalized pyrroles by cyclocondensation of 1,3-dicarbonyl dianions with α-azidoketones
2002
BCL-2 family antagonists for cancer therapy
2008
Isotope-targeted glycoproteomics (IsoTaG): a mass-independent platform for intact N- and O-glycopeptide discovery and analysis
2015 StandoutNobel
Protein tyrosine phosphatases: from genes, to function, to disease
2006
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
The two faces of PTP1B in cancer
2009
Targeting protein–protein interactions: Lessons from p53/MDM2
2007
SAR by NMR: Putting the Pieces Together
2006
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
2017 StandoutNobel
Isosteric exchange of the acylsulfonamide moiety in Abbott’s Bcl-XL protein interaction antagonist
2008
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Fragment-based lead discovery: a chemical update
2006
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
PTP1B as a drug target: recent developments in PTP1B inhibitor discovery
2007
When analoging is not enough: scaffold discovery in medicinal chemistry
2010
Palladium-catalyzed amidation–hydrolysis reaction of gem-dihaloolefins: efficient synthesis of homologated carboxamides from ketones
2009
Intrinsically disordered proteins in cellular signalling and regulation
2014 Standout
Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on ‘clicked’ serine/threonine–monosaccharide hybrids
2011
Continuous‐Flow Technology—A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients
2015 Standout
Transforming fragments into candidates: small becomes big in medicinal chemistry
2009
Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins
2012 Standout
Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin
2006
PTEN Deletion and Concomitant c-Myc Activation Do Not Lead to Tumor Formation in Pancreatic β Cells
2008 StandoutNobel
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
Endoplasmic Reticulum Stress Induces Leptin Resistance
2008
The rise of fragment-based drug discovery
2009
Copper‐Catalyzed Radical/Radical CH/PH Cross‐Coupling: α‐Phosphorylation of Aryl Ketone O‐Acetyloximes
2015
Searching for new allosteric sites in enzymes
2004
Targeting the translation machinery in cancer
2015
AKT/PKB Signaling: Navigating the Network
2017 Standout
Metal-catalysed approaches to amide bond formation
2011 Standout
Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
2006 Standout
Why nature really chose phosphate
2013 StandoutNobel
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
2009 Standout
Organic Azides: An Exploding Diversity of a Unique Class of Compounds
2005 Standout
A decade of fragment-based drug design: strategic advances and lessons learned
2007
Protein–protein interactions as targets for small molecule drug discovery
2006
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Binding Site Detection and Druggability Index from First Principles
2009
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
A Very Large Metallosupramolecular Capsule with Cube-like 43 Topology Assembled from Twelve Cu(II) Centers and Eight Tri-Bidentate Tri-Anionic Ligands Derived from 2,4,6-Triphenylazo-1,3,5-trihydroxybenzene
1999 StandoutNobel
Quantitative exploration of the molecular origin of the activation of GTPase
2013 StandoutNobel
Iron Catalysis in Organic Synthesis
2015 Standout
3d Transition Metals for C–H Activation
2018 Standout
Fluorine in medicinal chemistry
2007 Standout
Pd(II)-Catalyzed Phosphorylation of Aryl C–H Bonds
2013
Dehydrogenative Cross-Coupling Reaction by Cooperative Transition-Metal and Brønsted Acid Catalysis for the Synthesis of β-Quinolinyl α-Amino Acid Esters
2014
The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members
2007
Oxidative Coupling between Two Hydrocarbons: An Update of Recent C–H Functionalizations
2015 Standout
Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition toN-Activated Pyridines
2012 Standout
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition
2009 Standout
Pyridine-directed palladium-catalyzed electrochemical phosphonation of C(sp2)–H bond
2015
Preparation of One-Carbon Homologated Amides from Aldehydes or Primary Alcohols
2014
Recent advances in the trifluoromethylation methodology and new CF3-containing drugs
2014
Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs
2013
Design and NMR-Based Screening of LEF, a Library of Chemical Fragments with Different Local Environment of Fluorine
2009
Screening of Protein–Protein Interaction Modulators via Sulfo-Click Kinetic Target-Guided Synthesis
2011
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Homocamptothecins: Synthesis and Antitumor Activity of Novel E-Ring-Modified Camptothecin Analogues
1998
7-Silylcamptothecins (silatecans): A new family of camptothecin antitumor agents
1997
Total Synthesis of Camptothecin and Related Natural Products by a Flexible Strategy
2016
Asymmetric synthesis of a key camptothecin intermediate from 2-fluoropyridine
1995
Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
Aryl−Aryl Bond Formation by Transition-Metal-Catalyzed Direct Arylation
2007 Standout
Hydrogen Autotransfer in the N-Alkylation of Amines and Related Compounds using Alcohols and Amines as Electrophiles
2009 Standout
Synthesis of Triazole-Linked Amino Acid-Aryl C-Glycoside Hybrids via Click Chemistry as Novel PTP1B Inhibitors
2011
Total Synthesis of (+)‐Camptothecin
1996
Phosphorylation of C–H bonds of aromatic compounds using metals and metal complexes
2015
Addressing Open Questions about Phosphate Hydrolysis Pathways by Careful Free Energy Mapping
2012 StandoutNobel
A short synthesis of camptothecin via a 2-fluoro-1,4-dihydropyridine
2000
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
2017 Standout
Total Synthesis of Camptothecin and Related Natural Products by a Flexible Strategy
2016
Copper‐Catalyzed Radical/Radical CH/PH Cross‐Coupling: α‐Phosphorylation of Aryl Ketone O‐Acetyloximes
2015
Statistical Analysis of the Effects of Common Chemical Substituents on Ligand Potency
2008
Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
2011 Standout
Controlling Allosteric Networks in Proteins
2016
Advances in Synthetic Applications of Hypervalent Iodine Compounds
2016 Standout
Convergent catalytic asymmetric synthesis of camptothecin analog GI147211C
1997
A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation
2016 StandoutNobel
Microwave-assisted construction of triazole-linked amino acid–glucoside conjugates as novel PTP1B inhibitors
2011
Quantifying the Mechanism of Phosphate Monoester Hydrolysis in Aqueous Solution by Evaluating the Relevant Ab Initio QM/MM Free-Energy Surfaces
2013 StandoutNobel
Recent Advances in the Friedländer Reaction
2009
Direct C−H Phosphonylation of Electron‐Rich Arenes and Heteroarenes by Visible‐Light Photoredox Catalysis
2017
Visible‐Light Photocatalysis: Does It Make a Difference in Organic Synthesis?
2018 Standout
Palladium-Catalyzed Phosphorylation of Aryl Mesylates and Tosylates
2015
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Iron-catalyzed ketonization of 2-aryl-1,1-dibromoalkenes with KOAc: Synthesis of α-acetoxy aryl ketones via a Michael-like addition process
2011
Strategies for Coupling Molecular Units if Subsequent Decoupling Is Required
2012
Signalling to eIF4E in cancer
2015
Superoxide dismutase 1 (SOD1) is essential for H 2 O 2 -mediated oxidation and inactivation of phosphatases in growth factor signaling
2008
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
2017 StandoutNobel
Ozonolysis Applications in Drug Synthesis
2006
Works of Shen Wang being referenced
Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-x L from NMR and Parallel Synthesis
2005
Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism
2011
Allosteric inhibition of protein tyrosine phosphatase 1B
2004
Concise total syntheses of dl-camptothecin and related anticancer drugs
1993
Synthesis of 18-Noranhydrocamptothecin Analogs Which Retain Topoisomerase I Inhibitory Function
1994
Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA–Cap Interaction
2012
A Facile One-Carbon Homologation of Aryl Aldehydes to Amides
2002