Standout Papers
Citation Impact
Citing Papers
Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria
2009
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
2009 StandoutNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
2010
Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β
2015
Asc and Ipaf Inflammasomes Direct Distinct Pathways for Caspase-1 Activation in Response to Legionella pneumophila
2009
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
2010
Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia
2010
Cutting Edge: Inflammasome Activation by Alum and Alum’s Adjuvant Effect Are Mediated by NLRP3
2008
Anti-Inflammatory Activity of PYNOD and Its Mechanism in Humans and Mice
2010
COPs and POPs: Modulators of Inflammasome Activity
2007
Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome
2008
Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain
2009
ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages
2006
Untangling the ErbB signalling network
2001 Standout
The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system
1998
Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes
2010
NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury
2009
The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge
2014
CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells
2015
The role of the inflammasome in cellular responses to toxins and bacterial effectors
2007
Structure and function of the spleen
2005 Standout
Caspase‐1‐induced pyroptotic cell death
2011
IKKα negatively regulates ASC-dependent inflammasome activation
2014
Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis
2009
Gout-associated uric acid crystals activate the NALP3 inflammasome
2006 StandoutNature
Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation
2014
Correction of the TNF‐LTα‐Deficient Phenotype by Bone Marrow Transplantation
1997
Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation
2013
ASC is essential for LPS‐induced activation of procaspase‐1 independently of TLR‐associated signal adaptor molecules
2004
Pannexin-1 Couples to Maitotoxin- and Nigericin-induced Interleukin-1β Release through a Dye Uptake-independent Pathway
2006
Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages
2007
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production
2009
Marginal-zone B cells
2002
The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation
1995 Standout
Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms
2011
Emerging inflammasome effector mechanisms
2011
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
2006 Nature
Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer
2015
Cryopyrin and pyrin activate caspase-1, but not NF-κB, via ASC oligomerization
2005
Cryopyrin activates the inflammasome in response to toxins and ATP
2006 StandoutNature
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
2011 Standout
Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome
2011
Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System
2009
A role for mitochondria in NLRP3 inflammasome activation
2010 StandoutNature
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
2010
TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system
2007
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages
2006
Activation and regulation of the inflammasomes
2013 Standout
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
2013
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1
2006
Inflammatory caspases and inflammasomes: master switches of inflammation
2006
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
2015
Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization
2012
An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages
2012
Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation
2005
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
2008 Standout
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases
2014 Nature
The inflammasome: a danger sensing complex triggering innate immunity
2007
Phosphorylation of NLRC4 is critical for inflammasome activation
2012 Nature
Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases
2010
The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease
2015
Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal
2009
Blood Dendritic Cells Interact with Splenic Marginal Zone B Cells to Initiate T-Independent Immune Responses
2002
A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses
2007
Chemical probing reveals insights into the signaling mechanism of inflammasome activation
2010
Injection of Flagellin into the Host Cell Cytosol by Salmonella enterica Serotype Typhimurium
2007
Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements
1999
Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
2003
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo
2012 Nature
Rescue of the Cardiac Defect in ErbB2 Mutant Mice Reveals Essential Roles of ErbB2 in Peripheral Nervous System Development
1999
Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling
2007
Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity
2006
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Caspase Functions in Cell Death and Disease
2013 Standout
Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity
2012
Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor
2006 Standout
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
2006
Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages
2006
K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
2013 Standout
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation
2014
TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria
2012
Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenes
2010
Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation
2015
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
2007
Inflammasomes: mechanism of assembly, regulation and signalling
2016 Standout
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
2006
Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
2008
Non-canonical inflammasome activation targets caspase-11
2011 StandoutNature
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
2008 Nature
NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer
2000 Standout
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
2011 Nature
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
2012 Nature
Pyroptosis: host cell death and inflammation
2009 Standout
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
2009 Standout
Microbial Pathogen-Induced Necrotic Cell Death Mediated by the Inflammasome Components CIAS1/Cryopyrin/NLRP3 and ASC
2007
Active Caspase-1 Is a Regulator of Unconventional Protein Secretion
2008
Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome
2004
The Inflammasomes
2010 Standout
Mechanisms and Functions of Inflammasomes
2014 Standout
Function of Nod‐like receptors in microbial recognition and host defense
2008
Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme
2011
The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes
2007
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases
2009
A Dominant Complement Fixation Pathway for Pneumococcal Polysaccharides Initiated by SIGN-R1 Interacting with C1q
2006 StandoutNobel
Newly described pattern recognition receptors team up against intracellular pathogens
2013
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt
2015
Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation
2007
Cell Volume Regulation Modulates NLRP3 Inflammasome Activation
2012
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection
2006
The TNF and TNF Receptor Superfamilies
2001 Standout
Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits
2011
Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol
2013
Shigella Type III Secretion Protein MxiI Is Recognized by Naip2 to Induce Nlrc4 Inflammasome Activation Independently of Pkcδ
2014
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response
2014
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
2010
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
2007
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
2009 Nature
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
2011
Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria
2007
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
2002
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Pathogen Recognition and Innate Immunity
2006 Standout
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
2008 Nature
Molecules and mechanisms operating in septic shock: lessons from knockout mice
1997
Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing
2010
Inflammasomes in health and disease
2012 StandoutNature
Regulation of the Antimicrobial Response by NLR Proteins
2011
War and peace at mucosal surfaces
2004
TNFRSF1A mutations and autoinflammatory syndromes
2000
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf
2006
Neuregulin-1 and Human Epidermal Growth Factor Receptors 2 and 3 Play a Role in Human Lung Development In Vitro
2000
Basic Calcium Phosphate Crystals Induce Monocyte/Macrophage IL-1β Secretion through the NLRP3 Inflammasome In Vitro
2011
Cellular Pyrin Domain-Only Protein 2 Is a Candidate Regulator of Inflammasome Activation
2006
Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase
1999
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
2002 StandoutNobel
Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome
2007
The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
2011
GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals
2012 Science
Tumor Necrosis Factor Sustains the Generalized Lymphoproliferative Disorder ( gld ) Phenotype
2000
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
2010
NLRP3 recruitment by NLRC4 during Salmonella infection
2016
The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide ofStreptococcus pneumoniaein the marginal zone of mouse spleen
2003 StandoutNobel
Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella
2010
NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease
2008
Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function
2014
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
2011 StandoutNobel
Two distinctive pathways for recruitment of naïve and primed IgM+B cells to the gut lamina propria
2005 StandoutNobel
Caspase-11 Protects Against Bacteria That Escape the Vacuole
2013 Science
Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice
1997
Functional mapping of disease susceptibility loci using cell biology
2006 StandoutNobel
Distinct Roles of Lymphotoxin α and the Type I Tumor Necrosis Factor (TNF) Receptor in the Establishment of Follicular Dendritic Cells from Non–Bone Marrow–derived Cells
1997
Intracellular sensing of microbes and danger signals by the inflammasomes
2011
Multiple Roles of CLAN (Caspase-Associated Recruitment Domain, Leucine-Rich Repeat, and NAIP CIIA HET-E, and TP1-Containing Protein) in the Mammalian Innate Immune Response
2004
NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
2007
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
The Nalp3 inflammasome is essential for the development of silicosis
2008
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
The Inflammasomes: Guardians of the Body
2009 Standout
Apoptosis, Pyroptosis, and Necrosis: Mechanistic Description of Dead and Dying Eukaryotic Cells
2005 Standout
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome
2007
Inflammasomes and Their Roles in Health and Disease
2012
DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES
1999
A NOD2–NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide
2008
The IL-1–Dependent Sterile Inflammatory Response Has a Substantial Caspase-1–Independent Component That Requires Cathepsin C
2012
Pseudomonas aeruginosa activates caspase 1 through Ipaf
2008
Epiregulin Is Not Essential for Development of Intestinal Tumors but Is Required for Protection from Intestinal Damage
2004
Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection
2006
Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development
2012 StandoutNobel
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
2010 StandoutNobel
Recognition of Bacteria by Inflammasomes
2012
Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages
2007
TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
1999
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
2009
Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation
2011
Pyrin Critical to Macrophage IL-1β Response to Francisella Challenge
2009
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
2010
Antibody to Langerin/CD207 localizes large numbers of CD8α + dendritic cells to the marginal zone of mouse spleen
2009 StandoutNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Sharon Erickson being referenced
Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks
2000
Activation and accumulation of B cells in TACI-deficient mice
2001
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
2004 StandoutNature
Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice
1994 Nature
Impaired c-Jun Amino Terminal Kinase Activity and T Cell Differentiation in Death Receptor 6–deficient Mice
2001
ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2- and heregulin-deficient mice
1997