Citation Impact
Citing Papers
TRPA1 acts as a cold sensor in vitro and in vivo
2009
Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli
2009
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity
2003 StandoutScienceNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
General anesthetics activate a nociceptive ion channel to enhance pain and inflammation
2008
Control of excitatory synaptic transmission by capsaicin is unaltered in TRPV1 vanilloid receptor knockout mice
2007
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
2003 StandoutNobel
Heat hyperalgesia after incision requires TRPV1 and is distinct from pure inflammatory pain
2005
Nociceptors: a phylogenetic view
2009
TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation
2006
Lessons from peppers and peppermint: the molecular logic of thermosensation
2003 StandoutNobel
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Oleoylethanolamide excites vagal sensory neurones, induces visceral pain and reduces short‐term food intake in mice via capsaicin receptor TRPV1
2005
p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia
2002
The diversity in the vanilloid (TRPV) receptor family of ion channels
2002
Regulation of nociceptive neurons by nerve growth factor and glial cell line derived neurotrophic factor
2002
NGF rapidly increases membrane expression of TRPV1 heat‐gated ion channels
2005
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Vagal Afferent Fibers and Peripheral 5-HT3 Receptors Mediate Cisplatin-Induced Emesis in Dogs
1992
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Attenuation of experimental arthritis in TRPV1R knockout mice
2006
Clinical evaluation of 5-HT3 receptor antagonists as anti-emetics
1991
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
Transient receptor potential ion channels as participants in thermosensation and thermoregulation
2006
The Vanilloid Receptor TRPV1 Is Tonically Activated In Vivo and Involved in Body Temperature Regulation
2007
More than cool: Promiscuous relationships of menthol and other sensory compounds
2006 StandoutNobel
Immunoreactive TRPV‐2 (VRL‐1), a capsaicin receptor homolog, in the spinal cord of the rat
2004 StandoutNobel
ThermoTRP channels and beyond: mechanisms of temperature sensation
2003 StandoutNobel
Activin Acutely Sensitizes Dorsal Root Ganglion Neurons and Induces Hyperalgesia via PKC-Mediated Potentiation of Transient Receptor Potential Vanilloid I
2007
The delta opioid receptor: an evolving target for the treatment of brain disorders
2011
2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3
2004
Opposite thermosensor in fruitfly and mouse
2003 StandoutNatureNobel
Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain
2006
Piezo2 is required for Merkel-cell mechanotransduction
2014 StandoutNatureNobel
[3H]Resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution
2003
Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice
2005
Vanilloid receptor-1 (TRPV1)-dependent activation of inhibitory neurotransmission in spinal substantia gelatinosa neurons of mouse
2007
Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy
2007
Structure–functional intimacies of transient receptor potential channels
2009
Deletion of vanilloid receptor 1_expressing primary afferent neurons for pain control
2004
Roles of Substance P and NK1 Receptor in the Brainstem in the Development of Emesis
2003
Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators
2008
Targeting TRP channels for pain relief
2013
Transient receptor potential channels: targeting pain at the source
2008 StandoutNobel
Thermoreceptors and thermosensitive afferents
2009
Comparison of intracellular calcium signals evoked by heat and capsaicin in cultured rat dorsal root ganglion neurons and in a cell line expressing the rat vanilloid receptor, VR1
2001
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
2007 Standout
Biochemistry and pharmacology of endovanilloids
2007
Nociceptors Lacking TRPV1 and TRPV2 Have Normal Heat Responses
2004
Neurochemistry and neuropharmacology of emesis — the role of serotonin
2000
Receptor-targeting mechanisms of pain-causing toxins: How ow?
2012 StandoutNobel
Tonic Endovanilloid Facilitation of Glutamate Release in Brainstem Descending Antinociceptive Pathways
2007
TRPV channels as temperature sensors
2003
Neuronal TRP channels: thermometers, pathfinders and life-savers
2008
TRPV1 Receptors in the CNS Play a Key Role in Broad-Spectrum Analgesia of TRPV1 Antagonists
2006
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
Agonist Recognition Sites in the Cytosolic Tails of Vanilloid Receptor 1
2002
5-HT3 receptor antagonists in the prophylaxis of acute vomiting induced by moderately emetogenic chemotherapy—A randomised study
1993
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
2011 StandoutNatureNobel
Low‐threshold heat response antagonized by capsazepine in chick sensory neurons, which are capsaicin‐insensitive
2000
The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice
2006
Mechanisms of Disease: neuropathic pain—a clinical perspective
2006
Effects of TRPV1 receptor antagonists on stimulated iCGRP release from isolated skin of rats and TRPV1 mutant mice
2004
Double-blind, randomized comparison of the antiemetic efficacy of intravenous dolasetron mesylate and intravenous ondansetron in the prevention of acute cisplatin-induced emesis in patients with cancer. Dolasetron Comparative Chemotherapy-induced Emesis Prevention Group.
1996
Direct Phosphorylation of Capsaicin Receptor VR1 by Protein Kinase Cε and Identification of Two Target Serine Residues
2002
Methodological issues in antiemetic studies
1993
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
Treatment of nausea and vomiting: Gaps in our knowledge
2006
TRPV1
2014
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster
2005
Induction of vanilloid receptor channel activity by protein kinase C
2000 Nature
Chemotherapy-Induced Nausea and Vomiting
2008 Standout
Molecular basis of infrared detection by snakes
2010 StandoutNatureNobel
Extracellular Cations Sensitize and Gate Capsaicin Receptor TRPV1 Modulating Pain Signaling
2005
Altered Thermal Selection Behavior in Mice Lacking Transient Receptor Potential Vanilloid 4
2005
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
Temperature-dependent activation of recombinant rat vanilloid VR1 receptors expressed in HEK293 cells by capsaicin and anandamide
2001
The putative role of vanilloid receptor‐like protein‐1 in mediating high threshold noxious heat‐sensitivity in rat cultured primary sensory neurons
2002
Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide
2001
Uncoupling Proton Activation of Vanilloid Receptor TRPV1
2007
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
cAMP-Dependent Protein Kinase Regulates Desensitization of the Capsaicin Receptor (VR1) by Direct Phosphorylation
2002
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
2002 StandoutNatureNobel
Models and Mechanisms of Hyperalgesia and Allodynia
2009
Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain
2005
Phosphoinositide regulation of TRPV1 revisited
2015
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1‐directed internalization
2007
Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia
2001
A TRP Channel that Senses Cold Stimuli and Menthol
2002 StandoutNobel
Functional biology of the α2δ subunits of voltage-gated calcium channels
2007
Mechanosensation and pain
2004
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
TRPV channels as thermosensory receptors in epithelial cells
2005
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Central neurocircuitry associated with emesis
2001
A high‐threshold heat‐activated channel in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadolinium
2007
Intracellular Signaling in Primary Sensory Neurons and Persistent Pain
2008
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002 StandoutNobel
The menthol receptor TRPM8 is the principal detector of environmental cold
2007 StandoutNatureNobel
The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis
2005 StandoutNobel
Endovanilloids
2004
Overexpressed Transient Receptor Potential Vanilloid 3 Ion Channels in Skin Keratinocytes Modulate Pain Sensitivity via Prostaglandin E2
2008
Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1
2008
Anandamide-Evoked Activation of Vanilloid Receptor 1 Contributes to the Development of Bladder Hyperreflexia and Nociceptive Transmission to Spinal Dorsal Horn Neurons in Cystitis
2004
Warm Temperature-sensitive Transient Receptor Potential Vanilloid 4 (TRPV4) Plays an Essential Role in Thermal Hyperalgesia
2004
Sensing with TRP channels
2005
Thermosensation and pain
2004
Expression of capsaicin receptor immunoreactivity in human peripheral nervous system and in painful neuropathies
2006
TRPV1 Unlike TRPV2 Is Restricted to a Subset of Mechanically Insensitive Cutaneous Nociceptors Responding to Heat
2008
Structure of the δ-opioid receptor bound to naltrindole
2012 StandoutNatureNobel
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain
2010 StandoutNobel
Differential effects of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro
2009
Single‐channel properties of native and cloned rat vanilloid receptors
2002
Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells
2011 StandoutNobel
Selective Blockade of the Capsaicin Receptor TRPV1 Attenuates Bone Cancer Pain
2005 StandoutNobel
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
2006 StandoutNobel
Nociceptors—Noxious Stimulus Detectors
2007
TRPV3 is a temperature-sensitive vanilloid receptor-like protein
2002 Nature
The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans
2007
Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1
2002
Warm Temperatures Activate TRPV4 in Mouse 308 Keratinocytes
2003
The TRPV1/2/3 activator 2-aminoethoxydiphenyl borate sensitizes native nociceptive neurons to heat in wildtype but not TRPV1 deficient mice
2005
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
TRPV3 is a calcium-permeable temperature-sensitive cation channel
2002 Nature
Impaired Pressure Sensation in Mice Lacking TRPV4
2003
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
2001
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
2005
Contribution of TRPM8 Channels to Cold Transduction in Primary Sensory Neurons and Peripheral Nerve Terminals
2006
Nonthermal Activation of Transient Receptor Potential Vanilloid-1 Channels in Abdominal Viscera Tonically Inhibits Autonomic Cold-Defense Effectors
2007
The ligand that came from within
2001
Anandamide Excites Central Terminals of Dorsal Root Ganglion Neurons via Vanilloid Receptor-1 Activation
2001
A Role of TRPA1 in Mechanical Hyperalgesia is Revealed by Pharmacological Inhibition
2007 StandoutNobel
Primary Structure And Functional Expression of the 5HT 3 Receptor, A Serotonin-gated Ion Channel
1991 StandoutScienceNobel
Molecular and Cellular Limits to Somatosensory Specificity
2008
The TRP Superfamily of Cation Channels
2005
Influence of TRPV1 on Diabetes-Induced Alterations in Thermal Pain Sensitivity
2008
TRP Channels and Pain
2013 StandoutNobel
Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels
2001
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
2005 StandoutScienceNobel
Recommendations for the Use of Antiemetics: Evidence-Based, Clinical Practice Guidelines
1999
Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels
2001
Hot Receptors in the Brain
2006
AN INTRODUCTION TO TRP CHANNELS
2005 Standout
The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway
2001 StandoutNobel
TRP ION CHANNELS AND TEMPERATURE SENSATION
2006 StandoutNobel
Inflammatory mediators and modulators of pain
2006
Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia
2001
Prostaglandin and Protein Kinase A-Dependent Modulation of Vanilloid Receptor Function by Metabotropic Glutamate Receptor 5: Potential Mechanism for Thermal Hyperalgesia
2002
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
2002 StandoutScienceNobel
TRP Channels
2007 Standout
Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation
2005
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Ca2+ Regulation of TRP Ion Channels
2018
Works of Sharon Bingham being referenced
The neuropharmacology of loperamide-induced emesis in the ferret: The role of the area postrema, vagus, opiate and 5-HT3 receptors
1992
Dorsal root ganglion neurons show increased expression of the calcium channel α2δ-1 subunit following partial sciatic nerve injury
2001
Inhibition of Inflammation-Induced Thermal Hypersensitivity by Sumatriptan through Activation of 5-HT1B/1D Receptors
2001
Morphine 6‐glucuronide: a metabolite of morphine with greater emetic potency than morphine in the ferret
1992
Determination of changes in mRNA expression in a rat model of neuropathic pain by Taqman™ quantitative RT-PCR
2001
The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity
1990
Allodynia in rats infected with varicella zoster virus—a small animal model for post-herpetic neuralgia
2004
Carrageenan-induced thermal hyperalgesia in the mouse: role of nerve growth factor and the mitogen-activated protein kinase pathway
2000
Evidence for a Selective Role of the δ-Opioid Agonist [8 R-(4b S*,8aα,8aβ,12bβ)]7,10-Dimethyl-1-methoxy-11-(2-methylpropyl)oxycarbonyl 5,6,7,8,12,12b-hexahydro-(9 H)-4,8-methanobenzofuro[3,2-e]pyrrolo[2,3-g]isoquinoline Hydrochloride (SB-235863) in Blocking Hyperalgesia Associated with Inflammatory and Neuropathic Pain Responses
2003
Are all 5-HT3 receptor antagonists the same?
1992
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
2000 StandoutNature