Citation Impact
Citing Papers
p50 Nuclear Factor-κB Overexpression in Tumor-Associated Macrophages Inhibits M1 Inflammatory Responses and Antitumor Resistance
2006
Tumor Necrosis Factor-α Promotes Malignant Pleural Effusion
2007
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
CD4+CD25+ Regulatory Lymphocytes Induce Regression of Intestinal Tumors in ApcMin/+ Mice
2005
Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production
2007 StandoutScience
Hallmarks of Cancer: The Next Generation
2011 Standout
Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells
2008
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34
1999
Culprits in the degradation of cyclin E apprehended
1999
A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF- B and enhanced IRF-3/STAT1 activation)
2005
NEDD8 recruits E2-ubiquitin to SCF E3 ligase
2001
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
2004 Standout
Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation
2010
Cancer chemoprevention with dietary phytochemicals
2003 Standout
Altered macrophage differentiation and immune dysfunction in tumor development
2007
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Role of tumor-associated macrophages in tumor progression and invasion
2006
U Box Proteins as a New Family of Ubiquitin-Protein Ligases
2001
The I B Kinase: A Master Regulator of NF- B, Innate Immunity, and Epidermal Differentiation
1999
Harnessing the Ubiquitination Machinery to Target the Degradation of Specific Cellular Proteins
2000
The tumor-promoting actions of TNF-α involve TNFR1 and IL-17 in ovarian cancer in mice and humans
2009
SCFbeta-TrCP ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase
2000
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
2001 Nature
The hPLIC Proteins May Provide a Link between the Ubiquitination Machinery and the Proteasome
2000
The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell
1999
TLR4 enhances TGF-β signaling and hepatic fibrosis
2007 Standout
Wnt/β-Catenin Signaling Induces the Expression and Activity of βTrCP Ubiquitin Ligase Receptor
2000
Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast
2000
Smoldering and polarized inflammation in the initiation and promotion of malignant disease
2005 Standout
A cytokine-mediated link between innate immunity, inflammation, and cancer
2007 Standout
IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis
2005
β-TrCP Mediates the Signal-induced Ubiquitination of IκBβ
1999
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases
2000
Pseudosubstrate regulation of the SCF β-TrCP ubiquitin ligase by hnRNP-U
2002
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Inducible Degradation of IκBα by the Proteasome Requires Interaction with the F-box Protein h-βTrCP
1999
Recruitment of a ROC1–CUL1 Ubiquitin Ligase by Skp1 and HOS to Catalyze the Ubiquitination of IκBα
1999
Homodimer of Two F-box Proteins βTrCP1 or βTrCP2 Binds to IκBα for Signal-dependent Ubiquitination
2000
Identification of the Ubiquitin Carrier Proteins, E2s, Involved in Signal-induced Conjugation and Subsequent Degradation of IκBα
1999 StandoutNobel
Substrate Targeting in the Ubiquitin System
1999
The cytoprotective role of the Keap1–Nrf2 pathway
2011
Control of Meiotic and Mitotic Progression by the F Box Protein β-Trcp1 In Vivo
2003
Nuclear factor-κB in cancer development and progression
2006 StandoutNature
IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy
2005 Standout
The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro
1999
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
2009
Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors
2009
HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IκB and β-catenin
1999
Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression
2006
Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma
2007
Differential interaction of plakoglobin and β-catenin with the ubiquitin-proteasome system
2000 StandoutNobel
Immunity, Inflammation, and Cancer
2010 Standout
Regulatory functions of ubiquitination in the immune system
2002
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
Expression of activation-induced cytidine deaminase in human hepatocytes via NF-κB signaling
2007 StandoutNobel
NF-κB regulation in the immune system
2002 Standout
NF-kappa B p105 is a target of Ikappa B kinases and controls signal induction of Bcl-3-p50 complexes
1999
STATs in cancer inflammation and immunity: a leading role for STAT3
2009 Standout
Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture
2018
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
2009 Standout
Oncogenic aberrations of cullin-dependent ubiquitin ligases
2004
Direct Phosphorylation of NF-κB1 p105 by the IκB Kinase Complex on Serine 927 Is Essential for Signal-induced p105 Proteolysis
2001
Paradoxical roles of the immune system during cancer development
2006 Standout
Is NF-κB a good target for cancer therapy? Hopes and pitfalls
2008
Inflammation and Cancer: Is the Link as Simple as We Think?
2005
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
Ubiquitin-like proteins: new wines in new bottles
2000
Ubiquitin signalling in the NF-κB pathway
2005
Signaling to NF-κB
2004 Standout
Structure of a β-TrCP1-Skp1-β-Catenin Complex
2003
NF-κB: a key role in inflammatory diseases
2001 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
1999 StandoutNobel
The NF-κB Activation Pathway:A Paradigm in Information Transfer from Membrane to Nucleus
1999
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin
1999
Tumour necrosis factor and cancer
2009
Overexpressed Id‐1 is associated with a high risk of hepatocellular carcinoma development in patients with cirrhosis without transcriptional repression of p16
2005
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
2006 Standout
Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver
2007 Nature
E3 ubiquitin ligases as T cell anergy factors
2004
Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1
1999 StandoutNobel
The Role of Autophagy in Alpha-1-Antitrypsin Deficiency: A Specific Cellular Response in Genetic Diseases Associated with Aggregation-Prone Proteins
2006
A ubiquitin ligase complex essential for the NF-kappa B, Wnt/Wingless, and Hedgehog signaling pathways
1999
Cancer-related inflammation
2008 StandoutNature
Multiple Wnt Signaling Pathways Converge to Orient the Mitotic Spindle in Early C. elegans Embryos
2004
ROC1, a Homolog of APC11, Represents a Family of Cullin Partners with an Associated Ubiquitin Ligase Activity
1999
Phosphoserine/threonine-binding domains
2001
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Analysis of Domains in the IKKα and IKKβ Proteins That Regulate Their Kinase Activity
2000
The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions
2006
NF‐κB and cancer: Mechanisms and targets
2006
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
2005
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
2009 Standout
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Cancer related inflammation: The macrophage connection
2008
Modes of regulation of ubiquitin-mediated protein degradation
2000 StandoutNobel
Fen1 mutations result in autoimmunity, chronic inflammation and cancers
2007
Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice
2008
NF-κB: linking inflammation and immunity to cancer development and progression
2005 Standout
The Inflammatory Cytokine Tumor Necrosis Factor-α Generates an Autocrine Tumor-Promoting Network in Epithelial Ovarian Cancer Cells
2007
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
2006 StandoutScience
β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation
1999
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene
2005
Ovarian cancer cell–derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis
2007 Standout
The Inflammatory Cytokine Tumor Necrosis Factor-α Regulates Chemokine Receptor Expression on Ovarian Cancer Cells
2005
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase Complex
2000
A Nedd8 conjugation pathway is essential for proteolytic targeting of p27 Kip1 by ubiquitination
2000
SCF and Cullin/RING H2-Based Ubiquitin Ligases
1999
TNF-α inhibits asbestos-induced cytotoxicity via a NF-κB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis
2006
“Re-educating” tumor-associated macrophages by targeting NF-κB
2008
IFNγ-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice
2006
ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCFβTrCPUbiquitin Ligase
2001
The APC11 RING-H2 Finger Mediates E2-Dependent Ubiquitination
2000
Nedd8 Modification of Cul-1 Activates SCFβTrCP-Dependent Ubiquitination of IκBα
2000
The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1
2000
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
2004 StandoutNobel
Mechanisms Underlying Ubiquitination
2001 Standout
Shared Pathways of IκB Kinase-Induced SCFβTrCP-Mediated Ubiquitination and Degradation for the NF-κB Precursor p105 and IκBα
2001
Ubiquitin-mediated proteolysis: biological regulation via destruction
2000 StandoutNobel
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Ovarian Cancer Cells Polarize Macrophages Toward A Tumor-Associated Phenotype
2006
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
2007 Standout
Prophase Destruction of Emi1 by the SCFβTrCP/Slimb Ubiquitin Ligase Activates the Anaphase Promoting Complex to Allow Progression beyond Prometaphase
2003
The ubiquitin ligase Hyperplastic discs negatively regulateshedgehoganddecapentaplegicexpression by independent mechanisms
2002
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation
2006
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Degradation of the Transcription Factor Gcn4 Requires the Kinase Pho85 and the SCFCDC4Ubiquitin–Ligase Complex
2000
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells
2001 StandoutNobel
IκBα Ubiquitination Is Catalyzed by an SCF-like Complex Containing Skp1, Cullin-1, and Two F-Box/WD40-Repeat Proteins, βTrCP1 and βTrCP2
1999
Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer
2005 Standout
The Zinc Finger Domain of NEMO Is Selectively Required for NF-κB Activation by UV Radiation and Topoisomerase Inhibitors
2002
Structural Motifs Involved in Ubiquitin-Mediated Processing of the NF-κB Precursor p105: Roles of the Glycine-Rich Region and a Downstream Ubiquitination Domain
1999 StandoutNobel
An infernal triangle
2007 Nature
Macrophages Induce Invasiveness of Epithelial Cancer Cells Via NF-κB and JNK
2005
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity
2000 Standout
Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation
2001 Standout
Increased Susceptibility to Colitis-Associated Cancer of Mice Lacking TIR8, an Inhibitory Member of the Interleukin-1 Receptor Family
2007
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
βTrCP-Mediated Proteolysis of NF-κB1 p105 Requires Phosphorylation of p105 Serines 927 and 932
2002
Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe
2009
Dual Roles for Immunity in Gastrointestinal Cancers
2010
Impaired degradation of inhibitory subunit of NF-κB (IκB) and β-catenin as a result of targeted disruption of the β- TrCP1 gene
2003
Tumor-Driven Evolution of Immunosuppressive Networks during Malignant Progression
2006
Works of Sharon Amit being referenced
High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-κB activation
2000
NF-κB activation in cancer: a challenge for ubiquitination- and proteasome-based therapeutic approach
2003
NF-κB functions as a tumour promoter in inflammation-associated cancer
2004 StandoutNature
Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway
2002
Identification of the receptor component of the IκBα–ubiquitin ligase
1998 Nature